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Showing 1-30 of 255 results for "320498" within Papers
José M M Lima et al.
Journal of molecular modeling, 19(4), 1727-1737 (2013-01-09)
Nitric oxide (NO) is an important chemical compound involved in many physiological and pathological processes in living organisms. However, nitric oxide is a very reactive radical that needs to be carried through organisms to reach the desired biological target. With
Rieuwert Hoppes et al.
Journal of immunology (Baltimore, Md. : 1950), 193(10), 4803-4813 (2014-10-15)
Virus or tumor Ag-derived peptides that are displayed by MHC class I molecules are attractive starting points for vaccine development because they induce strong protective and therapeutic cytotoxic T cell responses. In thus study, we show that the MHC binding
Raúl González-Domínguez et al.
Journal of pharmaceutical and biomedical analysis, 107, 75-81 (2015-01-13)
Gas chromatography coupled to mass spectrometry is the most frequent tool for metabolomic profiling of low molecular weight metabolites. Its suitability in health survey is beyond doubt, given that primary metabolites involved in central pathways of metabolism are usually altered
Zhengyu Cao et al.
The Journal of pharmacology and experimental therapeutics, 350(3), 615-623 (2014-06-25)
Gambierol is a marine polycyclic ether toxin produced by the marine dinoflagellate Gambierdiscus toxicus and is a member of the ciguatoxin toxin family. Gambierol has been demonstrated to be either a low-efficacy partial agonist/antagonist of voltage-gated sodium channels or a
Lignin Modification for Biopolymer/Conjugated Polymer Hybrids as Renewable Energy Storage Materials.
Ting Yang Nilsson et al.
ChemSusChem, 8(23), 4081-4085 (2015-10-29)
Lignin derivatives, which arise as waste products from the pulp and paper industry and are mainly used for heating, can be used as charge storage materials. The charge storage function is a result of the quinone groups formed in the
So-Young Ma et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 113, 261-267 (2013-06-06)
The solid-state structures and unequivocal stereochemistries of isomeric pyridine-based leuco-triarylmethane (LTAM) dyes 2,2'-(2-(pyridin-4 or 3-yl)propane-1,3-diylidene)bis(5-chloro-1,3,3-trimethylindoline) derivatives were established by X-ray crystallography. Surprisingly, the EE isomer was formed for the 4-pyridinyl compound, whereas the 3-pyridinyl compound formed ZE isomers. In addition
Paul M O'Neill et al.
Journal of medicinal chemistry, 52(5), 1408-1415 (2009-02-19)
N-tert-Butyl isoquine (4) (GSK369796) is a 4-aminoquinoline drug candidate selected and developed as part of a public-private partnership between academics at Liverpool, MMV, and GSK pharmaceuticals. This molecule was rationally designed based on chemical, toxicological, pharmacokinetic, and pharmacodynamic considerations and
Dong Jin Lee et al.
International journal of pharmaceutics, 471(1-2), 127-134 (2014-05-27)
In this study, polypeptide-based nanoparticles [constituted using poly(L-lysine) coupled with deoxycholic acid (DOCA) and conjugated with 2,3-dimethylmaleic acid (DMA)] have high tumor selectivity once electrostatically switched by the acidic milieu of solid tumors. These nanoparticles exhibited a significantly increased in
Nicolas Zydziak et al.
Macromolecular rapid communications, 34(8), 672-680 (2013-03-19)
Single-walled carbon nanotubes (SWCNTs) are pre-functionalized with a pyridinyl-based dithioester to undergo a hetero Diels-Alder (HDA) reaction with cyclopentadienyl end-capped poly(methyl)methacrylate (Mn = 2700 g mol(-1) , PDI = 1.14). Fourier transform infrared spectroscopy, thermogravimetric analysis, elemental analysis (EA), and
K D Raemsch et al.
Hypertension (Dallas, Tex. : 1979), 5(4 Pt 2), II18-II24 (1983-07-01)
Nifedipine is almost completely absorbed from the gastrointestinal tract as shown by plasma levels after sublingual, oral, and rectal administration. Because of presystemic metabolism, the bioavailability is about 56% to 77%. After oral administration of 10 mg, the mean plasma
Junichi Hoshino et al.
Journal of nanoscience and nanotechnology, 13(7), 4593-4600 (2013-08-02)
Thymidine derivatives with carboxylic acid and pyridyl groups were synthesized for constructing one-dimensional network structure based on hydrogen bonding in crystalline state. The solid sate structures and hydrogen bonding networks of the thymidine derivatives were characterized by single X-ray diffraction
Jari Hovinen et al.
Bioconjugate chemistry, 20(3), 404-421 (2008-12-17)
The use of long-lifetime emitting lanthanide(III) chelate labels or probes together with time-resolved fluorometry in detection provides a method to generate sensitive bioaffinity assays. However, the use of stable chelates demands very complicated optimization of the chelate structure. A great
Sanyog Jain et al.
Molecular pharmaceutics, 12(11), 3871-3884 (2015-09-17)
In spite of extensive research over the decades, breast cancer treatment is still a major challenge due to nonspecific distribution of the chemotherapeutics. This void can be filled by restricting the distribution of chemotherapeutics toward the cancerous cells. In the
Sophie Drouillard et al.
Marine drugs, 13(11), 6723-6739 (2015-11-04)
Vibrio alginolyticus (CNCM I-4994) secretes an exopolysaccharide that can be used as an ingredient in cosmetic applications. The structure was resolved using chromatography and one- and two-dimensional NMR spectroscopy experiments. The results show that the carbohydrate backbone is made of
Simeon K Adesina et al.
Journal of pharmaceutical sciences, 103(8), 2546-2555 (2014-06-26)
The macromonomer method was used to prepare cross-linked, paclitaxel-loaded polylactide (PLA)-polyethylene glycol (stealth) nanoparticles using free-radical dispersion polymerization. The method can facilitate the attachment of other molecules to the nanoparticle surface to make it multifunctional. Proton nuclear magnetic resonance and
E Hurtado-Fernández et al.
Analytical and bioanalytical chemistry, 407(2), 547-555 (2014-11-10)
In order to investigate avocado fruit ripening, nontargeted GC-APCI-TOF MS metabolic profiling analyses were carried out. Principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) were used to explore the metabolic profiles from fruit samples of 13 varieties
Dian G T Su et al.
Journal of the American Chemical Society, 130(34), 11328-11337 (2008-08-06)
UVB irradiation of DNA produces photodimers in adjacent DNA bases and on rare occasions in nonadjacent bases. UVB irradiation (312 nm) of d(GTATCATGAGGTGC) gave rise to an unknown DNA photoproduct in approximately 40% yield at acidic pH of about 5.
Reyna-Cristina Colli-Dula et al.
Aquatic toxicology (Amsterdam, Netherlands), 156, 148-160 (2014-09-10)
17Alpha-ethinylestradiol (EE2), used for birth control in humans, is a potent estrogen that is found in wastewater at low concentrations (ng/l). EE2 has the ability to interfere with the endocrine system of fish, affecting reproduction which can result in population
Tsubasa Oyama et al.
Journal of pharmaceutical and biomedical analysis, 116, 71-79 (2015-07-15)
A new pre-column derivatization reagent with a 6-methoxy-4-quinolone (6-MOQ) moiety for amino acid analysis, 2,5-dioxopyrrolidin-1-yl(2-(6-methoxy-4-oxoquinolin-1(4H)-yl)ethyl) carbonate (6-MOQ-EtOCOOSu), was designed and synthesized. 6-MOQ is a thermo/photostable fluorophore with a high proton-affinity site and sensitive determination could be carried out by a
Marco Visentin et al.
Journal of separation science, 37(13), 1561-1569 (2014-04-12)
A gas chromatography with ion trap mass spectrometry method has been developed and validated for the analysis of 27 polar organic compounds in atmospheric aerosols. The target analytes were low-molecular-weight carboxylic acids and methoxyphenols, as relevant markers of source emissions
Sarah Schatschneider et al.
Molecular bioSystems, 10(10), 2663-2676 (2014-07-30)
The well-studied plant pathogenic bacterium Xanthomonas campestris pv. campestris (Xcc) synthesizes the biotechnologically important polysaccharide xanthan gum, which is also regarded as a virulence factor in plant interactions. In Xcc, sugars like glucose are utilized as a source to generate
Song P Seto et al.
Bioconjugate chemistry, 26(2), 286-293 (2015-01-27)
Bone morphogenetic protein-2 (BMP-2) plays an important role in bone and cartilage formation and is of interest in regenerative medicine. Heparin can interact electrostatically with BMP-2 and thus has been explored for controlled release and potential stabilization of this growth
Wajhul Qamar et al.
Experimental lung research, 40(9), 460-466 (2014-08-26)
Rat bronchoalveolar lavage fluid (BALF) metabolome can be used to obtain valuable, precise, and accurate information about underlying lung conditions in an experiment. The present study focuses on the evaluation of the lung epithelium metabolome in a rat model using
Hyang Yeon Kim et al.
Molecules (Basel, Switzerland), 20(2), 3107-3128 (2015-02-18)
In this study, we investigated the clinical changes induced by a high fat diet (HFD) and caffeine consumption in a rat model. The mean body weight of the HFD with caffeine (HFDC)-fed rat was decreased compared to that of the
T B R Papa et al.
Free radical research, 49(1), 102-111 (2014-11-05)
Astaxanthin when esterified with ferulic acid is better singlet oxygen quencher with k2 = (1.58 ± 0.1) 10(10) L mol(-1)s(-1) in ethanol at 25°C compared with astaxanthin with k2 = (1.12 ± 0.01) 10(9) L mol(-1)s(-1). The ferulate moiety in
Karol Kadlec et al.
Talanta, 147, 44-49 (2015-11-26)
The novel approach for hydroxyapatite (HA) surface characterization was proposed. The main aim of this investigation was to estimate surface properties of HA as a biomaterial in real system i.e. in simulated body fluid (SBF). One of the method, which
Martine Cao et al.
Pharmacological research, 100, 135-147 (2015-08-05)
Two new analogues of CDDO-Imidazolide (CDDO-Im), namely 1-[2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4(-pyridin-2-yl)-1H-imidazole ("CDDO-2P-Im") and 1-[2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4(-pyridin-3-yl)-1H-imidazole ("CDDO-3P-Im") have been synthesized and tested for their potential use as chemopreventive drugs. At nanomolar concentrations, they were equipotent to CDDO-Im for inducing differentiation and apoptosis in U937 leukemia
Xinrong Pan et al.
Journal of agricultural and food chemistry, 62(40), 9927-9935 (2014-09-10)
The mixed microbes coculture method in cane molasses wastewater (CMW) was adopted to produce 2-phenylethanol (2-PE). Comparative metabolomics combined with multivariate statistical analysis was performed to profile the differences of overall intracellular metabolites concentration for the mixed microbes cocultured under
Ye Wei et al.
Journal of the American Chemical Society, 135(10), 3756-3759 (2013-02-27)
We describe here a [3+3]-type condensation reaction of O-acetyl ketoximes and α,β-unsaturated aldehydes that is synergistically catalyzed by a copper(I) salt and a secondary ammonium salt (or amine). This redox-neutral reaction allows modular synthesis of a variety of substituted pyridines
Saet Buyl Lee et al.
Plant & cell physiology, 56(1), 48-60 (2014-10-13)
The aerial parts of all land plants are covered with hydrophobic cuticular wax layers that act as the first barrier against the environment. The MYB94 transcription factor gene is expressed in abundance in aerial organs and shows a higher expression
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