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Showing 1-30 of 376 results for "37291" within Papers
Rasna Sabharwal et al.
Experimental physiology, 100(7), 776-795 (2015-04-30)
What is the central question of this study? Is autonomic dysregulation in a mouse model of muscular dystrophy dependent on left ventricular systolic dysfunction and/or activation of the renin-angiotensin system (RAS) and does it predict development of dilated cardiomyopathy (DCM)?
Tai L Guo et al.
Toxicology and applied pharmacology, 280(3), 455-466 (2014-09-03)
Diet and phytoestrogens affect the development and progression of diabetes. The objective of the present study was to determine if oral exposure to phytoestrogen genistein (GE) by gavage changed blood glucose levels (BGL) through immunomodulation in streptozotocin (STZ)-induced diabetic male
Xin-Wei Liu et al.
Neuroscience letters, 595, 74-80 (2015-04-14)
Melatonin plays a neuroprotective role in different CNS injuries. However, the molecular mechanisms underlying neuroprotection by melatonin are not well understood. Here, we studied the effects of melatonin in hypoxia-induced N2a cells and our results demonstrated that melatonin not only
Rimpy Dhingra et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(51), E5537-E5544 (2014-12-10)
Doxorubicin (DOX) is widely used for treating human cancers, but can induce heart failure through an undefined mechanism. Herein we describe a previously unidentified signaling pathway that couples DOX-induced mitochondrial respiratory chain defects and necrotic cell death to the BH3-only
Xiao-Juan Chao et al.
CNS neuroscience & therapeutics, 20(9), 840-850 (2014-06-13)
Oxidative stress (OS) plays an important role in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). This study was designed to uncover the cellular and biochemical mechanisms underlying the neuroprotective effects of tacrine-3-caffeic acid (T3CA), a novel promising multifunctional
Katherine E Liu et al.
PloS one, 10(6), e0129667-e0129667 (2015-06-24)
BNIP3 is a dual function protein, able to activate autophagy and induce cell death. Upon expression of BNIP3, which is upregulated by hypoxia, the protein induces mitochondrial dysfunction, often leading to cell death. However, some highly respiring cells and cancer
Xuezhi Zhang et al.
Nature communications, 7, 10938-10938 (2016-03-02)
Extracellular traps (ETs) from neutrophils are reticulated nets of DNA decorated with anti-microbial granules, and are capable of trapping and killing extracellular pathogens. Various phagocytes of mammals and invertebrates produce ETs, however, the evolutionary history of this DNA-based host defence
Illkyu-O Lee et al.
The Journal of pharmacology and experimental therapeutics, 343(2), 253-257 (2012-07-28)
The recently developed oral anticoagulant dabigatran (Dabi) etexilate directly inhibits thrombin after activation by plasma esterases to dabigatran. Thrombin is involved in the pathogenesis of atherosclerosis. We investigated the effects of direct thrombin inhibition on atherosclerosis and endothelial function in
X Jiang et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 15(7), 1768-1781 (2015-03-03)
The loss of a functional microvascular bed in rejecting solid organ transplants is correlated with fibrotic remodeling and chronic rejection; in lung allografts, this pathology is predicted by bronchoalveolar fluid neutrophilia which suggests a role for polymorphonuclear cells in microcirculatory
Yang Yang et al.
Scientific reports, 5, 12377-12377 (2015-07-25)
Nuclear factor erythroid 2-related factor 2 (Nrf2) has emerged as a therapeutic target in many diseases, because it can induce antioxidant enzymes and other cytoprotective enzymes. Moreover, some Nrf2 activators have strong anti-inflammatory activities. Oxidative stress and inflammation are major
Miao Wang et al.
Cancer research, 75(23), 5058-5069 (2015-11-19)
Elevated oxidative stress is an aberration seen in many solid tumors, and exploiting this biochemical difference has the potential to enhance the efficacy of anticancer agents. Homeostasis of reactive oxygen species (ROS) is important for normal cell function, but excessive
Rossarin Suwanarusk et al.
The Journal of antimicrobial chemotherapy, 70(1), 124-129 (2014-08-26)
Methylene blue, once discarded due to its unsettling yet mild side effects, has now found a renewed place in the pharmacopoeia of modern medicine. The continued spread of drug-resistant Plasmodium vivax and Plasmodium falciparum has also led to a recent
Makiko Oboshi et al.
PloS one, 10(5), e0126611-e0126611 (2015-05-12)
Deep vein thrombosis (DVT) is a major cause of pulmonary thromboembolism and sudden death. Thus, it is important to consider the pathophysiology of DVT. Recently, iron has been reported to be associated with thrombotic diseases. Hence, in this study, we
Wenjiao Zhu et al.
Molecular and cellular endocrinology, 484, 25-33 (2019-01-27)
Unexplained hyperandrogenic oligoanovulation is a main feature of polycystic ovary syndrome (PCOS). P450c17 phosphorylation selectively increases 17,20-lyase activity and androgen biosynthesis but minimally affects 17α-hydroxylase. Studies have recently identified mitogen-activated protein kinase 14 (MAPK14, p38α) as the kinase responsible for
Sarah A C Falcão et al.
PLoS neglected tropical diseases, 9(3), e0003601-e0003601 (2015-03-11)
Neutrophils are the first line of defense against invading pathogens and are rapidly recruited to the sites of Leishmania inoculation. During Leishmania braziliensis infection, depletion of inflammatory cells significantly increases the parasite load whereas co-inoculation of neutrophils plus L. braziliensis
Lucas M Kangussu et al.
Fundamental & clinical pharmacology, 29(2), 150-163 (2015-01-27)
This study aimed to investigate the modulation of nitric oxide/reactive oxygen species in sodium nitroprusside relaxation in mice aorta. Sodium nitroprusside induced relaxation in endothelium-intact (e+) and endothelium-denuded (e-) aortas with greater potency in e+ than in e-. The nitric
Kanae Kuroda et al.
Toxicological sciences : an official journal of the Society of Toxicology, 146(2), 344-353 (2015-05-29)
Single treatment of rats with the noncompetitive N-methyl-D-aspartate receptor antagonist MK-801 induces neuronal cell degeneration and death in the retrosplenial/posterior cingulate cortex (RS/PC) region, along with local cerebral glucose utilization. However, the relationship between this neuronal cell degeneration and death
Zuli Wang et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 29(1), 263-274 (2020-10-02)
Ferroptosis is primarily caused by intracellular iron catalytic activity and lipid peroxidation. The potential interplay between ferroptosis and apoptosis remains poorly understood. Here, we show that the expression of a nuclear long non-coding RNA (lncRNA), LINC00618, is reduced in human
Kristina S Burrack et al.
Immunity, 48(4), 760-772 (2018-04-08)
Cerebral malaria is a deadly complication of Plasmodium infection and involves blood brain barrier (BBB) disruption following infiltration of white blood cells. During experimental cerebral malaria (ECM), mice inoculated with Plasmodium berghei ANKA-infected red blood cells develop a fatal CM-like
Sang-Hyun Lee et al.
Experimental cell research, 331(2), 267-277 (2015-01-13)
Scoparone, one of the bioactive components of Artemisia capillaris Thunb, has various biological properties including immunosuppressive, hepatoprotective, anti-allergic, anti-inflammatory, and antioxidant effects. This study aims at evaluating the anti-osteoporotic effect of scoparone and its underlying mechanism in vitro. Scoparone demonstrated
Ulisses V Hipólito et al.
Life sciences, 141, 99-107 (2015-09-20)
Investigate the effect of ascorbic acid (vitamin C) on the endothelial dysfunction induced by acute ethanol intake. Ethanol (1g/kg; p.o. gavage) effects were assessed within 30min in male Wistar rats. Ethanol intake decreased the endothelium-dependent relaxation induced by acetylcholine in
Shuying Shen et al.
Chemico-biological interactions, 218, 28-41 (2014-05-08)
Malignant gliomas are the most common primary brain tumors, and novel ways of treating gliomas are urgently needed. Ursolic acid (UA), a pentacyclic triterpenoid, has been reported to exhibit promising antitumor activity. Here, we evaluated the effects of UA on
Li Sun et al.
Neuroscience letters, 577, 1-5 (2014-06-10)
Oxygen therapy with hyperbaric oxygen (HBO) or normobaric hyperoxia (NBO) improves outcome in experimental cerebral ischemia. However, an increased formation of reactive oxygen species (ROS) may be an undesirable side effect of oxygen therapy. We investigated the effect of both
Yuxin Zhou et al.
Journal of cellular biochemistry, 116(8), 1624-1637 (2015-02-05)
Following our previous finding which revealed that FV-429 induces apoptosis in human hepatocellular carcinoma HepG2 cells, in this study, we found that FV-429 could also induce apoptosis in human gastric cancer cells. Firstly, FV-429 inhibited the viability of BGC-823 and
Thioredoxin 1 upregulates FOXO1 transcriptional activity in drug resistance in ovarian cancer cells.
Jianlin Wang et al.
Biochimica et biophysica acta, 1852(3), 395-405 (2014-12-09)
Drug resistance is the major cause of failure of cancer chemotherapy in ovarian cancer. However, the molecular mechanisms on the regulation of drug resistance are not fully understood. Here we showed that Trx1 and FOXO1 were involved in paclitaxel (PTX)-induced
Bainian Chen et al.
Cardiovascular diabetology, 13, 88-88 (2014-06-03)
The present study was to investigate the role of calpain in reactive oxygen species (ROS) production in endothelial cells and endothelium-dependent vascular dysfunction under experimental conditions of diabetes. Exposure to high glucose activated calpain, induced apoptosis and reduced nitric oxide
Fritz Maingrette et al.
Atherosclerosis, 241(2), 569-578 (2015-06-24)
Psychological stress (PS) has been associated with the development of cardiovascular diseases and adverse long-term outcomes after ischemic events. However, the precise mechanisms involved are not completely understood. Here we investigated the effect of PS on ischemia-induced neovascularization, and the
Jianli Chen et al.
Cancer chemotherapy and pharmacology, 75(6), 1217-1227 (2015-04-22)
This study was performed to determine whether or not in cervical, ovarian and lung cancer cell lines, free radicals (ROS) play a role in cisplatin cytotoxicity and activation of the mitochondrial and JNK/p38 pathways. The role of the enzyme, dihydrodiol
Daisuke Ichikawa et al.
American journal of physiology. Renal physiology, 308(2), F114-F121 (2014-10-24)
To demonstrate the renoprotective function of human liver-type fatty acid-binding protein (hL-FABP) expressed in proximal tubules in aldosterone (Aldo)-induced renal injury, hL-FABP chromosomal transgenic (Tg) and wild-type (WT) mice received systemic Aldo infusions (Tg-Aldo and WT-Aldo, respectively) were given 1%
Jhih-Jia Jhang et al.
Cellular & molecular immunology, 12(4), 424-434 (2014-08-12)
Gouty arthritis is an inflammatory disease that is caused by an accumulation of monosodium urate (MSU) crystals in the joints. MSU is capable of activating the nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3) inflammasome, leading to interleukin-1β (IL-1β)
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