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Showing 1-30 of 121 results for "375160" within Papers
Recent developments in fragment-based drug discovery.
Miles Congreve et al.
Journal of medicinal chemistry, 51(13), 3661-3680 (2008-05-07)
In reply to "ibuprofen for prevention of acute mountain sickness-is bigger really better?".
Jeffrey H Gertsch et al.
Wilderness & environmental medicine, 24(2), 178-179 (2013-06-04)
Michael W Konstan
Current opinion in pulmonary medicine, 14(6), 567-573 (2008-09-25)
Ibuprofen was first advocated as a chronic therapy for cystic fibrosis lung disease in 1995, following a favorable report of a 4-year controlled trial. However, clinical use has been limited primarily by the concern about adverse effects. Additional clinical studies
Ji Eun Lee et al.
Acta biomaterialia, 9(9), 8318-8327 (2013-06-19)
Surgical suture is a strand of biocompatible material designed for wound closure, and therefore can be a medical device potentially suitable for local drug delivery to treat pain at the surgical site. However, the preparation methods previously introduced for drug-delivery
Yahong Wei et al.
Wei sheng wu xue bao = Acta microbiologica Sinica, 51(5), 586-594 (2011-08-02)
Ibuprofen has been recognized as an environmental endocrine disruptor due to its ability to interfere with prostaglandin synthesis. In order to address the myriad challenges faced by the issue of ibuprofen in the environment, the recent research progress was summarized
Sorina Motoc et al.
Journal of environmental sciences (China), 25(4), 838-847 (2013-08-09)
This work describes the electrochemical behaviour of ibuprofen on two types of multi-walled carbon nanotubes based composite electrodes, i.e., multi-walled carbon nanotubes-epoxy (MWCNT) and silver-modified zeolite-multi-walled carbon nanotubes-epoxy (AgZMWCNT) composites electrodes. The composite electrodes were obtained using two-roll mill procedure.
Ghada Abdelbary et al.
Pharmaceutical development and technology, 19(6), 717-727 (2013-08-14)
This work aimed to incorporate Dexibuprofen (DXI), the pharmacologically active and more potent form of ibuprofen, into polymeric micelles based tablets with enhanced oral bioavailability. Thin film hydration technique was employed to prepare DXI polymeric micelles using Pluronic® F127 and/or
The advantages and limitations of the analgesics available for control of postoperative pain after a dental procedure.
Jasmin Davey
SAAD digest, 29, 70-81 (2013-04-02)
Francisco Guedes Pereira Alencar et al.
Journal of oral & facial pain and headache, 28(2), 119-127 (2014-05-14)
To compare the effectiveness of adding cyclobenzaprine, tizanidine, or placebo to patient education and a self-care management program for patients with myofascial pain and specifically presenting with jaw pain upon awakening. Forty-five patients with a diagnosis of myofascial pain based
Clinical problem-solving. Unfolding the diagnosis.
Gadi Lalazar et al.
The New England journal of medicine, 370(14), 1344-1348 (2014-04-04)
Quan Hu et al.
Journal of medicinal chemistry, 57(13), 5679-5685 (2014-06-13)
A positively charged porous drug carrier MOF-74-Fe(III) (1, MOF = metal-organic framework), which could not be directly synthesized using ferric salts, was prepared through the oxidation of the neutral crystal MOF-74-Fe(II). This cationic host material exhibits very low cytotoxicity upon
Samer Alabed et al.
The Cochrane database of systematic reviews, 8(8), CD010652-CD010652 (2014-08-29)
Pericarditis is the inflammation of the pericardium, the membranous sac surrounding the heart. Recurrent pericarditis is the most common complication of acute pericarditis, causing severe and disabling chest pains. Recurrent pericarditis affects one in three patients with acute pericarditis within
R Andrew Moore et al.
The Cochrane database of systematic reviews, (3)(3), CD007550-CD007550 (2009-07-10)
Dexibuprofen (S(+)-ibuprofen) is a non-steroidal anti-inflammatory drug (NSAID) licensed for use in rheumatic disease and other musculoskeletal disorders in the UK, and widely available in other countries worldwide. It is an active isomer of ibuprofen. This review sought to evaluate
Abraham M Rutchick et al.
PloS one, 8(3), e56175-e56175 (2013-03-08)
Pain contributes to health care costs, missed work and school, and lower quality of life. Extant research on psychological interventions for pain has focused primarily on developing skills that individuals can apply to manage their pain. Rather than examining internal
Christopher J Derry et al.
The Cochrane database of systematic reviews, 6(6), CD010210-CD010210 (2013-06-25)
Combining two different analgesics in fixed doses in a single tablet can provide better pain relief than either drug alone in acute pain. This appears to be broadly true across a range of different drug combinations, in postoperative pain and
Valentina Onnis et al.
Journal of medicinal chemistry, 53(5), 2286-2298 (2010-02-11)
Fatty acid amide hydrolase (FAAH) is the key hydrolytic enzyme for the endogenous cannabinoid receptor ligand anandamide. The synthesis and evaluation for their FAAH inhibitory activities of a series of 18 paracetamol esters are described. Structure-activity relationship studies indicated that
Naveen Poonai et al.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 186(18), 1358-1363 (2014-10-29)
Recent warnings from Health Canada regarding codeine for children have led to increased use of nonsteroidal anti-inflammatory drugs and morphine for common injuries such as fractures. Our objective was to determine whether morphine administered orally has superior efficacy to ibuprofen
Hosseinali Tabandeh et al.
Pakistan journal of pharmaceutical sciences, 27(3), 495-503 (2014-05-09)
This study was performed to achieve sustained-release Ibuprofen matrix tablets with a zero-order release kinetic while most of the previous formulations have shown Higuchi release kinetic. Considering the results from previous studies, ethyl cellulose, Carbopol 934P, Carbopol 974P, and Pemulen
F Jamali et al.
Journal of pharmaceutical sciences, 81(3), 221-225 (1992-03-01)
The influences of absorption rate and dosage size on the pharmacokinetics of ibuprofen (IB) enantiomers were studied in six healthy subjects. Rapidly absorbed solutions (50, 100, 200, 400, 600, and 1200 mg) and regular 600-mg tablets of racemic IB were
Markéta Paloncýová et al.
The journal of physical chemistry. B, 117(8), 2403-2410 (2013-02-08)
The penetration properties of drug-like molecules on human cell membranes are crucial for understanding the metabolism of xenobiotics and overall drug distribution in the human body. Here, we analyze partitioning of substrates of cytochrome P450s (caffeine, chlorzoxazone, coumarin, ibuprofen, and
Xiao Qu et al.
Biochemical pharmacology, 86(11), 1621-1625 (2013-09-18)
Ibuprofen and related 2-arylpropanoic acid (2-APA) drugs are often given as a racemic mixture and the R-enantiomers undergo activation in vivo by metabolic chiral inversion. The chiral inversion pathway consists of conversion of the drug to the coenzyme A ester
Deia Abd El-Hady et al.
Analytica chimica acta, 772, 68-74 (2013-04-02)
A new biosensor or protein label-free sensor composed of 1-butyl-3-methylimidazolium hexafluorophosphates (BMIMPF6)-human serum albumin (HSA) film on glassy carbon electrode (GCE) was produced. Unfortunately, the native proteins themselves are often unstable in physiological conditions. Here, we introduced conjugation with ionic
Marcello Allegretti et al.
Journal of medicinal chemistry, 48(13), 4312-4331 (2005-06-25)
The CXC chemokine CXCL8/IL-8 plays a major role in the activation and recruitment of polymorphonuclear (PMN) cells at inflammatory sites. CXCL8 activates PMNs by binding the seven-transmembrane (7-TM) G-protein-coupled receptors CXC chemokine receptor 1 (CXCR1) and CXC chemokine receptor 2
K Nezvalová-Henriksen et al.
BJOG : an international journal of obstetrics and gynaecology, 120(8), 948-959 (2013-03-16)
To investigate the individual effects of ibuprofen, diclofenac, naproxen, and piroxicam on pregnancy outcome. Cohort study. Norwegian population. A total of 90 417 women and singleton child pairs. The Norwegian Mother and Child Cohort Study and Medical Birth Registry of
Shutang Tan et al.
Cell reports, 33(9), 108463-108463 (2020-12-03)
The widely used non-steroidal anti-inflammatory drugs (NSAIDs) are derivatives of the phytohormone salicylic acid (SA). SA is well known to regulate plant immunity and development, whereas there have been few reports focusing on the effects of NSAIDs in plants. Our
Rescheduling of hydrocodone combination products.
The Medical letter on drugs and therapeutics, 56(1453), 101-102 (2014-10-09)
Acute generalized exanthematic pustulosis due to ibuprofen.
Lourdes Arochena et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 110(5), 386-387 (2013-04-30)
Eric E Bondarsky et al.
The American journal of emergency medicine, 31(9), 1357-1360 (2013-07-31)
Non-opioid analgesics are often administered to emergency department (ED) patients with musculoskeletal pain but if inadequate, opioids are given with associated potential adverse events. We tested the hypothesis that the reduction in pain scores with the combination of ibuprofen and
Massimo Imazio et al.
The New England journal of medicine, 369(16), 1522-1528 (2013-09-03)
Colchicine is effective for the treatment of recurrent pericarditis. However, conclusive data are lacking regarding the use of colchicine during a first attack of acute pericarditis and in the prevention of recurrent symptoms. In a multicenter, double-blind trial, eligible adults
Shannon L Michels et al.
Current medical research and opinion, 28(1), 89-99 (2011-10-25)
Exposure to over-the-counter (OTC) ibuprofen and other OTC non-steroidal anti-inflammatory drugs (NSAIDs) is substantial. Although the literature on gastrointestinal (GI) safety of NSAID therapy is extensive, the risk profiles of OTC and prescription dosing are seldom separated, and few studies
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