220116

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Showing 1-30 of 509 results for "220116" within Papers

(1)H NMR-based metabonomic investigation of the effect of two different exercise sessions on the metabolic fingerprint of human urine.

Alexandros Pechlivanis et al.

Journal of proteome research, 9(12), 6405-6416 (2010-10-12)

Physical exercise modifies animal metabolism profoundly. Until recently, biochemical investigations related to exercise focused on a small number of biomolecules. In the present study, we used a holistic analytical approach to investigate changes in the human urine metabolome elicited by

Formulation and evaluation of different floating tablets containing metronidazole to target stomach.

Zhiao C Loh et al.

Current drug delivery, 12(4), 425-443 (2015-05-01)

The purpose of this study is to formulate and develop tablets dosage form containing Metronidazole which has swelling and floating properties as a gastroretentive controlled-release drug delivery system to improve drug bioavailability. Fifteen different formulations of effervescence-forming floating systems were

Enantiomeric separation and discrimination of 2-hydroxy acids as O-trifluoroacetylated (S)-(+)-3-methyl-2-butyl esters by achiral dual-capillary column gas chromatography.

K R Kim et al.

Journal of chromatography. A, 874(1), 91-100 (2000-04-18)

An efficient method is described for the simultaneous enantiomeric separation of 18 different racemic 2-hydroxy acids for the determination of their absolute configurations. It involves the conversion of each enantiomer into a diastereomeric O-trifluoroacetylated (S)-(+)-3-methyl-2-butyl ester for the direct separation

Comparison of two FFPE preparation methods using label-free shotgun proteomics: Application to tissues of diverticulitis patients.

Florence Quesada-Calvo et al.

Journal of proteomics, 112, 250-261 (2014-09-15)

Formalin-fixed paraffin-embedded (FFPE) specimens of patients are useful sources of materials for clinical research and have recently gained interest for use in the discovery of clinical proteomic biomarkers. However, the critical step in this field is the ability to obtain

Efficacy of Sanitizer Treatments on Survival and Growth Parameters of Escherichia coli O157:H7, Salmonella, and Listeria monocytogenes on Fresh-Cut Pieces of Cantaloupe during Storage.

Dike O Ukuku et al.

Journal of food protection, 78(7), 1288-1295 (2015-07-22)

For health reasons, people are consuming fresh-cut fruits with or without minimal processing and, thereby, exposing themselves to the risk of foodborne illness if such fruits are contaminated with bacterial pathogens. This study investigated survival and growth parameters of Escherichia

Evaluation of nanohydroxyapatite-containing toothpaste for occluding dentin tubules.

Bennett T Amaechi et al.

American journal of dentistry, 28(1), 33-39 (2015-04-14)

To compare dentin tubule occlusion by dentifrices containing either nanohydroxyapatite (10%nHAP and 15%nHAP), sodium monofluorophosphate (Na-MFP) or NovaMin (NovaMin). All 80 participants wore four intraoral appliances bearing dentin blocks while using one of the four test dentifrices (n = 20/dentifrice)

In vivo and in vitro properties of STX2484: a novel non-steroidal anti-cancer compound active in taxane-resistant breast cancer.

C Stengel et al.

British journal of cancer, 111(2), 300-308 (2014-06-25)

STX2484 is a novel non-steroidal compound with potent anti-proliferative activity. These studies aimed to identify STX2484's mechanism of action, in vivo efficacy and activity in taxane-resistant breast cancer models. Effects of STX2484 and paclitaxel on proliferation, cell cycle and apoptosis

alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population.

Walter E Gall et al.

PloS one, 5(5), e10883-e10883 (2010-06-09)

Insulin resistance is a risk factor for type 2 diabetes and cardiovascular disease progression. Current diagnostic tests, such as glycemic indicators, have limitations in the early detection of insulin resistant individuals. We searched for novel biomarkers identifying these at-risk subjects.

Lumican deficiency results in cardiomyocyte hypertrophy with altered collagen assembly.

Loren E Dupuis et al.

Journal of molecular and cellular cardiology, 84, 70-80 (2015-04-19)

The ability of the heart to adapt to increased stress is dependent on the modification of its extracellular matrix (ECM) architecture that is established during postnatal development as cardiomyocytes differentiate, a process that is poorly understood. We hypothesized that the

Identification of the effective constituents for anti-inflammatory activity of Ju-Zhi-Jiang-Tang, an ancient traditional Chinese medicine formula.

Shufang Wang et al.

Journal of chromatography. A, 1348, 105-124 (2014-05-13)

The anti-inflammatory constituents of Ju-Zhi-Jiang-Tang (JZJT), a formula used for thousands of years in China, were identified by LC-MS and pharmacological activity evaluation. In this study, the whole extract of formula was separated into multiple components to facilitate the analytical

Reduction of aflatoxins (B₁, B₂, G₁, and G₂) in soybean-based model systems.

Jongin Lee et al.

Food chemistry, 189, 45-51 (2015-07-21)

The effects of chemical, physical, and cooking treatments on the reduction of aflatoxin B1 (AFB1), B2, G1, and G2 in soybean matrix were investigated. A HPLC-FLD with a Kobra cell system was used for the quantitative analysis of aflatoxins (AFs).

Temporal regulation of venous extracellular matrix components during arteriovenous fistula maturation.

Michael R Hall et al.

The journal of vascular access, 16(2), 93-106 (2014-09-30)

The venous limb of arteriovenous fistulae (AVF) adapts to the arterial environment by dilation and wall thickening; however, the temporal regulation of the expression of extracellular matrix (ECM) components in the venous limb of the maturing AVF has not been

Highly magneto-responsive multilayer microcapsules for controlled release of insulin.

Chunli Zheng et al.

International journal of pharmaceutics, 475(1-2), 17-24 (2014-08-28)

In this study, magneto-responsive polyelectrolyte multilayer microcapsules were successfully prepared by the formation of shell with biocompatible iron oxide nanoparticles (Fe₃O₄ NPs) and polyallylamine hydrochloride (PAH) by layer-by-layer (LbL) self-assembly technique. The self-assembled microcapsules were characterized by SEM, TEM and

The cough reflex is upregulated by lisinopril microinjected into the caudal nucleus tractus solitarii of the rabbit.

Elenia Cinelli et al.

Respiratory physiology & neurobiology, 219, 9-17 (2015-08-04)

We have previously shown that cough potentiation induced by intravenous administration of the AT1 receptor antagonist losartan is lower than that induced by the ACE inhibitor lisinopril in anesthetized and awake rabbits. Since losartan and lisinopril cross the blood-brain barrier

Effect of memantine on cough reflex sensitivity: translational studies in guinea pigs and humans.

Peter V Dicpinigaitis et al.

The Journal of pharmacology and experimental therapeutics, 352(3), 448-454 (2014-12-20)

Cough is the most common complaint for which outpatients in the United States seek medical attention, and yet available therapeutic options for cough lack proven efficacy and are further limited by safety and abuse liabilities. Thus, safe and effective cough

Purification and identification of Se-containing antioxidative peptides from enzymatic hydrolysates of Se-enriched brown rice protein.

Kunlun Liu et al.

Food chemistry, 187, 424-430 (2015-05-16)

As a further study of Se-containing proteins (Se-Pro) derived from Se-enriched brown rice (Se-BR), this paper aimed to purify and identify Se-containing antioxidative peptides (Se-antioxi-Peps) from Se-Pro hydrolysates. The total Se content in Se-BR was 6.26μg/g DW, and selenocystine, Se-methylselenocysteine

Simplagrin, a platelet aggregation inhibitor from Simulium nigrimanum salivary glands specifically binds to the Von Willebrand factor receptor in collagen and inhibits carotid thrombus formation in vivo.

Andrezza C Chagas et al.

PLoS neglected tropical diseases, 8(6), e2947-e2947 (2014-06-13)

Among the several challenges faced by bloodsucking arthropods, the vertebrate hemostatic response against blood loss represents an important barrier to efficient blood feeding. Here we report the first inhibitor of collagen-induced platelet aggregation derived from the salivary glands of a

Polymorphism and DNA methylation in the promoter modulate KISS1 gene expression and are associated with litter size in goats.

X P An et al.

Animal reproduction science, 155, 36-41 (2015-02-28)

Polymorphisms in the promoter region are likely to impact KISS1 gene transcription and reproductive traits. In this study, Guanzhong (GZ, n=350) and Boer (BE, n=196) goats were used to detect polymorphism in the promoter of the goat KISS1 gene by

Cr(VI) reduction by gluconolactone and hydrogen peroxide, the reaction products of fungal glucose oxidase: Cooperative interaction with organic acids in the biotransformation of Cr(VI).

Pamela Romo-Rodríguez et al.

Chemosphere, 134, 563-570 (2015-01-13)

The Cr(VI) reducing capability of growing cells of the environmental A. tubingensis Ed8 strain is remarkably efficient compared to reference strains A. niger FGSC322 and A. tubingensis NRRL593. Extracellular glucose oxidase (GOX) activity levels were clearly higher in colonies developed

Real-time UV imaging identifies the role of pH in insulin dissolution behavior in hydrogel-based subcutaneous tissue surrogate.

Sabrine S Jensen et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 69, 26-36 (2015-01-13)

For parenteral biopharmaceuticals, subcutaneous diffusion and, in the case of solid implants or suspensions, dissolution may govern the clinical profile of the drug product. Insight into the dissolution and diffusion processes of biopharmaceuticals after parenteral administration is fundamental in the

Hepatocellular heme oxygenase-1: a potential mechanism of erythropoietin-mediated protection after liver ischemia-reperfusion injury.

Kimberly J Riehle et al.

Shock (Augusta, Ga.), 42(5), 424-431 (2014-07-09)

Hepatic ischemia-reperfusion (IR) results in progressive injury; initiated by oxidative stress during ischemia and compounded by cytokine-mediated inflammation during reperfusion. Recovery requires strict regulation of these events. Recombinant human erythropoietin (rhEPO) is thought to mitigate hepatocellular IR injury by altering

Protein enrichment of an Opuntia ficus-indica cladode hydrolysate by cultivation of Candida utilis and Kluyveromyces marxianus.

Gabriel B Akanni et al.

Journal of the science of food and agriculture, 95(5), 1094-1102 (2014-11-06)

The cladodes of Opuntia ficus-indica (prickly pear cactus) have a low protein content; for use as a balanced feed, supplementation with other protein sources is therefore desirable. We investigated protein enrichment by cultivation of the yeasts Candida utilis and Kluyveromyces

Fragment ion diagnostic strategies for the comprehensive identification of chemical profile of Gui-Zhi-Tang by integrating high-resolution MS, multiple-stage MS and UV information.

Shufang Wang et al.

Journal of pharmaceutical and biomedical analysis, 98, 22-35 (2014-06-01)

Gui-Zhi-Tang was considered to be the most famous formula in Shang-Han-Lun, treating 32 symptoms of disease after adding up or cutting down crude drugs. The chemical constituents in Gui-Zhi-Tang were comprehensively studied by rapid resolution liquid chromatography quadrupole time-of-flight mass

Enhancing perception of contaminated food through acid-mediated modulation of taste neuron responses.

Yan Chen et al.

Current biology : CB, 24(17), 1969-1977 (2014-08-19)

Natural foods contain not only nutrients, but also nonnutritious and potentially harmful chemicals. Thus, animals need to evaluate food content in order to make adequate feeding decisions. Here, we investigate the effects of acids on the taste neuron responses and

3-O-galloylated procyanidins from Rumex acetosa L. inhibit the attachment of influenza A virus.

Andrea Derksen et al.

PloS one, 9(10), e110089-e110089 (2014-10-11)

Infections by influenza A viruses (IAV) are a major health burden to mankind. The current antiviral arsenal against IAV is limited and novel drugs are urgently required. Medicinal plants are known as an abundant source for bioactive compounds, including antiviral

Structural characteristics and physicochemical properties of lotus seed resistant starch prepared by different methods.

Shaoxiao Zeng et al.

Food chemistry, 186, 213-222 (2015-05-16)

Lotus seed resistant starch (LRS) is commonly known as resistant starch type 3 (LRS3). The objective of this study was to investigate the effect of different preparation methods on the structural characteristics and physicochemical properties of LRS3. The molar mass

In vivo characterization of the novel CD44v6-targeting Fab fragment AbD15179 for molecular imaging of squamous cell carcinoma: a dual-isotope study.

Anna-Karin Haylock et al.

EJNMMI research, 4(1), 11-11 (2014-03-07)

Patients with squamous cell carcinoma in the head and neck region (HNSCC) offer a diagnostic challenge due to difficulties to detect small tumours and metastases. Imaging methods available are not sufficient, and radio-immunodiagnostics could increase specificity and sensitivity of diagnostics.

Stability determination of the formulations containing hyaluronic acid.

A Olejnik et al.

International journal of cosmetic science, 37(4), 401-407 (2015-02-24)

The aim of this work was to investigate the long-term stability of four emulsions (creams and ointments) developed for carrying hyaluronic acid (HA) for dermal penetration. The stability of obtained formulations was analysed by multiple light scattering and laser diffraction

Mass spectrometry-based proteomic analysis of formalin-fixed paraffin-embedded extrahepatic cholangiocarcinoma.

Shimpei Maeda et al.

Journal of hepato-biliary-pancreatic sciences, 22(9), 683-691 (2015-04-29)

Extrahepatic cholangiocarcinoma is very difficult to diagnose at an early stage, and has a poor prognosis. Novel markers for diagnosis and optimal treatment selection are needed. However, there has been very limited data on the proteome profile of extrahepatic cholangiocarcinoma.

Characterization of antibiotic and disinfectant susceptibility profiles among Pseudomonas aeruginosa veterinary isolates recovered during 1994-2003.

R C Beier et al.

Journal of applied microbiology, 118(2), 326-342 (2014-11-29)

To evaluate susceptibility of Pseudomonas aeruginosa veterinary isolates to antibiotics and disinfectants. Pseudomonas aeruginosa isolates collected from dogs (n = 155) and other animals (n = 20) from sixteen states during 1994-2003 were tested for susceptibility. Most isolates were resistant

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