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Showing 1-30 of 209 results for "257222" within Papers
David Pépin et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(32), E4418-E4427 (2015-07-29)
To improve ovarian cancer patient survival, effective treatments addressing chemoresistant recurrences are particularly needed. Mullerian inhibiting substance (MIS) has been shown to inhibit the growth of a stem-like population of ovarian cancer cells. We have recently engineered peptide modifications to
Xin Xu et al.
Experimental and molecular pathology, 97(3), 579-584 (2014-12-03)
Melanoma-associated antigens (MAGEs) are a group of well-characterized members of the cancer/testis antigen (CTA) family, which is one of the largest groups of human tumor-associated antigens. MAGE-A9 is a particular member in the context of the MAGE-A gene family and
G R V de Sousa et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 47(9), 656-661 (2015-05-20)
DAX1 transcription factor is a key determinant of adrenogonadal development, acting as a repressor of SF1 targets in steroidogenesis. It was recently demonstrated that DAX1 regulates pluripotency and differentiation in murine embryonic stem cells. In this study, we investigated DAX1
Anja Heinemann et al.
Oncotarget, 6(25), 21507-21521 (2015-06-19)
Histone acetylation marks have an important role in controlling gene expression and are removed by histone deacetylases (HDACs). These marks are read by bromodomain and extra-terminal (BET) proteins and novel inhibitiors of these proteins are currently in clinical development. Inhibitors
Yunfan Ma et al.
Thoracic cancer, 6(3), 288-295 (2015-08-15)
Non-small cell lung cancer (NSCLC) accounts for 80% of lung cancers, and lung squamous cell carcinoma (SQCC) is one of the main types. Advances in the treatment of lung SQCC are lacking when compared to lung adenocarcinoma. The main treatment
Sai Yin Cheung et al.
Breast cancer research and treatment, 152(3), 489-498 (2015-07-01)
Triple-negative breast cancers (TNBCs) are a heterogeneous group of breast tumours that are often associated with adverse pathological characteristics, poorer clinical outcomes and lack of targeted therapeutic options. Epithelial-mesenchymal transition, which plays a crucial role in tumour development and progression
Renee M Tholey et al.
Molecular cancer research : MCR, 13(3), 439-448 (2014-10-23)
Mucin1 (MUC1) is overexpressed in pancreatic ductal adenocarcinoma (PDA) and is associated with tumor aggressiveness, suggesting that MUC1 is a promising therapeutic target for promoter-driven diphtheria toxin A (DTA). Endogenous MUC1 transcript levels were analyzed by quantitative PCR (qPCR) in
Sunhee Kang et al.
Anticancer research, 35(5), 2775-2782 (2015-05-13)
Recent studies have revealed aquaporins (AQPs) as targets for novel anti-tumor therapy since they are likely to play a role in carcinogenesis, tumor progression and invasion. Accordingly, we analyzed the prognostic impact of AQP3 expression and polymorphisms in a number
Su Jin Hwang et al.
Oncotarget, 6(24), 20434-20448 (2015-05-15)
Despite great efforts to improve survival rates, the prognosis of lung cancer patients is still very poor, mainly due to high invasiveness. We developed brain metastatic PC14PE6/LvBr4 cells through intracardiac injection of lung adenocarcinoma PC14PE6 cells. Western blot and RT-qPCR
Seong Beom Ahn et al.
PloS one, 10(2), e0117786-e0117786 (2015-02-19)
Urokinase plasminogen activator receptor (uPAR) has been proposed as a potential prognostic factor for colorectal cancer (CRC) patient survival. However, CRC uPAR expression remains controversial, especially regarding cell types where uPAR is overexpressed (e.g., epithelium (uPARE) or stroma-associated cells (uPARS))
Su-Jin Shin et al.
The oncologist, 20(11), 1253-1260 (2015-10-02)
Vascular endothelial growth factor pathway (VEGF)-tyrosine kinase inhibitors (TKIs) are used as the first-line treatment for patients with metastatic clear cell renal cell carcinoma (mCCRCC). Recently, programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) blockade emerged as promising therapy for
Elmer Hoekstra et al.
Oncotarget, 6(10), 8300-8312 (2015-03-27)
Phosphatases have long been regarded as tumor suppressors, however there is emerging evidence for a tumor initiating role for some phosphatases in several forms of cancer. Low Molecular Weight Protein Tyrosine Phosphatase (LMWPTP; acid phosphatase 1 [ACP1]) is an 18
Hongbo Zhang et al.
Angewandte Chemie (International ed. in English), 53(45), 12132-12136 (2014-09-25)
The terraces, edges, and facets of nanoparticles are all active sites for heterogeneous catalysis. These different active sites may cause the formation of various products during the catalytic reaction. Here we report that the step sites of Pd nanoparticles (NPs)
Ricardo M L Silva et al.
ACS applied materials & interfaces, 12(26), 29556-29565 (2020-05-26)
The combination of organic and inorganic materials at the nanoscale to form functional hybrid structures is a powerful strategy to develop novel electronic devices. The knowledge on semiconductor thin-film polarization brings direct benefits to the hybrid organic/inorganic electronics, becoming primordial
Ze-Yun Li et al.
PloS one, 10(3), e0120950-e0120950 (2015-03-19)
Curcumin, a principle bioactive component of Curcuma longa L, is well known for its anti-hyperlipidemia effect. However, no holistic metabolic information of curcumin on hyperlipidemia models has been revealed, which may provide us an insight into the underlying mechanism. In
George Pentheroudakis et al.
PloS one, 10(5), e0124612-e0124612 (2015-05-15)
Although host immune response is an emerging prognostic factor for colorectal cancer, there is no consensus on the optimal methodology, surrogate markers or tissue for study. Tumour blocks were prospectively collected from 344 patients with stage II/III colorectal cancer (CRC)
Megan J McGregor et al.
Anticancer research, 35(3), 1641-1645 (2015-03-10)
Biomarkers with prognostic and predictive value can help stratify patients with colorectal cancer (CRC) into appropriate treatment groups. We sought to evaluate the clinical utility of P53 protein expression as a biomarker in VICTOR, a large phase III trial of
Mahtab Farzin et al.
Pathology, 47(4), 302-307 (2015-05-06)
BRCA1-associated protein 1 (BAP1) is a tumour suppressor gene frequently inactivated in mesothelioma, rarely also in association with germline mutation. BAP1 mutations have been associated with improved prognosis and distinct clinicopathological features. We sought to determine the clinicopathological significance of
Wei Zhang et al.
World journal of gastroenterology, 21(29), 8836-8847 (2015-08-14)
To investigate the expression and oncogenic role of nemo-like kinase (NLK) in colorectal cancer. Expression of NLK protein was assessed by immunohistochemistry in tissue specimens from 56 cases of normal colorectal mucosa, 51 cases of colorectal adenoma, and 712 cases
Ariz Akhter et al.
Applied immunohistochemistry & molecular morphology : AIMM, 23(10), 733-739 (2015-02-25)
MicroRNA (MIR) signatures are critical to pathobiology and prognosis of acute myeloid leukemia (AML). MIR223 is expressed at low levels in progenitor cells, whereas high expression is induced by granulocytic differentiation. Novel-targeted therapies through epigenetic manipulation of MIR223 regulators are
Kristen L Capps et al.
Clinical psychology & psychotherapy, 22(3), 208-220 (2013-12-18)
The aim of the present study is to further the understanding of who cries in therapy and the relation of technique with crying behaviour in therapy. Psychological assessment feedback sessions, prior to the initiation of formal therapy for 52 patients
Yangxi Chu et al.
Physical chemistry chemical physics : PCCP, 17(30), 19789-19796 (2015-07-15)
Alkyl aminium sulfates (AASs) can affect the physicochemical properties of atmospheric aerosols such as hygroscopicity. Previous laboratory experiments have shown that the water content in AAS bulk solutions is higher than in aqueous ammonium sulfate solution in the range of
Sofia Sousa et al.
Breast cancer research : BCR, 17, 101-101 (2015-08-06)
The immune system plays a major role in cancer progression. In solid tumors, 5-40 % of the tumor mass consists of tumor-associated macrophages (TAMs) and there is usually a correlation between the number of TAMs and poor prognosis, depending on
Daniel Cuevas-Ramos et al.
The Journal of clinical endocrinology and metabolism, 100(1), 122-131 (2014-09-25)
GH-secreting pituitary adenomas exhibit heterogeneous natural history ranging from small tumors to large aggressive adenomas. To rigorously classify an acromegaly patient cohort defined by clinical, radiological, histopathological, and outcome characteristics. Cross-sectional study. Tertiary referral pituitary center. Subjects were selected from
T T Seppälä et al.
British journal of cancer, 112(12), 1966-1975 (2015-05-15)
The objective of the study was to examine the role of microsatellite instability (MSI) and BRAF(V600E)mutation in colorectal cancer (CRC) by categorising patients into more detailed subtypes based on tumour characteristics. Tumour samples from 762 population-based patients with sporadic CRC
Gabriel Eades et al.
Molecular cancer research : MCR, 13(2), 330-338 (2014-09-26)
Triple-negative (ER(-), HER2(-), PR(-)) breast cancer (TNBC) is an aggressive disease with a poor prognosis with no available molecularly targeted therapy. Silencing of microRNA-145 (miR-145) may be a defining marker of TNBC based on molecular profiling and deep sequencing. Therefore
J M MacLeod et al.
Langmuir : the ACS journal of surfaces and colloids, 31(25), 7016-7024 (2015-01-17)
The behavior of small molecules on a surface depends critically on both molecule-substrate and intermolecular interactions. We present here a detailed comparative investigation of 1,3,5-benzene tricarboxylic acid (trimesic acid, TMA) on two different surfaces: highly oriented pyrolytic graphite (HOPG) and
Matthias May et al.
Pathology, research and practice, 211(9), 641-645 (2015-06-21)
The purpose of the study was to assess the incidence and prognostic role of epithelial-to-mesenchymal-transition (EMT) in squamous cell carcinoma of the penis (SCCP). Sixty tumor specimens of surgically treated SCCP patients characterized by a central histopathologic review were stained
Ronak Dixit et al.
Scientific reports, 5, 16657-16657 (2015-11-14)
Head and neck squamous cell carcinoma (HNSCC) has a variety of causes. Recently, the human papilloma virus (HPV) has been implicated in the rising incidence of oropharyngeal cancer and has led to variety of studies exploring the differences between HPV-positive
Jemima Escamilla et al.
Cancer research, 75(6), 950-962 (2015-03-05)
Growing evidence suggests that tumor-associated macrophages (TAM) promote cancer progression and therapeutic resistance by enhancing angiogenesis, matrix-remodeling, and immunosuppression. In this study, prostate cancer under androgen blockade therapy (ABT) was investigated, demonstrating that TAMs contribute to prostate cancer disease recurrence
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