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Showing 1-30 of 2049 results for "372978" within Papers
Yuanyuan Zhou et al.
Molecules (Basel, Switzerland), 20(10), 19252-19262 (2015-10-28)
Among the classes of identified natural products, triterpenoids, one of the largest families, have been studied extensively for their diverse structures and variety of biological activities, including antitumor effects. In the present study, a phytochemical study of the green walnut
Eva Gorrochategui et al.
Analytica chimica acta, 854, 20-33 (2014-12-07)
A lipidomic study was developed in a human placental choriocarcinoma cell line (JEG-3) exposed to tributyltin (TBT) and to a mixture of perfluorinated chemicals (PFCs). The method was based on the application of multivariate curve resolution-alternating least squares (MCR-ALS) to
Toshiki Matsui et al.
Acta biomaterialia, 13, 32-41 (2014-12-03)
Polylactic acid (PLA) is a candidate material to prepare scaffolds for 3-D tissue regeneration. However, cells do not adhere or proliferate well on the surface of PLA because it is hydrophobic. We report a simple and rapid method for inducing
Servet Tural et al.
Chirality, 27(9), 635-642 (2015-07-07)
In this study, the combined use of the selectivity of metal chelate affinity chromatography with the capacity of epoxy supports to immobilize poly-His-tagged recombinant benzoylformate decarboxylase from Pseudomonas putida (BFD, E.C. 4.1.1.7) via covalent attachment is shown. This was achieved
Hyun-Ji Park et al.
Biomaterials, 50, 127-139 (2015-03-05)
Current protocols for human pluripotent stem cell (hPSC) expansion require feeder cells or matrices from animal sources that have been the major obstacle to obtain clinical grade hPSCs due to safety issues, difficulty in quality control, and high expense. Thus
Natsuhiko Sugimura et al.
European journal of mass spectrometry (Chichester, England), 21(2), 91-96 (2015-07-17)
To provide a practical guideline for the selection of a mass spectrometer ion source, we compared the applicability of three types of ion source: direct analysis in real time (DART), electrospray ionization (ESI) and fast atom bombardment (FAB), using an
Nur Ashikin Abdul-Hamid et al.
Journal of food science, 80(11), H2603-H2611 (2015-10-13)
This study aimed to examine the variation in the metabolite profiles and nitric oxide (NO) inhibitory activity of Ajwa dates that were subjected to 2 drying treatments and different extraction solvents. (1)H NMR coupled with multivariate data analysis was employed.
Dominique Bergonier et al.
Veterinary research, 45, 97-97 (2014-10-16)
Staphylococcus aureus is one of the main etiological agents of mastitis in ruminants. In the present retrospective study, we evaluated the potential interest of a previously described automated multiple loci Variable Number of Tandem Repeats (VNTR) Assay (MLVA) comprising 16
Sandeep Gawaskar et al.
Bioorganic & medicinal chemistry, 22(23), 6638-6646 (2014-12-03)
Due to their beneficial side effect profile, NMDA receptor antagonists interacting selectively with the allosteric ifenprodil binding site of the GluN2B subunit are of major interest for the treatment of neurological and neurodegenerative disorders. A series of benzo[7]annulen-7-amines 6 was
M A García-Sevillano et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 75-84 (2015-02-11)
Although mercury (Hg) is an important environmental and occupational pollutant, its toxicological effects, especially in serum and red blood cells (RBCs), have been scarcely studied. A toxicometabolomics workflow based on high resolution mass spectrometry approaches has been applied to investigate
Su'e Chang et al.
Oncotarget, 6(10), 7675-7685 (2015-03-13)
VitaminD3 signaling is involved in inhibiting the development and progression of gastric cancer (GC), while the active vitamin D metabolite 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3)-mediated gene regulatory mechanisms in GC remain unclear. We found that miR-145 is induced by 1,25(OH)2D3 in a
Jiyeon Si et al.
The Journal of general virology, 95(Pt 1), 171-178 (2013-10-08)
Enteric human adenoviruses (HAdVs; serotypes 40 and 41) have been identified as an emerging cause of drinking water contamination. Due to their fastidious characteristics, HAdVs are difficult to cultivate and therefore not detected easily by standard mammalian cell cultivation methods.
Charlotte V Hobbs et al.
PloS one, 9(7), e100138-e100138 (2014-07-06)
We have previously shown that the HIV protease inhibitor lopinavir-ritonavir (LPV-RTV) and the antibiotic trimethoprim sulfamethoxazole (TMP-SMX) inhibit Plasmodium liver stages in rodent malarias and in vitro in P. falciparum. Since clinically relevant levels are better achieved in the non-human-primate
Julia Wilflingseder et al.
PloS one, 9(8), e104164-e104164 (2014-08-06)
Acute kidney injury (AKI) affects roughly 25% of all recipients of deceased donor organs. The prevention of post-transplant AKI is still an unmet clinical need. We prospectively collected zero-hour, indication as well as protocol kidney biopsies from 166 allografts between
Aitor Larrañaga et al.
Journal of biomedical materials research. Part A, 103(12), 3815-3824 (2015-06-16)
Incorporation of bioactive glass (BG) particles to synthetic polymer scaffolds is a promising strategy to improve the bioactivity of bioinert materials and to stimulate specific cell responses. In this study, the influence of incorporating BG particles to lactide and caprolactone
Hanno C Erythropel et al.
Chemosphere, 134, 106-112 (2015-04-29)
The ubiquitous presence of the plasticizer di (2-ethylhexyl) phthalate (DEHP) in the environment is of concern due to negative biological effects associated with it and its metabolites. In particular, the metabolite mono (2-ethylhexyl) phthalate (MEHP) is a potential endocrine disruptor.
Emiley A Eloe-Fadrosh et al.
mBio, 6(2) (2015-04-16)
A mechanistic understanding of the purported health benefits conferred by consumption of probiotic bacteria has been limited by our knowledge of the resident gut microbiota and its interaction with the host. Here, we detail the impact of a single-organism probiotic
Xiao-Yu Wang et al.
International journal of biological macromolecules, 78, 354-362 (2015-04-26)
The prevalence of alcohol consumption has increased in modern dietary life and alcoholic liver injury can follow. Dendrobium huoshanense polysaccharide (DHP) is a homogeneous polysaccharide isolated from Dendrobium huoshanense, which possesses hepatoprotection function. In this study, we investigated the metabolic
Renata Mężyk-Kopeć et al.
PloS one, 10(7), e0132661-e0132661 (2015-07-16)
Tumor-associated lymphatic vessels actively participate in tumor progression and dissemination. ADAM17, a sheddase for numerous growth factors, cytokines, receptors, and cell adhesion molecules, is believed to promote tumor development, facilitating both tumor cell proliferation and migration, as well as tumor
K Meganathan et al.
Cell death & disease, 6, e1756-e1756 (2015-05-08)
Human embryonic stem cells (hESCs) may be applied to develop human-relevant sensitive in vitro test systems for monitoring developmental toxicants. The aim of this study was to identify potential developmental toxicity mechanisms of the histone deacetylase inhibitors (HDAC) valproic acid
Seok-Hwi Park et al.
Organic & biomolecular chemistry, 13(15), 4539-4550 (2015-03-18)
Concise and stereocontrolled syntheses of (+)-hyacinthacine A2 and sphingofungin B were achieved via a diastereomerically enriched oxazine intermediate. The key strategies include palladium(0)-catalyzed intramolecular oxazine formation and diastereoselective nucleophilic addition to an aldehyde. (+)-Hyacinthacine A2 was synthesized in 13 steps
Tyson J Smyth et al.
Biochimica et biophysica acta, 1838(11), 2954-2965 (2014-08-08)
Small endogenous vesicles called exosomes are beginning to be explored as drug delivery vehicles. The in vivo targets of exosomes are poorly understood; however, they are believed to be important in cell-to-cell communication and may play a prominent role in
U Taschler et al.
British journal of pharmacology, 172(17), 4419-4429 (2015-06-16)
Monoglyceride lipase (MGL) degrades 2-arachidonoyl glycerol (2-AG), an endogenous agonist of cannabinoid receptors (CB1/2 ). Because the CB1 receptor is involved in the control of gut function, we investigated the effects of pharmacological inhibition and genetic deletion of MGL on
Balananda-Dhurjati Kumar Putcha et al.
PloS one, 10(6), e0129216-e0129216 (2015-06-13)
For the rabphillin-3A-like (RPH3AL) gene, a putative tumor suppressor, the clinical significance of genetic alterations in breast cancers was evaluated. DNA and RNA were extracted from formalin-fixed, paraffin-embedded (FFPE) cancers and matching normal tissues. DNA samples were assessed for loss
G R Willis et al.
BJOG : an international journal of obstetrics and gynaecology, 121(13), 1596-1603 (2014-05-13)
To assess circulating biochemical indices of endothelial function and nitro-oxidative stress in women with polycystic ovary syndrome (PCOS). Case-control study. Seventeen women with PCOS and eighteen age- and body mass index-matched healthy volunteers. Nitric oxide (NO) metabolite levels were assessed
Mingming Gao et al.
PloS one, 10(3), e0119784-e0119784 (2015-03-15)
High-fat diet (HFD) has been applied to a variety of inbred mouse strains to induce obesity and obesity related metabolic complications. In this study, we determined HFD induced development of metabolic disorders on outbred female CD-1 mice in a time
Jane I Khudyakov et al.
Physiological genomics, 47(8), 318-330 (2015-06-04)
While much of our understanding of stress physiology is derived from biomedical studies, little is known about the downstream molecular consequences of adaptive stress responses in free-living animals. We examined molecular effectors of the stress hormones cortisol and aldosterone in
Nađa Kostić et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 962, 102-108 (2014-06-09)
This paper presents a LC-MS/MS method for the determination of antiepileptic drug vigabatrin in dried plasma spots (DPS). Due to its zwitterionic chemical structure, a pre-column derivatization procedure was performed, aiming to yield enhanced ionization efficiency and improved chromatographic behaviour.
Yan Ge et al.
Nature communications, 5, 5263-5263 (2014-10-16)
Proteins are co-translationally inserted into the bacterial plasma membrane via the SecYEG translocon by lateral release of hydrophobic transmembrane segments into the phospholipid bilayer. The trigger for lateral opening of the translocon is not known. Here we monitor lateral opening
Judith Grothe et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 35(4), 1437-1453 (2015-03-21)
Liver impairment, ranging from steatosis to cirrhosis, is frequent in cystic fibrosis (CF) patients and is becoming increasingly significant due to their improved life expectancy. One aspect of hepatic alterations is caused by increased fecal loss of the essential nutrient
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