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Showing 31-60 of 89 results for "220051" within Papers
Noriyasu Hada et al.
Carbohydrate research, 343(13), 2315-2324 (2008-06-07)
Novel neutral glycosphingolipids (NGSLs) containing Gal-alpha1-->6Gal, previously found in the Zygomycetes species Mucor hiemalis, were synthesized. The structures of these compounds are different from those of other fungal GSLs, and they are expected to be involved in host-parasite interactions. A
Juan Pablo Nicola et al.
The Journal of clinical endocrinology and metabolism, 100(10), E1353-E1361 (2015-07-24)
Iodide (I(-)), an essential constituent of the thyroid hormones, is actively accumulated in the thyroid by the Na(+)/I(-) symporter (NIS), a key plasma membrane protein encoded by the slc5a5 gene. Mutations in slc5a5 cause I(-) transport defects (ITDs), autosomal-recessive disorders
Shuo Shi et al.
PloS one, 10(1), e0116531-e0116531 (2015-01-27)
Despite recent improvements in the survival rates for nasopharyngeal carcinoma (NPC), novel treatment strategies are required to improve distant metastasis-free survival. The sodium iodine symporter (NIS) gene has been applied for in vivo imaging and cancer therapy. In this study
Hakim Bouamar et al.
Molecular and cellular biology, 35(8), 1329-1340 (2015-02-04)
In biological processes, the balance between positive and negative inputs is critical for an effective physiological response and to prevent disease. A case in point is the germinal center (GC) reaction, wherein high mutational and proliferation rates are accompanied by
Yuxin Qian et al.
The Journal of organic chemistry, 77(1), 96-107 (2011-12-07)
A novel class of 1-C-arylglycals was developed and subjected to N-iodosuccinimide-mediated glycosylations with alcohols. Unexpectedly, all reactions provided 2-iodo-β-D-ketopyranosides in high yields and excellent stereoselectivity. After removal of the 2-iodide by radical conditions, the aryl group was smoothly oxidized to
H Lee et al.
Mucosal immunology, 8(5), 1083-1098 (2015-02-12)
Intranasal (i.n.) vaccination generates immunity across local, regional, and distant sites. However, nasal dendritic cells (DCs), pivotal for the induction of i.n. vaccine-induced immune responses, have not been studied in detail. Here, by using a variety of parameters, we define
Xiaoyun Dai et al.
Molecular oncology, 9(4), 818-833 (2015-01-28)
Deregulated activation of oncogenic transcription factors such as signal transducer and activator of transcription 3 (STAT3) plays a pivotal role in proliferation and survival of hepatocellular carcinoma (HCC). Thus, agents which can inhibit STAT3 activation may have an enormous potential
Development of GSK's reagent guides ? embedding sustainability into reagent selection
Adams JP, et al.
Green Chemistry, 15, 220051-220051 (2013)
Chen Yao et al.
Oncology reports, 34(1), 59-66 (2015-05-09)
Since the sodium/iodide symporter (NIS) stimulates the iodine uptake in normal lactating breast, our study aimed to study the effect of NIS-mediated radioiodide therapy on ER-negative breast cancers. A recombinant lentivirus plasmid encoding the human NIS (hNIS) gene and firefly
Françoise I Bussière et al.
PloS one, 10(2), e0116509-e0116509 (2015-02-18)
E. tenella infection is associated with a severe intestinal disease leading to high economic losses in poultry industry. Mitogen activated protein kinases (MAPKs) are implicated in early response to infection and are divided in three pathways: p38, extracellular signal-regulated protein
Benjamin T Kopp et al.
Pediatric pulmonology, 50(8), 754-762 (2015-04-01)
Emerging evidence suggests that the prevalence of pathogens common in cystic fibrosis (CF) may be unevenly distributed across the United States (U.S.). However, very little is known regarding the U.S. distribution of other CF modifiers such as medication usage and
Vikas Singh et al.
The American journal of cardiology, 115(10), 1357-1366 (2015-04-01)
Despite the valuable role of intravascular ultrasound (IVUS) guidance in percutaneous coronary interventions (PCIs), its impact on clinical outcomes remains debatable. The aim of the present study was to compare the outcomes of PCIs guided by IVUS versus angiography in
Michael W Hornung et al.
Toxicological sciences : an official journal of the Society of Toxicology, 146(2), 254-264 (2015-05-09)
As in vitro assays are increasingly used to screen chemicals for their potential to produce endocrine disrupting adverse effects, it is important to understand their predictive capacity. The potential for a set of 6 benzothiazoles to affect endpoints related to thyroid
Stephen W Waldo et al.
Journal of the American College of Cardiology, 65(11), 1119-1126 (2015-03-21)
Public reporting of procedural outcomes may create disincentives to provide percutaneous coronary intervention (PCI) for critically ill patients. This study evaluated the association between public reporting with procedural management and outcomes among patients with acute myocardial infarction (AMI). Using the
B Šošić-Jurjević et al.
Experimental gerontology, 72, 85-98 (2015-09-19)
We previously reported that orchidectomy (Orx) of middle-aged rats (15-16-month-old; MA) slightly affected pituitary-thyroid axis, but decreased liver deiodinase (Dio) type 1 and pituitary Dio2 enzyme activities. At present, we examined the effects of subsequent testosterone-propionate treatment (5mg/kg; Orx+T), and
Jasper Dinkelaar et al.
Carbohydrate research, 341(10), 1723-1729 (2006-04-06)
A variety of thioglycosides are chemoselectively hydrolyzed to the corresponding 1-hydroxy glycosides using equimolar amounts of NIS/TFA as promoter systems.
Timothy Wen et al.
World neurosurgery, 84(1), 58-68 (2015-03-04)
Hospital-acquired conditions (HACs) are defined by the Centers for Medicaid and Medicare Services (CMS) as preventable adverse events that do not qualify for reimbursement of resulting hospital costs. HACs have been employed as a metric for quality of patient care.
Mark C Dobish et al.
Journal of the American Chemical Society, 134(14), 6068-6071 (2012-04-03)
Highly enantioselective halolactonizations have been developed that employ a chiral proton catalyst-N-iodosuccinimide (NIS) reagent system in which the Brønsted acid is used at catalyst loadings as low as 1 mol %. An approach that modulates the achiral counterion (equimolar to
M José Cano et al.
The Journal of organic chemistry, 78(18), 9196-9204 (2013-08-30)
Treatment of o-allyl phenols with catalytic NIS-PPh3 affords the corresponding spirodihydrobenzofuran derivatives in high yield with high regio- and total stereoselectivity under mild conditions. These results were utilized to achieve the first total synthesis of the protein kinase C inhibitor
Kihong Lim et al.
Journal of immunological methods, 426, 120-127 (2015-09-08)
β2 integrins play critical roles in migration of immune cells and in the interaction with other cells, pathogens, and the extracellular matrix. Among the β2 integrins, Mac-1 (Macrophage antigen-1), composed of CD11b and CD18, is mainly expressed in innate immune
Michael A Nelson et al.
Analytical and bioanalytical chemistry, 407(28), 8557-8569 (2015-09-09)
Given the critical role of pure, organic compound primary reference standards used to characterize and certify chemical Certified Reference Materials (CRMs), it is essential that associated mass purity assessments be fit-for-purpose, represented by an appropriate uncertainty interval, and metrologically sound.
Yoshihiko Yamamoto et al.
Journal of the American Chemical Society, 128(25), 8336-8340 (2006-06-22)
Highly substituted iodobenzenes were efficiently and regioselectively synthesized from readily available 1,6-diynes via two-step process consisting of silver-catalyzed Csp-H iodination and subsequent ruthenium-catalyzed [2 + 2 + 2] cycloaddition of resultant iododiynes. Some of the obtained iodobenzenes were subjected to
Sarah Sorg et al.
Cancer letters, 356(2 Pt B), 491-495 (2014-10-12)
The aim of this study is to determine whether circulating epithelial cells (CEC) detected in patients with differentiated thyroid cancer (DTC) stem from the thyroid gland. CEC have been described to increase in patients with progressive cancer disease and thus
Liqiang Xie et al.
Aquatic toxicology (Amsterdam, Netherlands), 164, 16-22 (2015-04-22)
Recent studies have shown that cyanobacteria-derived microcystins (MCs) have the potential to disrupt endocrine systems. However, the effects of microcystin-RR (MC-RR) and their underlying mechanisms are poorly resolved in fish. In this study, MC-RR exposure through submersion caused serious developmental
Alejandro A Arriagada et al.
Endocrinology, 156(4), 1540-1551 (2015-01-17)
Na+/I- symporter (NIS) mediates iodide (I-) uptake in the thyroid gland, the first and rate-limiting step in the biosynthesis of the thyroid hormones. The expression and function of NIS in thyroid cells is mainly regulated by TSH and by the
Paula M T Ferreira et al.
Amino acids, 39(2), 499-513 (2010-03-03)
Several new beta,beta-dihalo and beta-halo-beta-substituted dehydroalanines and dehydrodipeptides were synthesized by reacting the corresponding dehydroamino acid derivative with a N-halosuccinimide or in the case of beta,beta-di-iododehydroalanines with iodine. The results obtained confirmed that the stereochemical outcome of the halogenation reaction
Miao Zhang et al.
PloS one, 10(7), e0133952-e0133952 (2015-08-01)
Our study aimed to demonstrate the feasibility of using the sodium/iodide symporter (NIS) to monitor vascular endothelial growth factor (VEGF165) expression in vivo. We constructed a recombinant lentivirus plasmid with the MLC-2v promoter driving the sodium/iodide symporter (NIS) reporter gene
Vishal Kumar Rajput et al.
The Journal of organic chemistry, 73(17), 6924-6927 (2008-08-05)
Concise synthesis of the glycone part (a pentasaccharide) of the anti-leishmanial triterpenoid saponin isolated from Maesa balansae is reported. A late-stage TEMPO-mediated oxidation of a primary hydroxyl group to carboxylic acid has been achieved under phase-transfer conditions. Glycosylations were performed
Valentina Marchesin et al.
The Journal of cell biology, 211(2), 339-358 (2015-10-28)
Invasion of cancer cells into collagen-rich extracellular matrix requires membrane-tethered membrane type 1-matrix metalloproteinase (MT1-MMP) as the key protease for collagen breakdown. Understanding how MT1-MMP is delivered to the surface of tumor cells is essential for cancer cell biology. In
Diane A Schwartz et al.
The journal of trauma and acute care surgery, 79(1), 15-21 (2015-06-20)
Health care providers are increasingly focused on cost containment. One potential target for cost containment is in-hospital management of acute cholecystitis. Ensuring cholecystectomy within 24 hours for cholecystitis could mitigate costs associated with longer hospitalizations. We sought to determine the
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