CN
Search Within
320404
Applied Filters:
Keyword:'320404'
Showing 1-30 of 133 results for "320404" within Papers
Chris E Adkins et al.
Cancer prevention research (Philadelphia, Pa.), 8(1), 68-76 (2014-10-29)
The observation that approximately 15% of women with disseminated breast cancer will develop symptomatic brain metastases combined with treatment guidelines discouraging single-agent chemotherapeutic strategies facilitates the desire for novel strategies aimed at outright brain metastasis prevention. Effective and robust preclinical
Anna H Le et al.
PloS one, 9(8), e106013-e106013 (2014-08-26)
Angiogenesis, the formation of new blood vessels, is important for the survival of ovarian transplants and the restoration of ovarian functions. Without angiogenesis, transplanted ovarian tissue becomes more susceptible to tissue damage and necrosis. Administration of analgesics for pain management
2-Methylbutane (isopentane). CAS# 78-78-4.
J B Galvin et al.
Journal of toxicology and environmental health. Part A, 58(1-2), 23-33 (1999-10-28)
Pierre Abramowski et al.
Journal of neuroimmunology, 274(1-2), 111-124 (2014-08-05)
The 2-lysophosphatidylcholine analog edelfosine induces apoptosis in highly proliferating cells, e.g. activated immune cells. We examined mechanisms of action of edelfosine on immune functions in experimental autoimmune encephalomyelitis, a well-accepted animal model for multiple sclerosis. We observed activated caspase-3 expression
Corina Nagy et al.
Journal of neuropathology and experimental neurology, 74(5), 459-469 (2015-04-14)
Postmortem brain research is invaluable to the study of neurologic and neuropsychiatric disorders, including Alzheimer disease, schizophrenia, and major depression. A major confounder in molecular studies using human brain tissue is postmortem interval (i.e. the amount of time between a
Lauren M Reynolds et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(5), 1101-1112 (2014-10-23)
Initiation of drug use during adolescence is a strong predictor of both the incidence and severity of addiction throughout the lifetime. Intriguingly, adolescence is a period of dynamic refinement in the organization of neuronal connectivity, in particular medial prefrontal cortex
Melody P Lun et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(12), 4903-4916 (2015-03-27)
A sheet of choroid plexus epithelial cells extends into each cerebral ventricle and secretes signaling factors into the CSF. To evaluate whether differences in the CSF proteome across ventricles arise, in part, from regional differences in choroid plexus gene expression
John G Swales et al.
Analytical chemistry, 86(16), 8473-8480 (2014-08-02)
Cassette dosing of compounds for preclinical drug plasma pharmacokinetic analysis has been shown to be a powerful strategy within the pharmaceutical industry for increasing throughput while decreasing the number of animals used. Presented here for the first time is data
James R Pinney et al.
Biomaterials, 35(31), 8820-8828 (2014-07-23)
Chronic fibrosis caused by acute myocardial infarction (MI) leads to increased morbidity and mortality due to cardiac dysfunction. We have developed a therapeutic materials strategy that aims to mitigate myocardial fibrosis by utilizing injectable polymeric microstructures to mechanically alter the
Annelies Grimonprez et al.
Brain stimulation, 8(1), 13-20 (2014-12-03)
Depression is the most common psychiatric comorbidity in epilepsy patients. The lack of success with current pharmacological interventions for this patient population, highlights the importance of optimizing non-pharmacological neuromodulatory treatments such as vagus nerve stimulation (VNS). Studies on the antidepressant
U M Abdel-Motal et al.
Gene therapy, 21(9), 802-810 (2014-06-27)
Topical microbicides are a leading strategy for prevention of HIV mucosal infection to women; however, numerous pharmacokinetic limitations associated with coitally related dosing strategy have contributed to their limited success. Here we test the hypothesis that adeno-associated virus (AAV) mediated
Daria Guseva et al.
PloS one, 9(11), e112984-e112984 (2014-11-14)
L1 is among the few adhesion molecules that favors repair after trauma in the adult central nervous system of vertebrates by promoting neuritogenesis and neuronal survival, among other beneficial features. In the peripheral nervous system, L1 is up-regulated in Schwann
Brandon M Fritz et al.
Behavioural brain research, 273, 8-15 (2014-07-22)
Extrasynaptic GABAA receptors, often identified as those containing both α4 and δ subunits, demonstrate super-sensitivity to GABA and are involved in tonic inhibitory processes regulating activity within mesolimbocortical circuitry. Rodent studies testing the effects of the δ-subunit selective agonist Gaboxadol
Carmen Weigt et al.
The Journal of steroid biochemistry and molecular biology, 154, 12-22 (2015-07-03)
The leptin resistant Zucker diabetic fatty (ZDF) rats are hyperphagic and become obese, but whereas the males develop type 2 diabetes mellitus (T2DM), the females remain euglycaemic. As estrogen deficiency is known to increase the risk of developing T2DM, we
Céline Devroye et al.
Neuropharmacology, 89, 375-381 (2014-12-03)
The serotonin(2C) receptor (5-HT(2C)R) is known to control dopamine (DA) neuron function by modulating DA neuronal firing and DA exocytosis at terminals. Recent studies assessing the influence of 5-HT(2C)Rs on cocaine-induced neurochemical and behavioral responses have shown that 5-HT2CRs can
Ian M Packham et al.
PloS one, 9(9), e107503-e107503 (2014-09-23)
We sought to determine a role for platelets in in vivo angiogenesis, quantified by changes in the capillary to fibre ratio (C:F) of mouse skeletal muscle, utilising two distinct forms of capillary growth to identify differential effects. Capillary sprouting was
Anna K Kopec et al.
Toxicological sciences : an official journal of the Society of Toxicology, 141(2), 515-523 (2014-07-25)
Epidemiological studies suggest that exposure to environmental chemicals increases the risk of developing autoimmune liver disease. However, the identity of specific chemical perpetrators and the mechanisms whereby environmental chemicals modify liver disease is unclear. Previous studies link exposure to trichloroethylene
Manon M Roustit et al.
The Journal of endocrinology, 223(2), 143-154 (2014-08-15)
Insulin resistance (IR) in skeletal muscle is an important component of both type 2 diabetes and the syndrome of sarcopaenic obesity, for which there are no effective therapies. Urocortins (UCNs) are not only well established as neuropeptides but also have
José Hidalgo et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 8(3), 414-420 (2009-03-04)
A systematic study of the influence of the gradual temperature decrease on the UV-vis absorption and fluorescence emission spectra of betacarboline, 9H-pyrido[3,4-b]indole, BC, and other model systems, such as BC plus N(9)-methyl-9H-pyrido[3,4-b]indole, MBC, and BC plus pyridine, PY, has been
Christoph S Clemen et al.
Acta neuropathologica, 129(2), 297-315 (2014-11-15)
Mutations of the human desmin gene on chromosome 2q35 cause autosomal dominant, autosomal recessive and sporadic forms of protein aggregation myopathies and cardiomyopathies. We generated R349P desmin knock-in mice, which harbor the ortholog of the most frequently occurring human desmin
Melissa F Jackson et al.
Endocrinology, 155(5), 1771-1785 (2014-02-13)
Attenuating myostatin enhances striated muscle growth, reduces adiposity, and improves cardiac contractility. To determine whether myostatin influences tissue potency in a manner that could control such pleiotropic actions, we generated label-retaining mice with wild-type and mstn(-/-) (Jekyll) backgrounds in which
Mesenchymal stem cell pretreatment of non-heart-beating-donors in experimental lung transplantation.
Thorsten Wittwer et al.
Journal of cardiothoracic surgery, 9, 151-151 (2014-09-03)
Lung transplantation (LTx) is still limited by organ shortage. To expand the donor pool, lung retrieval from non-heart-beating donors (NHBD) was introduced into clinical practice recently. However, primary graft dysfunction with inactivation of endogenous surfactant due to ischemia/reperfusion-injury is a
Jyothi T Mony et al.
Multiple sclerosis (Houndmills, Basingstoke, England), 20(10), 1312-1321 (2014-02-21)
Myelin-specific T cells are implicated in multiple sclerosis (MS) and drive experimental autoimmune encephalomyelitis (EAE). EAE is commonly induced with short peptides, whereas in MS, whole myelin proteins are available for immune response. We asked whether immunization with the immunoglobulin-like
Ali Mehanna et al.
Experimental neurology, 261, 147-155 (2014-06-27)
The immune system plays important functional roles in regeneration after injury to the mammalian central and peripheral nervous systems. After damage to the peripheral nerve several types of immune cells, invade the nerve within hours after the injury. To gain
Caroline G M de Theije et al.
Neuropharmacology, 90, 15-22 (2014-12-03)
Allergy is suggested to exacerbate impaired behaviour in children with neurodevelopmental disorders. We have previously shown that food allergy impaired social behaviour in mice. Dietary fatty acid composition may affect both the immune and nervous system. The aim of this
G Seidel et al.
Journal of neuroimaging : official journal of the American Society of Neuroimaging, 8(2), 83-87 (1998-04-29)
Ultrasound contrast agents improve the signal-to-noise ratio of reflected ultrasound, enhancing the diagnostic value of transcranial Doppler (TCD). In dog studies, we investigated the time course of TCD signal amplitude after application of a phospholipid-containing ultrasound contrast agent (BY963) filled
Matthew S Alexander et al.
The Journal of clinical investigation, 124(6), 2651-2667 (2014-05-03)
Duchenne muscular dystrophy (DMD) is caused by mutations in the gene encoding dystrophin, which results in dysfunctional signaling pathways within muscle. Previously, we identified microRNA-486 (miR-486) as a muscle-enriched microRNA that is markedly reduced in the muscles of dystrophin-deficient mice
A A Toropov et al.
European journal of medicinal chemistry, 43(4), 714-740 (2007-07-17)
Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and organic compounds of different classes by optimal descriptors. Statistical characteristics of the best model (vitamins) are the
Elise Langenkamp et al.
Cancer research, 75(21), 4504-4516 (2015-09-13)
Glioblastoma is an aggressive brain tumor characterized by an abnormal blood vasculature that is hyperpermeable. Here, we report a novel role for CD93 in regulating angiogenesis in this setting by modulating cell-cell and cell-matrix adhesion of endothelial cells. Tissue microarray
Mark J de Lange et al.
Oncotarget, 6(35), 37824-37835 (2015-10-16)
Gene expression profiles as well as genomic imbalances are correlated with disease progression in uveal melanoma (UM). We integrated expression and genomic profiles to obtain insight into the oncogenic mechanisms in development and progression of UM. We used tumor tissue
Page 1 of 5