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Showing 1-30 of 1014 results for "328111" within Papers
S Cyboran et al.
Life sciences, 126, 1-9 (2015-02-24)
This study was undertaken to determine the biological activity of a green tea supplement with respect to cells and erythrocyte membranes and the molecular mechanism of that activity. The extract's activity was evaluated on the basis of its hemolytic, antioxidant
Phenol?Catalyzed Discharge in the Aprotic Lithium?Oxygen Battery.
Gao X, et al.
Angewandte Chemie (Weinheim an der Bergstrasse, Germany) (2017)
Eef Boets et al.
Nutrients, 7(11), 8916-8929 (2015-11-01)
Short chain fatty acids (SCFA), including acetate, propionate, and butyrate, are produced during bacterial fermentation of undigested carbohydrates in the human colon. In this study, we applied a stable-isotope dilution method to quantify the in vivo colonic production of SCFA
Zheng Qiao et al.
Journal of chromatography. A, 1393, 18-25 (2015-03-31)
In this present study, magnetic Fe3O4@SiO2 nanoparticles (MNPs) functionalized with octadecyl groups (Fe3O4@SiO2-C18 NPs) were synthesized, characterized and employed, for the first time, as powerful nanosorbent to extract endogenous volatile organic metabolites (EVOMs) namely, hexanal, heptanal, decanal, benzaldehyde, 4-heptanone, 5-methyl-2-furfural
Jiaqi Shi et al.
Environmental science and pollution research international, 20(9), 6138-6149 (2013-04-03)
The lethal doses (LD50s) of fluorinated, chlorinated, brominated, and iodinated benzene, phenol, and diphenyl ether in mice were ascertained respectively under the consistent condition. The acute toxicity of four benzenes orders in fluorobenzene (FB) < iodobenzene < chlorobenzene≈bromobenzene, that of four phenols orders in
Sumit Ghosh et al.
Cellular & molecular immunology, 12(2), 202-212 (2014-11-05)
Sensitization to fungi often leads to a severe form of asthma that is particularly difficult to manage clinically, resulting in increased morbidity and hospitalizations in these patients. Although B lymphocytes might exacerbate asthma symptoms through the production of IgE, these
Arun M Unni et al.
eLife, 4, e06907-e06907 (2015-06-06)
Human lung adenocarcinomas (LUAD) contain mutations in EGFR in ∼15% of cases and in KRAS in ∼30%, yet no individual adenocarcinoma appears to carry activating mutations in both genes, a finding we have confirmed by re-analysis of data from over
Maarke J E Roelofs et al.
Toxicology, 329, 10-20 (2015-01-13)
Although much information on the endocrine activity of bisphenol A (BPA) is available, a proper human hazard assessment of analogues that are believed to have a less harmful toxicity profile is lacking. Here the possible effects of BPA, bisphenol F
Umar Wazir et al.
Oncology reports, 33(3), 1450-1458 (2014-12-23)
Death-associated protein 1 (DAP1) is a highly conserved phosphoprotein involved in the regulation of autophagy. A previous clinical study by our group suggested an association between low DAP1 expression and clinicopathological parameters of human breast cancer. In the present study
Eun Ji Joo et al.
Chemico-biological interactions, 233, 25-34 (2015-04-01)
Ginsenoside Rg3 (Rg3), a pharmacologically active compound from red ginseng, has been reported to induce cell death in various cancer cell lines, although the specific mechanisms have not been well established. In the present study, Rg3 treatment to A549 human
F Guneral et al.
Clinical chemistry, 40(6), 862-866 (1994-06-01)
Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days to 16 years, subdivided into five age groups. We quantified 69
Chia-Hui Chuang et al.
Acta biomaterialia, 19, 85-99 (2015-03-10)
To manufacture tissue engineering-based functional tissues, scaffold materials that can be sufficiently vascularized to mimic the functionality and complexity of native tissues are needed. Currently, vascular network bioengineering is largely carried out using natural hydrogels as embedding scaffolds, but most
Khaleque Newaz Khan et al.
Reproductive sciences (Thousand Oaks, Calif.), 22(5), 585-594 (2014-10-31)
Endometriosis is a multifactorial disease mostly affecting women of reproductive age. An additive effect between inflammation and stress reaction on the growth of endometriosis has been demonstrated. Here we investigated the combined effect between 17β-estradiol (E2) and lipopolysaccharide (LPS) on
Rohan A Davis et al.
Journal of medicinal chemistry, 54(6), 1682-1692 (2011-02-22)
In order to discover novel probes that may help in the investigation and control of infectious diseases through a new mechanism of action, we have evaluated a library of phenol-based natural products (NPs) for enzyme inhibition against four recently characterized
Fazren Azmi et al.
Bioorganic & medicinal chemistry, 22(22), 6401-6408 (2014-12-03)
Peptides are of great interest to be used as vaccine antigens due to their safety, ease of manufacturing and specificity in generating immune response. There have been massive discoveries of peptide antigens over the past decade. However, peptides alone are
Hyung Joon Kim et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(44), 14872-14884 (2015-11-06)
RE-1 silencing transcription factor (REST), a master negative regulator of neuronal differentiation, controls neurogenesis by preventing the differentiation of neural stem cells. Here we focused on the role of REST in the early steps of differentiation and maturation of adult
Yaqi Hu et al.
The Analyst, 140(13), 4662-4667 (2015-05-20)
Direct and rapid detection of 1-hydroxypyrene (1-OHP) is of great importance owing to its high carcinogenicity, teratogenicity and toxicity. In this study, a simple colorimetric assay for rapid determination of 1-OHP is reported, which is based on non-crosslinking aggregation of
Jerry O Ebalunode et al.
Bioorganic & medicinal chemistry, 17(14), 5133-5138 (2009-06-13)
Current anesthetics, especially the inhaled ones, have troublesome side effects and may be associated with durable changes in cognition. It is therefore highly desirable to develop novel chemical entities that reduce these effects while preserving or enhancing anesthetic potency. In
Manni Sun et al.
BMC cell biology, 16, 21-21 (2015-09-04)
Preeclampsia, one of the major disorders of pregnancy, is characterized by inadequate trophoblast invasion and defective trophoblast-mediated remodeling of placental vasculature. MicroRNA-34a (miR-34a) has been found to be aberrantly expressed in the placentas of preeclamptic patients, yet its role in
Josh M Morganti et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(2), 748-760 (2015-01-16)
Traumatic brain injury (TBI) is a major risk factor for the development of multiple neurodegenerative diseases. With respect to the increasing prevalence of TBI, new therapeutic strategies are urgently needed that will prevent secondary damage to primarily unaffected tissue. Consistently
Je-Hyun Yoon et al.
Genes & development, 29(15), 1599-1604 (2015-08-09)
Eukaryotic gene expression is tightly regulated post-transcriptionally by RNA-binding proteins (RBPs) and microRNAs. The RBP AU-rich-binding factor 1 (AUF1) isoform p37 was found to have high affinity for the microRNA let-7b in vitro (Kd = ∼ 6 nM) in cells.
Subburaj Vanitha et al.
Toxicology and industrial health, 31(12), 1185-1194 (2013-05-31)
The present study was designed to investigate the antinociceptive effects of methanolic leaf extract of Swietenia mahagoni (MESM) on acrylamide-induced painful neuropathy in rats. The intraperitoneal administration of acrylamide (30 mg/kg; for 24 consecutive days) has been employed for the
Balananda-Dhurjati Kumar Putcha et al.
PloS one, 10(6), e0129216-e0129216 (2015-06-13)
For the rabphillin-3A-like (RPH3AL) gene, a putative tumor suppressor, the clinical significance of genetic alterations in breast cancers was evaluated. DNA and RNA were extracted from formalin-fixed, paraffin-embedded (FFPE) cancers and matching normal tissues. DNA samples were assessed for loss
Joshua J Corrigan et al.
The Journal of physiology, 592(17), 3901-3916 (2014-06-22)
We tested the hypothesis that development of hypothermia instead of fever in endotoxic shock is consequential to hypoxia. Endotoxic shock was induced by bacterial lipopolysaccharide (LPS, 500 μg kg(-1) i.v.) in rats at an ambient temperature of 22 °C. A
Nélida Nina et al.
Molecules (Basel, Switzerland), 20(10), 18144-18167 (2015-10-13)
Propolis is commercialized in Chile as an antimicrobial agent. It is obtained mainly from central and southern Chile, but is used for the same purposes regardless of its origin. To compare the antimicrobial effect, the total phenolic (TP), the total
Emiley A Eloe-Fadrosh et al.
mBio, 6(2) (2015-04-16)
A mechanistic understanding of the purported health benefits conferred by consumption of probiotic bacteria has been limited by our knowledge of the resident gut microbiota and its interaction with the host. Here, we detail the impact of a single-organism probiotic
Paul-Andre Genest et al.
Nucleic acids research, 43(4), 2102-2115 (2015-02-11)
Base J (β-D-glucosyl-hydroxymethyluracil) replaces 1% of T in the Leishmania genome and is only found in telomeric repeats (99%) and in regions where transcription starts and stops. This highly restricted distribution must be co-determined by the thymidine hydroxylases (JBP1 and
Yang Li et al.
Toxicology, 312, 108-114 (2013-08-27)
Benzene is a common occupational hazard as well as a widespread pollutant. Its metabolites play important roles in its toxicity to the hematopoietic system, but little is known about how benzene metabolites affect erythropoiesis. Our previous study demonstrated that benzene
Yohei Sakaguchi et al.
The Analyst, 140(6), 1965-1973 (2015-02-12)
We have developed a novel amino acid analysis method using derivatization of multiple functional groups (amino, carboxyl, and phenolic hydroxyl groups). The amino, carboxyl, and phenolic hydroxyl groups of the amino acids were derivatized with 1-bromobutane so that the hydrophobicities
Sandeep Kumar Dash et al.
Bioorganic chemistry, 63, 85-100 (2015-10-16)
The main complication in betulinic acid (BA) based drug delivery has been observed due to its bulk structure. The present study demonstrates the potential effects of self assembled nano size betulinic acid (SA-BA) by treating human leukemic cell lines (KG-1A
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