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Showing 1-30 of 376 results for "37291" within Papers
Xiaofei Xu et al.
Endocrinology, 155(4), 1510-1519 (2014-01-31)
Uterine leiomyomas (fibroids) are a major public health problem. Current medical treatments with GnRH analogs do not provide long-term benefit. Thus, permanent shrinkage or inhibition of fibroid growth via medical means remains a challenge. The AKT pathway is a major
Lidia Garcia-Bonilla et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(44), 14783-14793 (2015-11-06)
The scavenger receptor CD36 is a critical factor initiating ischemic brain injury, but the cell type(s) expressing CD36 and responsible for its harmful effects remain unknown. Using bone marrow (BM) chimeras subjected to transient middle cerebral artery occlusion, we found
Dhananjay Yadav et al.
Oxidative medicine and cellular longevity, 2018, 3124364-3124364 (2018-06-29)
In the current study, we have tested the nonenzymatic glycation activities of ketohexoses, such as tagatose and psicose. Although tagatose-treated apoA-I (t-A-I) and psicose-treated apoA-I (p-A-I) exerted more inhibitory activity you cupric ion-mediated low-density lipoprotein (LDL) oxidation and oxidized LDL
Dinesh M Tripathi et al.
American journal of physiology. Gastrointestinal and liver physiology, 309(5), G301-G309 (2015-07-04)
Increased hepatic vascular resistance is the primary factor in the development of portal hypertension. Metformin ameliorates vascular cells function in several vascular beds. Our study was aimed at evaluating the effects, and the underlying mechanisms, of metformin on hepatic and
Bernadette McEvoy et al.
The Journal of physiology, 593(23), 5167-5182 (2015-10-21)
The pancreatic β-cell has reduced antioxidant defences making it more susceptible to oxidative stress. In cystinosis, a lysosomal storage disorder, an altered redox state may contribute to cellular dysfunction. This rare disease is caused by an abnormal lysosomal cystine transporter
Mounia Chidiac et al.
Molecular medicine reports, 22(3), 1910-1920 (2020-06-26)
To the best of our knowledge, the vertebrate apolipoprotein L (APOL) family has not previously been ascribed to any definite pathophysiological function, although the conserved BH3 protein domain suggests a role in programmed cell death or an interference with mitochondrial
Rabindra K Mandal et al.
Cell reports, 35(6), 109094-109094 (2021-05-13)
Gut microbiota educate the local and distal immune system in early life to imprint long-term immunological outcomes while maintaining the capacity to dynamically modulate the local mucosal immune system throughout life. It is unknown whether gut microbiota provide signals that
Wei Li et al.
Free radical biology & medicine, 121, 117-126 (2018-05-08)
Mitochondrial oxidation is a major source of reactive oxygen species (ROS) and mitochondrial dysfunction plays a central role in development of heart failure (HF). Paraoxonase 2 deficient (PON2-def) mitochondria are impaired in function. In this study, we tested whether PON2-def
Qian Sun et al.
American journal of physiology. Gastrointestinal and liver physiology, 308(9), G757-G766 (2015-03-15)
Hepatic zinc deficiency has been well documented in alcoholic patients, but the mechanisms by which zinc deficiency mediates cell death have not been well defined. The objectives of this study were to determine whether alcohol perturbs subcellular zinc homeostasis and
Ufuk Ozer et al.
Molecular pharmacology, 88(6), 970-981 (2015-10-08)
Thymidylate synthase (TYMS; EC 2.1.1.15) catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) by N(5),N(10)-methyhlenetetrahydrofolate, forming dTMP for the maintenance of DNA replication and repair. Inhibitors of TYMS have been widely used in the treatment of neoplastic disease. A number of
Seung Tae Lee et al.
Biochemical pharmacology, 94(4), 257-269 (2015-03-04)
The present study sought to determine the correlation between 2-methoxyestradiol (2-MeO-E2)-induced cell cycle arrest and 2-MeO-E2-induced apoptosis. Exposure of Jurkat T cell clone (JT/Neo) to 2-MeO-E2 (0.5-1.0 μM) caused G2/M arrest, Bak activation, Δψm loss, caspase-9 and -3 activation, PARP
Xiang Xiao et al.
Experimental cell research, 336(1), 58-65 (2015-06-24)
Angiotensin (Ang) II, the main effector of the renin-angiotensin system, has been implicated in the pathogenesis of vascular diseases. Ang-(1-7) binds to the G protein-coupled Mas receptor (MasR) and can exert vasoprotective effects. We investigated the effects and underlying mechanisms
Prakash Pragya et al.
PloS one, 9(2), e88181-e88181 (2014-02-08)
The evolutionarily conserved innate immune system plays critical role for maintaining the health of an organism. However, a number of environmental chemicals including metals are known to exert adverse effects on immune system. The present study assessed the in vivo
Hong Pan et al.
PloS one, 9(12), e114186-e114186 (2014-12-04)
Retinal ischemia-reperfusion (I/R) injury induces oxidative stress, leukocyte infiltration, and neuronal cell death. Sulforaphane (SF), which can be obtained in cruciferous vegetables such as broccoli, exerts protective effects in response to oxidative stress in various tissues. These effects can be
Peng Wang et al.
Oncotarget, 6(25), 21148-21158 (2015-05-29)
The oncogenic K-Ras can transform various mammalian cells and plays a critical role in development of pancreatic cancer. MicroRNAs (miRNA) have been shown to contribute to tumorigenic progression. However, the nature of miRNAs involved in K-Ras transformation remains to be
Cristina Manguan-Garcia et al.
PloS one, 9(7), e101424-e101424 (2014-07-06)
The predominant X-linked form of Dyskeratosis congenita results from mutations in DKC1, which encodes dyskerin, a protein required for ribosomal RNA modification that is also a component of the telomerase complex. We have previously found that expression of an internal
Laure Campillo-Gimenez et al.
The Journal of allergy and clinical immunology, 134(5), 1142-1152 (2014-07-22)
Despite control of HIV infection under antiretroviral therapy (ART), immune T-cell activation persists in patients with controlled HIV infection, who are at higher risk of inflammatory diseases than the general population. PMNs play a key role in host defenses against
Bo Ra You et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(3), 2087-2095 (2014-11-14)
PX-12 (1-methylpropyl 2-imidazolyl disulfide) as a thioredoxin (Trx) inhibitor has an anti-tumor effect. However, there is no report about the toxicological effect of PX-12 on lung cancer cells. Here, we investigated the anti-growth effects of PX-12 on Calu-6 lung cancer
Ming Kang et al.
Journal of virology, 88(21), 12541-12550 (2014-08-22)
Superoxide dismutases (SODs) are metalloproteins that protect organisms from toxic reactive oxygen species by catalyzing the conversion of superoxide anion to hydrogen peroxide and molecular oxygen. Chlorovirus PBCV-1 encodes a 187-amino-acid protein that resembles a Cu-Zn SOD with all of
Morihiko Maeda et al.
PloS one, 10(4), e0123169-e0123169 (2015-04-17)
Impaired glucose tolerance characterized by postprandial hyperglycemia, which occurs frequently in elderly persons and represents an important preliminary step in diabetes mellitus, poses an independent risk factor for the development of atherosclerosis. Endothelial cellular senescence is reported to precede atherosclerosis.
Yi Han et al.
PloS one, 7(11), e50402-e50402 (2012-12-05)
Previous studies indicated that estrogen could improve endothelial function. However, whether estrogen protects vascular complications of diabetes has yet to be clarified. The study was designed to investigate the action of 17ß-estradiol on vascular endothelium in streptozotocin (STZ)-induced diabetic rats.
Vincenzo La Mura et al.
Journal of hepatology, 61(6), 1321-1327 (2014-07-20)
Sepsis is associated with microvascular dysfunction, which contributes to organ failure. Intrahepatic endothelial dysfunction occurs after exposure to lipopolysaccharide (LPS). The upregulation of inducible nitric oxide synthase (iNOS) has been shown to contribute to systemic vascular dysfunction after LPS administration.
Alexander V Ivanov et al.
Viruses, 7(6), 2745-2770 (2015-06-04)
Hepatitis C virus (HCV) infection is accompanied by the induction of oxidative stress, mediated by several virus proteins, the most prominent being the nucleocapsid protein (HCV core). Here, using the truncated forms of HCV core, we have delineated several mechanisms
Limei Liu et al.
Biochemical and biophysical research communications, 458(4), 796-801 (2015-02-18)
Activation of endoplasmic reticulum (ER) stress in endothelial cells leads to increased oxidative stress and often results in cell death, which has been implicated in hypertension. The present study investigated the effects of berberine, a botanical alkaloid purified from Coptidis
Gang Wang et al.
PloS one, 10(7), e0132046-e0132046 (2015-07-02)
Microwaves are used in one method of physical therapy and can increase muscle tissue temperature which is useful for improving muscle, tendon and bone injuries. In the study, we sought to determine whether titanium alloy internal fixations influence apoptosis in
Juyi Seo et al.
Molecules and cells, 34(2), 143-148 (2012-08-02)
We recently reported that the efficiency of adenoviral gene delivery and virus stability are significantly enhanced when a proteoliposome (PL) containing apolipoprotein (apo) A-I is used in an animal model. In the current study, we tested tumor removal activity of
Matilde Alique et al.
Clinical science (London, England : 1979), 127(1), 19-31 (2014-01-05)
ILK (integrin-linked kinase) is an intracellular serine/threonine kinase involved in cell-matrix interactions. ILK dysregulation has been described in chronic renal disease and modulates podocyte function and fibrosis, whereas data about its role in inflammation are scarce. AngII (angiotensin II) is
Anna Rita Fetoni et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(9), 4011-4023 (2013-03-01)
This study addresses the relationship between cochlear oxidative damage and auditory cortical injury in a rat model of repeated noise exposure. To test the effect of increased antioxidant defenses, a water-soluble coenzyme Q10 analog (Qter) was used. We analyzed auditory
Ji-Hye Ahn et al.
Journal of cancer research and clinical oncology, 141(2), 255-268 (2014-09-14)
Ecklonia cava is an abundant brown alga and has been reported to possess various bioactive compounds having anti-inflammatory effect. However, the anticancer effects of dieckol, a major active compound in E. cava, are poorly understood. In the present study, we
Rafael Herling Lambertucci et al.
Journal of cellular physiology, 227(6), 2511-2518 (2011-09-08)
The effects of a moderate electrical stimulation on superoxide and nitric oxide production by primary cultured skeletal muscle cells were evaluated. The involvement of the main sites of these reactive species production and the relationship between superoxide and nitric oxide
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