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Showing 1-30 of 376 results for "37291" within Papers
Bernadette McEvoy et al.
The Journal of physiology, 593(23), 5167-5182 (2015-10-21)
The pancreatic β-cell has reduced antioxidant defences making it more susceptible to oxidative stress. In cystinosis, a lysosomal storage disorder, an altered redox state may contribute to cellular dysfunction. This rare disease is caused by an abnormal lysosomal cystine transporter
Rabindra K Mandal et al.
Cell reports, 35(6), 109094-109094 (2021-05-13)
Gut microbiota educate the local and distal immune system in early life to imprint long-term immunological outcomes while maintaining the capacity to dynamically modulate the local mucosal immune system throughout life. It is unknown whether gut microbiota provide signals that
Anna Rita Fetoni et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(9), 4011-4023 (2013-03-01)
This study addresses the relationship between cochlear oxidative damage and auditory cortical injury in a rat model of repeated noise exposure. To test the effect of increased antioxidant defenses, a water-soluble coenzyme Q10 analog (Qter) was used. We analyzed auditory
Lidia Garcia-Bonilla et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(44), 14783-14793 (2015-11-06)
The scavenger receptor CD36 is a critical factor initiating ischemic brain injury, but the cell type(s) expressing CD36 and responsible for its harmful effects remain unknown. Using bone marrow (BM) chimeras subjected to transient middle cerebral artery occlusion, we found
Peng Li et al.
Neurotoxicity research, 28(3), 209-221 (2015-07-15)
Cobalt (Co) is a required divalent metal used in the production of metal alloys, batteries, and pigments and is a component of vitamin B12. Excessive uptake of Co is neurotoxic causing temporary or permanent hearing loss; however, its ototoxic effects
Dinesh M Tripathi et al.
American journal of physiology. Gastrointestinal and liver physiology, 309(5), G301-G309 (2015-07-04)
Increased hepatic vascular resistance is the primary factor in the development of portal hypertension. Metformin ameliorates vascular cells function in several vascular beds. Our study was aimed at evaluating the effects, and the underlying mechanisms, of metformin on hepatic and
Dhananjay Yadav et al.
Oxidative medicine and cellular longevity, 2018, 3124364-3124364 (2018-06-29)
In the current study, we have tested the nonenzymatic glycation activities of ketohexoses, such as tagatose and psicose. Although tagatose-treated apoA-I (t-A-I) and psicose-treated apoA-I (p-A-I) exerted more inhibitory activity you cupric ion-mediated low-density lipoprotein (LDL) oxidation and oxidized LDL
Ufuk Ozer et al.
Molecular pharmacology, 88(6), 970-981 (2015-10-08)
Thymidylate synthase (TYMS; EC 2.1.1.15) catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) by N(5),N(10)-methyhlenetetrahydrofolate, forming dTMP for the maintenance of DNA replication and repair. Inhibitors of TYMS have been widely used in the treatment of neoplastic disease. A number of
Wei Li et al.
Free radical biology & medicine, 121, 117-126 (2018-05-08)
Mitochondrial oxidation is a major source of reactive oxygen species (ROS) and mitochondrial dysfunction plays a central role in development of heart failure (HF). Paraoxonase 2 deficient (PON2-def) mitochondria are impaired in function. In this study, we tested whether PON2-def
Qian Sun et al.
American journal of physiology. Gastrointestinal and liver physiology, 308(9), G757-G766 (2015-03-15)
Hepatic zinc deficiency has been well documented in alcoholic patients, but the mechanisms by which zinc deficiency mediates cell death have not been well defined. The objectives of this study were to determine whether alcohol perturbs subcellular zinc homeostasis and
Mounia Chidiac et al.
Molecular medicine reports, 22(3), 1910-1920 (2020-06-26)
To the best of our knowledge, the vertebrate apolipoprotein L (APOL) family has not previously been ascribed to any definite pathophysiological function, although the conserved BH3 protein domain suggests a role in programmed cell death or an interference with mitochondrial
Matilde Alique et al.
Clinical science (London, England : 1979), 127(1), 19-31 (2014-01-05)
ILK (integrin-linked kinase) is an intracellular serine/threonine kinase involved in cell-matrix interactions. ILK dysregulation has been described in chronic renal disease and modulates podocyte function and fibrosis, whereas data about its role in inflammation are scarce. AngII (angiotensin II) is
Tomasz Wojcik et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(3), 512-521 (2014-12-23)
Although anthracycline antibiotics have been successfully used for nearly half a century in the treatment of various malignancies, their use is limited by their cardiac and vascular toxicities, and the mechanisms of these toxicities are still not entirely clear. Herein
Hong Pan et al.
PloS one, 9(12), e114186-e114186 (2014-12-04)
Retinal ischemia-reperfusion (I/R) injury induces oxidative stress, leukocyte infiltration, and neuronal cell death. Sulforaphane (SF), which can be obtained in cruciferous vegetables such as broccoli, exerts protective effects in response to oxidative stress in various tissues. These effects can be
Xiang Xiao et al.
Experimental cell research, 336(1), 58-65 (2015-06-24)
Angiotensin (Ang) II, the main effector of the renin-angiotensin system, has been implicated in the pathogenesis of vascular diseases. Ang-(1-7) binds to the G protein-coupled Mas receptor (MasR) and can exert vasoprotective effects. We investigated the effects and underlying mechanisms
Prakash Pragya et al.
PloS one, 9(2), e88181-e88181 (2014-02-08)
The evolutionarily conserved innate immune system plays critical role for maintaining the health of an organism. However, a number of environmental chemicals including metals are known to exert adverse effects on immune system. The present study assessed the in vivo
Peng Wang et al.
Oncotarget, 6(25), 21148-21158 (2015-05-29)
The oncogenic K-Ras can transform various mammalian cells and plays a critical role in development of pancreatic cancer. MicroRNAs (miRNA) have been shown to contribute to tumorigenic progression. However, the nature of miRNAs involved in K-Ras transformation remains to be
Ji-Hye Ahn et al.
Journal of cancer research and clinical oncology, 141(2), 255-268 (2014-09-14)
Ecklonia cava is an abundant brown alga and has been reported to possess various bioactive compounds having anti-inflammatory effect. However, the anticancer effects of dieckol, a major active compound in E. cava, are poorly understood. In the present study, we
Eric Plante et al.
Endocrinology, 156(4), 1416-1428 (2015-01-07)
Oxytocin (OT) is involved in the regulation of energy metabolism and in the activation of cardioprotective mechanisms. We evaluated whether chronic treatment with OT could prevent the metabolic and cardiac abnormalities associated with diabetes and obesity using the db/db mice
Bingfang Zhang et al.
Nature communications, 12(1), 1174-1174 (2021-02-21)
Adult hippocampal neurogenesis contributes to learning and memory, and is sensitive to a variety of environmental stimuli. Exposure to a hypomagnetic field (HMF) influences the cognitive processes of various animals, from insects to human beings. However, whether HMF exposure affect
Kyung-Hyun Cho et al.
Molecules (Basel, Switzerland), 23(5) (2018-05-13)
We investigated the antihypertensive effect of policosanol on spontaneously hypertensive rats (SHR). For this, we analyzed blood pressure, blood lipid, and lipoprotein properties in male SHR after consumption of Cuban policosanol (PCO). The experimental groups were as follows: normotensive Wistar
Sanjana Dayal et al.
PloS one, 9(9), e107734-e107734 (2014-09-17)
Diet-induced hyperhomocysteinemia produces endothelial and cardiac dysfunction and promotes thrombosis through a mechanism proposed to involve oxidative stress. Inducible nitric oxide synthase (iNOS) is upregulated in hyperhomocysteinemia and can generate superoxide. We therefore tested the hypothesis that iNOS mediates the
Rafael Herling Lambertucci et al.
Journal of cellular physiology, 227(6), 2511-2518 (2011-09-08)
The effects of a moderate electrical stimulation on superoxide and nitric oxide production by primary cultured skeletal muscle cells were evaluated. The involvement of the main sites of these reactive species production and the relationship between superoxide and nitric oxide
Arnone Nithichanon et al.
PLoS neglected tropical diseases, 9(7), e0003917-e0003917 (2015-07-30)
Burkholderia pseudomallei is a Gram-negative bacterium responsible for melioidosis, a serious and often fatal infectious disease that is poorly controlled by existing treatments. Due to its inherent resistance to the major antibiotic classes and its facultative intracellular pathogenicity, an effective
Cristina Manguan-Garcia et al.
PloS one, 9(7), e101424-e101424 (2014-07-06)
The predominant X-linked form of Dyskeratosis congenita results from mutations in DKC1, which encodes dyskerin, a protein required for ribosomal RNA modification that is also a component of the telomerase complex. We have previously found that expression of an internal
Laure Campillo-Gimenez et al.
The Journal of allergy and clinical immunology, 134(5), 1142-1152 (2014-07-22)
Despite control of HIV infection under antiretroviral therapy (ART), immune T-cell activation persists in patients with controlled HIV infection, who are at higher risk of inflammatory diseases than the general population. PMNs play a key role in host defenses against
Bo Ra You et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(3), 2087-2095 (2014-11-14)
PX-12 (1-methylpropyl 2-imidazolyl disulfide) as a thioredoxin (Trx) inhibitor has an anti-tumor effect. However, there is no report about the toxicological effect of PX-12 on lung cancer cells. Here, we investigated the anti-growth effects of PX-12 on Calu-6 lung cancer
Le Thi Thanh Thuy et al.
The American journal of pathology, 185(4), 1045-1060 (2015-02-11)
This study was conducted to clarify the role of cytoglobin (Cygb), a globin expressed in hepatic stellate cells (HSCs), in the development of liver fibrosis and cancer in nonalcoholic steatohepatitis (NASH). Cygb expression was assessed in patients with NASH and
Masaaki Korenaga et al.
Liver international : official journal of the International Association for the Study of the Liver, 35(4), 1303-1314 (2014-08-27)
Branched-chain amino acids (BCAA) reduce the incidence of hepatocellular carcinoma (HCC) in patients with cirrhosis. However, the mechanisms that underlie these effects remain unknown. Previously, we reported that oxidative stress in male transgenic mice that expressed hepatitis C virus polyprotein
Seung Tae Lee et al.
Biochemical pharmacology, 94(4), 257-269 (2015-03-04)
The present study sought to determine the correlation between 2-methoxyestradiol (2-MeO-E2)-induced cell cycle arrest and 2-MeO-E2-induced apoptosis. Exposure of Jurkat T cell clone (JT/Neo) to 2-MeO-E2 (0.5-1.0 μM) caused G2/M arrest, Bak activation, Δψm loss, caspase-9 and -3 activation, PARP
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