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Showing 31-60 of 89 results for "220051" within Papers
Yuxin Qian et al.
The Journal of organic chemistry, 77(1), 96-107 (2011-12-07)
A novel class of 1-C-arylglycals was developed and subjected to N-iodosuccinimide-mediated glycosylations with alcohols. Unexpectedly, all reactions provided 2-iodo-β-D-ketopyranosides in high yields and excellent stereoselectivity. After removal of the 2-iodide by radical conditions, the aryl group was smoothly oxidized to
Menstrual cycle distribution of uterine natural killer cells is altered in heavy menstrual bleeding.
Sourima Biswas Shivhare et al.
Journal of reproductive immunology, 112, 88-94 (2015-09-24)
Heavy menstrual bleeding (HMB) affects 30% of women of reproductive age and significantly interferes with quality of life. Altered endometrial vascular maturation has been reported in HMB and recurrent miscarriage, the latter associated with increased uterine natural killer (uNK) cell
Juan Zhang et al.
Organic & biomolecular chemistry, 10(46), 9237-9242 (2012-10-30)
A simple, efficient and practical copper-catalyzed aerobic oxidative synthesis of α-ketoamides from aryl methyl ketones, aliphatic amines and N-iodosuccinimide (NIS) has been developed. The one-pot reaction may proceed smoothly at room temperature in the open air. The possible mechanism for
Majed Afana et al.
Clinical cardiology, 38(1), 13-19 (2014-10-23)
Acute coronary syndromes account for half of all deaths secondary to cardiovascular disease and represent a significant economic burden in the United States. Therefore, assessing hospitalization costs relative to Medicare reimbursement for these patients is important in understanding the impact
Saumya Saurabh et al.
ACS nano, 8(11), 11138-11146 (2014-11-09)
While DNA-directed nanotechnology is now a well-established platform for bioinspired nanoscale assembly in vitro, the direct targeting of various nanomaterials in living biological systems remains a significant challenge. Hybrid biological systems with integrated and targeted nanomaterials may have interesting and
Juan Pablo Nicola et al.
The Journal of clinical endocrinology and metabolism, 100(10), E1353-E1361 (2015-07-24)
Iodide (I(-)), an essential constituent of the thyroid hormones, is actively accumulated in the thyroid by the Na(+)/I(-) symporter (NIS), a key plasma membrane protein encoded by the slc5a5 gene. Mutations in slc5a5 cause I(-) transport defects (ITDs), autosomal-recessive disorders
Noriyasu Hada et al.
Carbohydrate research, 343(13), 2315-2324 (2008-06-07)
Novel neutral glycosphingolipids (NGSLs) containing Gal-alpha1-->6Gal, previously found in the Zygomycetes species Mucor hiemalis, were synthesized. The structures of these compounds are different from those of other fungal GSLs, and they are expected to be involved in host-parasite interactions. A
Hakim Bouamar et al.
Molecular and cellular biology, 35(8), 1329-1340 (2015-02-04)
In biological processes, the balance between positive and negative inputs is critical for an effective physiological response and to prevent disease. A case in point is the germinal center (GC) reaction, wherein high mutational and proliferation rates are accompanied by
Shuo Shi et al.
PloS one, 10(1), e0116531-e0116531 (2015-01-27)
Despite recent improvements in the survival rates for nasopharyngeal carcinoma (NPC), novel treatment strategies are required to improve distant metastasis-free survival. The sodium iodine symporter (NIS) gene has been applied for in vivo imaging and cancer therapy. In this study
Adolfo Correa et al.
Maternal and child health journal, 19(3), 635-642 (2014-07-06)
To describe recent trends in prevalence of pre-existing diabetes mellitus (PDM) (i.e., type 1 or type 2 diabetes) and gestational diabetes mellitus (GDM) among delivery hospitalizations in the United States. Data on delivery hospitalizations from 1993 through 2009 were obtained
Volkmar Müller et al.
Oncology research and treatment, 37(12), 748-755 (2014-12-23)
This non-interventional surveillance study (NIS) collected data on the quality of life (QoL) of patients treated with capecitabine as mono- or combination chemotherapy in an outpatient setting. Capecitabine was administered orally for 14 days of each 21-day cycle. The main
Carsten-Endres Sowa et al.
Carbohydrate research, 346(12), 1546-1550 (2011-05-20)
After stereoselective addition of N-iodosuccinimide to glycals subsequent dehalogenation results in formation of N-glycopyranosyl succinimides. By UV irradiation both azepindiones and preferentially [5.3.1.0(2,6)] tricyclic oxalactams could be obtained. Their transformation into a number of novel sugar conjugates resembling some prominent
Marie-Therese Haider et al.
Bone, 81, 581-592 (2015-08-19)
Bone metastasis remains incurable with treatment restricted to palliative care. Cabozantinib (CBZ) is targeted against multiple receptor tyrosine kinases involved in tumour pathobiology, including hepatocyte growth factor receptor (MET) and vascular endothelial growth factor receptor 2 (VEGFR-2). CBZ has demonstrated
Ashish P Bharne et al.
Behavioural brain research, 291, 219-231 (2015-05-27)
Binge eating (BE) disrupts feeding and subverts reward mechanism. Since cocaine- and amphetamine-regulated transcript peptide (CART) mediates satiety as well as reward, its role in BE justifies investigation. To induce BE, rats were provided restricted access to high fat sweet
Samuel Luisier et al.
Nucleic acids symposium series (2004), (52)(52), 581-582 (2008-09-09)
The N-iodosuccinimide (NIS) induced nucleosidation of protected natural bases with bicyclo[3.3.0] sugar precursors was investigated. It was found that this method is particularly suited for the synthesis of N(1)-pyrimidine nucleosides and provides a selective entry into N(7)-purine nucleosides. This nucleosidation
Mohammed Shafik El-Ridy et al.
Drug delivery, 22(1), 21-36 (2013-12-24)
Tuberculosis (TB) is a worldwide health concern. In 2011, about 8.7 million new cases developed TB and 1.4 million people died from it. Enhancement of ethambutol hydrochloride activity and safety in treatment of TB through niosomal encapsulation. Niosomes were prepared
Gilles Moulay et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(7), 1211-1221 (2015-04-29)
Heart failure is a leading cause of morbidity and mortality, and cardiac gene delivery has the potential to provide novel therapeutic approaches. Adeno-associated virus serotype 9 (AAV9) transduces the rodent heart efficiently, but cardiotropism, immune tolerance, and optimal delivery strategies
Alejandro A Arriagada et al.
Endocrinology, 156(4), 1540-1551 (2015-01-17)
Na+/I- symporter (NIS) mediates iodide (I-) uptake in the thyroid gland, the first and rate-limiting step in the biosynthesis of the thyroid hormones. The expression and function of NIS in thyroid cells is mainly regulated by TSH and by the
Michael A Nelson et al.
Analytical and bioanalytical chemistry, 407(28), 8557-8569 (2015-09-09)
Given the critical role of pure, organic compound primary reference standards used to characterize and certify chemical Certified Reference Materials (CRMs), it is essential that associated mass purity assessments be fit-for-purpose, represented by an appropriate uncertainty interval, and metrologically sound.
Adil H Haider et al.
Annals of surgery, 262(2), 260-266 (2014-12-19)
To determine hospital costs and the adjusted risk of death associated with emergent versus elective surgery. Emergency surgery has a higher cost and worse outcomes compared with elective surgery. However, no national estimates of the excess burden of emergency surgery
Christian Schäfer et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 18(26), 8028-8031 (2012-06-08)
Ring out the old: The cycloisomerization of alkynyl silyl enol ethers proceeds at ambient temperature under the mild conditions of silver catalysis. Mono- or bicyclic spiro compounds can be obtained by 5-exo-dig reactions. Trapping the vinyl silver species with an
Delphine Solange Fontcha et al.
Journal of occupational and environmental medicine, 57(7), 814-826 (2015-07-07)
To describe the trends, correlates, and healthcare costs associated with industry-related injuries across the United States between 1998 and 2011. A retrospective, cross-sectional analysis of hospital discharges was conducted using the National Inpatient Sample. We used the International Classification of
Renate M van Well et al.
Carbohydrate research, 341(10), 1391-1397 (2006-05-16)
The stereochemical outcome of glycosylation reactions with model thioglycosides and selenoglycosides proved to be dependent on the source of promoter iodonium ion, with iodine giving different results to N-iodosuccinimide (NIS) alone or N-iodosuccinimide/trimethylsilyltrifluoromethanesulfonate (NIS/TMSOTf). In contrast to armed thioglycosides, which
Arunima Mukherjee et al.
Carbohydrate research, 346(12), 1569-1575 (2011-05-31)
Reactivity switching and selective activation of C-1 or C-3 in 2,3-unsaturated thioglycosides, namely, 2,3-dideoxy-1-thio-D-hex-2-enopyranosides are reported. The reactivity switching allowed activation of either C-1 or C-3, with the use of either N-iodosuccinimide (NIS)/triflic acid (TfOH) or TfOH alone. C-1 glycosylation
Paige S Katz et al.
Journal of neurotrauma, 32(5), 297-306 (2014-08-29)
Traumatic brain injury (TBI) is an increasingly frequent and poorly understood condition lacking effective therapeutic strategies. Inflammation and oxidative stress (OS) are critical components of injury, and targeted interventions to reduce their contribution to injury should improve neurobehavioral recovery and
Rachana Mishra et al.
Molecular neurobiology, 52(1), 719-733 (2014-10-05)
Children diagnosed with neuroblastomas often suffer from severe side as well as late effects of conventional treatments like chemotherapy and radiotherapy. Recent advances in understanding of molecular pathways involved in cellular differentiation and apoptosis have helped in the development of
Xiaoyi Xin et al.
The Journal of organic chemistry, 78(8), 4065-4074 (2013-03-12)
Metal-free cyclization and N-iodosuccinimide-induced electrophilic iodocyclization of readily available 3-aza-1,5-enynes have been developed. The reactions selectively give 1,2-dihydropyridines and 3-iodo-1,2-dihydropyridines involving an aza-Claisen rearrangement and a 6π-electrocyclization step. Furthermore, the reaction could be carried out in 10 g scale for
Zbigniew Adamczewski et al.
International journal of molecular sciences, 16(7), 14608-14622 (2015-07-02)
Administration of diagnostic activities of 131I, performed in order to detect thyroid remnants after surgery and/or thyroid cancer recurrence/metastases, may lead to reduction of iodine uptake. This phenomenon is called "thyroid stunning". We estimated radiation absorbed dose-dependent changes in genetic
Ah Ra Lee et al.
Nuclear medicine and biology, 42(7), 621-629 (2015-04-23)
In vivo tracking of the transplanted stem cells is important in pre-clinical research of stem cell therapy for myocardial infarction. We examined the feasibility of adenovirus-mediated sodium iodide symporter (NIS) gene to cell tracking imaging of transplanted stem cells in
Emad Mikhail et al.
American journal of obstetrics and gynecology, 213(5), 713-713 (2015-05-04)
We sought to investigate the most recent national trends of bilateral salpingectomy (BS) and bilateral salpingo-oophorectomy (BSO) at the time of hysterectomy performed for benign indications. We conducted a national cross-sectional analysis of all inpatient discharges for women aged ≥18
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