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Showing 1-30 of 235 results for "30960" within Papers

p53 Modulates Notch Signaling in MCF-7 Breast Cancer Cells by Associating With the Notch Transcriptional Complex Via MAML1.

Jieun Yun et al.

Journal of cellular physiology, 230(12), 3115-3127 (2015-06-03)

p53 and Notch-1 play important roles in breast cancer biology. Notch-1 inhibits p53 activity in cervical and breast cancer cells. Conversely, p53 inhibits Notch activity in T-cells but stimulates it in human keratinocytes. Notch co-activator MAML1 binds p53 and functions

A large genomic deletion leads to enhancer adoption by the lamin B1 gene: a second path to autosomal dominant adult-onset demyelinating leukodystrophy (ADLD).

Elisa Giorgio et al.

Human molecular genetics, 24(11), 3143-3154 (2015-02-24)

Chromosomal rearrangements with duplication of the lamin B1 (LMNB1) gene underlie autosomal dominant adult-onset demyelinating leukodystrophy (ADLD), a rare neurological disorder in which overexpression of LMNB1 causes progressive central nervous system demyelination. However, we previously reported an ADLD family (ADLD-1-TO)

Ionic complex of risedronate with positively charged deoxycholic acid derivative: evaluation of physicochemical properties and enhancement of intestinal absorption in rats.

Jin Woo Park et al.

Archives of pharmacal research, 37(12), 1560-1569 (2013-11-21)

Risedronate is widely used clinically to treat osteoporosis, Paget's disease, hypercalcemia, bone metastasis, and multiple myeloma. However, its oral efficacy is restricted due to its low bioavailability and severe gastrointestinal adverse effects. This study was designed to evaluate the effect

TNIP1 reduction of HSPA6 gene expression occurs in promoter regions lacking binding sites for known TNIP1-repressed transcription factors.

Vincent P Ramirez et al.

Gene, 555(2), 430-437 (2014-12-03)

TNFα-induced protein 3-interacting protein 1 (TNIP1) represses signaling pathways initiated by specific nuclear and transmembrane receptors. This effect results in reduced activity of distinct transcription factors such as retinoic acid receptors (RAR), peroxisome-proliferator-activated receptors (PPAR), and NFκB. TNIP1-null and TNIP1-knockin

Cetuximab-resistant oral squamous cell carcinoma cells become sensitive in anchorage-independent culture conditions through the activation of the EGFR/AKT pathway.

Yuichi Ohnishi et al.

International journal of oncology, 47(6), 2165-2172 (2015-10-27)

We have previously shown that growth of the oral squamous cell carcinoma cell line SAS, is resistant to cetuximab in monolayer culture conditions, even though epidermal growth factor receptor (EGFR) was phosphorylated, but the growth of SAS aggregates was sensitive

Endocarditis due to a co-infection of Candida albicans and Candida tropicalis in a drug abuser.

Shirinsadat Hashemi Fesharaki et al.

Journal of medical microbiology, 62(Pt 11), 1763-1767 (2013-08-27)

In recent decades the incidence of Candida endocarditis has increased dramatically. Despite the application of surgery and antifungal therapy, Candida endocarditis remains a life-threatening infection with significant morbidity and mortality. We report a 37-year-old male drug abuser presenting with high

Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate.

Danielle L Gomez et al.

PloS one, 10(8), e0133862-e0133862 (2015-08-20)

Neurogenin 3 (NGN3) is necessary and sufficient for endocrine differentiation during pancreatic development and is expressed by a population of progenitor cells that give rise exclusively to hormone-secreting cells within islets. NGN3 protein can be detected in the adult rodent

CD95 and CD95L promote and protect cancer stem cells.

Paolo Ceppi et al.

Nature communications, 5, 5238-5238 (2014-11-05)

CD95 (APO-1/Fas) is a death receptor used by immune cells to kill cancer cells through induction of apoptosis. However, the elimination of CD95 or its ligand, CD95L, from cancer cells results in death induced by CD95R/L elimination (DICE), a type

Microbiome: the bacterial tightrope.

Katherine Bourzac

Nature, 516(7529), S14-S16 (2014-12-04)

In vitro drug susceptibility of Leishmania infantum isolated from humans and dogs.

Carla Maia et al.

Experimental parasitology, 135(1), 36-41 (2013-06-12)

Visceral leishmaniasis (VL) caused by parasites of Leishmania donovani complex is a severe human disease which often leads to death if left untreated. Domestic dogs are the main reservoir hosts for zoonotic human visceral infection caused by Leishmania infantum. In

Exercise maintains blood-brain barrier integrity during early stages of brain metastasis formation.

Gretchen Wolff et al.

Biochemical and biophysical research communications, 463(4), 811-817 (2015-06-10)

Tumor cell extravasation into the brain requires passage through the blood-brain barrier, which is a highly protected microvascular environment fortified with tight junction (TJ) proteins. TJ integrity can be regulated under physiological and pathophysiological conditions. There is evidence that exercise

pH-responsive mechanism of a deoxycholic acid and folate comodified chitosan micelle under cancerous environment.

Daiqin Chen et al.

The journal of physical chemistry. B, 117(5), 1261-1268 (2013-01-15)

Smart pH-responsive polymeric micelles have attracted much attention as one of the most promising drug delivery candidates. In this paper, a different substitution of deoxycholic acid (DCA) and folic acid (FA) comodified hydroxypropyl chitosans (HPCHS) were synthesized for doxorubicin (DOX)

Matrix metalloproteinase-9 leads to blood-brain barrier leakage in mice with eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis.

Ping-Sung Chiu et al.

Acta tropica, 140, 141-150 (2014-08-27)

Blood-brain barrier (BBB) disruption is associated with tight junction protein degradation, basal membrane disruption, and astrocyte damage. This study aims to investigate the role of matrix metalloproteinase (MMP)-9 in BBB disruption during Angiostrongylus cantonensis infection. We used mice infected with

Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity.

Antonis Kourtidis et al.

Nature cell biology, 17(9), 1145-1157 (2015-08-25)

E-cadherin and p120 catenin (p120) are essential for epithelial homeostasis, but can also exert pro-tumorigenic activities. Here, we resolve this apparent paradox by identifying two spatially and functionally distinct junctional complexes in non-transformed polarized epithelial cells: one growth suppressing at

Endogenous ursodeoxycholic acid and cholic acid in liver disease due to cystic fibrosis.

Jeffery L Smith et al.

Hepatology (Baltimore, Md.), 39(6), 1673-1682 (2004-06-09)

Focal biliary cirrhosis causes significant morbidity and mortality in cystic fibrosis (CF). Although the mechanisms of pathogenesis remain unclear, bile acids have been proposed as potential mediators of liver injury. This study examined bile acid composition in CF and assessed

Epithelial-derived nuclear IL-33 aggravates inflammation in the pathogenesis of reflux esophagitis.

Jing Shan et al.

Journal of gastroenterology, 50(4), 414-423 (2014-08-19)

IL-33 is a new tissue-derived cytokine constitutively expressed in epithelial cells and plays a role in sensing damage caused by inflammatory diseases. The function of IL-33 in the esophageal mucosa has not been previously described. Accordingly, we examined the expression

GNRs@SiO₂-FA in combination with radiotherapy induces the apoptosis of HepG2 cells by modulating the expression of apoptosis-related proteins.

Bin Gao et al.

International journal of molecular medicine, 36(5), 1282-1290 (2015-12-10)

The aim of the present study was to examine the apoptosis of the hepatocellular carcinoma cell line, HepG2, induced by treatment with folic acid-conjugated silica-coated gold nanorods (GNRs@SiO2-FA) in combination with radiotherapy, and to determine the involvement of apoptosis-related proteins.

Dietary glucosylceramides suppress tumor growth in a mouse xenograft model of head and neck squamous cell carcinoma by the inhibition of angiogenesis through an increase in ceramide.

Hiroaki Yazama et al.

International journal of clinical oncology, 20(3), 438-446 (2014-08-01)

We previously reported that dietary glucosylceramides show cancer-prevention activity in a mouse xenograft model of human head and neck cancer cells (SCCKN). However, the mechanism was unclear. Ceramides, metabolites of glucosylceramides, induce apoptotic cell death in various malignancies. Here, we

Repeated treatment with electroconvulsive seizures induces HDAC2 expression and down-regulation of NMDA receptor-related genes through histone deacetylation in the rat frontal cortex.

Hong Geun Park et al.

The international journal of neuropsychopharmacology, 17(9), 1487-1500 (2014-03-13)

The enzymatic activity of histone deacetylases (HDACs) leads to a histone deacetylation-mediated condensed chromatic structure, resulting in transcriptional repression, which has been implicated in the modifications of neural circuits and behaviors. Repeated treatment with electroconvulsive seizure (ECS) induces changes in

Bile acid induces MUC2 expression and inhibits tumor invasion in gastric carcinomas.

Jung-Soo Pyo et al.

Journal of cancer research and clinical oncology, 141(7), 1181-1188 (2014-12-06)

Bile acids might induce mucin expression and regulate tumor behavior in esophageal and colon cancers. However, little is known about the effect of bile acids on tumor invasiveness of gastric carcinoma (GC). The aim of the current study was to

Plasma deoxycholic acid concentration is elevated in postmenopausal women with newly diagnosed breast cancer.

V Costarelli et al.

European journal of clinical nutrition, 56(9), 925-927 (2002-09-05)

High concentrations of plasma deoxycholic acid (DCA) are found in human breast cyst fluid and it has been hypothesised that this may be related to risk of breast cancer. The aim of this pilot study was to ascertain whether plasma

FE65 and FE65L1 amyloid precursor protein-binding protein compound null mice display adult-onset cataract and muscle weakness.

Jaehong Suh et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(6), 2628-2639 (2015-03-12)

FE65 and FE65L1 are cytoplasmic adaptor proteins that bind a variety of proteins, including the amyloid precursor protein, and that mediate the assembly of multimolecular complexes. We previously reported that FE65/FE65L1 double knockout (DKO) mice display disorganized laminin in meningeal

Modulation of a pore in the capsid of JC polyomavirus reduces infectivity and prevents exposure of the minor capsid proteins.

Christian D S Nelson et al.

Journal of virology, 89(7), 3910-3921 (2015-01-23)

JC polyomavirus (JCPyV) infection of immunocompromised individuals results in the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML). The viral capsid of JCPyV is composed primarily of the major capsid protein virus protein 1 (VP1), and pentameric arrangement of VP1 monomers

Cancer: An acidic link.

Suzanne Devkota et al.

Nature, 499(7456), 37-38 (2013-06-28)

Marker-based assays for studying gut transit in gnotobiotic and conventional mouse models.

Sean T Koester et al.

STAR protocols, 2(4), 100938-100938 (2021-11-23)

Gastrointestinal motility is regulated by a variety of environmental factors including gut microbes and metabolites. The ability to interrogate mouse models of gut motility has enabled elucidation of these relationships. Here we describe integration of the red carmine dye and

Prolonged treatment of cells with genistein modulates the expression and function of the cystic fibrosis transmembrane conductance regulator.

A Schmidt et al.

British journal of pharmacology, 153(6), 1311-1323 (2008-01-29)

Cystic fibrosis (CF) is caused by dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel. In the search for new CF therapies, small molecules have been identified that rescue the defective channel gating of CF mutants (termed CFTR

Inhibition of MMP-13 prevents diet-induced obesity in mice and suppresses adipogenesis in 3T3-L1 preadipocytes.

Chia-Li M Shih et al.

Molecular biology reports, 42(7), 1225-1232 (2015-02-16)

Adipose tissue remodeling by the matrix metalloproteases (MMPs) is critical for tissue hypertrophy and obesity. MMP-13 is an important protein that is highly expressed in adipose tissue but whose potential role in adipose tissue expansion is poorly characterized. We investigated

Comparative metabolism and structure of BCKD-E2 in primary biliary cirrhosis.

J M Turchany et al.

Journal of autoimmunity, 6(4), 459-466 (1993-08-01)

The identification and cloning of the mitochondrial autoantigens in primary biliary cirrhosis (PBC) have provided new clues in disease pathogenesis. The two major autoantigens are the E2 subunits of pyruvate dehydrogenase and branched-chain ketoacid dehydrogenase (BCKD). Interestingly, one of these

Effect of the common bile acids on the fibrin/fibrinogen fragments in rheumatoid synovial fluid. A possible clue to the ameliorating effect of jaundice in rheumatoid arthritis.

R B Andersen et al.

Scandinavian journal of rheumatology, 4(3), 158-164 (1975-01-01)

Fibrin/fibrinogen degradation products observed in rheumatoid synovial fluid exhibit resistance to plasmin proteolysis. In the present study, the influence of the common bile acids on the plasmin digestion of these degradation products in 16 rheumatoid synovial fluids were quantitated immunologically

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract.

Ross Monasky et al.

Journal of visualized experiments : JoVE, (161) (2020-07-28)

Candida albicans hyphal morphogenesis in the gastrointestinal (GI) tract is tightly controlled by various environmental signals, and plays an important role in the dissemination and pathogenesis of this opportunistic fungal pathogen. However, methods to visualize fungal hyphae in the GI

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