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Cytokines alter glucocorticoid receptor phosphorylation in airway cells: role of phosphatases.

Belaid Bouazza et al.

American journal of respiratory cell and molecular biology, 47(4), 464-473 (2012-05-18)

Corticosteroid insensitivity (CSI) represents a profound challenge in managing patients with asthma. We recently demonstrated that short exposure of airway smooth muscle cells (ASMCs) to proasthmatic cytokines drastically reduced their responsiveness to glucocorticoids (GCs), an effect that was partially mediated

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