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Showing 1-30 of 48 results for "22790" within Papers
Tsuyoshi Fukushima et al.
Cell reports, 29(12), 4144-4158 (2019-12-19)
Quiescent hematopoietic stem cells (HSCs) are typically dormant, and only a few quiescent HSCs are active. The relationship between "dormant" and "active" HSCs remains unresolved. Here we generate a G0 marker (G0M) mouse line that visualizes quiescent cells and identify
Mohammed Shahid Ali et al.
Journal of AOAC International, 90(1), 82-93 (2007-03-22)
This paper presents a simple, specific, and precise high-performance liquid chromatographic method for the simultaneous determination of paracetamol (PCM), chlorzoxazone (CXZ), and their related impurities in bulk raw materials and solid dosage forms. The mobile phase consisted of water-methanol-glacial acetic
Tangali R Ravikumar Naik et al.
Preparative biochemistry & biotechnology, 38(1), 115-128 (2007-12-18)
With the aim of evaluating interaction between double-stranded calf thymus (ds)DNA and sulphur containing fused planar rings, the derivatives of 1,8-naphthyridine containing thiono groups were synthesized by the condensation of 2-mercapto-3-formyl[1,8]naphthyridines using 1-chloroacetone, 2-chloroacetamide, chloroaceticacid, and 2-chloro-1-phenylethanone in the presence
Anton Khmelinskii et al.
Nature, 516(7531), 410-413 (2014-12-19)
The nuclear envelope is a double membrane that separates the nucleus from the cytoplasm. The inner nuclear membrane (INM) functions in essential nuclear processes including chromatin organization and regulation of gene expression. The outer nuclear membrane is continuous with the
Nadia Efremova et al.
Plant molecular biology, 56(5), 821-837 (2005-04-02)
In Arabidopsis, loss of function of the epidermis-specific FDH gene coding for a putative beta-ketoacyl-CoA synthase results in ectopic organ fusions in mutants. Corresponding mutants are not available for Antirrhinum majus, however, organ fusions can be induced in both species
Charlotte P Choi et al.
eLife, 10 (2021-02-16)
Piwi-interacting RNAs (piRNAs) play essential roles in silencing repetitive elements to promote fertility in metazoans. Studies in worms, flies, and mammals reveal that piRNAs are expressed in a sex-specific manner. However, the mechanisms underlying this sex-specific regulation are unknown. Here
Daniel L Carlson et al.
Journal of agricultural and food chemistry, 54(13), 4740-4750 (2006-06-22)
Despite the prevalence of chloroacetamides as herbicides, little is known about the rates or products of acid- or base-catalyzed hydrolysis of these compounds. Mechanisms of acid-catalyzed reactions may parallel those catalyzed by (hydr)oxide minerals, while base-catalyzed processes have as important
Hector H Huang et al.
Nature communications, 11(1), 1931-1931 (2020-04-24)
Enhancing the efficacy of proteasome inhibitors (PI) is a central goal in myeloma therapy. We proposed that signaling-level responses after PI may reveal new mechanisms of action that can be therapeutically exploited. Unbiased phosphoproteomics after treatment with the PI carfilzomib surprisingly demonstrates
Active sensitization to chloracetamide.
A Fonia et al.
Contact dermatitis, 60(1), 58-59 (2009-01-08)
Christian Eckermann et al.
Phytochemistry, 64(6), 1045-1054 (2003-10-22)
Chloroacetamide herbicides inhibit very-long-chain fatty acid elongase, and it has been suggested that covalent binding to the active site cysteine of the condensing enzyme is responsible [Pest Manage Sci 56 (2000), 497], but direct evidence was not available. The proposal
Joel Selkrig et al.
Nature microbiology, 5(9), 1119-1133 (2020-06-10)
The interplay between host and pathogen relies heavily on rapid protein synthesis and accurate protein targeting to ensure pathogen destruction. To gain insight into this dynamic interface, we combined Click chemistry with pulsed stable isotope labelling of amino acids in
Bernd Matthes et al.
Zeitschrift fur Naturforschung. C, Journal of biosciences, 57(9-10), 843-852 (2002-11-21)
In the present study membrane fatty acids were analyzed to find a link between the biosynthesis inhibition of very-long-chain fatty acids and the phytotoxic effects of herbicidal chloroacetamides. Accordingly, we have isolated membranes of cucumber seedlings (Cucumis sativus) by two-phase
Richard S Marshall et al.
Cell, 177(3), 766-781 (2019-04-09)
During autophagy, vesicle dynamics and cargo recruitment are driven by numerous adaptors and receptors that become tethered to the phagophore through interactions with lipidated ATG8/LC3 decorating the expanding membrane. Most currently described ATG8-binding proteins exploit a well-defined ATG8-interacting motif (AIM
Agne Kazlauskaite et al.
EMBO reports, 16(8), 939-954 (2015-06-28)
Mutations in the mitochondrial protein kinase PINK1 are associated with autosomal recessive Parkinson disease (PD). We and other groups have reported that PINK1 activates Parkin E3 ligase activity both directly via phosphorylation of Parkin serine 65 (Ser(65))--which lies within its
P J Britto et al.
The Journal of biological chemistry, 277(32), 29018-29027 (2002-05-23)
Of the 20 cysteines of rat brain tubulin, some react rapidly with sulfhydryl reagents, and some react slowly. The fast reacting cysteines cannot be distinguished with [14C]iodoacetamide, N-[(14)C]ethylmaleimide, or IAEDANS ([5-((((2-iodoacetyl)amino)ethyl)amino) naphthalene-1-sulfonic acid]), since modification to mole ratios 1 cysteine/dimer
Thomas Götz et al.
Zeitschrift fur Naturforschung. C, Journal of biosciences, 59(7-8), 549-553 (2005-04-09)
The first elongation step to form very-long-chain fatty acids (VLCFAs) is catalyzed by the VLCFA-synthase. CoA-activated fatty acids react with malonyl-CoA to condense a C2-unit. As shown with recombinant enzyme this reaction is specifically inhibited by chloroacetamide herbicides. The inhibition
Amir Sapir et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(37), E3880-E3889 (2014-09-05)
Many metabolic pathways are critically regulated during development and aging but little is known about the molecular mechanisms underlying this regulation. One key metabolic cascade in eukaryotes is the mevalonate pathway. It catalyzes the synthesis of sterol and nonsterol isoprenoids
Frédéric Lamoliatte et al.
Nature communications, 5, 5409-5409 (2014-11-14)
Small ubiquitin-related modifiers (SUMO) are evolutionarily conserved ubiquitin-like proteins that regulate several cellular processes including cell cycle progression, intracellular trafficking, protein degradation and apoptosis. Despite the importance of protein SUMOylation in different biological pathways, the global identification of acceptor sites
Erin M Kolonko et al.
Journal of the American Chemical Society, 131(21), 7327-7333 (2009-05-28)
The applications of block copolymers are myriad, ranging from electronics to functionalized resins to therapeutics. The ring-opening metathesis polymerization (ROMP) is an especially valuable reaction for block copolymer assembly because each block can be generated with length control. We sought
Phosphoproteomic approach to characterize protein mono- and poly(ADP-ribosyl)ation sites from cells.
Casey M Daniels et al.
Journal of proteome research, 13(8), 3510-3522 (2014-06-13)
Poly(ADP-ribose), or PAR, is a cellular polymer implicated in DNA/RNA metabolism, cell death, and cellular stress response via its role as a post-translational modification, signaling molecule, and scaffolding element. PAR is synthesized by a family of proteins known as poly(ADP-ribose)
Ayuko Kimura et al.
Journal of proteomics, 130, 33-41 (2015-09-08)
Ubiquitination is the posttranslational modification of a protein by covalent attachment of ubiquitin. Controlled proteolysis via the ubiquitin-proteasome system (\UPS) alleviates cellular stress by clearing misfolded proteins. In budding yeast, UPS within the nucleus degrades the nuclear proteins as well
Cleonice Rocha et al.
Environmental pollution (Barking, Essex : 1987), 152(1), 239-244 (2007-07-17)
Solid-phase microextraction coupled with gas chromatography-mass spectrometry (SPME-GC-MS) was used to analyze two triazine (atrazine and simazine) and three chloroacetamide herbicides (acetochlor, alachlor, and metolachlor) in water samples from a midwest US agricultural drainage ditch for two growing seasons. The
Luca Palazzo et al.
The Biochemical journal, 468(2), 293-301 (2015-03-20)
ADP-ribosylation is a post-translational modification (PTM) of proteins found in organisms from all kingdoms of life which regulates many important biological functions including DNA repair, chromatin structure, unfolded protein response and apoptosis. Several cellular enzymes, such as macrodomain containing proteins
Katherine T Barglow et al.
Chemistry & biology, 11(11), 1523-1531 (2004-11-24)
Proteomics aims to identify new markers and targets for the diagnosis and treatment of human disease. To realize this goal, methods and reagents are needed to profile proteins based on their functional properties, rather than mere abundance. Here, we describe
Xiao-Feng Yang et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 65(5), 1063-1068 (2006-07-11)
A novel chromogenic probe for thiourea, N-chloroacetyl parafuchsin (CAP), was designed and synthesized. The method was based on the reaction of CAP with thiourea, resulting in the initial formation of the S-substituted thioformamidine hydrochloride, which would then undergo the intramolecular
Michelle L Hladik et al.
Environmental science & technology, 39(17), 6561-6574 (2005-09-30)
Although laboratory studies have revealed that many different neutral degradates of chloroacetamide herbicides can form during thermochemical, biological, and photochemical transformations, relatively few have been sought in the environment, despite their likely generation in appreciable amounts, relative persistence, and known
Jun Zhang et al.
Journal of agricultural and food chemistry, 59(9), 4614-4621 (2011-03-23)
A butachlor-degrading strain, designated FLY-8, was isolated from rice field soil and was identified as Paracoccus sp. Strain FLY-8 could degrade and utilize six chloroacetamide herbicides as carbon sources for growth, and the degradation rates followed the order alachlor >
J. Martinez et al.
Tetrahedron Letters, 24, 5219-5219 (1983)
Lihua Jiang et al.
Cell, 183(1), 269-283 (2020-09-12)
Determining protein levels in each tissue and how they compare with RNA levels is important for understanding human biology and disease as well as regulatory processes that control protein levels. We quantified the relative protein levels from over 12,000 genes
Gabriele A Fontana et al.
Nature communications, 10(1), 2535-2535 (2019-06-12)
Rif1 is involved in telomere homeostasis, DNA replication timing, and DNA double-strand break (DSB) repair pathway choice from yeast to human. The molecular mechanisms that enable Rif1 to fulfill its diverse roles remain to be determined. Here, we demonstrate that
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