365548

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BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation.

Matsubara T, et al.

The Journal of Biological Chemistry, 283(43), 29119-29125 (2008)

CD47 Deficiency in Mice Exacerbates Chronic Fatty Diet-Induced Steatohepatitis Through Its Role in Regulating Hepatic Inflammation and Lipid Metabolism.

Hui-Chao Tao et al.

Frontiers in immunology, 11, 148-148 (2020-03-12)

Inflammation is one of the hallmarks of non-alcoholic steatohepatitis. CD47 is a widely expressed transmembrane protein that signals through inhibitory receptor signal regulatory protein α (SIRPα) to inhibit macrophage activation and phagocytosis. In this study, we sought to investigate the

Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis.

Shaogui Wang et al.

Autophagy, 15(11), 1954-1969 (2019-03-22)

Impaired macroautophagy/autophagy has been implicated in experimental and human pancreatitis. However, the transcriptional control governing the autophagy-lysosomal process in pancreatitis is largely unknown. We investigated the role and mechanisms of TFEB (transcription factor EB), a master regulator of lysosomal biogenesis

Comparison of photocatalytic degradation of dyes in relation to their structure.

R Byberg et al.

Environmental science and pollution research international, 20(6), 3570-3581 (2013-02-21)

The photocatalytic degradation of a series of six acid dyes (Direct Red 80, Direct Red 81, Direct Red 23, Direct Violet 51, Direct Yellow 27, and Direct Yellow 50) has been tested compared in terms of color removal, mineralization, and

Comprehensive validation of cardiovascular magnetic resonance techniques for the assessment of myocardial extracellular volume.

Christopher A Miller et al.

Circulation. Cardiovascular imaging, 6(3), 373-383 (2013-04-05)

Extracellular matrix expansion is a key element of ventricular remodeling and a potential therapeutic target. Cardiovascular magnetic resonance (CMR) T1-mapping techniques are increasingly used to evaluate myocardial extracellular volume (ECV); however, the most widely applied methods are without histological validation.

Histomorphometric estimation of age in paraffin-embedded ribs: a feasibility study.

Catherine Cannet et al.

International journal of legal medicine, 125(4), 493-502 (2010-04-07)

Estimation of age at death from human bones in legal medicine or in anthropology and archaeology is hampered by controversial results from the various macroscopic and histological techniques. This study attempted an estimation of age at death by histomorphometric analysis

Evaluation of collagen in connective tissue walls of odontogenic cysts--a histochemical study.

Ruchieka Vij et al.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 40(3), 257-262 (2010-10-26)

The purpose of this study was to evaluate the nature of collagen in the connective tissue walls of odontogenic cysts, like the odontogenic keratocyst (OKC), dentigerous cyst and radicular cyst using picrosirius red stained sections. Furthermore, it was intended to

EphrinA1-Fc Attenuates Ventricular Remodeling and Dysfunction in Chronically Nonreperfused WT but not EphA2-R-M mice.

K'Shylah S Whitehurst et al.

International journal of molecular sciences, 21(16) (2020-08-23)

EphrinA1-Fc abolishes acute I/R injury and attenuates nonreperfused cardiac injury 4 days after permanent occlusion in mice. The goal of this study was to assess the capacity of a single intramyocardial administration of ephrinA1-Fc at the time of coronary artery

Drug Targeting of Plasminogen Activator Inhibitor-1 Inhibits Metabolic Dysfunction and Atherosclerosis in a Murine Model of Metabolic Syndrome.

Hekmat B Khoukaz et al.

Arteriosclerosis, thrombosis, and vascular biology, 40(6), 1479-1490 (2020-04-10)

Enhanced expression of PAI-1 (plasminogen activator inhibitor-1) has been implicated in atherosclerosis formation in humans with obesity and metabolic syndrome. However, little is known about the effects of pharmacological targeting of PAI-1 on atherogenesis. This study examined the effects of

Differential Roles of Endothelial Cell-Derived and Smooth Muscle Cell-Derived Fibronectin Containing Extra Domain A in Early and Late Atherosclerosis.

Prakash Doddapattar et al.

Arteriosclerosis, thrombosis, and vascular biology, 40(7), 1738-1747 (2020-05-22)

The extracellular matrix of atherosclerotic arteries contains abundant deposits of cellular Fn-EDA (fibronectin containing extra domain A), suggesting a functional role in the pathophysiology of atherosclerosis. Fn-EDA is synthesized by several cell types, including endothelial cells (ECs) and smooth muscle

The construction, expression, and enhanced anti-tumor activity of YM101: a bispecific antibody simultaneously targeting TGF-β and PD-L1.

Ming Yi et al.

Journal of hematology & oncology, 14(1), 27-27 (2021-02-18)

Therapeutic antibodies targeting programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) axis induce potent and durable anti-tumor responses in multiple types of cancers. However, only a subset of patients benefits from anti-PD-1/PD-L1 therapies. As a negative regulator of anti-tumor

Retinol from hepatic stellate cells via STRA6 induces lipogenesis on hepatocytes during fibrosis.

Injoo Hwang et al.

Cell & bioscience, 11(1), 3-3 (2021-01-08)

Hepatic stellate cells (HSCs) are activated in response to liver injury with TIF1γ-suppression, leading to liver fibrosis. Here, we examined the mechanism how reduction of TIF1γ in HSCs induces damage on hepatocytes and liver fibrosis. Lrat:Cas9-ERT2:sgTif1γ mice were treated Tamoxifen

Melanoma-derived extracellular vesicles instigate proinflammatory signaling in the metastatic microenvironment.

Tzlil Gener Lahav et al.

International journal of cancer, 145(9), 2521-2534 (2019-06-20)

The major cause of melanoma mortality is metastasis to distant organs, including lungs and brain. Reciprocal interactions of metastasizing tumor cells with stromal cells in secondary sites play a critical role in all stages of tumorigenesis and metastasis. Changes in

Modeling dysbiosis of human NASH in mice: Loss of gut microbiome diversity and overgrowth of Erysipelotrichales.

James K Carter et al.

PloS one, 16(1), e0244763-e0244763 (2021-01-05)

Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease (NAFLD) that is responsible for a growing fraction of cirrhosis and liver cancer cases worldwide. Changes in the gut microbiome have been implicated in NASH pathogenesis, but the

A novel method for accurate collagen and biochemical assessment of pulmonary tissue utilizing one animal.

Corrine R Kliment et al.

International journal of clinical and experimental pathology, 4(4), 349-355 (2011-05-18)

The purpose of this study was to develop an improved method for collagen and protein assessment of fibrotic lungs while decreasing animal use. 8-10 week old, male C57BL/6 mice were given a single intratracheal instillation of crocidolite asbestos or control

Ablation of Hepatocyte Smad1, Smad5, and Smad8 Causes Severe Tissue Iron Loading and Liver Fibrosis in Mice.

Chia-Yu Wang et al.

Hepatology (Baltimore, Md.), 70(6), 1986-2002 (2019-05-28)

A failure of iron to appropriately regulate liver hepcidin production is central to the pathogenesis of hereditary hemochromatosis. SMAD1/5 transcription factors, activated by bone morphogenetic protein (BMP) signaling, are major regulators of hepcidin production in response to iron; however, the

High-fat diet pre-conditioning improves microvascular remodelling during regeneration of ischaemic mouse skeletal muscle.

Emmanuel Nwadozi et al.

Acta physiologica (Oxford, England), 229(1), e13449-e13449 (2020-02-06)

Critical limb ischaemia (CLI) is characterized by inadequate angiogenesis, arteriolar remodelling and chronic myopathy, which are most severe in type 2 diabetic patients. Hypertriglyceridaemia, commonly observed in these patients, compromises macrovascular function. However, the effects of high-fat diet-induced increases in

Functional melanocortin-2 receptors are expressed by mouse aorta-derived mesenchymal progenitor cells.

Jodi F Evans et al.

Molecular and cellular endocrinology, 355(1), 60-70 (2012-02-07)

A local melanocortin system is active during tissue injury and inflammation. Thus far this system has been described as autocrine in nature where local production of pro-opiomelanocortin (POMC) peptides by leukocytes feeds back on melanocortin receptor (MC-R) expressing immune cells

Pressure overload by suprarenal aortic constriction in mice leads to left ventricular hypertrophy without c-Kit expression in cardiomyocytes.

Amy M Nicks et al.

Scientific reports, 10(1), 15318-15318 (2020-09-20)

Animal models of pressure overload are valuable for understanding hypertensive heart disease. We characterised a surgical model of pressure overload-induced hypertrophy in C57BL/6J mice produced by suprarenal aortic constriction (SAC). Compared to sham controls, at one week post-SAC systolic blood

Effects of adenovirus-mediated delivery of the human hepatocyte growth factor gene in experimental radiation-induced heart disease.

Shunying Hu et al.

International journal of radiation oncology, biology, physics, 75(5), 1537-1544 (2009-11-26)

Irradiation to the heart may lead to late cardiovascular complications. The purpose of this study was to investigate whether adenovirus-mediated delivery of the human hepatocyte growth factor gene could reduce post-irradiation damage of the rat heart and improve heart function.

Nrf2 Ameliorates DDC-Induced Sclerosing Cholangitis and Biliary Fibrosis and Improves the Regenerative Capacity of the Liver.

Athanassios Fragoulis et al.

Toxicological sciences : an official journal of the Society of Toxicology, 169(2), 485-498 (2019-03-03)

The Nrf2 pathway protects against oxidative stress and induces regeneration of various tissues. Here, we investigated whether Nrf2 protects from sclerosing cholangitis and biliary fibrosis and simultaneously induces liver regeneration. Diet containing 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) was fed to Nrf2-KO mice (Nrf2-/-)

TGF-β1 diminishes collagen production during long-term cyclic stretching of engineered connective tissue: implication of decreased ERK signaling.

Zeeshan H Syedain et al.

Journal of biomechanics, 44(5), 848-855 (2011-01-22)

Cyclic stretching and growth factors like TGF-β have been used to enhance extracellular matrix (ECM) production by cells in engineered tissue to achieve requisite mechanical properties. In this study, the effects of TGF-β1 were evaluated during long-term cyclic stretching of

FURIN Inhibition Reduces Vascular Remodeling and Atherosclerotic Lesion Progression in Mice.

Gopala K Yakala et al.

Arteriosclerosis, thrombosis, and vascular biology, 39(3), 387-401 (2019-01-18)

Objective- Atherosclerotic coronary artery disease is the leading cause of death worldwide, and current treatment options are insufficient. Using systems-level network cluster analyses on a large coronary artery disease case-control cohort, we previously identified PCSK3 (proprotein convertase subtilisin/kexin family member

Immunohistological characterization of newly formed tissues after regenerative procedure in immature dog teeth.

Nozomu Yamauchi et al.

Journal of endodontics, 37(12), 1636-1641 (2011-11-22)

In a previous report, we showed that 2 types of mineralized tissues were formed in the canal spaces of dogs after tissue engineering treatments of immature teeth with apical periodontitis: (1) dentin- associated mineralized tissue (DAMT) and (2) bony islands

A testis-derived macroporous 3D scaffold as a platform for the generation of mouse testicular organoids.

Tohid Rezaei Topraggaleh et al.

Biomaterials science, 7(4), 1422-1436 (2019-01-23)

Extracellular matrix-derived scaffolds provide an efficient platform for the generation of organ-like structures. Successful development of testicular organoids (TOs) with the capability of supporting complete spermatogenesis has not been reported yet. Here, we have developed an optimized method for the

Differences in collagen fibres in the capsule walls of parakeratinized and orthokeratinized odontogenic cysts.

J-Y Zhang et al.

International journal of oral and maxillofacial surgery, 40(11), 1296-1300 (2011-07-12)

Epithelial-mesenchymal interactions are thought to play an important role in the pathogenesis of odontogenic lesions. Keratocystic odontogenic tumour (KCOT) is a benign cystic neoplasm with a characteristic parakeratinized epithelial lining, which differs histologically and behaviourally from the so-called orthokeratinized odontogenic

In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: a potential new therapy for hepatic fibrosis.

George J, et al.

Proceedings of the National Academy of Sciences of the USA, 96(22), 12719-12724 (1999)

Enhanced decolourization of Direct Red-80 dye by the white rot fungus Phanerochaete chrysosporium employing sequential design of experiments.

Sukhwinder Singh et al.

Biodegradation, 21(4), 501-511 (2009-12-05)

Decolourization of Direct Red 80 (DR-80) by the white rot fungus Phanerochaete chrysosporium MTCC 787 was investigated employing sequential design of experiments. Media components for growing the white rot fungus were first screened using Plackett-Burman design and then optimized using

Time-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactors.

Gian Nutal Schädli et al.

Communications biology, 4(1), 110-110 (2021-01-27)

Progress in bone scaffold development relies on cost-intensive and hardly scalable animal studies. In contrast to in vivo, in vitro studies are often conducted in the absence of dynamic compression. Here, we present an in vitro dynamic compression bioreactor approach

IFT20 is critical for collagen biosynthesis in craniofacial bone formation.

Hiroyuki Yamaguchi et al.

Biochemical and biophysical research communications, 533(4), 739-744 (2020-09-30)

Intraflagellar transport (IFT) is essential for assembling primary cilia required for bone formation. Disruption of IFT frequently leads to bone defects in humans. While it has been well studied about the function of IFT in osteogenic cell proliferation and differentiation

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