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Showing 1-30 of 360 results for "293040" within Papers
Anindya Sarkar et al.
The Journal of biological chemistry, 290(35), 21615-21628 (2015-07-03)
Heat shock protein 90 (hsp90) drives heme insertion into the β1 subunit of soluble guanylate cyclase (sGC) β1, which enables it to associate with a partner sGCα1 subunit and mature into a nitric oxide (NO)-responsive active form. We utilized fluorescence
John A Hangasky et al.
Biochemistry, 52(9), 1594-1602 (2013-01-29)
Oxygen homeostasis plays a critical role in angiogenesis, erythropoiesis, and cell metabolism. Oxygen homeostasis is set by the hypoxia inducible factor-1α (HIF-1α) pathway, which is controlled by factor inhibiting HIF-1α (FIH). FIH is a non-heme Fe(II), α-ketoglutarate (αKG)-dependent dioxygenase that
Jae-Min Ha et al.
Soft matter, 11(29), 5821-5827 (2015-06-11)
We have investigated the distributions of individually isolated and hydrophilically functionalized single-walled carbon nanotubes (p-SWNTs) in the Pluronic L121-water system at the reverse hexagonal phase using small-angle X-ray scattering (SAXS) and contrast-matched small-angle neutron scattering (SANS) measurements. As the p-SWNT-L121-water
Di Gao et al.
ACS applied materials & interfaces, 7(24), 13524-13537 (2015-05-29)
Ultrasound as an external stimulus for enhanced gene transfection represents a safe, noninvasive, cost-effective delivery strategy for gene therapy. Herein, we have developed an ultrasound-triggered phase-transition cationic nanodroplet based on a novel perfluorinated amphiphilic poly(amino acid), which could simultaneously load
Christina O'Rourke et al.
Annals of botany, 116(2), 225-236 (2015-06-27)
During evolution, plants have acquired and/or lost diverse sugar residues as cell-wall constituents. Of particular interest are primordial cell-wall features that existed, and in some cases abruptly changed, during the momentous step whereby land-plants arose from charophytic algal ancestors. Polysaccharides
Tina A Crook et al.
Journal of the Academy of Nutrition and Dietetics, 112(12), 1993-1998 (2012-11-24)
Anthropometrics and body mass index are only proxies in the evaluation of adiposity in the pediatric population. Air displacement plethysmography technology was not available for children aged 6 months to 9 years until recently. Our study was designed to test
Shirin Ghods et al.
Applied and environmental microbiology, 81(12), 4026-4036 (2015-04-05)
Pseudomonas syringae pv. actinidiae is the major cause of bacterial canker and is a severe threat to kiwifruit production worldwide. Many aspects of the disease caused by P. syringae pv. actinidiae, such as the pathogenicity-relevant formation of a biofilm composed
Yanfen Fu et al.
Applied microbiology and biotechnology, 99(10), 4397-4408 (2015-01-27)
Systems metabolic engineering has made the renewable production of industrial chemicals a feasible alternative to modern operations. One major example of a renewable process is the production of carboxylic acids, such as octanoic acid (C8), from Escherichia coli, engineered to
Guanhua Yang et al.
Biopolymers, 104(1), 11-20 (2014-12-05)
Caveolin-1 is a main structural component of caveolae and essential for the invagination of caveolae by forming a hairpin-shaped structure in the membrane-inserting domain (residues, 102-122). In this article, we determined the tertiary structures of the peptides comprising residues 93-126
Lei Hou et al.
Soft matter, 11(35), 7059-7065 (2015-08-08)
The UCST-type transition of poly(acrylamide-co-acrylonitrile) (P(AAm-co-AN)) (molar fraction of AN: 13.3%; PDI = 3.2) in H2O and D2O is explored and compared by applying turbidity, DLS as well as FTIR measurements. The transition temperature of P(AAm-co-AN) in D2O is observed
Tadasu Urashima et al.
Glycoconjugate journal, 32(6), 361-370 (2015-06-07)
Structural characterizations of marsupial milk oligosaccharides have been performed in four species to date: the tammar wallaby (Macropus eugenii), the red kangaroo (Macropus rufus), the koala (Phascolarctos cinereus) and the common brushtail possum (Trichosurus vulpecula). To clarify the homology and
Golo M J Meyer et al.
Analytical and bioanalytical chemistry, 407(3), 761-778 (2014-09-23)
Mesembrine and mesembrenone are the main alkaloids of Sceletium tortuosum, a plant species that was used for sedation and analgesia by the KhoiSan, previously known as Hottentots, a tribe in South Africa. After fermentation, the obtained preparation called "Kanna" or
Xiaoqin Huang et al.
Food chemistry, 166, 62-67 (2014-07-24)
The conformational changes of the glycated ovalbumin were studied by hydrogen/deuterium exchange coupled with high resolution mass spectrometry technique (HDX-MS). After incubation with glucose at 50 °C for 6 h, 9 glycated peptides were detected and the corresponding glycation sites
Valeria Cagno et al.
Antimicrobial agents and chemotherapy, 59(9), 5250-5259 (2015-06-17)
The agmatine-containing poly(amidoamine) polymer AGMA1 was recently shown to inhibit the infectivity of several viruses, including human papillomavirus 16 (HPV-16), that exploit cell surface heparan sulfate proteoglycans (HSPGs) as attachment receptors. The aim of this work was to assess the
Guolin Ma et al.
Nature communications, 6, 7826-7826 (2015-07-18)
Store-operated Ca(2+) entry mediated by STIM1 and ORAI1 constitutes one of the major Ca(2+) entry routes in mammalian cells. The molecular choreography of STIM1-ORAI1 coupling is initiated by endoplasmic reticulum (ER) Ca(2+) store depletion with subsequent oligomerization of the STIM1
Ripen Misri et al.
Nanomedicine : nanotechnology, biology, and medicine, 11(7), 1785-1795 (2015-05-20)
We report the synthesis and characterization of a polymeric nanoparticle (NP) based on hyperbranched polyglycerol (HPG) containing a hydrophobic core and a hydrophilic shell, and assessed its suitability to be developed as a systemic anticancer drug carrier. HPG NP displayed
Yumiko Mizukoshi et al.
ChemMedChem, 10(4), 736-741 (2015-03-12)
Numerous small organic compounds exist in equilibrium among monomers, soluble oligomers, and insoluble aggregates in aqueous solution. Compound aggregation is a major reason for false positives in drug screening, and even soluble oligomers can interfere with structural and biochemical analyses.
Merrell A Johnson et al.
The Journal of membrane biology, 248(4), 695-703 (2015-02-19)
We show that the interaction of aromatic amino acids with lipid bilayers can be characterized by conventional 1D [Formula: see text]H NMR spectroscopy using reference spectra obtained in isopropanol-d8/D[Formula: see text]O solutions. We demonstrate the utility of this method with
Nella Barshteyn et al.
Chemical research in toxicology, 22(5), 918-925 (2009-03-26)
Previously, our laboratory has shown that hydroxymethylvinyl ketone (HMVK), a Michael acceptor oxidation product of the 1,3-butadiene metabolite, 3-butene-1,2-diol, readily reacts with hemoglobin at physiological conditions and that mass spectrometry of trypsin-digested peptides suggested adduct formation with various nucleophilic amino
Longyan Zhao et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(27), 8284-8289 (2015-06-24)
Selective inhibition of the intrinsic coagulation pathway is a promising strategy for developing safer anticoagulants that do not cause serious bleeding. Intrinsic tenase, the final and rate-limiting enzyme complex in the intrinsic coagulation pathway, is an attractive but less explored
Suvimol Surassmo et al.
Colloids and surfaces. B, Biointerfaces, 130, 229-236 (2015-05-06)
Mucoadhesive poly (lactic-co-glycolic acid) (PLGA) nanoparticles having a modified shell-matrix derived from polyvinyl alcohol (PVA) and Carbopol (CP), a biodegradable polymer coating, to improve the adhesion and cell transfection properties were developed. The optimum formulations utilized a CP concentration in
Masahiko Terauchi et al.
Macromolecular bioscience, 15(7), 953-964 (2015-03-27)
Although bone morphogenetic protein-2 (BMP-2) has received considerable attention because of its strong osteoinductivity, the clinical application of BMP-2 is limited due to its degradation and deactivation under physiological conditions. Negatively charged heparin is known to form polyelectrolyte complexes with
Frank J Symons et al.
Pain medicine (Malden, Mass.), 16(2), 249-256 (2014-09-23)
Assessing and treating pain in nonverbal children with developmental disabilities are a clinical challenge. Current assessment approaches rely on clinical impression and behavioral rating scales completed by proxy report. Given the growing health relevance of the salivary metabolome, we undertook
Serge Y Ongagna-Yhombi et al.
Applied and environmental microbiology, 81(1), 351-363 (2014-10-26)
Vibrio parahaemolyticus is a halophile that is the predominant cause of bacterial seafood-related gastroenteritis worldwide. To survive in the marine environment, V. parahaemolyticus must have adaptive strategies to cope with salinity changes. Six putative compatible solute (CS) transport systems were
Masahito Wakita et al.
Journal of neurophysiology, 114(2), 1109-1118 (2015-05-29)
The effects of heavy water (deuterium oxide, D2O) on GABAergic and glutamatergic spontaneous and evoked synaptic transmission were investigated in acute brain slice and isolated "synaptic bouton" preparations of rat hippocampal CA3 neurons. The substitution of D2O for H2O reduced
Xiao Jiang et al.
Biomedical microdevices, 17(1), 20-20 (2015-02-06)
Growth of the MDA-MB-231 breast cancer cell line in microfluidic channels was inhibited when culture media was delivered to the channels via microbore Tygon® tubing. Culture media incubated within this tubing also inhibited growth of these cells in conventional 96-well
Xiangfeng Meng et al.
Applied microbiology and biotechnology, 99(14), 5885-5894 (2015-01-15)
Glucansucrases are exclusively found in lactic acid bacteria and synthesize a variety of α-glucans from sucrose. They are large multidomain enzymes belonging to the CAZy family 70 of glycoside hydrolase enzymes (GH70). The crystal structure of the N-terminal truncated GTF180
Jiang-hua Feng et al.
Molecular and cellular endocrinology, 394(1-2), 59-69 (2014-07-06)
Prenatal nicotine exposure causes adverse birth outcome. However, the corresponding metabonomic alterations and underlying mechanisms of nicotine-induced developmental toxicity remain unclear. The aims of this study were to characterize the metabolic alterations in biofluids in nicotine-induced intrauterine growth retardation (IUGR)
Sonali Ghosh et al.
Journal of bacteriology, 197(5), 992-1001 (2014-12-31)
This work was undertaken to obtain information on levels of metabolism in dormant spores of Bacillus species incubated for weeks at physiological temperatures. Spores of Bacillus megaterium and Bacillus subtilis strains were harvested shortly after release from sporangia and incubated
Brandon K Tate et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(28), 10160-10169 (2015-06-11)
Alkoxide-bridged disilver cations react with dihydrogen to form hydride-bridged cations, releasing free alcohol. Hydrogenolysis of neutral silver fluorides affords hydride-bridged disilver cations as their bifluoride salts. These reactions proceed most efficiently when the supporting ligands are expanded N-heterocyclic carbenes (NHCs)
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