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Showing 1-30 of 133 results for "320404" within Papers
Chris E Adkins et al.
Cancer prevention research (Philadelphia, Pa.), 8(1), 68-76 (2014-10-29)
The observation that approximately 15% of women with disseminated breast cancer will develop symptomatic brain metastases combined with treatment guidelines discouraging single-agent chemotherapeutic strategies facilitates the desire for novel strategies aimed at outright brain metastasis prevention. Effective and robust preclinical
Anna H Le et al.
PloS one, 9(8), e106013-e106013 (2014-08-26)
Angiogenesis, the formation of new blood vessels, is important for the survival of ovarian transplants and the restoration of ovarian functions. Without angiogenesis, transplanted ovarian tissue becomes more susceptible to tissue damage and necrosis. Administration of analgesics for pain management
Jyothi T Mony et al.
Multiple sclerosis (Houndmills, Basingstoke, England), 20(10), 1312-1321 (2014-02-21)
Myelin-specific T cells are implicated in multiple sclerosis (MS) and drive experimental autoimmune encephalomyelitis (EAE). EAE is commonly induced with short peptides, whereas in MS, whole myelin proteins are available for immune response. We asked whether immunization with the immunoglobulin-like
Mesenchymal stem cell pretreatment of non-heart-beating-donors in experimental lung transplantation.
Thorsten Wittwer et al.
Journal of cardiothoracic surgery, 9, 151-151 (2014-09-03)
Lung transplantation (LTx) is still limited by organ shortage. To expand the donor pool, lung retrieval from non-heart-beating donors (NHBD) was introduced into clinical practice recently. However, primary graft dysfunction with inactivation of endogenous surfactant due to ischemia/reperfusion-injury is a
Elise Langenkamp et al.
Cancer research, 75(21), 4504-4516 (2015-09-13)
Glioblastoma is an aggressive brain tumor characterized by an abnormal blood vasculature that is hyperpermeable. Here, we report a novel role for CD93 in regulating angiogenesis in this setting by modulating cell-cell and cell-matrix adhesion of endothelial cells. Tissue microarray
Dorota Haznar-Garbacz et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 81(2), 334-338 (2012-03-20)
A novel liquefied gas based drug delivery system for the oral delivery of liquid and semi-solid drug formulations is presented. The capsule-shaped system is equipped with a capillary as an element controlling the release rate. The delivery mechanism is based
A D Moodie et al.
Analytical biochemistry, 189(1), 103-106 (1990-08-15)
A design for an improved freeze-quench apparatus is presented. A freeze-quench apparatus has two main parts: the apparatus which mixes the reactants and after a set time sprays the reacting mixture into the quencher, and the quenching apparatus itself. The
Benjamin Vitre et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(46), E6321-E6330 (2015-11-19)
Centrosomes are microtubule-organizing centers that facilitate bipolar mitotic spindle assembly and chromosome segregation. Recognizing that centrosome amplification is a common feature of aneuploid cancer cells, we tested whether supernumerary centrosomes are sufficient to drive tumor development. To do this, we
Jessica Santollo et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(12), R1396-R1404 (2014-10-31)
Previous studies show that the angiotensin type 1 receptor (AT1R) is susceptible to rapid desensitization, but that more chronic treatments that stimulate ANG II lead to sensitization of several responses. It is unclear, however, if the processes of desensitization and
Burn caused by isopentane and liquefied petroleum gas in an insecticide.
N Oiso et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 23(2), 170-171 (2008-04-16)
Alexander V Kolesnikov et al.
The Journal of physiology, 593(22), 4923-4941 (2015-09-10)
This study explores the molecular mechanisms that regulate the recycling of chromophore required for pigment regeneration in mammalian cones. We report that two chromophore binding proteins, retinol dehydrogenase 8 (RDH8) and photoreceptor-specific ATP-binding cassette transporter (ABCA4) accelerate the dark adaptation
Susanne Steu et al.
Virchows Archiv : an international journal of pathology, 452(3), 305-312 (2008-02-07)
Different methods for snap freezing surgical human tissue specimens exist. At pathology institutes with higher work loads, solid carbon dioxide, freezing sprays, and cryostat freezing are commonly used as coolants for diagnosing frozen tissue sections, whereas for tissue banking, liquid
Rohan Jagirdar et al.
Experimental neurology, 273, 92-104 (2015-08-05)
A prominent role of epigenetic mechanisms in manifestation of epilepsy has been proposed. Thus altered histone H3 and H4 acetylation has been demonstrated in experimental models of temporal lobe epilepsy (TLE). We now investigated changes in the expression of the
Andreia Teixeira-Castro et al.
Brain : a journal of neurology, 138(Pt 11), 3221-3237 (2015-09-17)
Polyglutamine diseases are a class of dominantly inherited neurodegenerative disorders for which there is no effective treatment. Here we provide evidence that activation of serotonergic signalling is beneficial in animal models of Machado-Joseph disease. We identified citalopram, a selective serotonin
Gary L Bratthauer
Methods in molecular biology (Clifton, N.J.), 588, 67-73 (2009-12-17)
The analysis of frozen tissue by antibodies can be accomplished by the quick freezing of a small tissue sample in liquid nitrogen. Super-cooled isopentane can also be used to further the preservation process. Freezing preserves the available proteins in a
Kun Liu et al.
Autophagy, 11(2), 271-284 (2015-02-05)
Recent evidence that excessive lipid accumulation can decrease cellular levels of autophagy and that autophagy regulates immune responsiveness suggested that impaired macrophage autophagy may promote the increased innate immune activation that underlies obesity. Primary bone marrow-derived macrophages (BMDM) and peritoneal
Mireia Recasens et al.
Journal of neuroinflammation, 18(1), 31-31 (2021-01-24)
When the homeostasis of the central nervous system (CNS) is altered, microglial cells become activated displaying a wide range of phenotypes that depend on the specific site, the nature of the activator, and particularly the microenvironment generated by the lesion.
G Cisbani et al.
Neurobiology of disease, 82, 430-444 (2015-08-02)
The neuroprotective properties of cystamine identified in pre-clinical studies have fast-tracked this compound to clinical trials in Huntington's disease, showing tolerability and benefits on motor symptoms. We tested whether cystamine could have such properties in a Parkinson's disease murine model
Chary Marquez Batista et al.
Neural plasticity, 2014, 451639-451639 (2014-08-12)
Pigment epithelium derived factor (PEDF) exerts trophic actions to motoneurons and modulates nonneuronal restorative events, but its effects on neuroplasticity responses after spinal cord (SC) injury are unknown. Rats received a low thoracic SC photothrombotic ischemia and local injection of
Selective oligomerization of isobutene on lewis acid catalyst: kinetic modeling
Sarkar A, et al.
Industrial & Engineering Chemistry Research, 53, 18982-18992 (2014)
Melissa F Jackson et al.
Endocrinology, 155(5), 1771-1785 (2014-02-13)
Attenuating myostatin enhances striated muscle growth, reduces adiposity, and improves cardiac contractility. To determine whether myostatin influences tissue potency in a manner that could control such pleiotropic actions, we generated label-retaining mice with wild-type and mstn(-/-) (Jekyll) backgrounds in which
Maarten Ooms et al.
Nuclear medicine and biology, 41(8), 695-704 (2014-07-09)
In vivo visualization of PDE10A using PET provides a tool to evaluate the role of PDE10A in various neuropsychiatric diseases and can also be useful in the clinical evaluation of PDE10A inhibitor drug candidates. We evaluated several carbon-11 and fluorine-18
S Chiba et al.
Nihon hoigaku zasshi = The Japanese journal of legal medicine, 45(2), 128-137 (1991-04-01)
n-Pentane and isopentane have a wide range of use, for example, for cleaning precision machinery, extracting essence and oil, and as liquid fuel for now very popular disposable lighters. They are contained in liquefied petroleum gas and natural gas as
Minmin Luo
BioEssays : news and reviews in molecular, cellular and developmental biology, 26(1), 6-9 (2003-12-30)
A substance in rabbit milk, 2-methylbut-2-enal (2MB2), has been identified as a pheromone that triggers stereotypical searching behavior from rabbit pups. Pups respond to the odor of 2MB2 solutions in concentration-dependent manner, but fail to respond to 20 other volatile
Paula Sanchez-Molina et al.
Biomolecules, 10(8) (2020-07-30)
Fourier Transform Infrared microspectroscopy (μFTIR) is a very useful method to analyze the biochemical properties of biological samples in situ. Many diseases affecting the central nervous system (CNS) have been studied using this method, to elucidate alterations in lipid oxidation
Nathan E Reticker-Flynn et al.
Cancer discovery, 5(2), 168-181 (2014-11-26)
Metastasis is the leading cause of cancer-associated deaths. Although dissemination of tumor cells likely occurs early in tumorigenesis, the constituents of the microenvironment play essential rate-limiting roles in determining whether these cells will form clinically relevant tumors. Recent studies have
Wook-Joon Yu et al.
Regulatory toxicology and pharmacology : RTP, 60(1), 136-143 (2011-03-23)
This study investigated the potential reproductive toxicity of 2-methylbutane in a one-generation reproductive toxicity study using Sprague-Dawley rats. A total of 24 male and female rats per group were given 2-methylbutane by gavage at 0, 100, 300, and 1000 mg/kg/day.
Mark J de Lange et al.
Oncotarget, 6(35), 37824-37835 (2015-10-16)
Gene expression profiles as well as genomic imbalances are correlated with disease progression in uveal melanoma (UM). We integrated expression and genomic profiles to obtain insight into the oncogenic mechanisms in development and progression of UM. We used tumor tissue
Matthew S Alexander et al.
The Journal of clinical investigation, 124(6), 2651-2667 (2014-05-03)
Duchenne muscular dystrophy (DMD) is caused by mutations in the gene encoding dystrophin, which results in dysfunctional signaling pathways within muscle. Previously, we identified microRNA-486 (miR-486) as a muscle-enriched microRNA that is markedly reduced in the muscles of dystrophin-deficient mice
A A Toropov et al.
European journal of medicinal chemistry, 43(4), 714-740 (2007-07-17)
Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and organic compounds of different classes by optimal descriptors. Statistical characteristics of the best model (vitamins) are the
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