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Showing 1-30 of 46 results for "34071" within Papers
V Dohnal et al.
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 56(4), 174-177 (2007-11-01)
The paper is focused on the occurrence and methods for the detection of T-2 toxin, one of the most toxic trichothecene Fusarium mycotoxin. Due to its physical-chemical properties and high toxicity, T-2 toxin is classified as a potential biological warfare
Ann Osselaere et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 51, 350-355 (2012-10-27)
Mycotoxins lead to economic losses in animal production. A way to counteract mycotoxicosis is the use of detoxifiers. The European Food Safety Authority stated that the efficacy of detoxifiers should be investigated based on toxicokinetic studies. Little information is available
Susan P McCormick et al.
Applied and environmental microbiology, 78(24), 8694-8702 (2012-10-09)
Trichothecenes are sesquiterpenoid toxins produced by Fusarium species. Since these mycotoxins are very stable, there is interest in microbial transformations that can remove toxins from contaminated grain or cereal products. Twenty-three yeast species assigned to the Trichomonascus clade (Saccharomycotina, Ascomycota)
Veronica M T Lattanzio et al.
Journal of mass spectrometry : JMS, 47(4), 466-475 (2012-06-13)
The presence of glucoside derivatives of T-2 and HT-2 toxins (type A trichothecene mycotoxins) in naturally contaminated wheat and oats is reported for the first time. The use of advanced high-resolution mass spectrometry based on Orbitrap technology allowed to obtain
Li-Yan Sun et al.
Biological trace element research, 150(1-3), 371-375 (2012-07-05)
It has been strongly suggested that two factors are involved in the development of Kaschin-Beck Disease (KBD), namely grains contamination with T-2 toxin and selenium deficiency. So our team undertook a survey about grains and drinking water in three rural
Wayne E Steinmetz et al.
European journal of medicinal chemistry, 44(11), 4485-4489 (2009-07-10)
Trichothecene mycotoxins, toxic natural products of fungi from the family Hypocreaceae, are potent inhibitors of protein synthesis. The application of 3D QSAR to these toxins explored the structural basis for their biological activities. A CoMFA (Q(2)=0.619, R(2)=0.921) model was developed
Hamide Z Senyuva et al.
Journal of AOAC International, 95(6), 1701-1708 (2013-03-05)
A comparison has been made of an LC/MS/MS method using direct analysis of acetonitrile extracts of feed and cereal samples and a method using acetonitrile extraction and subsequent immunoaffinity column (IAC) cleanup. Naturally contaminated samples containing one or more of
Jing Wu et al.
Toxicology letters, 232(3), 573-579 (2014-12-30)
T-2 toxin is a secondary metabolite produced by Fusarium genus and is a common contaminant in food and feedstuffs of cereal origin. In porcine granulosa cells(GC), T-2 toxin has been shown to inhibit the steroidogenesis; however, the mechanism has not
Lei Yang et al.
Biological trace element research, 190(2), 295-302 (2018-11-09)
The combination of excess mycotoxin exposure and selenium deficiency has been widely considered as a cause of Kashin-Beck disease (KBD). The present study aimed to investigate the expression profiles of selenium-related genes in human chondrocytes after exposure to T-2 toxin
Melinda Kovács et al.
Animal reproduction science, 137(3-4), 245-252 (2013-02-12)
T-2 toxin (T-2) was administered to adult Pannon White (n = 10/group) male rabbits for 65 days, first in a suspension by gavage (0.05, 0.1 or 0.2 mg/animal/day), and secondly mixed into the feed (0.33 and 0.66 mg/kg feed). In
T-2 toxin enhances catabolic activity of hypertrophic chondrocytes through ROS-NF-κB-HIF-2α pathway.
Juan Tian et al.
Toxicology in vitro : an international journal published in association with BIBRA, 26(7), 1106-1113 (2012-07-18)
T-2 toxin (T-2), one of the most important and toxic trichothecene mycotoxins, can cause many medical problems, such as diarrhea, nervous disorders, immunodepression and death, and is also believed as an etiological factor of Kashin-Beck disease, an endemic osteochondropathy prevailing
M C Ferreras et al.
Journal of comparative pathology, 148(2-3), 236-242 (2012-07-24)
A flock of approximately 1,000 sheep were exposed intermittently to food contaminated with T-2 toxin (T-2), a potent type-A trichothecene mycotoxin produced primarily by Fusarium sporotrichioides and Fusarium poae. In the acute stage of the intoxication, affected sheep developed anorexia
M Venkataramana et al.
Journal of food science and technology, 51(9), 1920-1928 (2014-09-06)
Fumonisins are one of the most agriculturally significant environmental toxins produced by Fusarium and Aspergillus species that grow on agricultural commodities in the field or during storage. Cereals contaminated with fumonisins causes serious loss to agricultural produce leads to health
D G Ndossi et al.
Toxicology letters, 214(3), 268-278 (2012-09-18)
Trichothecenes are a large family of chemically related mycotoxins. Deoxynivalenol (DON), T-2 and HT-2 toxins belong to this family and are produced by various species of Fusarium. The H295R steroidogenesis assay, regulation of steroidogenic gene expression and reporter gene assays
Arpad Czeh et al.
Journal of immunological methods, 384(1-2), 71-80 (2012-07-31)
Exposure to multiple mycotoxins through the food chain represents a major potential health hazard to both humans and livestock. They can cause a variety of severe acute as well as chronic diseases. Eliminating mycotoxins from various grain crops is a
A Osselaere et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 55, 150-155 (2013-01-15)
The effects of the mycotoxin T-2 on hepatic and intestinal drug-metabolizing enzymes (cytochrome P450) and drug transporter systems (MDR1 and MRP2) in poultry were investigated during this study. Broiler chickens received either uncontaminated feed, feed contaminated with 68μg/kg or 752μg/kg
Wayne E Steinmetz et al.
Journal of natural products, 71(4), 589-594 (2008-03-11)
A combination of NMR spectroscopy and molecular modeling has been employed to characterize the conformation and dynamics of the macrolide ring in verrucarin A and roridin A, two closely related toxins in the trichothecene mycotoxin family. Longitudinal carbon-13 relaxation times
Elisabetta De Angelis et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 30(2), 345-355 (2012-11-20)
Deoxynivalenol, T-2 and HT-2 toxins are mycotoxins frequently occurring in cereals and cereal-based products along with their conjugated forms. In this paper, we provide insights into the fate of deoxynivalenol, T-2 and HT-2 toxins and their glucoside derivatives during bread
Elin Verbrugghe et al.
Research in veterinary science, 93(3), 1139-1141 (2012-07-28)
The aim of the study was to investigate the effect of a modified glucomannan binder on the course of a Salmonella Typhimurium infection in pigs. Therefore, four pig diets were provided during 23 days: (1) free of mycotoxins, (2) containing
Soujanya Ratna Edupuganti et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 923-924, 98-101 (2013-03-19)
An affinity purification method that isolates T-2 toxin-specific IgY utilizing a T-2-toxin-immobilized column was developed. The T-2 toxin was covalently coupled via a carbonyldiimidazole-activated hydroxyl functional group to amine-activated sepharose beads. The affinity-purified IgY was characterized by gel electrophoresis, fast
Yanshen Li et al.
Journal of agricultural and food chemistry, 59(8), 3441-3453 (2011-03-23)
This review focuses on the toxicity and metabolism of T-2 toxin and analytical methods used for the determination of T-2 toxin. Among the naturally occurring trichothecenes in food and feed, T-2 toxin is a cytotoxic fungal secondary metabolite produced by
Patrick B Njobeh et al.
Toxins, 4(10), 836-848 (2012-11-20)
A total of 92 commercial compound feeds from South Africa were investigated for various mycotoxins. The data reveal the highest incidence of feed contamination for fumonisins (FB) (range: 104-2999 µg/kg) followed by deoxynivalenol (DON) (range: 124-2352 µg/kg) and zearalenone (ZEA)
Maria Weidner et al.
PloS one, 8(3), e60484-e60484 (2013-04-02)
The trichothecene mycotoxin T-2 toxin is a common contaminant of food and feed and is also present in processed cereal derived products. Cytotoxic effects of T-2 toxin and its main metabolite HT-2 toxin are already well described with apoptosis being
Xu Wang et al.
The Analyst, 140(5), 1453-1458 (2015-01-21)
A simple, sensitive and cost-effective method for the analysis of the mycotoxin aflatoxin B1 (AFB1) has been established based on controlled growth of immunogold. AFB1-BSA conjugate modified magnetic beads were employed as capture probe and anti-AFB1 antibody-coated gold colloids were
Suquan Song et al.
Journal of chromatography. A, 1292, 111-120 (2012-11-28)
Direct determination of urinary mycotoxins is a better approach to assess individual's exposure than the indirect estimation from average dietary intakes. In this study, a new analytical method was developed and validated for simultaneous analysis of aflatoxin B1, deoxynivalenol, fumonisin
Biljana D Škrbić et al.
Food additives & contaminants. Part B, Surveillance, 10(4), 256-267 (2017-06-18)
The aim of this study was to determine levels of 11 mycotoxins, 10 trace elements, and 6 phthalates in rice samples from Serbian and Chinese market. Mycotoxins were not detected in any of the analysed rice samples. Results revealed similar
Maria Weidner et al.
Chemical research in toxicology, 26(3), 347-355 (2013-02-01)
The trichothecene mycotoxin T-2 toxin, which is produced by fungi of the Fusarium species, is a worldwide occurring contaminant of cereal based food and feed. The cytotoxic properties of T-2 toxin are already well described with apoptosis being a major
Jing Wu et al.
Environmental toxicology and pharmacology, 36(2), 493-500 (2013-07-03)
To investigate the reproductive toxicity and cytotoxicity of T-2 toxin, which is a mycotoxin, and to explore its potential apoptotic induction mechanism. ovarian granulosa cells of rats were treated with T-2 toxin (1-100nM) for 24h. The cytotoxicity was assessed with
A S Ficheux et al.
Toxicon : official journal of the International Society on Toxinology, 60(6), 1171-1179 (2012-08-28)
Mycotoxins such as beauvericin (BEA), deoxynivalenol (DON), enniatin B (ENB), fumonisin B1 (FB1), T-2 toxin and zearalenone (ZEA) can co-occur in food commodities. This aim of this study was to assess the myelotoxicity of these mycotoxins in couple using in vitro
K Obremski et al.
Polish journal of veterinary sciences, 16(2), 341-349 (2013-08-27)
The immune system is one of the main toxicity targets of the T-2 toxin. In view of scant research data demonstrating the effect of T-2 on cellular and humoral responses in gut-associated lymphoid tissue (GALT), this study set out to
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