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Showing 1-30 of 1334 results for "302643" within Papers
Alix de Brogniez et al.
Journal of virology, 89(17), 8945-8956 (2015-06-19)
Viruses have coevolved with their host to ensure efficient replication and transmission without inducing excessive pathogenicity that would indirectly impair their persistence. This is exemplified by the bovine leukemia virus (BLV) system in which lymphoproliferative disorders develop in ruminants after
Valerie A Marshall et al.
Birth defects research. Part B, Developmental and reproductive toxicology, 104(1), 1-10 (2015-02-06)
Histiotrophic nutrition via the visceral yolk sac is an essential nutritional pathway of the rodent conceptus, and inhibition of this pathway may cause growth retardation, malformations, and death in rodent embryos. Morphologic differences among species during early development indicate that
Chia-Jen Lee et al.
Anticancer research, 34(11), 6467-6472 (2014-11-05)
Aim/Materials and Methods: In order to develop better drugs against non-small cell lung cancer (NSCLC), we screened a variety of compounds and treated the human lung adenocarcinoma cell line A549 with different drug concentrations. We then examined the cell viability
Yi Tang et al.
American journal of cancer research, 5(2), 498-513 (2015-05-15)
Autophagy plays a protective role in colorectal carcinoma. Arginine ADP-ribosyltransferase 1 (ART1) is an important mono-ADP-ribose transferase, which has been shown to play a role in biological processes such as proliferation and invasion of cancer cells. Interestingly, the role of
K Subedi et al.
Breast cancer research and treatment, 149(1), 17-29 (2014-11-25)
The 20 and 22 carbon n-3 long-chain polyunsaturated fatty acids (LCPUFA) inhibit the growth of tumors in vitro and in animal models, but less is known about the 18 carbon n-3, stearidonic acid (SDA). This study aimed to establish and
Wolfgang Klein et al.
PloS one, 10(3), e0120886-e0120886 (2015-03-26)
The cyclodepsipeptide cotransin was described to inhibit the biosynthesis of a small subset of proteins by a signal sequence-discriminatory mechanism at the Sec61 protein-conducting channel. However, it was not clear how selective cotransin is, i.e. how many proteins are sensitive.
Julie Prigent et al.
Cell transplantation, 24(8), 1639-1652 (2014-05-23)
Xenotransplantation of human cells in animal models is an essential tool for evaluation of safety and efficacy of cell-based products for therapeutic use. Sensitive and reproducible methods are needed to detect and quantify human cells engrafted into the host tissue
Shirya Rashid et al.
Circulation, 130(5), 431-441 (2014-07-30)
Proprotein convertase subtilisin kexin type 9 (PCSK9) promotes the degradation of the low-density lipoprotein (LDL) receptor (LDLR), and its deficiency in humans results in low plasma LDL cholesterol and protection against coronary heart disease. Recent evidence indicates that PCSK9 also
Ji Wook Hong et al.
Cornea, 34(4), 460-463 (2014-12-05)
The aim of this study was to investigate the effect of intracameral injection of bisulfite-containing phenylephrine on rabbit corneal endothelium cells in rabbits. Fifteen eyes of 15 New Zealand white rabbits were divided into 3 groups. Five eyes from each
Anindita Das et al.
Basic research in cardiology, 110(3), 31-31 (2015-04-26)
Diabetic patients suffer augmented severity of myocardial infarction. Excessive activation of the mammalian target of rapamycin (mTOR) and decreased activation of STAT3 are implicated in diabetic complications. Considering the potent cardioprotective effect of mTOR inhibitor, rapamycin, we hypothesized that reperfusion
Euan R O Allan et al.
Journal of immunology (Baltimore, Md. : 1950), 192(11), 4989-5001 (2014-04-30)
The chemistries within phagosomes of APCs mediate microbial destruction as well as generate peptides for presentation on MHC class II. The antimicrobial effector NADPH oxidase (NOX2), which generates superoxide within maturing phagosomes, has also been shown to regulate activities of
Caifeng Wan et al.
Molecular medicine reports, 12(2), 2835-2841 (2015-05-06)
The aim of the present study was to investigate the efficacy and safety of ultrasound-targeted microbubble destruction (UTMD)-mediated polyethylenimine (PEI) transfection in cultured human retinal pigment epithelial (RPE) cells in vitro and rat retinas in vivo. An enhanced green fluorescent
Valentina Pozzi et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 36(2), 784-798 (2015-05-30)
Head and neck squamous cell carcinoma (HNSCC) ranks sixth worldwide for tumor-related mortality. A subpopulation of tumor cells, termed cancer stem cells (CSCs), has the ability to support cancer growth. Therefore, profiling CSC-enriched populations could be a reliable tool to
Wei Liu et al.
PloS one, 10(4), e0122366-e0122366 (2015-04-08)
Vasicine (VAS), a potential natural cholinesterase inhibitor, exhibited promising anticholinesterase activity in preclinical models and has been in development for treatment of Alzheimer's disease. This study systematically investigated the in vitro and in vivo metabolism of VAS in rat using
Norman Nausch et al.
PloS one, 6(2), e16860-e16860 (2011-02-25)
Acquired immunity against helminths is characterised by a complex interplay between the effector Th1 and Th2 immune responses and it slowly manifests with age as a result of cumulative exposure to parasite antigens. Data from experimental models suggest that immunity
Edyta Bąbolewska et al.
Cellular immunology, 293(2), 67-73 (2015-01-13)
Cathelicidins, a family of antimicrobial peptides, are well known for their role in host defense, particularly against bacteria. Apart from direct killing of microbes through the membrane disruption, cathelicidins can also exert immunomodulatory effects on cells involved in inflammatory processes.
Holger Haselmann et al.
Frontiers in neurology, 6, 136-136 (2015-07-01)
Autoantibodies (aAB) to the presynaptic located enzyme glutamate decarboxylase 65 (GAD65) are a characteristic attribute for a variety of autoimmune diseases of the central nervous system including subtypes of limbic encephalitis, stiff person-syndrome, cerebellar ataxia, and Batten's disease. Clinical signs
Rajesh Parikh et al.
Drug delivery, 21(6), 406-411 (2013-11-13)
Tuberculosis (TB) is a chronic infectious disease with increasing incidence of drug resistance. Oral treatment for TB and multidrug resistance (MDR)-TB can have serious side effects. The causative agent of TB, Mycobacterium tuberculosis, resides in alveolar macrophages (AM). Pulmonary administration
Compound 331 selectively induces glioma cell death by upregulating miR-494 and downregulating CDC20.
Lei Zhang et al.
Scientific reports, 5, 12003-12003 (2015-07-15)
Malignant gliomas are the most common malignant tumors in the central nervous system (CNS). Up to date, the prognosis of glioma is still very poor, effective therapy with less side-effect is very necessary. Herein, we identify a compound named as
Maria Theresa E Montales et al.
Carcinogenesis, 35(9), 2102-2112 (2014-05-17)
Many adult chronic diseases are thought to be influenced during early life by maternal nutrition; however, the underlying mechanisms remain largely unknown. Obesity-related diseases may be due partly to high fat consumption. Herein, we evaluated mammary tumor risk in female
Sunny O Abarikwu et al.
Pesticide biochemistry and physiology, 118, 90-98 (2015-03-11)
Atrazine (ATZ) is a well known herbicide that is frequently detected in ground and surface water at significant levels. Our objective was to study the toxic effect of ATZ on the human neuroblastoma (SH-SY5Y) cells, and the degree of cytotoxicity
Wenkai Xiao et al.
International journal of oncology, 46(1), 360-368 (2014-10-31)
Tetrandrine, a bisbenzylisoquinoline alkaloid, is known to inhibit tumor cell proliferation and induce apoptosis in cancer models in vitro and in vivo. In the present study, tetrandrine significantly inhibited the proliferation of mouse endothelial cells (EOMA cell) and induced G1/S arrest in
Hui Wang et al.
Infection and immunity, 82(9), 3567-3579 (2014-06-11)
Subtilase cytotoxin (SubAB) is the prototype of a recently emerged family of AB5 cytotoxins produced by Shiga-toxigenic Escherichia coli (STEC). Its mechanism of action involves highly specific A-subunit-mediated proteolytic cleavage of the essential endoplasmic reticulum (ER) chaperone BiP. Our previous
Kyung Hye Seo et al.
Phytotherapy research : PTR, 29(11), 1753-1760 (2015-08-28)
Mangosenone F (MSF), a natural xanthone, was isolated form Carcinia mangotana, and a few studies have reported its glycosidase inhibitor effect. In this study we investigated the anti lung cancer effect of MSF both in vitro and in vivo. MSF
Annette Dalrymple et al.
Regulatory toxicology and pharmacology : RTP, 72(1), 141-149 (2015-04-08)
Smoking is a cause of serious diseases, including lung cancer, emphysema, chronic bronchitis and heart disease. DNA damage is thought to be one of the mechanisms by which cigarette smoke (CS) initiates disease in the lung. Indeed, CS induced DNA
Astrid Milić et al.
European journal of drug metabolism and pharmacokinetics, 39(4), 263-276 (2013-10-12)
The purpose of this study was to evaluate the impact of structural modifications on the 15-membered macrolactone ring and/or substituents on the in vitro ADME properties and in vivo pharmacokinetic (PK) profile for selected derivatives in rodents in comparison to
Guohua Yu et al.
PloS one, 7(11), e48146-e48146 (2012-11-08)
Prion protein (PrP) is well studied for its pathogenic role in prion disease, but its potential contribution to other pathological processes is less understood. PrP is expressed in a variety of cancers and at least in pancreatic and breast cancers
Abebe Genetu Bayih et al.
PLoS neglected tropical diseases, 8(12), e3391-e3391 (2014-12-17)
To date, no universally effective and safe vaccine has been developed for general human use. Leishmania donovani Peroxidoxin-1 (LdPxn-1) is a member of the antioxidant family of proteins and is predominantly expressed in the amastigote stage of the parasite. The
Emrullah Beyazyıldız et al.
Stem cells international, 2014, 250230-250230 (2014-08-20)
Purpose. The current study was set out to address the therapeutic efficacy of topically applied mesenchymal stem cells (MSCs) on dry eye syndrome (DES) induced by benzalkonium chloride (BAC) in rats. Methods. Rats were divided into two groups just after
Shiying Shao et al.
Proteomics, 15(21), 3711-3721 (2015-08-20)
The amount of sample available for clinical and biological proteomic research is often limited and thus significantly restricts clinical and translational research. Recently, we have integrated pressure cycling technology (PCT) assisted sample preparation and SWATH-MS to perform reproducible proteomic quantification
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