289396

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Selective inhibition of TNFR1 reduces osteoclast numbers and is differentiated from anti-TNF in a LPS-driven model of inflammatory bone loss.

A I Espirito Santo et al.

Biochemical and biophysical research communications, 464(4), 1145-1150 (2015-07-26)

The treatment of autoimmune disorders has been revolutionised by the introduction of biologics such as anti-tumour necrosis factor (anti-TNF). Although in rheumatoid arthritis patients a bone sparing effect of anti-TNF has been shown, the mechanism is not fully understood. Anti-TNF

The endothelial protein C receptor enhances hemostasis of FVIIa administration in hemophilic mice in vivo.

Giulia Pavani et al.

Blood, 124(7), 1157-1165 (2014-06-25)

Recombinant activated human factor VII (rhFVIIa) is an established hemostatic agent in hemophilia, but its mechanism of action remains unclear. Although tissue factor (TF) is its natural receptor, rhFVIIa also interacts with the endothelial protein C receptor (EPCR) through its

From design of bio-based biocomposite electrospun scaffolds to osteogenic differentiation of human mesenchymal stromal cells.

Julien Ramier et al.

Journal of materials science. Materials in medicine, 25(6), 1563-1575 (2014-03-04)

Electrospinning coupled with electrospraying provides a straightforward and robust route toward promising electrospun biocomposite scaffolds for bone tissue engineering. In this comparative investigation, four types of poly(3-hydroxybutyrate) (PHB)-based nanofibrous scaffolds were produced by electrospinning a PHB solution, a PHB/gelatin (GEL)

Multiple characterization study on porosity and pore structure of calcium phosphate cements.

David Pastorino et al.

Acta biomaterialia, 28, 205-214 (2015-09-20)

Characterization of the intricate pore structure of calcium phosphate cements is a key step to successfully link the structural properties of these synthetic bone grafts with their most relevant properties, such as in vitro or in vivo behaviour, drug loading

Effects of low dose FGF-2 and BMP-2 on healing of calvarial defects in old mice.

Lyndon F Charles et al.

Experimental gerontology, 64, 62-69 (2015-02-15)

There is an age-associated reduction in the bone healing activity of bone morphogenetic protein-2 (BMP-2) that is currently addressed by administering higher doses of BMP-2 in elderly patients. The unwanted medical complications from high dose BMP-2 motivated this investigation to

Functional characterization of a yellow laccase from Leucoagaricus gongylophorus.

Priscila Tomie Leme Ike et al.

SpringerPlus, 4, 654-654 (2015-11-07)

In this work we have identified, using mass spectrometry, two laccases produced by Leucoagaricus gongylophorus. One of them, Lac1Lg, was isolated, purified and characterized. Lac1Lg, a monomeric enzyme, was studied using ABTS and syringaldazine substrates. Lac1Lg presented kcat/Km almost threefold

Enhanced osteogenic potential of human mesenchymal stem cells on electrospun nanofibrous scaffolds prepared from eri-tasar silk fibroin.

Niladri Nath Panda et al.

Journal of biomedical materials research. Part B, Applied biomaterials, 103(5), 971-982 (2014-09-02)

This study evaluated the mechanical properties and osteogenic potential of a silk fibroin scaffold prepared from a 70:30 blend of Eri (Philosamia ricini) and Tasar (Antheraea mylitta) silk, respectively (ET scaffolds). An electrospinning process was used to prepare uniformly blended

High-throughput bone and cartilage micropellet manufacture, followed by assembly of micropellets into biphasic osteochondral tissue.

Betul Kul Babur et al.

Cell and tissue research, 361(3), 755-768 (2015-05-01)

Engineered biphasic osteochondral tissues may have utility in cartilage defect repair. As bone-marrow-derived mesenchymal stem/stromal cells (MSC) have the capacity to make both bone-like and cartilage-like tissues, they are an ideal cell population for use in the manufacture of osteochondral

Substrate-dependent nitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages.

Yoshikuni Goto et al.

Journal of biochemistry, 157(6), 439-449 (2015-01-13)

In this study, we examined the role of aminopeptidases with reference to endoplasmic reticulum aminopeptidase 1 (ERAP1) in nitric oxide (NO) synthesis employing murine macrophage cell line RAW264.7 cells activated by lipopolysaccharide (LPS) and interferon (IFN)-γ and LPS-activated peritoneal macrophages

Turning an antiviral into an anticancer drug: nanoparticle delivery of acyclovir monophosphate.

Jing Yao et al.

Journal of controlled release : official journal of the Controlled Release Society, 170(3), 414-420 (2013-06-25)

Anti-herpes simplex virus (HSV) drug acyclovir (ACV) is phosphorylated by the viral thymidine kinase (TK), but not the cellular TK. Phosphorylated ACV inhibits cellular DNA synthesis and kills the infected cells. We hypothesize that ACV monophosphate (ACVP), which is an

Engineering, expression in transgenic plants and characterisation of E559, a rabies virus-neutralising monoclonal antibody.

Craig J van Dolleweerd et al.

The Journal of infectious diseases, 210(2), 200-208 (2014-02-11)

Rabies post-exposure prophylaxis (PEP) currently comprises administration of rabies vaccine together with rabies immunoglobulin (RIG) of either equine or human origin. In the developing world, RIG preparations are expensive, often in short supply, and of variable efficacy. Therefore, we are

Biomineralized biomimetic organic/inorganic hybrid hydrogels based on hyaluronic acid and poloxamer.

Hyun Wook Huh et al.

Carbohydrate polymers, 126, 130-140 (2015-05-03)

A biomineralized hydrogel system containing hyaluronic acid (HA) and poloxamer composed of a poly(ethylene oxide)/poly(propylene oxide)/poly(ethylene oxide) (PEO-PPO-PEO) block copolymer was developed as a biomimetic thermo-responsive injectable hydrogel system for bone regeneration. Using HA and poloxamer macromers with polymerizable residues

Evaluation of adenoviral vascular endothelial growth factor-activated chitosan/hydroxyapatite scaffold for engineering vascularized bone tissue using human osteoblasts: In vitro and in vivo studies.

Aysel Koç et al.

Journal of biomaterials applications, 29(5), 748-760 (2014-07-27)

Bone tissue is dependent on an efficient blood supply to ensure delivery of nutrients and oxygen. One method to acquire a vascular-engineered bone tissue could be the use of an angiogenic gene-activated scaffold. In the current study, porous chitosan/hydroxyapatite (C/HA)

Dental demineralization and caries in patients with head and neck cancer.

Jie Deng et al.

Oral oncology, 51(9), 824-831 (2015-07-23)

Concurrent chemoradiation (CCR) therapy is a standard treatment for patients with locally advanced head and neck cancer (HNC). It is well documented that CCR causes profound acute and late toxicities. Xerostomia (the symptom of dry mouth) and hyposalivation (decreased salivary

Effects of pH on the production of phosphate and pyrophosphate by matrix vesicles' biomimetics.

Ana Maria S Simão et al.

Calcified tissue international, 93(3), 222-232 (2013-08-15)

During endochondral bone formation, chondrocytes and osteoblasts synthesize and mineralize the extracellular matrix through a process that initiates within matrix vesicles (MVs) and ends with bone mineral propagation onto the collagenous scaffold. pH gradients have been identified in the growth

Characterization of Species Differences in Tissue Diltiazem Deacetylation Identifies Ces2a as a Rat-Specific Diltiazem Deacetylase.

Takaya Kurokawa et al.

Drug metabolism and disposition: the biological fate of chemicals, 43(8), 1218-1225 (2015-05-17)

Diltiazem, a calcium channel blocker, is mainly metabolized via demethylation or deacetylation in humans. Diltiazem demethylation is catalyzed by cytochrome P450 2D6 and 3A4. Although it was previously reported that the area under the curve ratio of deacetyldiltiazem to diltiazem

Enhanced enterovirus 71 virus-like particle yield from a new baculovirus design.

Shih-Yeh Lin et al.

Biotechnology and bioengineering, 112(10), 2005-2015 (2015-05-23)

Enterovirus 71 (EV71) is responsible for the outbreaks of hand-foot-and-mouth disease in the Asia-Pacific region. To produce the virus-like particle (VLP) vaccine, we previously constructed recombinant baculoviruses to co-express EV71 P1 polypeptide and 3CD protease using the Bac-to-Bac(®) vector system.

Volatile Glycosylation in Tea Plants: Sequential Glycosylations for the Biosynthesis of Aroma β-Primeverosides Are Catalyzed by Two Camellia sinensis Glycosyltransferases.

Shoji Ohgami et al.

Plant physiology, 168(2), 464-477 (2015-04-30)

Tea plants (Camellia sinensis) store volatile organic compounds (VOCs; monoterpene, aromatic, and aliphatic alcohols) in the leaves in the form of water-soluble diglycosides, primarily as β-primeverosides (6-O-β-D-xylopyranosyl-β-D-glucopyranosides). These VOCs play a critical role in plant defenses and tea aroma quality

Effects of titanate coupling agent on the mechanical, thermal, and morphological properties of poly (methyl methacrylate)/hydroxyapatite denture base composites.

Tham WL, et al.

Journal of Composite Materials, 45(22), 2335-2345 (2011)

Isolation of B subunit-specific monoclonal antibody clones that strongly neutralize the toxicity of Shiga toxin 2.

Hideyuki Arimitsu et al.

Microbiology and immunology, 59(2), 71-81 (2014-12-19)

Shiga toxin 2 (Stx2)-specific mAb-producing hybridoma clones were generated from mice. Because mice tend to produce small amounts of B subunit (Stx2B)-specific antibodies at the polyclonal antibody level after immunization via the parenteral route, mice were immunized intranasally with Stx2

In-situ dispersed photopolymerization of cyclic acetals/hydroxyapatite composites: effects of the content of hydroxyapatite.

Ruixue Yin et al.

Materials science & engineering. C, Materials for biological applications, 46, 239-245 (2014-12-11)

In this work, hydroxyapatite (HA) was first dispersed into cyclic acetal unit based monomers (EHD), and then EHD/HA composites were obtained by in-situ photopolymerization. FTIR and XRD analyses were used to successfully confirm the chemical composition of this composite. Real-time

A high-affinity native human antibody neutralizes human cytomegalovirus infection of diverse cell types.

Lawrence M Kauvar et al.

Antimicrobial agents and chemotherapy, 59(3), 1558-1568 (2014-12-24)

Human cytomegalovirus (HCMV) is the most common infection causing poor outcomes among transplant recipients. Maternal infection and transplacental transmission are major causes of permanent birth defects. Although no active vaccines to prevent HCMV infection have been approved, passive immunization with

Selective monoamine oxidase B inhibition by an Aphanizomenon flos-aquae extract and by its constitutive active principles phycocyanin and mycosporine-like amino acids.

Stefano Scoglio et al.

Phytomedicine : international journal of phytotherapy and phytopharmacology, 21(7), 992-997 (2014-04-03)

Aphanizomenon flos-aquae (AFA) is a fresh water unicellular blue-green alga that has been traditionally used for over 25 years for its health-enhancing properties. Recent studies have shown the ability of a proprietary AFA extract (Klamin(®)) to improve mood, counteract anxiety

Biofilm community diversity after exposure to 0·4% stannous fluoride gels.

C Reilly et al.

Journal of applied microbiology, 117(6), 1798-1809 (2014-09-30)

To test the effect of 0·4% stannous fluoride (SnF2 ) glycerine-based gels on specific portions of the bacterial community in both a clinical observational study and in vitro multispecies plaque-derived (MSPD) biofilm model. Potential changes to specific portions of the

Endocultivation: Histomorphological effects of repetitive rhBMP-2 application into prefabricated hydroxyapatite scaffolds at extraskeletal sites.

Benedicta E Beck-Broichsitter et al.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 43(6), 981-988 (2015-05-16)

The timing of application of recombinant human bone morphogenic protein-2 (rhBMP-2) may be important in determining the final outcome of engineered bone tissue. This study investigates the impact of repetitive rhBMP-2 application on hard and soft tissue morphology in endocultivation.

Sustained release of platelet-derived growth factor and vascular endothelial growth factor from silk/calcium phosphate/PLGA based nanocomposite scaffold.

Mehdi Farokhi et al.

International journal of pharmaceutics, 454(1), 216-225 (2013-07-17)

To exploit the therapeutic potential of growth factors in tissue regeneration, it is necessary to design a porous scaffold in order to concurrently accommodate cells and release angiogenic factors in a controlled manner. In an attempt to address these issues

Haloarchaea Endowed with Phosphorus Solubilization Attribute Implicated in Phosphorus Cycle.

Ajar Nath Yadav et al.

Scientific reports, 5, 12293-12293 (2015-07-29)

Archaea are unique microorganisms that are present in ecological niches of high temperature, pH and salinity. A total of 157 archaea were obtained from thirteen sediment, water and rhizospheric soil samples collected from Rann of Kutch, Gujarat, India. With an

An injectable BMP cocktail for fracture-healing--a study that others have only imagined: commentary on an article by Thomas Lyon, MD, et al.: "Efficacy and safety of recombinant human bone morphogenetic protein-2/calcium phosphate matrix for closed tibial diaphyseal fracture. a double-blind, randomized, controlled phase-II/III trial".

Cory Collinge

The Journal of bone and joint surgery. American volume, 95(23), e1891-e1892 (2013-12-07)

Porous titanium particles for acetabular reconstruction in total hip replacement show extensive bony armoring after 15 weeks. A loaded in vivo study in 10 goats.

Lucas H B Walschot et al.

Acta orthopaedica, 85(6), 600-608 (2014-09-23)

The bone impaction grafting technique restores bone defects in total hip replacement. Porous titanium particles (TiPs) are deformable, like bone particles, and offer better primary stability. We addressed the following questions in this animal study: are impacted TiPs osteoconductive under

A Drosophila model identifies a critical role for zinc in mineralization for kidney stone disease.

Thomas Chi et al.

PloS one, 10(5), e0124150-e0124150 (2015-05-15)

Ectopic calcification is a driving force for a variety of diseases, including kidney stones and atherosclerosis, but initiating factors remain largely unknown. Given its importance in seemingly divergent disease processes, identifying fundamental principal actors for ectopic calcification may have broad

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