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Showing 1-30 of 37 results for "34392" within Papers
Undisclosed methyldibromo glutaronitrile causing allergic contact dermatitis in a NSAID cream.
Cristina Amaro et al.
Contact dermatitis, 67(3), 173-174 (2012-08-18)
M E Marcano et al.
Contact dermatitis, 57(2), 126-127 (2007-07-14)
We inform about a case of occupational allergic contact dermatitis (OACD) to methyldibromoglutaronitrile (MDBGN) in industrial hand degreasing moist toilet paper. To our knowledge, this is the first published case of OACD to MDBGN in industrial hand degreasing toilet papers.
Yusuke Yamamoto et al.
The Journal of toxicological sciences, 44(9), 585-600 (2019-09-03)
Amino acid derivative reactivity assay (ADRA) has previously been developed as an alternative method to direct peptide reactivity assay (DPRA) to evaluate key event 1 in skin sensitization mechanisms. However, when using alternative methods for skin sensitization, integrated approaches to
National Toxicology Program technical report series, (555)(555), 1-171 (2010-08-21)
1,2-Dibromo-2,4-dicyanobutane is used in cosmetics and other household products. 1,2-Dibromo-2,4-dicyanobutane was nominated for study by the National Institute of Environmental Health Sciences because of its widespread use as a component of numerous over-the-counter health care products. Male and female F344/N
Jacob P Thyssen et al.
Contact dermatitis, 62(2), 102-108 (2010-02-09)
Most cosmetics and industrial products contain preservatives. Preservative allergy is common and, historically, changing contact allergy epidemics caused by preservatives have been observed. In 1997, Alan Dillarstone predicted a stable development of preservative allergy following mandatory ingredient labelling on cosmetic
M T Bordel-Gómez et al.
Actas dermo-sifiliograficas, 100(3), 201-204 (2009-05-22)
Euxyl K400 is a widely used preservative in cosmetics, topical drugs, cutting fluids, etc. This antimicrobial product has two active components: methyldibromoglutaronitrile (MDGN), also known as 1,2-dibromo-2,4-dicyanobutane, and 2-phenoxyethanol, in a proportion of 1 to 4. The aim of this
L A Fischer et al.
The British journal of dermatology, 159(5), 1138-1143 (2008-09-18)
Methyldibromoglutaronitrile (MDBGN) is a preservative, which was approved for use in cosmetics in the mid-1980s. The incidence of allergy to MDBGN rose during the 1990s, but is now decreasing due to regulatory intervention. Experimental studies with other allergens have shown
Ian R Jowsey et al.
Contact dermatitis, 59(2), 90-95 (2008-09-02)
A key consideration when undertaking risk assessments should be the potential for synergy between contact allergens. Previously, this concept has only been investigated during elicitation in contact allergic individuals. To determine whether there exists evidence for synergy between contact allergens
Kazutoshi Saito et al.
Toxicology in vitro : an international journal published in association with BIBRA, 40, 11-25 (2016-12-15)
To evaluate chemicals (e.g. lipophilic chemicals, pre/pro-haptens) that are difficult to correctly evaluate using in vitro skin sensitization tests (e.g. DPRA, KeratinoSens or h-CLAT), we developed a novel in vitro test termed "Epidermal Sensitization Assay: EpiSensA" that uses reconstructed human
Methyldibromoglutaronitrile in rinse?off products causes allergic contact dermatitis: an experimental study
Jensen.DC, et al.
British Journal of Dermatology, 150, 90-95 (2004)
Jeanne D Johansen et al.
Contact dermatitis, 59(1), 48-51 (2008-06-10)
The preservative methyldibromo glutaronitrile (MDBGN) has been banned, first from stay-on, and later from rinse-off cosmetics, in the EU countries because of increasing rates of contact allergy. To evaluate the frequency of contact allergy to MDBGN among patients patch tested
Follow-up of the monitored levels of preservative sensitivity in Europe: overview of the years 2001-2008.
Cecilia Svedman et al.
Contact dermatitis, 67(5), 312-314 (2012-10-09)
Methyldibromoglutaronitrile (Euxyl K400): A new and important sensitizer in the United States?
Jackson M.J, et al.
Journal of the American Academy of Dermatology, 38, 934-937 (1998)
B C Carlsen et al.
The British journal of dermatology, 160(1), 103-106 (2008-11-19)
It is not known if reduced elicitation thresholds are evident among polysensitized individuals when using allergens to which the patients are already sensitized. Reduced elicitation thresholds may be an expression of increased reactivity in this patient group. To examine and
Manuela Pellegrini et al.
Journal of pharmaceutical and biomedical analysis, 56(5), 1112-1116 (2011-08-30)
A simple and rapid gas chromatography (GC) method with mass spectrometry (MS) detection has been developed for the determination of methyldibromo glutaronitrile (MDBGN) in cosmetic products. The presence of this preservative in commercial cosmetic samples is prohibited since 2007 because
Marléne Isaksson et al.
Dermatitis : contact, atopic, occupational, drug, 18(4), 203-207 (2007-11-21)
Contact allergy to and allergic contact dermatitis from methyldibromoglutaronitrile (MDBGN) have been frequently reported since the 1990s. This study was initiated to help determine the optimal test preparation for MDBGN and to help determine the clinical relevance of such a
Decreasing trends in methyldibromo glutaronitrile contact allergy?following regulatory intervention
Johansen DJ, et al.
Contact Dermatitis, 59, 48-51 (2008)
Lars Bendahl et al.
Journal of pharmaceutical and biomedical analysis, 40(3), 648-652 (2006-01-19)
Ultra performance liquid chromatography (UPLC) was coupled to inductively coupled plasma mass spectrometry (ICP-MS) for fast analysis of three bromine-containing preservatives, monitoring the 79Br and 81Br isotopes simultaneously. Due to the efficiency of the 1.7 microm column packing material, the
David A Basketter
Cutaneous and ocular toxicology, 29(1), 4-9 (2009-11-04)
Preservatives can be a frequent cause of allergic contact dermatitis (ACD). A quantitative risk assessment (QRA) method for identifying safe exposure levels has been suggested as a more effective tool for this purpose. This work assesses the validity of QRA
Huijun Liu et al.
Bulletin of environmental contamination and toxicology, 92(4), 451-454 (2014-02-20)
The dissipation and residues of bromothalonil in apple and soil under field condition were analyzed by QuEChERS (quick, easy, cheap, effective, rugged and safe) combined with gas chromatography-mass spectrometer method. The recoveries were ranged from 80.8 % to 106 %
Louise Arup Fischer et al.
Contact dermatitis, 64(6), 337-342 (2011-05-04)
Allergic contact dermatitis is triggered by chemicals in the environment. Primary prevention is aimed at minimizing the risk of induction, whereas secondary and tertiary prevention are aimed at reducing elicitation. To identify the elicitation doses that will elicit an allergic
Patch testing with methyldibromoglutaronitrile
Geier J, et al.
American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society, 11, 207-212 (2000)
Determination of methyldibromoglutaronitrile in cosmetic products by high-performance liquid chromatography with electrochemical detection: Method validation
Rastogi CS, et al.
Journal of Chromatography A, 1031(1-2), 315-317 (2004)
J Geier et al.
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 62(10), 751-756 (2011-09-09)
Ever-changing exposure to contact allergens, partly due to statutory directives (e.g. nickel, chromate, methyldibromo glutaronitrile) or recommendations from industrial associations (e.g. hydroxyisohexyl 3-cyclohexene carboxaldehyde), requires on-going epidemiologic surveillance of contact allergy. In this paper, the current state with special focus
Charlotte Gotthard Mortz et al.
Current opinion in allergy and clinical immunology, 8(5), 428-432 (2008-09-05)
To give selected new information on contact allergy and allergic contact dermatitis with focus on diagnostic procedures and pitfalls. Recent studies dealing with common contact allergens have improved our understanding of the relationship between positive patch tests and the clinical
S Ada et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 24(10), 1192-1196 (2010-03-20)
Cosmetics are the causative agents in 8-15% of patients suspected of having allergic contact dermatitis. Patch testing with standard series identifies 70-80% of the responsible allergens in all contact dermatitis; however, many important cosmetic-related allergens may be missed by using
G Pónyai et al.
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 146(1), 53-56 (2011-02-15)
In order to map the frequency of contact hypersensitivity (CH) to epoxy resin, methyldibromoglutaronitrile (MDBGN), tixocortol pivalate (TP) and budesonide patch tests were carried out. The tests were performed in 1448 patients. Most patients belong to the allergic and irritative
M D Lynch et al.
The British journal of dermatology, 176(1), 184-196 (2016-06-11)
Delayed-type hypersensitivity represents a significant clinical and public health challenge. Patients undergoing patch testing may exhibit positive reactions to more than one allergen. It is recognized that reactions to specific pairs of allergens are associated, reflecting a combination of exposure
Axel Schnuch et al.
Contact dermatitis, 56(6), 331-337 (2007-06-20)
Although genetic factors probably account for differences in susceptibility to contact allergy, they have not yet been identified, partly due to an insufficient understanding of 'susceptibility'. Regarding polysensitization (PS) as a sign of increased susceptibility, we studied the relationship between
Louise Arup Fischer et al.
Contact dermatitis, 61(4), 201-208 (2009-10-15)
Allergic contact dermatitis is common and can be prevented. The relationship between thresholds for patch tests and the repeated open application test (ROAT) is unclear. It would be desirable if patch test and ROAT data from already sensitized individuals could
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