320102

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Showing 1-30 of 243 results for "320102" within Papers

Pinoresinol reductase 1 impacts lignin distribution during secondary cell wall biosynthesis in Arabidopsis.

Qiao Zhao et al.

Phytochemistry, 112, 170-178 (2014-08-12)

Pinoresinol reductase (PrR) catalyzes the conversion of the lignan (-)-pinoresinol to (-)-lariciresinol in Arabidopsis thaliana, where it is encoded by two genes, PrR1 and PrR2, that appear to act redundantly. PrR1 is highly expressed in lignified inflorescence stem tissue, whereas

Metabolic changes in paraquat poisoned patients and support vector machine model of discrimination.

Xianqin Wang et al.

Biological & pharmaceutical bulletin, 38(3), 470-475 (2015-03-12)

Numerous people die of paraquat (PQ) poisoning every year in the world. Although several studies regarding paraquat (PQ) poisoning have been conducted, the metabolic changes in plasma remain unknown. In this study, the metabolomics of 15 PQ poisoned patients with

Short and scalable synthesis of an anhydride precursor of the environment-sensitive fluorophore 6-dimethylaminonaphthalimide.

Kishore Baathulaa et al.

Nature protocols, 6(12), 1990-1997 (2011-12-03)

Environment-sensitive fluorophores have different quantum yields in different solvents. 6-Dimethylaminonaphthalimide (6-DMN), for example, has a low quantum yield in aqueous solutions, but is highly fluorescent in nonpolar solvents or when bound to hydrophobic sites in proteins or membranes. 6-DMN has

Long-distance retinoid signaling in the zebra finch brain.

Tina C Roeske et al.

PloS one, 9(11), e111722-e111722 (2014-11-14)

All-trans retinoic acid (ATRA), the main active metabolite of vitamin A, is a powerful signaling molecule that regulates large-scale morphogenetic processes during vertebrate embryonic development, but is also involved post-natally in regulating neural plasticity and cognition. In songbirds, it plays

Optimization of an analytical methodology for the simultaneous determination of different classes of ultraviolet filters in cosmetics by pressurized liquid extraction-gas chromatography tandem mass spectrometry.

Marlene Vila et al.

Journal of chromatography. A, 1405, 12-22 (2015-06-21)

A methodology based on pressurized liquid extraction (PLE) followed by gas chromatography-tandem mass spectrometry (GC-MS/MS) has been developed for the simultaneous analysis of different classes of UV filters including methoxycinnamates, benzophenones, salicylates, p-aminobenzoic acid derivatives, and others in cosmetic products.

The application of metabolite profiling to Mycobacterium spp.: determination of metabolite changes associated with growth.

Margit Drapal et al.

Journal of microbiological methods, 106, 23-32 (2014-08-12)

In order to decipher the complex biological networks underlying biochemical and physiological processes, cellular regulation at all levels must be studied. The metabolites determined by metabolomics represent the end-point of cellular regulation and thus vital components of any integrative network.

Derivatization with acetic anhydride: applications to the analysis of biogenic amines and psychiatric drugs by gas chromatography and mass spectrometry.

G B Baker et al.

Journal of pharmacological and toxicological methods, 31(3), 141-148 (1994-06-01)

Acetylation with acetic anhydride, under both aqueous and anhydrous conditions, has been utilized to derivatize various biogenic amines and psychotropic drugs for subsequent analysis by gas chromatography (GC) or gas chromatography-mass spectrometry (GC-MS). Under basic aqueous conditions, acetic anhydride derivatizes

Gas chromatography time-of-flight mass spectrometry (GC-TOF-MS)-based metabolomics for comparison of caffeinated and decaffeinated coffee and its implications for Alzheimer's disease.

Kai Lun Chang et al.

PloS one, 9(8), e104621-e104621 (2014-08-08)

Findings from epidemiology, preclinical and clinical studies indicate that consumption of coffee could have beneficial effects against dementia and Alzheimer's disease (AD). The benefits appear to come from caffeinated coffee, but not decaffeinated coffee or pure caffeine itself. Therefore, the

Covalent adduct formation between the plasmalogen-derived modification product 2-chlorohexadecanal and phloretin.

Andreas Üllen et al.

Biochemical pharmacology, 93(4), 470-481 (2015-01-13)

Hypochlorous acid added as reagent or generated by the myeloperoxidase (MPO)-H2O2-Cl(-) system oxidatively modifies brain ether-phospholipids (plasmalogens). This reaction generates a sn2-acyl-lysophospholipid and chlorinated fatty aldehydes. 2-Chlorohexadecanal (2-ClHDA), a prototypic member of chlorinated long-chain fatty aldehydes, has potent neurotoxic potential

Co-localization of TRPV2 and insulin-like growth factor-I receptor in olfactory neurons in adult and fetal mouse.

Hitoshi Matsui et al.

Biological & pharmaceutical bulletin, 37(12), 1907-1912 (2014-12-03)

TRPV2, a member of the transient receptor potential family, has been isolated as a capsaicin-receptor homolog and is thought to respond to noxious heat. Here we show that TRPV2 mRNA is predominantly expressed in the subpopulation of olfactory sensory neurons

Metabolomic analyses reveal that anti-aging metabolites are depleted by palmitate but increased by oleate in vivo.

David P Enot et al.

Cell cycle (Georgetown, Tex.), 14(15), 2399-2407 (2015-06-23)

Recently, we reported that saturated and unsaturated fatty acids trigger autophagy through distinct signal transduction pathways. Saturated fatty acids like palmitate (PA) induce autophagic responses that rely on phosphatidylinositol 3-kinase, catalytic subunit type 3 (PIK3C3, best known as VPS34) and

GC-MS Method for the Quantitation of Carbohydrate Intermediates in Glycation Systems.

Sanja Milkovska-Stamenova et al.

Journal of agricultural and food chemistry, 63(25), 5911-5919 (2015-06-06)

Glycation is a ubiquitous nonenzymatic reaction of carbonyl compounds with amino groups of peptides and proteins, resulting in the formation of advanced glycation end-products (AGEs) and thereby affecting the properties and quality of thermally processed foods. In this context, mechanisms

Isotope labeling pattern study of central carbon metabolites using GC/MS.

Joon-Young Jung et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 974, 101-108 (2014-12-03)

Determination of fluxes by (13)C tracer experiments depends on monitoring the (13)C labeling pattern of metabolites during isotope experiments. In metabolome-based (13)C metabolic flux analysis, liquid chromatography combined with mass spectrometry or tandem mass spectrometry (LC/MS or LC/MS/MS, respectively) has

Studies on the chemical modification of goat liver cystatin and the effect on its anti-papain inhibitory activity.

Aaliya Shah et al.

Journal of fluorescence, 22(6), 1627-1632 (2012-07-27)

Goat liver cystatin was subjected to various chemical modifications in order to ascertain the amino acid residues responsible for its structural and functional integrity. Modification of tryptophan by HNBB led to the complete inactivation of the protein. The inactivation was

Genome-wide transcript profiling reveals novel breast cancer-associated intronic sense RNAs.

Sang Woo Kim et al.

PloS one, 10(3), e0120296-e0120296 (2015-03-24)

Non-coding RNAs (ncRNAs) play major roles in development and cancer progression. To identify novel ncRNAs that may identify key pathways in breast cancer development, we performed high-throughput transcript profiling of tumor and normal matched-pair tissue samples. Initial transcriptome profiling using

Systemic differences in serum metabolome: a cross sectional comparison of women with localised and widespread pain and controls.

J Hadrévi et al.

Scientific reports, 5, 15925-15925 (2015-11-03)

Chronic musculoskeletal pain exists either as localised to a single region or as widespread to multiple sites in several quadrants of the body. Prospective studies indicate that widespread pain could act as a far end of a continuum of musculoskeletal

Plasma metabolite profiling and chemometric analyses of lung cancer along with three controls through gas chromatography-mass spectrometry.

Syed Ghulam Musharraf et al.

Scientific reports, 5, 8607-8607 (2015-02-26)

Lung cancer has been the most common death causing cancer in the world for several decades. This study is focused on the metabolite profiling of plasma from lung cancer (LC) patients with three control groups including healthy non-smoker (NS), smokers

Quantification of plasma HIV RNA using chemically engineered peptide nucleic acids.

Chao Zhao et al.

Nature communications, 5, 5079-5079 (2014-10-07)

The remarkable stability of peptide nucleic acids (PNAs) towards enzymatic degradation makes this class of molecules ideal to develop as part of a diagnostic device. Here we report the development of chemically engineered PNAs for the quantitative detection of HIV

Markers of mesterolone abuse in sulfate fraction for doping control in human urine.

P Kiousi et al.

Journal of mass spectrometry : JMS, 50(12), 1409-1419 (2015-12-05)

This manuscript describes the direct detection of mesteroloe sulfo-conjugated metabolites by liquid chromatography/quadrupole/time of flight mass spectrometry (LC/Q/TOFMS) with special focus on evaluation of their retrospective detectability and their structure elucidation. A comparison of their long-term detectability, with the mesterolone

Dual mode single agent thermochemical ablation by simultaneous release of heat energy and acid: hydrolysis of electrophiles.

Erik N K Cressman et al.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 29(1), 71-78 (2013-01-15)

This study aimed to investigate two readily available electrophilic reagents, acetyl chloride (AcCl), and acetic anhydride (Ac(2)O), for their potential in tissue ablation. Reagents were diluted in diglyme as solutions up to 8 mol/L and tested in a gel phantom with

Defensive Armor of Potato Tubers: Nonpolar Metabolite Profiling, Antioxidant Assessment, and Solid-State NMR Compositional Analysis of Suberin-Enriched Wound-Healing Tissues.

Keyvan Dastmalchi et al.

Journal of agricultural and food chemistry, 63(30), 6810-6822 (2015-07-15)

The cultivation, storage, and distribution of potato tubers are compromised by mechanical damage and suboptimal healing. To investigate wound-healing progress in cultivars with contrasting russeting patterns, metabolite profiles reported previously for polar tissue extracts were complemented by GC/MS measurements for

Metabolomics identifies the intersection of phosphoethanolamine with menaquinone-triggered apoptosis in an in vitro model of leukemia.

Suganthagunthalam Dhakshinamoorthy et al.

Molecular bioSystems, 11(9), 2406-2416 (2015-07-16)

Altered metabolism is increasingly acknowledged as an important aspect of cancer, and thus serves as a potentially fertile area for the identification of therapeutic targets or leads. Our recent work using transcriptional data to predict metabolite levels in cancer cells

On-line liquid chromatography-gas chromatography: A novel approach for the analysis of phytosterol oxidation products in enriched foods.

Birgit Scholz et al.

Journal of chromatography. A, 1396, 98-108 (2015-04-22)

A novel methodology for the automated qualitative and quantitative determination of phytosterol oxidation products in enriched foods via on-line liquid chromatography-gas chromatography (LC-GC) was established. The approach is based on the LC pre-separation of acetylated phytosterols and their corresponding oxides

Combinatorialization of fungal polyketide synthase-peptide synthetase hybrid proteins.

Thomas B Kakule et al.

Journal of the American Chemical Society, 136(51), 17882-17890 (2014-12-02)

The programming of the fungal polyketide synthase (PKS) is quite complex, with a simple domain architecture leading to elaborate products. An additional level of complexity has been found within PKS-based pathways where the PKS is fused to a single module

Occurrence, removal, and fate of progestogens, androgens, estrogens, and phenols in six sewage treatment plants around Dianchi Lake in China.

Bin Huang et al.

Environmental science and pollution research international, 21(22), 12898-12908 (2014-07-01)

The occurrence and behavior of endocrine disrupting chemicals (EDCs) in sewage treatment plants (STPs), especially estrogens and phenols, have been closely concerned in previous studies. However, the systematical researches about progestogens and androgens were scarce in STPs adopting different treatment

Metabolite profiling of red and white pitayas (Hylocereus polyrhizus and Hylocereus undatus) for comparing betalain biosynthesis and antioxidant activity.

Dong Ho Suh et al.

Journal of agricultural and food chemistry, 62(34), 8764-8771 (2014-08-08)

Metabolite profiling of red and white pitayas (Hylocereus polyrhizus and Hylocereus undatus) was performed using gas chromatography-time-of-flight-mass spectrometry and ultraperformance liquid chromatography-quadrupole-time-of-flight-mass spectrometry with multivariate analysis. Different species and parts of pitayas (red peel, RP; white peel, WP; red flesh

An efficient synthesis of new caffeine-based chalcones, pyrazolines and pyrazolo[3,4-b][1,4]diazepines as potential antimalarial, antitrypanosomal and antileishmanial agents.

Braulio Insuasty et al.

European journal of medicinal chemistry, 93, 401-413 (2015-03-01)

A new series of chalcones 5a-f were synthesized from caffeine-based aldehyde 3 and substituted acetophenones 4a-f. Treatment of compounds 5a-f with hydrazine hydrate led to pyrazolines 6a-f, and their subsequent reaction with acetic anhydride or formic acid afforded the corresponding

Examination of the kinetic isotopic effect to the acetylation derivatization for the gas chromatographic-combustion-isotope ratio mass spectrometric doping control analysis of endogenous steroids.

Yiannis S Angelis et al.

Drug testing and analysis, 4(12), 923-927 (2012-03-01)

In gas chromatographic-combustion-isotope ratio mass spectrometry (GC-C-IRMS) doping control analysis, endogenous androgenic anabolic steroids and their metabolites are commonly acetylated using acetic anhydride reagent, thus incorporating exogenous carbon that contributes to the measured isotope ratio. Comparison of the endogenous δ(13)C

Chemokine-mediated B cell trafficking during early rabbit GALT development.

Shi-Kang Zhai et al.

Journal of immunology (Baltimore, Md. : 1950), 193(12), 5951-5959 (2014-11-12)

Microbial and host cell interactions stimulate rabbit B cells to diversify the primary Ab repertoire in GALT. B cells at the base of appendix follicles begin proliferating and diversifying their V-(D)-J genes around 1 wk of age, ∼5 d after

The Wnt adaptor protein ATP6AP2 regulates multiple stages of adult hippocampal neurogenesis.

Simon T Schafer et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(12), 4983-4998 (2015-03-27)

In the mammalian hippocampus, canonical Wnt signals provided by the microenvironment regulate the differentiation of adult neural stem cells (NSCs) toward the neuronal lineage. Wnts are part of a complex and diverse set of signaling pathways and the role of

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