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Showing 1-30 of 209 results for "257222" within Papers
Jin Zhou et al.
Carcinogenesis, 36(4), 441-451 (2015-03-07)
Gastric cancer (GC) is the second leading cause of global cancer mortality worldwide. However, the molecular mechanism underlying its carcinogenesis and drug resistance is not well understood. To identify novel functionally important genes that were differentially expressed due to combinations
Shafei Wu et al.
Thoracic cancer, 6(4), 413-420 (2015-08-15)
c-ros oncogene 1 (ROS1) rearrangement presents one of the newest molecular targets in non-small cell lung cancer (NSCLC). ROS1 rearrangement is predominantly found in adenocarcinoma cases and is exclusive to other oncogenes, such as epidermal growth factor receptor (EGFR), Kirsten
M M Al-Kaabi et al.
British journal of cancer, 112(5), 901-911 (2015-02-18)
Checkpoint kinase1 (CHK1), which is a key component of DNA-damage-activated checkpoint signalling response, may have a role in breast cancer (BC) pathogenesis and influence response to chemotherapy. This study investigated the clinicopathological significance of phosphorylated CHK1 (pCHK1) protein in BC.
Robert H Temperton et al.
Physical chemistry chemical physics : PCCP, 21(3), 1393-1398 (2019-01-03)
Ultra-thin aluminium oxide was grown on a rutile titanium dioxide surface by atomic layer deposition using trimethylaluminium and water precursors. This process, carried out using realistic temperatures and pressures (1 mbar, 450 K), was monitored in situ using near-ambient pressure
Shahram Khosravi et al.
The Journal of investigative dermatology, 135(5), 1358-1367 (2015-01-07)
Human cutaneous melanoma is a devastating skin cancer because of its invasive nature and high metastatic potential. We used tissue microarray to study the role of human eukaryotic translation initiation factor 4E (eIF4E) in melanoma progression in 448 melanocytic lesions
Martina Kluth et al.
International journal of oncology, 46(4), 1637-1642 (2015-01-28)
Prostate cancer is characterized by structural rearrangements, most frequently including translocations between androgen-dependent genes and members of the ETS family of transcription factor like TMPRSS2:ERG. In a recent whole genome sequencing study we identified 140 gene fusions that were unrelated
J Cheng et al.
Prostate cancer and prostatic diseases, 18(2), 182-189 (2015-04-15)
Fatty-acid synthase (FASN), selectively overexpressed in prostate cancer (PCa) cells, has been described as linked to the aggressiveness of PCa. Constitutional genetic variation of the FASN gene and the expression levels of FASN protein in cancer cells could thus be
Sarah L Larsen et al.
PloS one, 10(2), e0118346-e0118346 (2015-02-24)
The underlying mechanisms leading to antiestrogen resistance in estrogen-receptor α (ER)-positive breast cancer is still poorly understood. The aim of this study was therefore to identify biomarkers and novel treatments for antiestrogen resistant breast cancer. We performed a kinase inhibitor
Anna Bergamaschi et al.
Breast cancer research : BCR, 16(5), 436-436 (2014-09-13)
The forkhead transcription factor FOXM1 coordinates expression of cell cycle-related genes and plays a pivotal role in tumorigenesis and cancer progression. We previously showed that FOXM1 acts downstream of 14-3-3ζ signaling, the elevation of which correlates with a more aggressive
Zhen Ning Wee et al.
Nature communications, 6, 8746-8746 (2015-10-28)
Metastatic tumour recurrence due to failed treatments remains a major challenge of breast cancer clinical management. Here we report that interleukin-1 receptor-associated kinase 1 (IRAK1) is overexpressed in a subset of breast cancers, in particular triple-negative breast cancer (TNBC), where
Neerja Vajpayee et al.
Clinical lymphoma, myeloma & leukemia, 15(3), 159-163 (2014-12-03)
The mammalian target of rapamycin (mTOR) pathway regulates many major cellular processes and is implicated in an increasing number of neoplasms, including lymphoma. We correlated immunohistochemical expression of mTOR with germinal center and nongerminal center phenotype, B cell lymphoma-2 (bcl-2)
Qi Bai et al.
BMC cancer, 15, 880-880 (2015-11-11)
Aberrant sialylated carbohydrate synthesis is frequently noted in various cancers. Sialyltransferase ST3GAL-1, which adds a sialic acid in an α-2,3 linkage to Gal β1,3 GalNAc, preforms an important role in modulating cellular behaviors. However, little is known about prognostic significance
Bo Gun Jang et al.
Virchows Archiv : an international journal of pathology, 467(3), 285-294 (2015-06-14)
Olfactomedin 4 (OLFM4) has been demonstrated to be upregulated in various cancers and involved in many cellular processes such as cell adhesion, apoptosis, and cell proliferation. In gastric cancer, clinicopathological relevance of OLFM4 expression has been reported. However, there are
Jonathan W Riess et al.
Anticancer research, 35(2), 669-676 (2015-02-11)
Thymic epithelial tumors (TET) are rare. Wingless and INT (WNT), NOTCH and sonic hedgehog pathway interactions between thymocytes and thymic stroma are important to thymus and T-cell development. We analyzed a thymoma tissue microarray (TMA) for glioma associated oncogene homolog
Yun Hyun Huh et al.
Oncotarget, 6(15), 13060-13071 (2015-06-17)
Ectopic expression of Swiprosin-1, an actin-binding protein (also known as EF hand domain containing 2; EFHD2), enhanced motile protrusions associated with actin, such as lamellipodia and membrane ruffles. Swiprosin-1 levels were increased in various human cancer tissues, particularly at highly
Wanming Hu et al.
Medicine, 94(27), e979-e979 (2015-07-15)
CPEB4 plays an important role in cancer progression. However, the clinicopathological significance of CPEB4 expression to glioma and its expression levels in glioma tissues and cell lines are unknown. The present study investigated the potential prognostic value of CPEB4 for
Sukhmani K Padda et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 10(3), 500-508 (2014-11-18)
Blockade of the immune checkpoint programmed death receptor ligand-1 (PD-L1)/PD-1 pathway has well-established clinical activity across many tumor types. PD-L1 protein expression by immunohistochemistry is emerging as a predictive biomarker of response to these therapies. Here, we examine PD-L1 expression
Melissa R Junttila et al.
Science translational medicine, 7(314), 314ra186-314ra186 (2015-11-20)
Cancer stem cells (CSCs) are hypothesized to actively maintain tumors similarly to how their normal counterparts replenish differentiated cell types within tissues, making them an attractive therapeutic target for the treatment of cancer. Because most CSC markers also label normal
TRIMETHYLALUMINUM: THERMODYNAMIC FUNCTIONS IN THE SOLID AND LIQUID STATES, 0-380?K.; VAPOR PRESSURE, HEAT OF VAPORIZATION, AND ENTROPY IN THE IDEAL GAS STATE
J. P. McCullough, et al.
The Journal of Physical Chemistry (1963)
Kitty Pavlakis et al.
Pathology oncology research : POR, 21(2), 273-282 (2014-08-08)
To investigate the immunohistochemical expression of p85 in a cohort of trastuzumab-treated HER2-positive and HER2-negative metastatic breast cancer patients. The medical records of all patients with metastatic breast cancer treated with trastuzumab-based regimens between 1998 and 2010 were reviewed and
Catherine A Powell et al.
Oncotarget, 6(8), 6373-6385 (2015-03-18)
Fatty acid binding protein 5 (FABP5), an intracellular lipid binding protein, has been shown to play a role in various cancers, including breast cancer. However, FABP5 and its role in triple negative breast cancer (TNBC) have not been studied. We
Susann Busch et al.
Cancer research, 75(7), 1457-1469 (2015-04-04)
One third of the patients with estrogen receptor α (ERα)-positive breast cancer who are treated with the antiestrogen tamoxifen will either not respond to initial therapy or will develop drug resistance. Endocrine response involves crosstalk between ERα and TGFβ signaling
Min Zheng et al.
Oncology letters, 10(3), 1655-1661 (2015-12-02)
Ras homolog enriched in brain (Rheb) is a key regulator of mammalian target of rapamycin complex 1 (mTORC1). The Rheb-mTORC1 axis is a pivotal pathway that mediates cell growth. It was previously reported that upon energy-stress stimulation, the phosphorylation of
Stefan Steurer et al.
Urologic oncology, 32(8), 1225-1233 (2014-08-19)
Although most patients with urinary bladder cancer present with noninvasive and low-malignant stages of the disease, about 20% eventually develop life-threatening metastatic tumors. This study was designed to evaluate the potential of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI)
Qi Fei et al.
Nature communications, 6, 8651-8651 (2015-10-17)
SETDB1 is a histone H3K9 methyltransferase that has a critical role in early development. It is located within a melanoma susceptibility locus and facilitates melanoma formation. However, the mechanism by which SETDB1 regulates tumorigenesis remains unknown. Here we report the
Sebastian Trousil et al.
Cancer research, 74(23), 6867-6877 (2014-10-01)
Metabolic rearrangements subsequent to malignant transformation are not well characterized in endometrial cancer. Identification of altered metabolites could facilitate imaging-guided diagnosis, treatment surveillance, and help to identify new therapeutic options. Here, we used high-resolution magic angle spinning magnetic resonance mass
William Chiappim et al.
Nanomaterials (Basel, Switzerland), 10(2) (2020-02-23)
In this paper, we report the plasma-enhanced atomic layer deposition (PEALD) of TiO2 and TiO2/Al2O3 nanolaminate films on p-Si(100) to fabricate metal-oxide-semiconductor (MOS) capacitors. In the PEALD process, we used titanium tetraisopropoxide (TTIP) as a titanium precursor, trimethyl aluminum (TMA)
Jia-Ray Yu et al.
Genes & development, 29(3), 250-261 (2015-02-04)
The mechanisms by which TGF-β promotes lung adenocarcinoma (ADC) metastasis are largely unknown. Here, we report that in lung ADC cells, TGF-β potently induces expression of DOCK4, but not other DOCK family members, via the Smad pathway and that DOCK4
Vita Golubovskaya et al.
Journal of cancer research and clinical oncology, 141(9), 1613-1631 (2015-02-07)
Focal adhesion kinase is an important survival signal in cancer. Recently, we demonstrated that the autophosphorylation inhibitor of FAK, Y15, effectively inhibited cancer cell growth. We detected many cancer cell lines sensitive to Y15 and also detected several cell lines
Nicolas A Giraldo et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(13), 3031-3040 (2015-02-18)
Clear cell renal cell carcinoma (ccRCC) has shown durable responses to checkpoint blockade therapies. However, important gaps persist in the understanding of its immune microenvironment. This study aims to investigate the expression and prognostic significance of immune checkpoints in primary
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