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Showing 1-30 of 45 results for "318337" within Papers
Basudev Maity et al.
European journal of medicinal chemistry, 57, 250-258 (2012-10-16)
Polypyridyl platinum(II) complexes (1-5), viz., [Pt(pyphen)Cl]Cl (1), [Pt(pyphen)(C≡CFc)]Cl (2), [Pt(pydppz)Cl]Cl (3), [Pt(pydppz)(C≡CPh)]Cl (4) and [Pt(pydppz)(C≡CFc)]Cl (5), where pyphen is 6-(2-pyridyl)-1,10-phenanthroline, pydppz is 6-(2-pyridyl)-dipyrido-[3,2-a:2',3'-c]-phenazine, FcC≡CH is ferrocenyl acetylene and PhC≡CH is phenyl acetylene, were synthesized, characterized and their DNA binding and
Yasuko Fukushi et al.
Biochemical and biophysical research communications, 447(1), 38-43 (2014-04-01)
Secretion from the gastric gland involves the activation of various types of cells in a coordinated manner. In order to elucidate the mechanisms underlying the coordination of secretion, we studied live fluorescence images of guinea pig gastric glands stained with
Hong-xiang Wang et al.
Zhonghua yi xue za zhi, 92(26), 1828-1831 (2012-09-05)
To ascertain the epididymal sperm nuclear maturity in obstructive azoospermia (OA) patients. A total of 81 infertile males from andriatry clinic of Renji hospital were selected, including 32 OA patients (OA group) and 49 asthenospermia patients (asthenospermia group). Another 32
Dan Gareau et al.
Journal of biomedical optics, 17(6), 066018-066018 (2012-06-28)
For rapid, intra-operative pathological margin assessment to guide staged cancer excisions, multimodal confocal mosaic scan image wide surgical margins (approximately 1 cm) with sub-cellular resolution and mimic the appearance of conventional hematoxylin and eosin histopathology (H&E). The goal of this
Grace Emily Okuthe
Acta histochemica, 115(2), 178-184 (2012-07-17)
Oogenesis involves a sequence of cellular divisions and developmental changes leading to the formation of oocytes, whose role in development is to transfer genomic information to the next generation. During this process, the gene expression pattern changes considerably concomitant with
Yuan Qin et al.
Acta pharmacologica Sinica, 40(6), 724-736 (2018-10-14)
Increasing evidence suggests that Ras-related in brain 7 (Rab7), an endosome-localized small GTPase contributes to cerebral ischemic brain injury. In the present study, we investigated the role of Rab7 in ischemic stroke-induced formation of astrogliosis and glial scar. Rats were
Jonathan Pratt et al.
Glycobiology, 22(9), 1245-1255 (2012-06-14)
Pre-clinical trials for cancer therapeutics support the anti-neoplastic properties of the lectin from Canavalia ensiformis (Concanavalin-A, ConA) in targeting apoptosis and autophagy in a variety of cancer cells. Given that membrane type-1 matrix metalloproteinase (MT1-MMP), a plasma membrane-anchored matrix metalloproteinase
Ruth Kläver et al.
Journal of assisted reproduction and genetics, 29(9), 943-950 (2012-06-14)
Assess short- and mid-term impact of cryopreservation on DNA methylation status of different genes in spermatozoa. Semen samples from 10 healthy normozoospermic men were collected at the Department of Clinical Andrology of the Centre of Reproductive Medicine and Andrology (Muenster
Zehra Boz et al.
Scientific reports, 10(1), 19185-19185 (2020-11-07)
Olanzapine is a second-generation antipsychotic (AP) drug commonly prescribed for the treatment of schizophrenia. Recently, olanzapine has been found to cause brain tissue volume loss in rodent and primate studies; however, the underlying mechanism remains unknown. Abnormal autophagy and oxidative
Sophia Karastogianni et al.
Journal of inorganic biochemistry, 118, 48-58 (2012-11-06)
The mononuclear complex [Mn(thiophenyl-2-carboxylate)(2)(H(3)tea)] (1), where H(3)tea=triethanolamine has been synthesized, characterized, while the DNA binding properties and the antioxidant activity were studied. The crystal structure of 1 is also reported. The interaction between 1 and calf thymus double stranded (ds)
Takao Matsubara et al.
Clinical orthopaedics and related research, 471(3), 792-802 (2012-09-26)
Wide-margin resections are an accepted method for treating soft tissue sarcoma. However, a wide-margin resection sometimes impairs function because of the lack of normal tissue. To preserve the normal tissue surrounding a tumor, we developed a less radical (ie, without
Michael M Fisher et al.
International journal of radiation oncology, biology, physics, 107(4), 793-803 (2020-04-17)
We examined the capacity of the pan-fibroblast growth factor receptor (FGFR) inhibitor AZD4547 to augment radiation response across a panel of head and neck squamous cell carcinoma (HNSCC) cell lines and xenografts. FGFR1, FGFR2, and FGFR3 RNA in situ hybridization
Gopika SenthilKumar et al.
Molecular cancer therapeutics, 19(6), 1255-1265 (2020-05-07)
FGFRs are commonly altered in non-small cell lung cancer (NSCLC). FGFRs activate multiple pathways including RAS/RAF/MAPK, PI3K/AKT, and STAT, which may play a role in the cellular response to radiation. We investigated the effects of combining the selective FGFR 1-3
Autophagy-dependent senescence in response to DNA damage and chronic apoptotic stress
Singh K, et.al.
Autophagy, 8, 236-251 (2012)
Shufang Zhang et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 97, 521-525 (2012-07-31)
The interaction of luteolin with calf thymus deoxyribonucleic acid (ctDNA) under physiological conditions (Tris-HCl buffer solutions, pH 7.4) was studied by UV-Vis spectroscopy, fluorescence spectroscopy and viscosity measurement method, respectively. The results indicated that a complex of luteolin with ctDNA
Magdalena Pilz et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 30(12), 2046-2051 (2012-06-08)
Although combination of surgery with chemotherapy has noticeably improved the survival rate of osteosarcoma patients, the application of anticancer drugs is still associated with significant adverse reactions, for instance acquisition of drug-resistant phenotypes, necessitating the development of new chemotherapeutical agents.
M F Shishova et al.
Ontogenez, 43(6), 413-424 (2013-02-14)
Comparative analysis of the transport activity of proton pumps (plasmalemma H+-ATPase, vacuolar H+-ATPase, and vacuolar H+-pyrophosphatase) in the membrane preparations obtained from coleoptile cells ofetiolated maize seedlings (Zea mays L.) was carried out. The highest level ofvacuolar pyrophosphatase activity was
Chingju Lin et al.
International journal of oncology, 42(3), 993-1000 (2013-01-29)
Baicalin is one of the major compounds in the traditional Chinese medicinal herb from Scutellaria baicalensis Georgi. We investigated the molecular mechanisms of cell autophagy induced by baicalin in human bladder cancer T24 cells. Baicalin inhibited cell survival as shown
Ilgım Göktürk et al.
Artificial cells, nanomedicine, and biotechnology, 41(2), 78-84 (2013-01-12)
The aim of this study is to label the cells with polymeric nanoparticles properly and efficiently. For this purpose, acridine orange (AO)-loaded poly(2-hydroxyethyl methacrylate) (PHEMA) nanoparticles were synthesized by miniemulsion polymerization. PHEMA nanoparticles were characterized by zeta sizer, zeta potential
Kseniya V Shishova et al.
Developmental biology, 397(2), 267-281 (2014-12-08)
It is well known that fully-grown mammalian oocytes, rather than typical nucleoli, contain prominent but structurally homogenous bodies called "nucleolus-like bodies" (NLBs). NLBs accumulate a vast amount of material, but their biochemical composition and functions remain uncertain. To clarify the
Q L Chen et al.
Talanta, 97, 48-54 (2012-07-31)
We have utilized various valving scheme to leverage purely rotation-regulated flow control to enable comprehensive cell-based bioassays (CBBs) on centrifuge-based lab-on-a-disc (LOAD). A LOAD has been developed to examine allergic degranulation from live basophils for allergens screening for the first
Cheng Zeng et al.
Aquatic toxicology (Amsterdam, Netherlands), 149, 25-32 (2014-02-22)
We previously demonstrated that cyanobacteria-derived microcystin-leucine-arginine (MCLR) is able to induce developing toxicity, such as malformation, growth delay and also decreased heart rates in zebrafish embryos. However, the molecular mechanisms by which MCLR induces its toxicity during the development of
Chao-Yen Ho et al.
Environmental toxicology, 36(2), 185-193 (2020-09-28)
Autophagy plays a dual function in cancer progression; autophagy activation can support cancer cell survival or contribute to cell death. Miconazole, a Food and Drug Administration-approved antifungal drug, has been implicated in oncology research recently. Miconazole was found to exert
Shagun Arora et al.
International journal of medicinal mushrooms, 15(3), 301-314 (2013-05-15)
Cancer is one of the most prevalent chronic diseases of the world. Certain edible mushroom species are rich in antioxidants, which perform a vital role in preventing this risk in manifesting itself. Initial screening was followed by qualitative phytochemical analysis;
Sayeed Ur Rehman et al.
Archives of biochemistry and biophysics, 566, 7-14 (2014-12-22)
Non-covalent interactions of chlorambucil with calf thymus DNA was investigated using multi-spectroscopic techniques and molecular docking study. Binding constant calculated was found to be 1.54×10(4)M(-1) at 290K, significantly lower than various known intercalators. Quenching process was found to be static
Viriditoxin regulates apoptosis and autophagy via mitotic catastrophe and microtubule formation in human prostate cancer cells.
Kundu S, et.al.
International Journal of Oncology, 45, 2331-2340 (2014)
Egarit Noulsri et al.
Asian Pacific journal of allergy and immunology, 30(2), 123-129 (2012-07-27)
We have previously developed an affordable flow cytometric method for absolute cell count using glutaraldehyde-fixed chicken red blood cells. However, its use is limited to CD4+ T cells. In the current investigation, we studied the potential use of glutaraldehyde-fixed chicken
Barbara Chudzik et al.
PloS one, 14(9), e0222775-e0222775 (2019-10-01)
Compounds belonging to the group of 5-substituted 4-(1,3,4-thiadiazol-2-yl) benzene-1,3-diols exhibit a broad spectrum of biological activity, including antibacterial, antifungal, and anticancer properties. The mechanism of the antifungal activity of compounds from this group has not been described to date. Among
Joanna Polewska et al.
The Journal of pharmacology and experimental therapeutics, 346(3), 393-405 (2013-07-05)
Imidazoacridinone 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) is an antitumor inhibitor of topoisomerase II and FMS-like tyrosine kinase 3 receptor. In this study, we describe the unique sequence of cellular responses to C-1311 in human non-small cell lung cancer (NSCLC) cell lines, A549 and
Guowen Zhang et al.
Food chemistry, 141(1), 41-47 (2013-06-19)
The interaction between sodium benzoate (SB) and calf thymus DNA in simulated physiological buffer (pH 7.4) using acridine orange (AO) dye as a fluorescence probe, was investigated by UV-Vis absorption, fluorescence and circular dichroism (CD) spectroscopy along with DNA melting
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