212-202-8 | Sigma-Aldrich

Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease.

Fei Liu et al.

The Journal of biological chemistry, 280(3), 1790-1796 (2004-11-18)

Protein phosphatase (PP) 5 is highly expressed in the mammalian brain, but few physiological substrates have yet been identified. Here, we investigated the kinetics of dephosphoryation of phospho-tau by PP5 and found that PP5 had a K(m) of 8-13 microm

Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease.

Fei Liu et al.

The Journal of biological chemistry, 280(3), 1790-1796 (2004-11-18)

Protein phosphatase (PP) 5 is highly expressed in the mammalian brain, but few physiological substrates have yet been identified. Here, we investigated the kinetics of dephosphoryation of phospho-tau by PP5 and found that PP5 had a K(m) of 8-13 microm

Neurodegeneration in heterozygous Niemann-Pick type C1 (NPC1) mouse: implication of heterozygous NPC1 mutations being a risk for tauopathy.

Wenxin Yu et al.

The Journal of biological chemistry, 280(29), 27296-27302 (2005-05-28)

Niemann-Pick type C1 (NPC1) disease is an autosomal recessive, fatal disorder characterized by a defect in cholesterol trafficking and progressive neurodegeneration. The disease is predominantly caused by mutations in the NPC1 gene; however, it has been assumed that heterozygous NPC1