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Peptide adsorption to lipid bilayers: slow processes revealed by linear dichroism spectroscopy.

Sue M Ennaceur et al.

Biophysical journal, 96(4), 1399-1407 (2009-02-17)

The adsorption and insertion kinetics for the association of two 34-residue cyclic peptides with phosphocholine membranes have been studied using circular and linear dichroism approaches. The two peptides studied are identical with the exception of two residues, which are both

A Conserved Pattern of Primer-Dependent Transcription Initiation in Escherichia coli and Vibrio cholerae Revealed by 5' RNA-seq.

Sergey Y Druzhinin et al.

PLoS genetics, 11(7), e1005348-e1005348 (2015-07-02)

Transcription initiation that involves the use of a 2- to ~4-nt oligoribonucleotide primer, "primer-dependent initiation," (PDI) has been shown to be widely prevalent at promoters of genes expressed during the stationary phase of growth in Escherichia coli. However, the extent

Qualitative and quantitative analysis of N-acetyllactosamine and lacto-N-biose, the two major building blocks of human milk oligosaccharides in human milk samples by high-performance liquid chromatography-tandem mass spectrometry using a porous graphitic carbon column.

Réka Balogh et al.

Journal of chromatography. A, 1422, 140-146 (2015-10-20)

This study presents a validated, porous graphitic carbon stationary phase-based LC-MS/MS method for the identification and quantification of lacto-N-biose (LNB) and N-acetyllactosamine (LacNAc). These compounds are the major building blocks of human milk oligosaccharides, however the presence of their unbound

Apoptosis of Oligodendrocytes during Early Development Delays Myelination and Impairs Subsequent Responses to Demyelination.

Andrew V Caprariello et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(41), 14031-14041 (2015-10-16)

During mammalian development, myelin-forming oligodendrocytes are generated and axons ensheathed according to a tightly regulated sequence of events. Excess premyelinating oligodendrocytes are eliminated by apoptosis and the timing of the onset of myelination in any specific CNS region is highly

Macrophage colony-stimulating factor augments Tie2-expressing monocyte differentiation, angiogenic function, and recruitment in a mouse model of breast cancer.

Mary A Forget et al.

PloS one, 9(6), e98623-e98623 (2014-06-04)

Reports demonstrate the role of M-CSF (CSF1) in tumor progression in mouse models as well as the prognostic value of macrophage numbers in breast cancer patients. Recently, a subset of CD14+ monocytes expressing the Tie2 receptor, once thought to be

Microscale extraction and phase separation using a porous capillary.

Thomas W Phillips et al.

Lab on a chip, 15(14), 2960-2967 (2015-06-10)

We report the use of a porous polytetrafluoroethylene capillary for the inline separation of liquid-liquid segmented flows, based on the selective wetting and permeation of the porous capillary walls by one of the liquids. Insertion of a narrow flow restriction

Lyophilized silica lipid hybrid (SLH) carriers for poorly water-soluble drugs: physicochemical and in vitro pharmaceutical investigations.

Rokhsana Yasmin et al.

Journal of pharmaceutical sciences, 103(9), 2950-2959 (2014-03-04)

Lyophilization was investigated to produce a powdery silica-lipid hybrid (SLH) carrier for oral delivery of poorly water-soluble drugs. The silica to lipid ratio, incorporation of cryoprotectant, and lipid loading level were investigated as performance indicators for lyophilized SLH carriers. Celecoxib

Polyvinylpyrrolidone oral films of enrofloxacin: film characterization and drug release.

G Prem Kumar et al.

International journal of pharmaceutics, 471(1-2), 146-152 (2014-05-27)

Enrofloxacin is a fluoroquinolone derivative used for treating urinary tract, respiratory and skin infections in animals. However, low solubility and low bioavailability prevented it from using on humans. Polyvinylpyrrolidone (PVP) is an inert, non toxic polymer with excellent hydrophilic properties

Isolation and immortalization of MIP-GFP neurons from the hypothalamus.

Zi Chen Wang et al.

Endocrinology, 155(6), 2314-2319 (2014-03-13)

The mouse insulin I promoter (MIP) construct was developed to eliminate the promoter activity detected with the rat insulin II promoter in specific hypothalamic neurons that may have unintended effects on glucose and energy homeostasis in transgenic models. Thus, the

Actinobacillus pleuropneumoniae induces SJPL cell cycle arrest in G2/M-phase and inhibits porcine reproductive and respiratory syndrome virus replication.

Jérémy A Ferreira Barbosa et al.

Virology journal, 12, 188-188 (2015-11-19)

Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important pathogens in the swine industry and causes important economic losses. No effective antiviral drugs against it are commercially available. We recently reported that the culture supernatant of

Analysis of triterpenoids and phytosterols in vegetables by thin-layer chromatography coupled to tandem mass spectrometry.

Katerina Naumoska et al.

Journal of chromatography. A, 1381, 229-238 (2015-01-20)

Three TLC methods were used for an initial screening of some common plant triterpenoids and phytosterols in cuticular wax extracts of different vegetables (zucchini, eggplant, tomato, red pepper, mangold, spinach, lettuce, white-colored radicchio di Castelfranco, raddichio Leonardo, white cabbage, red

Mistic's membrane association and its assistance in overexpression of a human GPCR are independent processes.

Jacopo Marino et al.

Protein science : a publication of the Protein Society, 24(1), 38-48 (2014-10-10)

The interaction of the Bacillus subtilis protein Mistic with the bacterial membrane and its role in promoting the overexpression of other membrane proteins are still matters of debate. In this study, we aimed to determine whether individual helical fragments of

Differentially circulating miRNAs after recent osteoporotic fractures can influence osteogenic differentiation.

Sylvia Weilner et al.

Bone, 79, 43-51 (2015-06-01)

Osteoporosis is the consequence of altered bone metabolism resulting in the systemic reduction of bone strength and increased risk of fragility fractures. MicroRNAs (miRNAs) regulate gene expression on a post-transcriptional level and are known to take part in the control

Cytotoxic and pathogenic properties of Klebsiella oxytoca isolated from laboratory animals.

Alison Darby et al.

PloS one, 9(7), e100542-e100542 (2014-07-25)

Klebsiella oxytoca is an opportunistic pathogen implicated in various clinical diseases in animals and humans. Studies suggest that in humans K. oxytoca exerts its pathogenicity in part through a cytotoxin. However, cytotoxin production in animal isolates of K. oxytoca and

Isolevuglandin-type lipid aldehydes induce the inflammatory response of macrophages by modifying phosphatidylethanolamines and activating the receptor for advanced glycation endproducts.

Lilu Guo et al.

Antioxidants & redox signaling, 22(18), 1633-1645 (2015-03-10)

Increased lipid peroxidation occurs in many conditions associated with inflammation. Because lipid peroxidation produces lipid aldehydes that can induce inflammatory responses through unknown mechanisms, elucidating these mechanisms may lead to development of better treatments for inflammatory diseases. We recently demonstrated

A role for the pattern recognition receptor Nod2 in promoting recruitment of CD103+ dendritic cells to the colon in response to Trichuris muris infection.

R Bowcutt et al.

Mucosal immunology, 7(5), 1094-1105 (2014-01-23)

The ability of the colon to generate an immune response to pathogens, such as the model pathogen Trichuris muris, is a fundamental and critical defense mechanism. Resistance to T. muris infection is associated with the rapid recruitment of dendritic cells

Antioxidant and prophylactic effects of Delonix elata L., stem bark extracts, and flavonoid isolated quercetin against carbon tetrachloride-induced hepatotoxicity in rats.

Pradeepa Krishnappa et al.

BioMed research international, 2014, 507851-507851 (2014-07-06)

Delonix elata L. (Ceasalpinaceae), is widely used by the traditional medical practitioners of Karnataka, India, to cure jaundice, and bronchial and rheumatic problems. The objective of this study was to screen the in vitro antioxidant and hepatoprotective activity of the

Probing the Carbonyl Functionality of a Petroleum Resin and Asphaltene through Oximation and Schiff Base Formation in Conjunction with N-15 NMR.

Kevin A Thorn et al.

PloS one, 10(11), e0142452-e0142452 (2015-11-12)

Despite recent advances in spectroscopic techniques, there is uncertainty regarding the nature of the carbonyl groups in the asphaltene and resin fractions of crude oil, information necessary for an understanding of the physical properties and environmental fate of these materials.

Characterization of CpG sites that escape methylation on the inactive human X-chromosome.

Erika L Moen et al.

Epigenetics, 10(9), 810-818 (2015-07-17)

In many whole genome studies of gene expression or modified cytosines, data from probes localized to the X-chromosome are removed from analyses due to gender bias. Previously, we observed population differences in cytosine modifications between Caucasian and African lymphoblastoid cell

Identification and characterization of a novel Geobacillus thermoglucosidasius bacteriophage, GVE3.

Leonardo Joaquim van Zyl et al.

Archives of virology, 160(9), 2269-2282 (2015-07-01)

The study of extremophilic phages may reveal new phage families as well as different mechanisms of infection, propagation and lysis to those found in phages from temperate environments. We describe a novel siphovirus, GVE3, which infects the thermophile Geobacillus thermoglucosidasius.

Mitochondrial Analysis of the Most Basal Canid Reveals Deep Divergence between Eastern and Western North American Gray Foxes (Urocyon spp.) and Ancient Roots in Pleistocene California.

Natalie S Goddard et al.

PloS one, 10(8), e0136329-e0136329 (2015-08-20)

Pleistocene aridification in central North America caused many temperate forest-associated vertebrates to split into eastern and western lineages. Such divisions can be cryptic when Holocene expansions have closed the gaps between once-disjunct ranges or when local morphological variation obscures deeper

pH-triggered release of manganese from MnAu nanoparticles that enables cellular neuronal differentiation without cellular toxicity.

Suk Ho Bhang et al.

Biomaterials, 55, 33-43 (2015-05-03)

At high concentrations, manganese (Mn) promotes cellular neurodevelopment but causes toxicity. Here, we report that Mn ion at high concentrations can be delivered to pheochromocytoma 12 (PC12) cells using gold nanoparticles (AuNPs) to enhance cellular neurodevelopment without toxicity. Mn(2+) release

TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma.

David F Choy et al.

Science translational medicine, 7(301), 301ra129-301ra129 (2015-08-21)

Increasing evidence suggests that asthma is a heterogeneous disorder regulated by distinct molecular mechanisms. In a cross-sectional study of asthmatics of varying severity (n = 51), endobronchial tissue gene expression analysis revealed three major patient clusters: TH2-high, TH17-high, and TH2/17-low.

Binding of bis-(2-ethylhexyl) phthalate at the surface of hydrozincite nanocrystals: An example of organic molecules absorption onto nanocrystalline minerals.

Roberta Sanna et al.

Journal of colloid and interface science, 457, 298-306 (2015-07-22)

As a contribution to understand the interactions between mineral surfaces and organic molecules, this study reports an accurate characterization of the bis-(2-ethylhexyl) phthalate (DEHP)-Hydrozincite (DEHP-HY), that has been conduced combining the following techniques: FTIR, NMR, XAS spectroscopies and XRD. XRD

Rewiring Host Lipid Metabolism by Large Viruses Determines the Fate of Emiliania huxleyi, a Bloom-Forming Alga in the Ocean.

Shilo Rosenwasser et al.

The Plant cell, 26(6), 2689-2707 (2014-06-13)

Marine viruses are major ecological and evolutionary drivers of microbial food webs regulating the fate of carbon in the ocean. We combined transcriptomic and metabolomic analyses to explore the cellular pathways mediating the interaction between the bloom-forming coccolithophore Emiliania huxleyi

Interactions between phospholipids and titanium dioxide particles.

Quoc-Chon Le et al.

Colloids and surfaces. B, Biointerfaces, 123, 150-157 (2014-09-23)

A systematic study was carried out on monolayer films and lipid vesicles to elucidate the interactions between membrane lipids and commercial particles of titanium dioxide TiO2 (TiO2-P25). Pressure-area isotherms of lipids at various pH values were recorded on a Langmuir

Factors affecting ultrasonic release from eLiposomes.

James R Lattin et al.

Journal of pharmaceutical sciences, 104(4), 1373-1384 (2015-02-03)

Liposomes containing emulsion droplets (eLiposomes) were studied as ultrasound-responsive liposomal drug carriers. This paper presents the effects of temperature, eLiposome size, and ultrasound parameters on the ultrasonically actuated release of calcein, to test hypotheses concerning the physics of acoustic droplet

Heavy Rainfall Impacts on Trihalomethane Formation in Contrasting Northwestern European Potable Waters.

Ianis Delpla et al.

Journal of environmental quality, 44(4), 1241-1251 (2015-10-06)

There is emerging concern over the impact of extreme events such as heavy rainfall on the quality of water entering the drinking water supply from aboveground sources, as such events are expected to increase in magnitude and frequency in response

Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds.

Kara L Spiller et al.

Biomaterials, 37, 194-207 (2014-12-03)

In normal tissue repair, macrophages exhibit a pro-inflammatory phenotype (M1) at early stages and a pro-healing phenotype (M2) at later stages. We have previously shown that M1 macrophages initiate angiogenesis while M2 macrophages promote vessel maturation. Therefore, we reasoned that

A predictive ligand-based Bayesian model for human drug-induced liver injury.

Sean Ekins et al.

Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17)

Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify compounds

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