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Showing 1-30 of 1192 results for "270997" within Papers
Nicholas J Schaub et al.
PloS one, 10(9), e0136780-e0136780 (2015-09-05)
The surface of aligned, electrospun poly-L-lactic acid (PLLA) fibers was chemically modified to determine if surface chemistry and hydrophilicity could improve neurite extension from chick dorsal root ganglia. Specifically, diethylenetriamine (DTA, for amine functionalization), 2-(2-aminoethoxy)ethanol (AEO, for alcohol functionalization), or
Ali Es-Haghi et al.
Talanta, 128, 231-236 (2014-07-26)
Sol-gel based solid-phase microextraction fibers supported by a stainless steel wire were fabricated and employed for GC-MS determination of oxadiargyl in real samples. The fibers were based on four compounds with different polarity: polar and non-polar (end-capped) poly(dimethylsiloxane) (PDMS), polyethylene
Hua-Yang Liao et al.
Talanta, 143, 50-55 (2015-06-17)
A fast and accurate drug screening to identify the possible presence of a wide variety of pharmaceutical and illicit drugs is increasingly requested in forensic and clinical toxicology. The current first-line screening relies on immunoassays. They determine only certain common
Development and evaluation of electromembrane extraction across a hollow polymer inclusion membrane.
Nor Akma Mamat et al.
Journal of chromatography. A, 1406, 34-39 (2015-07-05)
In this work, a new variation of the electromembrane extraction (EME) approach employing a hollow polymer inclusion membrane (HPIM) was developed. In this method, a HPIM was prepared by casting a solution of the desired proportions of cellulose acetate (CTA)
Jizhi Lin et al.
Nanoscale, 7(32), 13663-13670 (2015-07-28)
We report the controlled synthesis of [Au25(PPh3)10(SR1)5X2](2+) nanorods (H-SR1: alkyl thiol, H-SC2H4Ph and H-S(n-C6H13)) and Au25(SR2)18 nanospheres (H-SR2: aromatic thiol, H-SPh and H-SNap) under the one-phase thiol etching reaction of the polydisperse Aun(PPh3)m parent-particles (core diameter: 1.3 ± 0.4 nm
Chao Zhao et al.
Nature communications, 5, 5079-5079 (2014-10-07)
The remarkable stability of peptide nucleic acids (PNAs) towards enzymatic degradation makes this class of molecules ideal to develop as part of a diagnostic device. Here we report the development of chemically engineered PNAs for the quantitative detection of HIV
Angela L Zachman et al.
Biomaterials, 35(36), 9635-9648 (2014-08-27)
Peripheral artery disease (PAD) is characterized by vessel occlusion and ischemia in the limbs. Treatment for PAD with surgical interventions has been showing limited success. Moreover, recent clinical trials with treatment of angiogenic growth factors proved ineffective as increased angiogenesis
Franziska Janusch et al.
Environmental toxicology and pharmacology, 38(3), 792-799 (2014-10-13)
The application of antibiotics including fluoroquinolones to farming animals is widespread and may lead to the development of antibiotic resistance and other environmental effects. To calculate environmental loads and for a proper risk assessment it is necessary to determine the
Alycia M Palmer et al.
ChemMedChem, 9(6), 1260-1265 (2014-04-23)
Two new complexes, cis-H,H-[Rh2 (OCCH3 NH)2 (LL)(CH3 CN)2 ](2+) , where LL=bpy (2, bpy=2,2'-bipyridine) and dppz (3, dppz=dipyrido[3,2-a:2',3'-c]phenazine), were prepared from the reaction of cis-H,H-[Rh2 (OCCH3 NH)2 (CH3 CN)6 ](2+) (1) with the corresponding bidentate ligand. The bpy and dppz
Askin Birgul et al.
Archives of environmental contamination and toxicology, 68(1), 46-63 (2014-12-07)
Ambient air polycyclic aromatic hydrocarbon (PAH) samples were collected at traffic, residential, coastal, and semiurban sites in Bursa, Turkey, between June 2008 and June 2009. For the traffic, residential, coastal, and semiurban sites, the average gas phase total PAH (∑12PAH)
Benedetta Carlotti et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 16(7), 1440-1450 (2015-03-03)
Three (donor-π-acceptor)(+) systems with a methyl pyridinium or quinolinium as the electron-deficient group, a dimethyl amino as the electron-donor group, and an ethylene or butadiene group as the spacer have been investigated in a joint spectroscopic and TD-DFT computational study.
Bat-Chen Cohen et al.
PloS one, 10(3), e0121645-e0121645 (2015-03-11)
Milk fat globule size is determined by the size of its precursors-intracellular lipid droplets-and is tightly associated with its composition. We examined the relationship between phospholipid composition of mammary epithelial cells and the size of both intracellular and secreted milk
Qian Wang et al.
Biomaterials, 35(29), 8385-8393 (2014-07-06)
Microparticle-based vaccine delivery systems are known to promote enhanced immune responses to protein antigens and can elicit TH1-biased responses when used in combination with Toll-like receptor (TLR) agonists. It is important to understand the kinetics of the immune responses to
Q Q He et al.
Organic & biomolecular chemistry, 13(13), 4070-4079 (2015-03-05)
This study investigated the unexpected decomposition and associated intermediates of compound 1, a specific member of a drug discovery library based on a monosaccharide scaffold. LC/MS and NMR spectroscopic analyses indicated that, under acidic conditions, 1 can be converted into
Benito F García et al.
Molecules (Basel, Switzerland), 20(11), 20079-20106 (2015-11-13)
The citrus by-products released from citrus processing plants may contain high levels of potentially bioactive compounds such as flavonoids, which are a widely distributed group of polyphenolic compounds with health-related properties based on their antioxidant activity. In the study reported
Yajie Gao et al.
Pharmaceutical research, 32(8), 2649-2662 (2015-02-14)
The purpose of the present study was to design and fabricate endosomal pH-sensitive dual-ligand-modified micellar nanoparticles to achieve enhanced drug delivery to tumor cells and facilitated intracellular drug release. End-group-carboxylated poly(2-ethyl-2-oxazoline)-poly(D,L-lactide) and cyclic Arg-Gly-Asp-Tyr-Lys- and anti-prostate specific membrane antigen antibody-modified
Joo Youn Lee et al.
BioMed research international, 2019, 6125068-6125068 (2019-09-19)
Cdc2-like kinases (CLKs) play a crucial role in the alternative splicing of eukaryotic pre-mRNAs through the phosphorylation of serine/arginine-rich proteins (SR proteins). Dysregulation of this processes is linked with various diseases including cancers, neurodegenerative diseases, and many genetic diseases. Thus
H J Clewell
Toxicology, 102(1-2), 83-94 (1995-09-01)
The interplay between chemical risk assessment and scientific research is discussed in the context of recent attempts to improve the scientific basis for estimates of the human carcinogenic risk from methylene chloride. A combination of basic biochemical research and risk
Nichole Coleman et al.
Molecular pharmacology, 86(3), 342-357 (2014-06-25)
Small-conductance (KCa2) and intermediate-conductance (KCa3.1) calcium-activated K(+) channels are voltage-independent and share a common calcium/calmodulin-mediated gating mechanism. Existing positive gating modulators like EBIO, NS309, or SKA-31 activate both KCa2 and KCa3.1 channels with similar potency or, as in the case
Steven M Colegate et al.
Journal of ethnopharmacology, 172, 179-194 (2015-06-19)
Asmachilca is a Peruvian medicinal herb preparation ostensibly derived from Aristeguietia gayana (Wedd.) R.M. King & H. Rob. (Asteraceae: Eupatorieae). Decoctions of the plant have a reported bronchodilation effect that is purported to be useful in the treatment of respiratory
Jiajia Xue et al.
Biomaterials, 35(34), 9395-9405 (2014-08-20)
Infection is the major reason for guided tissue regeneration/guided bone regeneration (GTR/GBR) membrane failure in clinical application. In this work, we developed GTR/GBR membranes with localized drug delivery function to prevent infection by electrospinning of poly(ε-caprolactone) (PCL) and gelatin blended
Thorsten Müller et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 94, 333-341 (2015-06-17)
In a former publication the authors showed that low amounts of amorphous content (LOQ of 0.5%) in a hydrophobic model API (Ciclesonide) can be measured with an individually adjusted one-step dynamic organic vapor sorption (DVS). In this investigation the applicability
Liezl Rae Balaoing et al.
PloS one, 10(6), e0130749-e0130749 (2015-06-20)
Valve endothelial cells (VEC) have unique phenotypic responses relative to other types of vascular endothelial cells and have highly sensitive hemostatic functions affected by changes in valve tissues. Furthermore, effects of environmental factors on VEC hemostatic function has not been
Dennis B Pacardo et al.
Nanoscale, 7(28), 12096-12103 (2015-07-01)
A multifunctional gold nanorod (AuNR) complex is described with potential utility for theranostic anticancer treatment. The AuNR was functionalized with cyclodextrin for encapsulation of doxorubicin, with folic acid for targeting, and with a photo-responsive dextran-azo compound for intracellular controlled drug
Nicholas B Carrigy et al.
Journal of aerosol medicine and pulmonary drug delivery, 27(4), 290-298 (2013-11-14)
During the aerosol delivery device design and optimization process, in vitro lung dose (LD) measurements are often performed using soft face models, which may provide a more clinically relevant representation of face mask dead volume (MDV) and face mask seal
Man-Jeong Paik et al.
Sleep & breathing = Schlaf & Atmung, 18(3), 517-523 (2014-01-10)
The apnea-hypopnea index (AHI) is closely related with the severity of daytime sleepiness, but excessive daytime sleepiness (EDS) is not presented on all patients with obstructive sleep apnea (OSA). It is unclear why daytime sleepiness is not always present in
Júlia Aliz Baán et al.
Journal of translational medicine, 13, 1-1 (2015-01-17)
Myostatin (Mstn) is a key regulator of heart metabolism and cardiomyocyte growth interacting tightly with insulin-like growth factor I (IGF-I) under physiological conditions. The pathological role of Mstn has also been suggested since Mstn protein was shown to be upregulated
Ana Masiá et al.
Journal of chromatography. A, 1345, 86-97 (2014-05-06)
Ultra-high pressure liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QqTOF-MS) acquiring full scan MS data for quantification, and automatic data dependent information product ion spectra (IDA-MS/MS) without any predefinition of the ions by the user was checked for identifying organic contaminants in
Fathima N M Khalid et al.
Environmental science and pollution research international, 22(17), 12975-12981 (2015-04-29)
The concentration changes of 18 different polycyclic aromatic hydrocarbons (PAHs) in two different biochars were assessed after (1) chemical oxidative treatment with a solution of H2O2 and Na2S2O8, (2) exposure to sunlight with intermittent wetting, and (3) exposure to sunlight with intermittent
Elizabeth Cocks et al.
Drug development and industrial pharmacy, 41(3), 522-528 (2014-03-22)
The effect of suspension stabilizers, internal aqueous phase volume and polymer amount were investigated for the production of protein loaded poly(d,l lactide-co-glycolide) (PLGA) microparticles suitable for pulmonary drug delivery. PLGA microparticles were produced adopting water-in-oil-in-water (W/O/W) solvent evaporation technique and were
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