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Showing 1-30 of 209 results for "257222" within Papers
G R V de Sousa et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 47(9), 656-661 (2015-05-20)
DAX1 transcription factor is a key determinant of adrenogonadal development, acting as a repressor of SF1 targets in steroidogenesis. It was recently demonstrated that DAX1 regulates pluripotency and differentiation in murine embryonic stem cells. In this study, we investigated DAX1
Anja Heinemann et al.
Oncotarget, 6(25), 21507-21521 (2015-06-19)
Histone acetylation marks have an important role in controlling gene expression and are removed by histone deacetylases (HDACs). These marks are read by bromodomain and extra-terminal (BET) proteins and novel inhibitiors of these proteins are currently in clinical development. Inhibitors
Elmer Hoekstra et al.
Oncotarget, 6(10), 8300-8312 (2015-03-27)
Phosphatases have long been regarded as tumor suppressors, however there is emerging evidence for a tumor initiating role for some phosphatases in several forms of cancer. Low Molecular Weight Protein Tyrosine Phosphatase (LMWPTP; acid phosphatase 1 [ACP1]) is an 18
David Pépin et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(32), E4418-E4427 (2015-07-29)
To improve ovarian cancer patient survival, effective treatments addressing chemoresistant recurrences are particularly needed. Mullerian inhibiting substance (MIS) has been shown to inhibit the growth of a stem-like population of ovarian cancer cells. We have recently engineered peptide modifications to
Xin Xu et al.
Experimental and molecular pathology, 97(3), 579-584 (2014-12-03)
Melanoma-associated antigens (MAGEs) are a group of well-characterized members of the cancer/testis antigen (CTA) family, which is one of the largest groups of human tumor-associated antigens. MAGE-A9 is a particular member in the context of the MAGE-A gene family and
George Pentheroudakis et al.
PloS one, 10(5), e0124612-e0124612 (2015-05-15)
Although host immune response is an emerging prognostic factor for colorectal cancer, there is no consensus on the optimal methodology, surrogate markers or tissue for study. Tumour blocks were prospectively collected from 344 patients with stage II/III colorectal cancer (CRC)
Matthias May et al.
Pathology, research and practice, 211(9), 641-645 (2015-06-21)
The purpose of the study was to assess the incidence and prognostic role of epithelial-to-mesenchymal-transition (EMT) in squamous cell carcinoma of the penis (SCCP). Sixty tumor specimens of surgically treated SCCP patients characterized by a central histopathologic review were stained
Kristen L Capps et al.
Clinical psychology & psychotherapy, 22(3), 208-220 (2013-12-18)
The aim of the present study is to further the understanding of who cries in therapy and the relation of technique with crying behaviour in therapy. Psychological assessment feedback sessions, prior to the initiation of formal therapy for 52 patients
Gabriel Eades et al.
Molecular cancer research : MCR, 13(2), 330-338 (2014-09-26)
Triple-negative (ER(-), HER2(-), PR(-)) breast cancer (TNBC) is an aggressive disease with a poor prognosis with no available molecularly targeted therapy. Silencing of microRNA-145 (miR-145) may be a defining marker of TNBC based on molecular profiling and deep sequencing. Therefore
Yunfan Ma et al.
Thoracic cancer, 6(3), 288-295 (2015-08-15)
Non-small cell lung cancer (NSCLC) accounts for 80% of lung cancers, and lung squamous cell carcinoma (SQCC) is one of the main types. Advances in the treatment of lung SQCC are lacking when compared to lung adenocarcinoma. The main treatment
Sai Yin Cheung et al.
Breast cancer research and treatment, 152(3), 489-498 (2015-07-01)
Triple-negative breast cancers (TNBCs) are a heterogeneous group of breast tumours that are often associated with adverse pathological characteristics, poorer clinical outcomes and lack of targeted therapeutic options. Epithelial-mesenchymal transition, which plays a crucial role in tumour development and progression
Photo-induced current and its degradation in Al4C3/Al2O3 (0001) grown by metalorganic chemical vapor deposition
Kim D, et al.
Thin Solid Films, 557, 216-221 (2014)
Seong Beom Ahn et al.
PloS one, 10(2), e0117786-e0117786 (2015-02-19)
Urokinase plasminogen activator receptor (uPAR) has been proposed as a potential prognostic factor for colorectal cancer (CRC) patient survival. However, CRC uPAR expression remains controversial, especially regarding cell types where uPAR is overexpressed (e.g., epithelium (uPARE) or stroma-associated cells (uPARS))
Su Jin Hwang et al.
Oncotarget, 6(24), 20434-20448 (2015-05-15)
Despite great efforts to improve survival rates, the prognosis of lung cancer patients is still very poor, mainly due to high invasiveness. We developed brain metastatic PC14PE6/LvBr4 cells through intracardiac injection of lung adenocarcinoma PC14PE6 cells. Western blot and RT-qPCR
Su-Jin Shin et al.
The oncologist, 20(11), 1253-1260 (2015-10-02)
Vascular endothelial growth factor pathway (VEGF)-tyrosine kinase inhibitors (TKIs) are used as the first-line treatment for patients with metastatic clear cell renal cell carcinoma (mCCRCC). Recently, programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) blockade emerged as promising therapy for
Yangxi Chu et al.
Physical chemistry chemical physics : PCCP, 17(30), 19789-19796 (2015-07-15)
Alkyl aminium sulfates (AASs) can affect the physicochemical properties of atmospheric aerosols such as hygroscopicity. Previous laboratory experiments have shown that the water content in AAS bulk solutions is higher than in aqueous ammonium sulfate solution in the range of
Takashi Murakami et al.
Dental materials journal, 34(2), 189-195 (2015-03-06)
This study investigated high-cycle fatigue behavior in three β-Ti wires (TMA, Resolve, Gummetal). Fatigue was evaluated using a static three-point bending test and a high-cycle fatigue test with a three-point bending mode. The surfaces of fractured wires were observed with
Shinkyo Yoon et al.
Oncology, 89(6), 351-359 (2015-10-07)
Recently, enzymes of the serine synthetic pathway (SSP) have been suggested as key player in the metabolic adaptation of oncogenesis. We assessed the expression of enzymes of the SSP in colonic tumor tissue (TT) and paired normal tissue (pNT) and
Francesco Morra et al.
Oncotarget, 6(14), 12697-12709 (2015-04-18)
CCDC6 gene product is a pro-apoptotic protein substrate of ATM, whose loss or inactivation enhances tumour progression. In primary tumours, the impaired function of CCDC6 protein has been ascribed to CCDC6 rearrangements and to somatic mutations in several neoplasia. Recently
J Wang et al.
Oncogene, 34(47), 5781-5795 (2015-03-03)
Yes-associated protein (YAP) is overexpressed and has an oncogenic role in hepatocellular carcinoma (HCC). However, whether membrane protein can serve not only as a tumor marker that reflects YAP function but also as a therapeutic target that stimulates tumorigenesis in
William H Yong et al.
PloS one, 10(10), e0141334-e0141334 (2015-10-28)
Glioblastoma stem cells (GSC) co-exhibiting a tumor-initiating capacity and a radio-chemoresistant phenotype, are a compelling cell model for explaining tumor recurrence. We have previously characterized patient-derived, treatment-resistant GSC clones (TRGC) that survived radiochemotherapy. Compared to glucose-dependent, treatment-sensitive GSC clones (TSGC)
Wei Zhang et al.
World journal of gastroenterology, 21(29), 8836-8847 (2015-08-14)
To investigate the expression and oncogenic role of nemo-like kinase (NLK) in colorectal cancer. Expression of NLK protein was assessed by immunohistochemistry in tissue specimens from 56 cases of normal colorectal mucosa, 51 cases of colorectal adenoma, and 712 cases
Laura A Marlow et al.
Endocrine-related cancer, 22(5), 777-792 (2015-07-25)
Anaplastic thyroid carcinoma is a highly aggressive undifferentiated carcinoma with a mortality rate near 100% due to an assortment of genomic abnormalities which impede the success of therapeutic options. Our laboratory has previously identified that RhoB upregulation serves as a
Sofia Sousa et al.
Breast cancer research : BCR, 17, 101-101 (2015-08-06)
The immune system plays a major role in cancer progression. In solid tumors, 5-40 % of the tumor mass consists of tumor-associated macrophages (TAMs) and there is usually a correlation between the number of TAMs and poor prognosis, depending on
Ariz Akhter et al.
Applied immunohistochemistry & molecular morphology : AIMM, 23(10), 733-739 (2015-02-25)
MicroRNA (MIR) signatures are critical to pathobiology and prognosis of acute myeloid leukemia (AML). MIR223 is expressed at low levels in progenitor cells, whereas high expression is induced by granulocytic differentiation. Novel-targeted therapies through epigenetic manipulation of MIR223 regulators are
Sunhee Kang et al.
Anticancer research, 35(5), 2775-2782 (2015-05-13)
Recent studies have revealed aquaporins (AQPs) as targets for novel anti-tumor therapy since they are likely to play a role in carcinogenesis, tumor progression and invasion. Accordingly, we analyzed the prognostic impact of AQP3 expression and polymorphisms in a number
Renee M Tholey et al.
Molecular cancer research : MCR, 13(3), 439-448 (2014-10-23)
Mucin1 (MUC1) is overexpressed in pancreatic ductal adenocarcinoma (PDA) and is associated with tumor aggressiveness, suggesting that MUC1 is a promising therapeutic target for promoter-driven diphtheria toxin A (DTA). Endogenous MUC1 transcript levels were analyzed by quantitative PCR (qPCR) in
Hongbo Zhang et al.
Angewandte Chemie (International ed. in English), 53(45), 12132-12136 (2014-09-25)
The terraces, edges, and facets of nanoparticles are all active sites for heterogeneous catalysis. These different active sites may cause the formation of various products during the catalytic reaction. Here we report that the step sites of Pd nanoparticles (NPs)
O D Supekar et al.
Nanotechnology, 27(49), 49LT02-49LT02 (2016-11-12)
Focused ion beam (FIB) micromachining is a powerful tool for maskless lithography and in recent years FIB has been explored as a tool for strain engineering. Ion beam induced deformation can be utilized as a means for folding freestanding thin
Ricardo M L Silva et al.
ACS applied materials & interfaces, 12(26), 29556-29565 (2020-05-26)
The combination of organic and inorganic materials at the nanoscale to form functional hybrid structures is a powerful strategy to develop novel electronic devices. The knowledge on semiconductor thin-film polarization brings direct benefits to the hybrid organic/inorganic electronics, becoming primordial
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