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Showing 1-30 of 44 results for "371173" within Papers
C Schöfl et al.
Endocrinology, 141(11), 4065-4071 (2000-11-23)
Insulin secretion is under multifactorial control by glucose and neurohumoral factors like acetylcholine (ACH), which activate the Ca2+/phospholipase C signaling pathway. All insulin secretagogues elevate cytosolic free Ca2+ ([Ca2+]i) that is central to the stimulation of insulin secretion. The actions
Jeremy J P Shaw et al.
Molecular cancer therapeutics, 19(12), 2621-2633 (2020-10-23)
Therapies for head and neck squamous cell carcinoma (HNSCC) are, at best, moderately effective, underscoring the need for new therapeutic strategies. Ceramide treatment leads to cell death as a consequence of mitochondrial damage by generating oxidative stress and causing mitochondrial
Orientation and conformation of methyl pyruvate on Ni (111).
Castonguay M, et al.
Journal of the American Chemical Society, 122(3), 518-524 (2000)
Enantioselective hydrogenation I. Surface conditions during methyl pyruvate hydrogenation catalyzed by cinchonidine-modified platinum/silica (EUROPT-1).
Sutherland IM, et al.
J. Catal., 125(1), 77-88 (1990)
Young-Ra Cho et al.
Molecular oncology, 12(7), 1203-1215 (2018-05-24)
Matrine is a natural compound extracted from the herb Sophora flavescens Ait which is widely used in traditional Chinese medicine for treating various diseases. Recently, matrine was reported to have antitumor effects against a variety of cancers without any obvious
Gabriella M Dahlgren et al.
Biochimica et biophysica acta, 1724(1-2), 23-36 (2005-05-11)
Glucose induces complex patterns of oscillations in intracellular Ca2+ concentration ([Ca2+]i), metabolism and secretion in islets of Langerhans including "slow" and "fast" pulses with period of 2-5 min and 10-20 s respectively. In an effort to elucidate the origin of
Jong Gab Jung et al.
Molecular and cellular endocrinology, 345(1-2), 79-87 (2011-08-02)
Elevated fatty acid levels have been thought to contribute to insulin resistance. Repression of the glucose transporter 4 (GLUT4) gene as well as impaired GLUT4 translocation may be a mediator for fatty acid-induced insulin resistance. This study was initiated to
Y-H Suh et al.
The Journal of endocrinology, 183(1), 133-144 (2004-11-05)
The short heterodimer partner (SHP) (NR0B2) is an orphan nuclear receptor whose function in pancreatic beta-cells is unclear. Mitochondrial uncoupling protein (UCP2) in beta-cells is upregulated in obesity-related diabetes, causing impaired glucose-stimulated insulin secretion (GSIS). We investigated whether SHP plays
Hideaki Tagashira et al.
Biochimica et biophysica acta, 1840(12), 3320-3334 (2014-09-02)
Amyotrophic lateral sclerosis (ALS) is a disease caused by motor neuron degeneration. Recently, a novel SIGMAR1 gene variant (p.E102Q) was discovered in some familial ALS patients. We address mechanisms underlying neurodegeneration caused by the mutation using Neuro2A cells overexpressing σ1R(E102Q)
Emma Heart et al.
American journal of physiology. Endocrinology and metabolism, 292(5), E1295-E1300 (2007-01-11)
Pulsatile insulin output, paralleled by oscillations in intracellular Ca(2+), reflect oscillating metabolism within beta-cells in response to secretory fuels. Here we question whether oscillatory periodicity is conserved or varied from stimulation to stimulation, whether glycolysis is essential for the manifestation
Jun-Kyu Byun et al.
EMBO reports, 20(6) (2019-04-17)
Oncogenic signals contribute to enhanced glycolysis and mTORC1 activity, leading to rapid cell proliferation in cancer. Regulation of glycolysis and mTORC1 by PI3K/Akt signaling is well established, but how KRAS-induced MEK signaling regulates these pathways remains poorly understood. Here, we
Martina Düfer et al.
The Biochemical journal, 368(Pt 3), 817-825 (2002-09-28)
In pancreatic beta-cells, methyl pyruvate is a potent secretagogue and is widely used to study stimulus-secretion coupling. In contrast with pyruvate, which barely stimulates insulin secretion, methyl pyruvate was suggested to act as an effective mitochondrial substrate. We show that
Durgesh Nandini Das et al.
Free radical biology & medicine, 112, 452-463 (2017-08-28)
Mitophagy, a special type of autophagy, plays an important role in the mitochondria quality control and cellular homeostasis. In this study, we examined the molecular mechanism of mitophagy induction with benzo[a]pyrene (B[a]P), a ubiquitous polycyclic aromatic hydrocarbon, which acts as
Dimethyl 2, 3-Dimethylenebutanedioate from Methyl Pyruvate and Methyl Acrylate.
Grundke C and Hoffman HMR.
Chemische Berichte, 120(8), 1461-1462 (1987)
Chirag B Godiya et al.
Journal of environmental management, 231, 1012-1020 (2019-01-04)
A big challenge for the civilization in energy saving/waste management can be "the regeneration of monomers from the waste plastics followed by their re-polymerization" using an ideal recycling method. Herein, we investigate the thermal depolymerization of poly(methyl methacrylate) (PMMA) using
Enantioselective hydrogenation of methyl pyruvate over polymer-stabilized and supported iridium clusters.
Zuo X, et al.
J. Mol. Catal. A: Chem., 147(1), 63-72 (1999)
Bo Fan et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 43(3), 1003-1011 (2017-10-03)
Tetrandrine and Fangchinoline (Fcn) are two natural products that are found in Stephania tetrandra. Tetrandrine is a known anti-bladder cancer compound, but the effects of Fcn on bladder cancer have been previously unclear. In the present study, we focused on
Ye Zhuo et al.
Antonie van Leeuwenhoek, 113(3), 365-375 (2019-11-07)
A novel Gram-stain-positive bacterial strain, CHu50b-6-2T, was isolated from a 67-cm-long sediment core collected from the Daechung Reservoir at a water depth of 17 m, Daejeon, Republic of Korea. The cells of strain CHu50b-6-2T were aerobic non-motile and formed yellow colonies
P Maechler et al.
The EMBO journal, 16(13), 3833-3841 (1997-07-01)
In the pancreatic beta-cell, insulin secretion is stimulated by glucose metabolism resulting in membrane potential-dependent elevation of cytosolic Ca2+ ([Ca2+]c). This cascade involves the mitochondrial membrane potential (delta psi[m]) hyperpolarization and elevation of mitochondrial Ca2+ ([Ca2+]m) which activates the Ca(2+)-sensitive
Fundamental aspects of enantioselective heterogeneous catalysis: the surface chemistry of methyl pyruvate on Pt {111}.
The Journal of Physical Chemistry B, 104(41), 9696-9703 (2000)
Raymond Liang et al.
Cell stem cell, 26(3), 359-376 (2020-02-29)
Quiescence is a fundamental property that maintains hematopoietic stem cell (HSC) potency throughout life. Quiescent HSCs are thought to rely on glycolysis for their energy, but the overall metabolic properties of HSCs remain elusive. Using combined approaches, including single-cell RNA
D A Basketter et al.
Contact dermatitis, 49(1), 37-41 (2003-12-04)
The accepted approach to the interpretation of local lymph node assay (LLNA) data requires comparison of responses in the test groups with background activity found in concurrent vehicle-treated controls. However, of established value in the interpretation of toxicity test data
Jonathan V Rocheleau et al.
The Journal of biological chemistry, 279(30), 31780-31787 (2004-05-19)
Glucose-stimulated insulin secretion is a multistep process dependent on beta-cell metabolic flux. Our previous studies on intact pancreatic islets used two-photon NAD(P)H imaging as a quantitative measure of the combined redox signal from NADH and NADPH (referred to as NAD(P)H).
N Lembert et al.
The Biochemical journal, 354(Pt 2), 345-350 (2001-02-15)
The role of mitochondria in stimulus-secretion coupling of pancreatic beta-cells was examined using methyl pyruvate (MP). MP stimulated insulin secretion in the absence of glucose, with maximal effect at 5 mM. K+ (30 mM) alone, or in combination with diazoxide
Elisabetta Babetto et al.
Nature neuroscience, 23(10), 1215-1228 (2020-08-19)
Axon degeneration is a hallmark of many neurodegenerative disorders. The current assumption is that the decision of injured axons to degenerate is cell-autonomously regulated. Here we show that Schwann cells (SCs), the glia of the peripheral nervous system, protect injured
Alice Rossi et al.
Cell reports, 30(7), 2332-2348 (2020-02-23)
Mitochondria are key organelles for brain health. Mitochondrial alterations have been reported in several neurodegenerative disorders, including Alzheimer's disease (AD), and the comprehension of the underlying mechanisms appears crucial to understand their relationship with the pathology. Using multiple genetic, pharmacological
Colleen R Reczek et al.
Nature chemical biology, 13(12), 1274-1279 (2017-10-24)
Paraquat, a herbicide linked to Parkinson's disease, generates reactive oxygen species (ROS), which causes cell death. Because the source of paraquat-induced ROS production remains unknown, we conducted a CRISPR-based positive-selection screen to identify metabolic genes essential for paraquat-induced cell death.
I Valverde et al.
International journal of molecular medicine, 7(6), 621-623 (2001-05-15)
Methyl pyruvate (MP) stimulates insulin release both in vivo and in vitro. The present study aims at investigating whether MP is also able to enhance the B-cell secretory response to glucagon-like peptide 1 (GLP-1). In anaesthetized rats receiving a primed
Meng Li et al.
Cancer cell, 35(6), 916-931 (2019-06-12)
Diffuse large B cell lymphomas (DLBCLs) are genetically heterogeneous and highly proliferative neoplasms derived from germinal center (GC) B cells. Here, we show that DLBCLs are dependent on mitochondrial lysine deacetylase SIRT3 for proliferation, survival, self-renewal, and tumor growth in vivo
Prashanta Kumar Panda et al.
Biochimica et biophysica acta, 1865(3), 480-495 (2017-12-13)
PUMA, a BH3-only pro-apoptotic Bcl2 family protein, is known to translocate from the cytosol into the mitochondria in order to induce apoptosis. Interestingly, the induction of PUMA by p53 plays a critical role in DNA damage-induced apoptosis. In this study
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