322415

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Formulation and evaluation of cholesterol-rich nanoemulsion (LDE) for drug delivery potential of cholesteryl-maleoyl-5-fluorouracil.

Fars K Alanazi et al.

Pharmaceutical development and technology, 20(3), 266-270 (2013-11-26)

It has been reported that cholesterol-rich nanoemulsions (LDE) can bind to low density lipoprotein (LDL) receptors which can concentrate anticancer drugs in the tissues via LDL receptor overexpression and reduced the adverse effects of the treatment. Therefore, in this study

Method validation and application of a liquid chromatography-tandem mass spectrometry method for drugs of abuse testing in exhaled breath.

Niclas Stephanson et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 189-196 (2015-02-18)

A mass spectrometric method for drugs of abuse testing in exhaled breath employing a sampling device collecting aerosol particles was developed and applied in routine use. Analytes covered were amphetamine, methamphetamine, 6-acetylmorphine, morphine, cocaine, benzoylecgonine, diazepam, oxazepam and tetrahydrocannabinol. The

High-Throughput and Comprehensive Lipidomic Analysis Using Ultrahigh-Performance Supercritical Fluid Chromatography-Mass Spectrometry.

Miroslav Lísa et al.

Analytical chemistry, 87(14), 7187-7195 (2015-06-23)

New analytical approach for high-throughput and comprehensive lipidomic analysis of biological samples using ultrahigh-performance supercritical fluid chromatography (UHPSFC) with electrospray ionization-mass spectrometry (ESI-MS) is presented in this work as an alternative approach to established shotgun MS or high-performance liquid chromatography-MS.

Evaluation of phenolic profile, antioxidant and anticancer potential of two main representants of Zingiberaceae family against B164A5 murine melanoma cells.

Corina Danciu et al.

Biological research, 48, 1-1 (2015-02-06)

Curcuma longa Linnaeus and Zingiber officinale Roscoe are two main representatives of Zingiberaceae family studied for a wide range of therapeutic properties, including: antioxidant, anti-inflammatory, anti-angiogenic, antibacterial, analgesic, immunomodulatory, proapoptotic, anti-human immunodeficiency virus properties and anticancer effects. This study was

A pilot phase I dose finding safety study of the thrombopoietin-receptor agonist, eltrombopag, in patients with myelodysplastic syndrome treated with azacitidine.

Tobias Svensson et al.

European journal of haematology, 93(5), 439-445 (2014-05-24)

Thrombocytopenia is an independent adverse prognostic factor in patients with Myelodysplastic syndromes (MDS). Azacitidine, first-line treatment for the majority of patients with higher-risk MDS, is associated with aggravated thrombocytopenia during the first cycles. Eltrombopag is a novel thrombopoietin receptor agonist

Increased endobiotic fatty acid methyl esters following exposure to methanol.

B S Kaphalia et al.

Fundamental and applied toxicology : official journal of the Society of Toxicology, 28(2), 264-273 (1995-12-01)

Human exposure to methanol is likely to increase in the future due to its proposed use as an alternate automobile fuel. Since alcohols are known to esterify the fatty acids in the body and some of those esterified esters are

Hybrid scaffold bearing polymer-siloxane Schiff base linkage for bone tissue engineering.

Bindu P Nair et al.

Materials science & engineering. C, Materials for biological applications, 52, 333-342 (2015-05-09)

Scaffolds that can provide the requisite biological cues for the fast regeneration of bone are highly relevant to the advances in tissue engineering and regenerative medicine. In the present article, we report the fabrication of a chitosan-gelatin-siloxane scaffold bearing interpolymer-siloxane

Profiling Chlamydomonas metabolism under dark, anoxic H2-producing conditions using a combined proteomic, transcriptomic, and metabolomic approach.

Venkataramanan Subramanian et al.

Journal of proteome research, 13(12), 5431-5451 (2014-10-22)

Chlamydomonas reinhardtii is well adapted to survive under different environmental conditions due to the unique flexibility of its metabolism. Here we report metabolic pathways that are active during acclimation to anoxia, but were previously not thoroughly studied under dark, anoxic

Assessment of strobilurin fungicides' content in soya-based drinks by liquid micro-extraction and liquid chromatography with tandem mass spectrometry.

Natalia Campillo et al.

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(12), 2039-2047 (2015-09-29)

Seven strobilurin fungicides were pre-concentrated from soya-based drinks using dispersive liquid-liquid micro-extraction (DLLME) with a prior protein precipitation step in acid medium. The enriched phase was analysed by liquid chromatography (LC) with dual detection, using diode array detection (DAD) and

Immunomodulatory activity of methanolic leaf extract of Moringa oleifera in Wistar albino rats.

Joshua Nfambi et al.

Journal of basic and clinical physiology and pharmacology, 26(6), 603-611 (2015-06-24)

Globally, Moringa oleifera is used by different communities to treat various ailments including modulation of the immune system though with limited scientific evidence. The aim was to study the immunomodulatory activity of M. oleifera methanolic leaf extract in Wistar albino

Quantitation of various indolinyl caged glutamates as their o-phthalaldehyde derivatives by high performance liquid chromatography coupled with tandem spectroscopic detections: derivatization, stoichiometry and stability studies.

A Vasanits-Zsigrai et al.

Journal of chromatography. A, 1394, 81-88 (2015-04-05)

Quantification, stability and unique spectroscopic properties of indolinyl-caged glutamates (ICGs), with the o-phthalaldehyde-3-mercaptopropionic acid (OPA-MPA) reagent, were described, at first. As new principle to the field, reactivity and stoichiometry of variously substituted OPA-MPA derivatized ICGs, such as 4-methoxy-7-nitroindolinyl-(MNI-Glu), 4-methoxy-5,7-dinitroindolinyl-(DNI-Glu), 2-dimethylamino-propoxy

Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.

Robert O'Brien et al.

The Journal of biological chemistry, 290(31), 19287-19306 (2015-05-31)

The cascade of events that lead to cognitive decline, motor deficits, and psychiatric symptoms in patients with Huntington disease (HD) is triggered by a polyglutamine expansion in the N-terminal region of the huntingtin (HTT) protein. A significant mechanism in HD

Intrinsic and extrinsic apoptotic pathways are involved in rat testis by cold water immersion-induced acute and chronic stress.

Adriana Lizbeth Juárez-Rojas et al.

Systems biology in reproductive medicine, 61(4), 211-221 (2015-04-14)

Testicular apoptosis is activated by stress, but it is not clear which signaling pathway is activated in response to stress. The aim of this study was to investigate whether intrinsic, extrinsic, or both apoptotic signaling pathways are activated by acute

An improved method for the analysis of GHB in human hair by liquid chromatography tandem mass spectrometry.

Eshwar Jagerdeo et al.

Journal of analytical toxicology, 39(2), 83-88 (2014-11-30)

The abuse of gamma-hydroxybutyric acid (GHB) and its suspicion in cases of suspected drug-facilitated sexual assault is of keen interest to forensic toxicology laboratories. This paper reports an extraction, separation and detection procedure for GHB in hair utilizing a combination

Simultaneous analysis of herbicides pendimethalin, oxyfluorfen, imazethapyr and quizalofop-p-ethyl by LC-MS/MS and safety evaluation of their harvest time residues in peanut (Arachis hypogaea L.).

Ajoy Saha et al.

Journal of food science and technology, 52(7), 4001-4014 (2015-07-04)

This paper reports a simple and rapid method for simultaneous determination of the residues of selected herbicides viz. pendimethalin, oxyfluorfen, imazethapyr and quizalofop-p-ethyl in peanut by liquid chromatography-tandem mass spectrometry (LC-MS/MS). A modified approach of the QuEChERS methodology was used

Endogenous protein "barcode" for data validation and normalization in quantitative MS analysis.

Wooram Lee et al.

Analytical chemistry, 86(13), 6379-6386 (2014-05-27)

Quantitative proteomic experiments with mass spectrometry detection are typically conducted by using stable isotope labeling and label-free quantitation approaches. Proteins with housekeeping functions and stable expression level such actin, tubulin, and glyceraldehyde-3-phosphate dehydrogenase are frequently used as endogenous controls. Recent

Ribosomal protein P2 localizes to the parasite zoite-surface and is a target for invasion inhibitory antibodies in Toxoplasma gondii and Plasmodium falciparum.

Rajagopal Sudarsan et al.

Parasitology international, 64(1), 43-49 (2014-10-05)

In the malarial parasite Plasmodium falciparum, the conserved ribosomal stalk protein P2 (PfP2) exhibits extra-ribosomal stage-specific oligomerization and trafficking to the host red cell membrane. Antibodies directed against PfP2 arrested cell division. We sought to examine whether P2 from a

Helix 8 of the angiotensin- II type 1A receptor interacts with phosphatidylinositol phosphates and modulates membrane insertion.

Daniel J Hirst et al.

Scientific reports, 5, 9972-9972 (2015-07-01)

The carboxyl-terminus of the type 1 angiotensin II receptor (AT1A) regulates receptor activation/deactivation and the amphipathic Helix 8 within the carboxyl-terminus is a high affinity interaction motif for plasma membrane lipids. We have used dual polarisation interferometry (DPI) to examine

Chemometrics resolution and quantification power evaluation: Application on pharmaceutical quaternary mixture of Paracetamol, Guaifenesin, Phenylephrine and p-aminophenol.

Ali M Yehia et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 152, 491-500 (2015-08-10)

Three advanced chemmometric-assisted spectrophotometric methods namely; Concentration Residuals Augmented Classical Least Squares (CRACLS), Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) and Principal Component Analysis-Artificial Neural Networks (PCA-ANN) were developed, validated and benchmarked to PLS calibration; to resolve the severely overlapped spectra

Responses to various exposure durations of levonorgestrel during early-life stages of fathead minnows (Pimephales promelas).

Matthew D Overturf et al.

Aquatic toxicology (Amsterdam, Netherlands), 161, 33-40 (2015-02-11)

Pharmaceuticals are routinely detected in the environment; and several of these compounds have been extensively researched due to their potential impacts to the endocrine system of aquatic organisms. The negative reproductive consequences of synthetic progestins in teleost species have only

Mass Spectrometry of Single GABAergic Somatic Motorneurons Identifies a Novel Inhibitory Peptide, As-NLP-22, in the Nematode Ascaris suum.

Christopher J Konop et al.

Journal of the American Society for Mass Spectrometry, 26(12), 2009-2023 (2015-07-16)

Neuromodulators have become an increasingly important component of functional circuits, dramatically changing the properties of both neurons and synapses to affect behavior. To explore the role of neuropeptides in Ascaris suum behavior, we devised an improved method for cleanly dissecting

Autophagy facilitates secretion and protects against degeneration of the Harderian gland.

Ulrich Koenig et al.

Autophagy, 11(2), 298-313 (2014-12-09)

The epithelial derived Harderian gland consists of 2 types of secretory cells. The more numerous type A cells are responsible for the secretion of lipid droplets, while type B cells produce dark granules of multilamellar bodies. The process of autophagy

Inefficient microbial production of refractory dissolved organic matter in the ocean.

Helena Osterholz et al.

Nature communications, 6, 7422-7422 (2015-06-19)

Dissolved organic matter (DOM) in the oceans constitutes a major carbon pool involved in global biogeochemical cycles. More than 96% of the marine DOM resists microbial degradation for thousands of years. The composition of this refractory DOM (RDOM) exhibits a

Toxicological findings in a fatal multidrug intoxication involving mephedrone.

Enrico Gerace et al.

Forensic science international, 243, 68-73 (2014-05-23)

The distribution of mephedrone in the body fluids and tissues of a subject found dead after the concomitant intake of cocaine and mephedrone is reported. Mephedrone (4-methylmethcathinone) is a designer drug of the phenethylamine family that is able to cause

Mitochondrial translocation of EGFR regulates mitochondria dynamics and promotes metastasis in NSCLC.

Ting-Fang Che et al.

Oncotarget, 6(35), 37349-37366 (2015-10-27)

Dysfunction of the mitochondria is well-known for being associated with cancer progression. In the present study, we analyzed the mitochondria proteomics of lung cancer cell lines with different invasion abilities and found that EGFR is highly expressed in the mitochondria

Nanoparticle formulation improves the anticonvulsant effect of clonazepam on the pentylenetetrazole-induced seizures: behavior and electroencephalogram.

Gerardo Leyva-Gómez et al.

Journal of pharmaceutical sciences, 103(8), 2509-2519 (2014-06-12)

To document the efficacy of clonazepam (CLZ) either free as a solution or loaded in solid lipid nanoparticles (CLZ-SLN) or mixed micelles (CLZ-MM), the in vitro blood-brain barrier permeability of the formulations was determined. Behavior and/or electroencephalograms (EEGs) of rodents

Disposition of bisphenol AF, a bisphenol A analogue, in hepatocytes in vitro and in male and female Harlan Sprague-Dawley rats and B6C3F1/N mice following oral and intravenous administration.

Suramya Waidyanatha et al.

Xenobiotica; the fate of foreign compounds in biological systems, 45(9), 811-819 (2015-04-30)

1. Bisphenol AF (BPAF) is used as a crosslinking agent for polymers and is being considered as a replacement for bisphenol A (BPA). 2. In this study, comparative clearance and metabolism of BPAF and BPA in hepatocytes and the disposition and metabolism

Simultaneous determination of puerarin, daidzin, daidzein, paeoniflorin, albiflorin, liquiritin and liquiritigenin in rat plasma and its application to a pharmacokinetic study of Ge-Gen Decoction by a liquid chromatography-electrospray ionization-tandem mass spectrometry.

Yan Yan et al.

Journal of pharmaceutical and biomedical analysis, 95, 76-84 (2014-03-19)

A liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) method was developed and validated for simultaneous determination of seven constituents including puerarin, daidzin, daidzein, paeoniflorin, albiflorin, liquiritin and liquiritigenin in rat plasma using schisandrin as the internal standard (IS). The plasma samples

Hepatocyte produced matrix metalloproteinases are regulated by CD147 in liver fibrogenesis.

Sarah R Calabro et al.

PloS one, 9(7), e90571-e90571 (2014-07-31)

The classical paradigm of liver injury asserts that hepatic stellate cells (HSC) produce, remodel and turnover the abnormal extracellular matrix (ECM) of fibrosis via matrix metalloproteinases (MMPs). In extrahepatic tissues MMP production is regulated by a number of mechanisms including

Herbal medicine Guan Chang Fu Fang enhances 5-fluorouracil cytotoxicity and affects drug-associated genes in human colorectal carcinoma cells.

Chen Yu et al.

Oncology letters, 9(2), 701-708 (2015-01-27)

Guan Chang Fu Fang (GCFF) is a natural compound, which is extracted from three medicinal plants

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