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Showing 1-30 of 1359 results for "30970" within Papers
Bingxiang Wang et al.
Journal of molecular and cellular cardiology, 82, 22-32 (2015-03-05)
Calcium-activated chloride channels (CaCCs) have been implicated in hypertension; however, the mechanism underlying their involvement is unknown. The aim of this study was to determine whether the CaCC ANO1 is involved in the pathogenesis of spontaneous hypertension. Arterial ANO1 expression
Michele Scarola et al.
Nature communications, 6, 7631-7631 (2015-07-15)
Pseudogene-derived, long non-coding RNAs (lncRNAs) act as epigenetic regulators of gene expression. Here we present a panel of new mouse Oct4 pseudogenes and demonstrate that the X-linked Oct4 pseudogene Oct4P4 critically impacts mouse embryonic stem cells (mESCs) self-renewal. Sense Oct4P4
Y Fujikawa et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 27(7), 1010-1023 (2015-05-12)
Enteric glial cells (EGCs) play important roles in enteric integrity and regulation of gastrointestinal function. However, whether EGCs undergo pathophysiological changes in stress-associated gastrointestinal disorders is unknown. We investigated structural and functional alterations in colonic EGCs and their roles in
Jagmohan Singh et al.
American journal of physiology. Gastrointestinal and liver physiology, 309(5), G292-G300 (2015-07-04)
Changes in oxidative stress may affect basal tone and relaxation of the internal anal sphincter (IAS) smooth muscle in aging. We examined this issue by investigating the effects of the oxidative stress inducer 6-anilino-5,8-quinolinedione (LY-83583) in basal as well as
Daniel K C Chung et al.
Nature communications, 6, 7742-7742 (2015-07-25)
DNA double-strand breaks (DSBs) are often targeted to nuclear pore complexes (NPCs) for repair. How targeting is achieved and the DNA repair pathways involved in this process remain unclear. Here, we show that the kinesin-14 motor protein complex (Cik1-Kar3) cooperates
George Sam Wang et al.
The Annals of pharmacotherapy, 47(2), e9-e9 (2013-01-31)
To report a case of accidental amphotericin B overdose that was treated with plasmapheresis. A 60-year-old woman with a history of kidney transplant 4 years prior to presentation for a congenital abnormality was admitted for a suspected systemic fungal infection.
Daniel P Morris et al.
PloS one, 10(8), e0134442-e0134442 (2015-08-06)
In mammals, increasing evidence supports mechanisms of co-transcriptional gene regulation and the generality of genetic control subsequent to RNA polymerase II (Pol II) recruitment. In this report, we use Pol II Chromatin Immunoprecipitation to investigate relationships between the mechanistic events
Sébastien M Labbé et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(5), 2046-2058 (2015-02-15)
The present study was designed to investigate the effects of cold on brown adipose tissue (BAT) energy substrate utilization in vivo using the positron emission tomography tracers [(18)F]fluorodeoxyglucose (glucose uptake), 14(R,S)-[(18)F]fluoro-6-thia-heptadecanoic acid [nonesterified fatty acid (NEFA) uptake], and [(11)C]acetate (oxidative
Johanna Tüshaus et al.
The EMBO journal, 39(20), e105693-e105693 (2020-09-22)
To understand how cells communicate in the nervous system, it is essential to define their secretome, which is challenging for primary cells because of large cell numbers being required. Here, we miniaturized secretome analysis by developing the "high-performance secretome protein
Miruna S Stan et al.
Chemico-biological interactions, 220, 102-115 (2014-07-06)
Si/SiO2 quantum dots (QDs) are novel particles with unique physicochemical properties that promote them as potential candidates for biomedical applications. Although their interaction with human cells has been poorly investigated, oxidative stress appears to be the main factor involved in
Liwei Dong et al.
International journal of molecular sciences, 16(7), 14655-14668 (2015-07-02)
Echinacoside is a natural compound with potent reactive oxygen species (ROS)-scavenging and anti-oxidative bioactivities, which protect cells from oxidative damages. As cancer cells are often under intense oxidative stress, we therefore tested if Echinacoside treatment would promote cancer development. Surprisingly
Joseph P Salisbury et al.
BMC genomics, 16, 166-166 (2015-04-17)
The brown ghost knifefish (Apteronotus leptorhynchus) is a weakly electric teleost fish of particular interest as a versatile model system for a variety of research areas in neuroscience and biology. The comprehensive information available on the neurophysiology and neuroanatomy of
Michael Kuncewitch et al.
Shock (Augusta, Ga.), 43(3), 268-275 (2014-12-17)
Renal ischemia-reperfusion (IR) injury (IRI) after shock states or transplantation causes tissue damage and delayed graft function, respectively. The Wnt/β-catenin signaling pathway plays a critical role in nephrogenesis. We therefore hypothesized that pharmacological activation of the Wnt/β-catenin signaling by the
Kitti B Kovács et al.
Thrombosis research, 135(4), 718-726 (2015-01-27)
Protein C (PC) is a major anticoagulant and numerous distinct mutations in its coding gene result in quantitative or qualitative PC deficiency with high thrombosis risk. Homozygous or compound heterozygous PC deficiency usually leads to life-threatening thrombosis in neonates. The
Gisele Espinha et al.
Molecular and cellular biochemistry, 404(1-2), 281-297 (2015-03-12)
Rac1 GTPase controls essential cellular functions related to the cytoskeleton, such as motility and adhesion. Rac1 is overexpressed in many tumor cells, including breast cancers, where it is also involved in the proliferation and checkpoint control necessary for the cell's
Yongchao Ma et al.
Cancer cell international, 15, 59-59 (2015-06-27)
This study sought to explore the exact mechanism of Matrine inhibited migration and invasion of human pancreatic cancer cells. HPAC or Capan-1 cells were cultured in completed RPMI-1640 medium, contained with 50 μg/ml Matrine or 0.05 μg/ml docetaxel, respectively. Cell viability was
Guangran Li et al.
PloS one, 10(6), e0128207-e0128207 (2015-06-25)
The sodium-dependent neutral amino acid transporter 2 (SNAT2), which has dual transport/receptor functions, is well documented in eukaryotes and some mammalian systems, but has not yet been verified in piglets. The objective of this study was to investigate the characteristics
Brajendra K Tripathi et al.
The Journal of cell biology, 207(5), 627-642 (2014-12-03)
DLC1 is a tumor suppressor protein whose full activity depends on its presence at focal adhesions, its Rho-GTPase activating protein (Rho-GAP) function, and its ability to bind several ligands, including tensin and talin. However, the mechanisms that regulate and coordinate
Jiann-Hwa Chen et al.
International journal of molecular sciences, 16(6), 11873-11891 (2015-05-29)
Ischemia-reperfusion injury resulting from arterial occlusion or hypotension in patients leads to tissue hypoxia with glucose deprivation, which causes endoplasmic reticulum (ER) stress and neuronal death. A proteomic approach was used to identify the differentially expressed proteins in the brain
Yan Chang et al.
Biochemical and biophysical research communications, 463(4), 606-611 (2015-06-06)
ERp44, an endoplasmic reticulum (ER) resident protein, regulates intracellular Ca(2+) release and involves in the maturation of many proteins in mammalian cells. In this study, we investigated the effects and mechanism of ERp44 on cell apoptosis by using ERp44 knockdown
Lucie Aumailley et al.
Experimental gerontology, 72, 192-203 (2015-11-03)
Werner syndrome (WS) is a premature aging disorder caused by mutations in a DNA helicase/exonuclease. Mice lacking the helicase domain of this protein exhibit metabolic abnormalities that are reversed by vitamin C. In this study, we used a targeted metabolomic
Naruji Kugimiya et al.
Journal of cellular and molecular medicine, 19(7), 1569-1581 (2015-02-18)
c-MYC overexpression is frequently observed in various cancers including colon cancer and regulates many biological activities such as aberrant cell proliferation, apoptosis, genomic instability, immortalization and drug resistance. However, the mechanism by which c-MYC confers drug resistance remains to be
Jiaojiao Su et al.
PloS one, 9(12), e114420-e114420 (2014-12-05)
Insulin-like growth factor 1 receptor (IGF1R) is a transmembrane receptor that is activated by insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors and plays an important
Weiwei Miao et al.
BMC complementary medicine and therapies, 20(1), 187-187 (2020-06-20)
To evaluate the in vitro antibacterial effect of flavonoids-rich Ziziphus jujuba Mill. extract (FZM) against the formation of bacterial biofilms (BBFs) in Staphylococcus aureus. FZM can effectively inhibit the formation of S. aureus biofilms in vitro. Morphological observation showed a
Mona Basha et al.
Journal of liposome research, 23(3), 203-210 (2013-04-24)
The objective of this study was to develop an efficient ocular nanovesicular carrier providing a controlled delivery of Clotrimazole (CLT); a water insoluble antifungal drug. The nanovesicular carriers were formulated using Span 60 with one of the following edge activators
Judith Müller et al.
Nature communications, 5, 5712-5712 (2014-12-17)
Increased expression of the Microphthalmia-associated transcription factor (MITF) contributes to melanoma progression and resistance to BRAF pathway inhibition. Here we show that the lack of MITF is associated with more severe resistance to a range of inhibitors, while its presence
Marc Gentzel et al.
Methods (San Diego, Calif.), 164-165, 67-72 (2019-04-07)
The identification of bona fide protein-protein interactions and the mapping of proteomes was greatly enhanced by protein tagging for generic affinity purification methods and analysis by mass spectrometry (AP-MS). The high quality of AP-MS data permitted the development of proteomic
Diana M Shih et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(9), 3805-3817 (2013-06-12)
We examined the effects of a natural secondary bile acid, hyodeoxycholic acid (HDCA), on lipid metabolism and atherosclerosis in LDL receptor-null (LDLRKO) mice. Female LDLRKO mice were maintained on a Western diet for 8 wk and then divided into 2
Liqiong Gui et al.
American journal of physiology. Lung cellular and molecular physiology, 308(2), L221-L228 (2014-11-25)
Cellular therapy via direct intratracheal delivery has gained interest as a novel therapeutic strategy for treating various pulmonary diseases including cystic fibrosis lung disease. However, concerns such as insufficient cell engraftment in lungs and lack of large animal model data
Su Yao et al.
The Journal of pathology, 236(1), 65-77 (2014-12-19)
The epidermal growth factor receptor (EGFR) is implicated in many types of cancer, including colorectal cancer (CRC), and has become one of the most common candidates for targeted therapy. Here, we found that Erbin, a member of the leucine-rich repeat
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