269255

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Showing 1-12 of 12 results for "269255" within Papers

Long-acting antituberculous therapeutic nanoparticles target macrophage endosomes.

Benson J Edagwa et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(12), 5071-5082 (2014-08-15)

Eradication of Mycobacterium tuberculosis (MTB) infection requires daily administration of combinations of rifampin (RIF), isoniazid [isonicotinylhydrazine (INH)], pyrazinamide, and ethambutol, among other drug therapies. To facilitate and optimize MTB therapeutic selections, a mononuclear phagocyte (MP; monocyte, macrophage, and dendritic cell)-targeted

In vivo absorption, metabolism, and urinary excretion of alpha,beta-unsaturated aldehydes in experimental animals. Relevance to the development of cardiovascular diseases by the dietary ingestion of thermally stressed polyunsaturate-rich culinary oils.

M Grootveld et al.

The Journal of clinical investigation, 101(6), 1210-1218 (1998-04-29)

Thermal stressing of polyunsaturated fatty acid (PUFA)- rich culinary oils according to routine frying or cooking practices generates high levels of cytotoxic aldehydic products (predominantly trans-2-alkenals, trans,trans-alka-2,4-dienals, cis,trans-alka-2, 4-dienals, and n-alkanals), species arising from the fragmentation of conjugated hydroperoxydiene precursors.

Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines.

Lindsey J Macpherson et al.

Nature, 445(7127), 541-545 (2007-01-24)

The nervous system senses peripheral damage through nociceptive neurons that transmit a pain signal. TRPA1 is a member of the Transient Receptor Potential (TRP) family of ion channels and is expressed in nociceptive neurons. TRPA1 is activated by a variety

Comparison of Aroma-Active Volatiles in Oolong Tea Infusions Using GC-Olfactometry, GC-FPD, and GC-MS.

JianCai Zhu et al.

Journal of agricultural and food chemistry, 63(34), 7499-7510 (2015-08-11)

The aroma profile of oolong tea infusions (Dongdingwulong, DDWL; Tieguanyin, TGY; Dahongpao, DHP) were investigated in this study. Gas chromatography-olfactometry (GC-O) with the method of aroma intensity (AI) was employed to investigate the aroma-active compounds in tea infusions. The results

Effects of aliphatic aldehydes on the growth and patulin production of Penicillium expansum in apple juice.

Tomoyasu Taguchi et al.

Bioscience, biotechnology, and biochemistry, 77(1), 138-144 (2013-01-08)

The effects of 16 aliphatic aldehydes with 3-10 carbons on the growth and patulin production of Penicillium expansum were examined. When P. expansum spores were inoculated into apple juice broth, some alkenals, including 2-propenal, (E)-2-butenal, (E)-2-pentenal, and (E)-2-hexenal, inhibited fungal

Multiple cation channels mediate increases in intracellular calcium induced by the volatile irritant, trans-2-pentenal in rat trigeminal neurons.

Takashi Inoue et al.

Cellular and molecular neurobiology, 30(1), 35-41 (2009-07-02)

Trans-2-Pentenal (pentenal), an alpha,beta-unsaturated aldehyde, induces increases in [Ca(2+)](i) in cultured neonatal rat trigeminal ganglion (TG) neurons. Since all pentenal-sensitive neurons responded to a specific TRPA1 agonist, allyl isothiocyanate (AITC) and neurons from TRPA1 knockouts failed to respond to pentenal

Rate coefficients for the reaction of OH with (E)-2-pentenal, (E)-2-hexenal, and (E)-2-heptenal.

M E Davis et al.

Physical chemistry chemical physics : PCCP, 9(18), 2240-2248 (2007-05-10)

Rate coefficients for the gas-phase reaction of the OH radical with (E)-2-pentenal (CH(3)CH(2)CH[double bond]CHCHO), (E)-2-hexenal (CH(3)(CH(2))(2)CH[double bond]CHCHO), and (E)-2-heptenal (CH(3)(CH(2))(3)CH[double bond]CHCHO), a series of unsaturated aldehydes, over the temperature range 244-374 K at pressures between 23 and 150 Torr (He

Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.

Pier Giovanni Baraldi et al.

Journal of medicinal chemistry, 53(14), 5085-5107 (2010-04-02)

Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX.

Daniel T Cohen et al.

Cell reports, 30(10), 3229-3239 (2020-03-12)

BCL-2 family proteins converge at the mitochondrial outer membrane to regulate apoptosis and maintain the critical balance between cellular life and death. This physiologic process is essential to organism homeostasis and relies on protein-protein and protein-lipid interactions among BCL-2 family

Kinetics studies of the gas-phase reactions of NO3 radicals with series of 1-alkenes, dienes, cycloalkenes, alkenols, and alkenals.

Zhijun Zhao et al.

The journal of physical chemistry. A, 115(44), 12161-12172 (2011-10-15)

The gas-phase reactions of NO(3) radicals with series of 1-alkenes, dienes, cycloalkenes, alkenols, and alkenals were studied in pure N(2) or 20% O(2)/80% N(2) bath gas at room temperature and atmospheric pressure using a relative rates technique. Rate coefficients were

Comparison of tomatillo and tomato volatile compounds in the headspace by selected ion flow tube mass spectrometry (SIFT-MS).

Yichi Xu et al.

Journal of food science, 75(3), C268-C273 (2010-05-25)

The concentration of 31 volatiles were measured in the headspace of tomatillos using selected ion flow tube-mass spectrometry (SIFT-MS), and were compared with those in vine-ripened tomato, roma tomato, cherry tomato, and grape tomato. None of the volatiles were higher

Mutation induction in Chinese hamster lung V79 cells by five alk-2-enals produced by lipid peroxidation.

R Canonero et al.

Mutation research, 244(2), 153-156 (1990-06-01)

Five alk-2-enals--pent-2-enal, hex-2-enal, hept-2-enal, oct-2-enal and non-2-enal--produced by lipid peroxidation were tested for mutagenic activity in V79 Chinese hamster cells. At concentrations ranging from 0.003 to 0.3 mM all 5 alk-2-enals induced a dose-dependent increase in the frequency of 6-thioguanine-resistant

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