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Showing 1-30 of 434 results for "30089" within Papers
Seema Joshi et al.
Human & experimental toxicology, 24(1), 13-17 (2005-02-25)
L-histidine, L-cysteine, reduced glutathione (GSH) and other bioligands, which are ubiquitously present in biological systems, are recognized as antioxidants. Studies have shown that nickel (II) complexed with these ligands catalyzes the disproportionation of H2O2, leading to the generation of hydroxyl
Elisabeth Eckert et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 965, 54-60 (2014-07-06)
We developed and validated an analytical method for the simultaneous determination of methyl mercapturic acid (MeMA), ethyl mercapturic acid (EtMA), n-propyl mercapturic acid (PrMA) and iso-propyl mercapturic acid (iPrMA) in human urine. These alkyl mercapturic acids are known or presumed
Jane M Rodgers et al.
Glia, 63(5), 768-779 (2015-01-06)
Inflammatory signals present in demyelinated multiple sclerosis lesions affect the reparative remyelination process conducted by oligodendrocyte progenitor cells (OPCs). Interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and interleukin (IL)-6 have differing effects on the viability and growth of OPCs, however the
Ronald A Thisted et al.
Clinical therapeutics, 28(10), 1607-1618 (2006-12-13)
Pain associated with diabetic peripheral neuropathy (DPN) has a substantial negative impact on patients' quality of life. The primary objective of this study was to evaluate the tolerability of capsules containing dextromethorphan (DM) and quinidine (Q) in patients with painful
Dennis Bakker et al.
Infection and immunity, 82(10), 4222-4232 (2014-07-23)
In the past decade, Clostridium difficile has emerged as an important gut pathogen. Symptoms of C. difficile infection range from mild diarrhea to pseudomembranous colitis. Besides the two main virulence factors toxin A and toxin B, other virulence factors are
Ning-Kui Niu et al.
Drug design, development and therapy, 9, 1555-1584 (2015-03-21)
Osteosarcoma (OS) is the most common malignant bone tumor occurring mostly in children and adolescents between 10 and 20 years of age with poor response to current therapeutics. Alisertib (ALS, MLN8237) is a selective Aurora kinase A inhibitor that displays
Jung-Sub Park et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(27), 9911-9916 (2014-06-25)
Noise-induced hearing loss is one of the most common types of sensorineural hearing loss. In this study, we examined the expression and localization of leukotriene receptors and their respective changes in the cochlea after hazardous noise exposure. We found that
Edward T Chouchani et al.
Nature medicine, 19(6), 753-759 (2013-05-28)
Oxidative damage from elevated production of reactive oxygen species (ROS) contributes to ischemia-reperfusion injury in myocardial infarction and stroke. The mechanism by which the increase in ROS occurs is not known, and it is unclear how this increase can be
T Rajah et al.
Toxicology and applied pharmacology, 278(2), 100-106 (2014-04-29)
The caspase inhibitor benzyloxycarbony (Cbz)-l-Val-Ala-Asp (OMe)-fluoromethylketone (z-VAD-FMK) has recently been shown to inhibit T cell proliferation without blocking caspase-8 and caspase-3 activation in primary T cells. We showed in this study that z-VAD-FMK treatment leads to a decrease in intracellular
Hong-Yan Lin et al.
Biochemical pharmacology, 96(2), 93-106 (2015-05-11)
The high incidence of cancer and the side effects of traditional anticancer drugs motivate the search for new and more effective anticancer drugs. In this study, we synthesized 17 kinds of aryl dihydrothiazol acyl shikonin ester derivatives and evaluated their
Jonathan M Ostrem et al.
Nature, 503(7477), 548-551 (2013-11-22)
Somatic mutations in the small GTPase K-Ras are the most common activating lesions found in human cancer, and are generally associated with poor response to standard therapies. Efforts to target this oncogene directly have faced difficulties owing to its picomolar
Jan Rybniker et al.
The Biochemical journal, 459(3), 467-478 (2014-02-20)
The complex multiprotein systems for the assembly of protein-bound iron-sulfur (Fe-S) clusters are well defined in Gram-negative model organisms. However, little is known about Fe-S cluster biogenesis in other bacterial species. The ISC (iron-sulfur cluster) operon of Mycobacterium tuberculosis lacks
S Iyer et al.
The Journal of biological chemistry, 276(15), 12153-12161 (2000-11-19)
The angiogenic molecule placenta growth factor (PlGF) is a member of the cysteine-knot family of growth factors. In this study, a mature isoform of the human PlGF protein, PlGF-1, was crystallized as a homodimer in the crystallographic asymmetric unit, and
Kohei Togami et al.
Biological & pharmaceutical bulletin, 38(2), 270-276 (2015-03-10)
In the present in vitro study, we assessed the delivery of pirfenidone incorporated into liposomes modified with truncated basic fibroblast growth factor (tbFGF) to lung fibroblasts and investigated the anti-fibrotic effect of the drug. The tbFGF peptide, KRTGQYKLC, was used
Takeshi Hano et al.
Bulletin of environmental contamination and toxicology, 95(3), 340-343 (2015-04-24)
We evaluated the bioconcentration and elimination of polycarbamate, a popular antifoulant classified as a dithiocarbamate fungicide, in a marine teleost fish, mummichog (Fundulus heteroclitus), and a polychaete (Perinereis nuntia). Following polycarbamate exposure and depuration, the calculated bioconcentration factor (BCF) and
Paul J Kennedy et al.
Psychopharmacology, 232(8), 1357-1371 (2014-10-24)
A visuospatial episodic memory impairment has recently been identified in irritable bowel syndrome. Increased tryptophan metabolism along the kynurenine pathway has also been reported in irritable bowel syndrome, which may play a role in altered cognitive performance as peripheral kynurenine
Janina Schmitz et al.
ChemMedChem, 10(8), 1365-1377 (2015-06-30)
Cleavage of the invariant chain is the key event in the trafficking pathway of major histocompatibility complex class II. Cathepsin S is the major processing enzyme of the invariant chain, but cathepsin F acts in macrophages as its functional synergist which is as
Jiangge Zheng et al.
Biochemical and biophysical research communications, 456(3), 737-742 (2014-12-20)
Locusta migratoria (Lmig) causes enormous losses to agricultural products, especially because it often infests the world with great swarms as locust plagues. Locusts find their plant hosts on which they feed through their olfactory system, in which odorant binding proteins
Shekhar U Kadam et al.
Ultrasonics sonochemistry, 23, 308-316 (2014-12-03)
The objective of this study was to investigate the effect of key extraction parameters of extraction time (5-25 min), acid concentration (0-0.06 M HCl) and ultrasound amplitude (22.8-114 μm) on yields of bioactive compounds (total phenolics, fucose and uronic acid)
V Calabrese et al.
Neurochemical research, 28(9), 1321-1328 (2003-08-27)
Recent studies suggest that NO and its reactive derivative peroxynitrite are implicated in the pathogenesis of multiple sclerosis (MS). Patients dying with MS demonstrate increased astrocytic inducible nitric oxide synthase activity, as well as increased levels of iNOS mRNA. Peroxynitrite
Wei Li et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 963, 113-118 (2014-06-21)
A rapid and sensitive liquid chromatography-mass spectrometry (LC-MS) method was developed and validated for the simultaneous determination of microcystin-RR (MC-RR) and its glutathione and cysteine conjugates (MC-RR-GSH and MC-RR-Cys, respectively) in fish plasma and bile. The analytes were extracted using
N André Sasaki et al.
Bioorganic & medicinal chemistry, 17(6), 2310-2320 (2009-03-06)
2,3-Diaminopropionic acid (Dap) and N-terminal Dap peptides have been found to inhibit in vitro protein-modifications by methylglyoxal (MG), one of the highly reactive alpha-dicarbonyl compounds. MG scavenging potency of the newly synthesized N-terminal Dap peptides is demonstrated by RP-HPLC, SDS-PAGE
Susan T Stephenson et al.
The Journal of allergy and clinical immunology, 136(2), 454-461 (2015-03-10)
The mechanisms underlying glucocorticoid responsiveness are largely unknown. Although redox regulation of the glucocorticoid receptor (GR) has been reported, it has not been studied in asthmatic patients. We characterized systemic cysteine oxidation and its association with inflammatory and clinical features
Emanuele Bellacchio et al.
Gene, 549(2), 286-294 (2014-07-30)
Autoimmunity can develop from an often undetermined interplay of genetic and environmental factors. Rare forms of autoimmune conditions may also result from single gene mutations as for autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, an autosomal recessive disease associated with mutated forms of the
Frank H Yu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(20), 7577-7585 (2003-08-22)
The principal alpha subunit of voltage-gated sodium channels is associated with auxiliary beta subunits that modify channel function and mediate protein-protein interactions. We have identified a new beta subunit termed beta4. Like the beta1-beta3 subunits, beta4 contains a cleaved signal
Satoshi Hara et al.
Biochemical and biophysical research communications, 456(1), 339-343 (2014-12-02)
The redox states of proteins in cells are key factors in many cellular processes. To determine the redox status of cysteinyl thiol groups in proteins in vivo, we developed a new maleimide reagent, a photocleavable maleimide-conjugated single stranded DNA (DNA-PCMal).
Justin W Kenney et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(7), 3034-3047 (2015-02-24)
The rapid regulation of cell signaling in response to calcium in neurons is essential for real-time processing of large amounts of information in the brain. A vital regulatory component, and one of the most energy-intensive biochemical processes in cells, is
Siddhartha Sankar Boxi et al.
Dalton transactions (Cambridge, England : 2003), 44(47), 20464-20474 (2015-11-07)
Arsenic poisoning from drinking water has been an important global issue in recent years. Because of the high level toxicity of arsenic to human health, an easy, inexpensive, low level and highly selective detection technique is of great importance to
Kazuaki Miyamoto et al.
BMC microbiology, 15, 118-118 (2015-06-10)
Most recent studies of Clostridium perfringens plasmids have focused on toxin-encoding or antibiotic resistance plasmids. To cause intestinal disease, a toxigenic strain must grow in the intestines to levels allowing for sufficient toxin production and this in vivo growth often
Feng Wang et al.
Cell, 153(6), 1379-1393 (2013-06-12)
Some species mount a robust antibody response despite having limited genome-encoded combinatorial diversity potential. Cows are unusual in having exceptionally long CDR H3 loops and few V regions, but the mechanism for creating diversity is not understood. Deep sequencing reveals
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