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Keyword:'378674'
Showing 1-30 of 67 results for "378674" within Papers
P A Guerrero et al.
Oncogene, 34(20), 2621-2630 (2014-07-22)
Glioblastoma is the most common and aggressive primary brain tumor in adults, with a poor prognosis because of its resistance to radiotherapy and chemotherapy. Merlin/NF2 (moesin-ezrin-radixin-like protein/neurofibromatosis type 2) is a tumor suppressor found to be mutated in most nervous
Jie Lin et al.
Journal of natural products, 73(5), 905-910 (2010-04-23)
The new polyketides leptosphaerins A-G (1-7) and the known compounds monodictysin B (8), 2-(2,6-dihydroxybenzoyl)-3-hydroxy-5-methylbenzoic acid (9), and 2-(2,6-dihydroxy-4-methylbenzoyl)-6-hydroxybenzoic acid (10) have been isolated from solid cultures of the ascomycete fungus Leptosphaeria sp. The absolute configurations of compounds 1, 2, and
Claudio Ronco et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 30(5), 849-858 (2015-03-13)
Non-euvolaemia in peritoneal dialysis (PD) patients is associated with elevated mortality risk. There is an urgent need to collect data to help us understand the association between clinical practices and hydration and nutritional status, and their effects on patient outcome.
Katherine C Bankert et al.
Journal of immunology (Baltimore, Md. : 1950), 194(9), 4319-4327 (2015-03-22)
Blocking the interaction of CD40 with its ligand CD154 is a desirable goal of therapies for preventing and/or ameliorating autoimmune diseases and transplant rejection. CD154-blocking mAbs used in human clinical trials resulted in unanticipated vascular complications, leading to heightened interest
Ignazio Caruana et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(13), 2952-2962 (2015-02-19)
Adoptive transfer of Epstein-Barr virus (EBV)-specific and cytomegalovirus (CMV)-specific cytotoxic T cells (CTL) genetically modified to express a chimeric antigen receptor (CAR) induces objective tumor responses in clinical trials. In vivo expansion and persistence of these cells are crucial to
Jinghua Zhou et al.
Reproductive toxicology (Elmsford, N.Y.), 51, 64-71 (2014-12-23)
Benomyl and carbendazim are benzimidazole fungicides that are used throughout the world against a wide range of fungal diseases of agricultural products. There is as yet little information regarding the toxicity of benzimidazole fungicides to human placenta. In this study
Carrie P Earthman
JPEN. Journal of parenteral and enteral nutrition, 39(7), 787-822 (2015-08-20)
Because of the key role played by the body's lean tissue reserves (of which skeletal muscle is a major component) in the response to injury and illness, its maintenance is of central importance to nutrition status. With the recent development
Xiangxiang Jin et al.
Environmental science and pollution research international, 20(9), 6282-6289 (2013-04-17)
The effect of coexisting pesticide on adsorption/desorption and mobility of another one was investigated with carbendazim (CBD), imidacloprid (IDP), and atrazine (ATR). The data indicated that adsorption of CBD, ATR, and IDP on the tested soil was fitted well by
Erno van Schaick et al.
Journal of pharmacokinetics and pharmacodynamics, 42(4), 315-332 (2015-07-01)
Development of novel therapies for bone diseases can benefit from mathematical models that predict drug effect on bone remodeling biomarkers. Therefore, a bone cycle model (BCM) was developed that takes into consideration the concept of the basic multicellular unit and
Natarajan Arumugam et al.
Bioorganic & medicinal chemistry letters, 22(3), 1375-1379 (2012-01-11)
A facile and efficient synthesis of novel chromeno[4,3-b]pyrroles has been accomplished by intramolecular 1,3-dipolar cycloaddition which on subsequent Pictet-Spengler cyclisation in presence of p-toluenesulfonic acid yielded indolizino[6,7-b]indoles. The synthesized chromenopyrroles and indolizinoindoles were evaluated for their antimicrobial and antioxidant activities.
Rolf Schiffmann et al.
Journal of medicinal chemistry, 49(2), 511-522 (2006-01-20)
We report the discovery of thiabendazole as a potent inhibitor (K(i) = 0.4 microM) of Escherichia coli methionine aminopeptidase (ecMetAP) and the synthesis and pharmacological evaluation of thiabendazole congeners with activity in the upper nanomolar range. Elucidation of the X-ray
David Coleman et al.
The Journal of antimicrobial chemotherapy, 66(1), 146-150 (2010-11-13)
to explore the effect of low incubation temperatures and the consequent slowing of bacterial metabolism on the bactericidal action of anti-tuberculosis drugs against Mycobacterium tuberculosis. counting of surviving bacteria during exposure of static cultures to 1 mg/L isoniazid, 2 mg/L
Natarajan Arumugam et al.
Bioorganic & medicinal chemistry letters, 20(12), 3698-3702 (2010-05-21)
Synthesis of novel beta-lactam fused spiroisoxazolidine chromanones and tetralones ring systems has been achieved by intermolecular 1,3-dipolar cycloaddition reaction of bicyclic nitrone with unusual dipolarophiles, arylidene chromanones/tetralones under different reaction conditions. The synthesized compounds were evaluated for antimicrobial activities. It
Subhamoy Dasgupta et al.
The Journal of clinical investigation, 125(3), 1174-1188 (2015-02-11)
Metabolic pathway reprogramming is a hallmark of cancer cell growth and survival and supports the anabolic and energetic demands of these rapidly dividing cells. The underlying regulators of the tumor metabolic program are not completely understood; however, these factors have
R Suhas et al.
European journal of medicinal chemistry, 46(2), 704-711 (2011-01-08)
The peptides of elastin sequences chosen for the present study included tetrapeptides, pentapeptides and tricosapeptides (30 amino acids), synthesized by classical solution phase method and conjugated to [3-(4-piperidyl)-6-fluoro-1,2-benzisoxazole]. The structures of the compounds were confirmed by physical and spectroscopic techniques
Gabriela Cobo et al.
Journal of nephrology, 28(4), 503-510 (2014-12-17)
The phenotype associated to reduced physical activity (PA) in dialysis patients is poorly documented. We here evaluate weekly PA in two independent cohorts. Cross-sectional study with PA assessed by the number of steps/day measured by pedometer in two cohorts of
Marilyn M Li et al.
Cancer genetics, 208(11), 525-536 (2015-10-12)
Cytogenomic microarray analysis (CMA) offers high resolution, genome-wide copy number information and is widely used in clinical laboratories for diagnosis of constitutional abnormalities. The Cancer Genomics Consortium (CGC) conducted a multiplatform, multicenter clinical validation project to compare the reliability and
Maria Luger et al.
European journal of anaesthesiology, 32(8), 543-548 (2015-06-13)
Stress related to surgery and critical illness depletes thiamine, essential in energy metabolism, and might result in high blood lactate concentrations and higher mortality. We hypothesised that thiamine supplementation would increase blood concentration of thiamine and reduce blood lactate concentration
Tessa Gargett et al.
Journal of immunotherapy (Hagerstown, Md. : 1997), 38(1), 12-23 (2014-11-22)
Cancer immunotherapy has long been used in the treatment of metastatic melanoma, and an anti-CTLA-4 monoclonal antibody treatment has recently been approved by the US Food and Drug Administration. Targeted therapies such as small molecule kinase inhibitors targeting deregulated mitogen-activated
María Expósito-Serrano et al.
Current biology : CB, 30(16), 3212-3222 (2020-06-06)
An important question in cell biology is how cellular organelles partition during cell division. In organisms undergoing closed mitosis, the elongation of an intranuclear spindle drives nuclear division, generating two identically sized nuclei [1, 2]. However, how the site of
Nancy E McCarroll et al.
Mutation research, 512(1), 1-35 (2002-09-11)
The known aneuploidogens, benomyl and its metabolite, carbendazim (methyl 2-benzimidazole carbamate (MBC)), were selected for the third in a series of ongoing projects with selected pesticides. Mutagenicity and carcinogenicity data submitted to the US Environmental Protection Agency's (US EPA's) Office
M Nakai et al.
Journal of andrology, 13(6), 507-518 (1992-11-01)
The effects of carbendazim (methyl 2-benzimidazole carbamate) on the testis, efferent ductules, and sperm were determined in the adult rat after a single oral dose. Two experimental trials were performed: a time response between 2 hours and 32 days after
Gene expression responses linked to reproduction effect concentrations (EC10,20,50,90) of dimethoate, atrazine and carbendazim, in Enchytraeus albidus.
Novais SC, et al.
PLoS ONE, 7(4) (2012)
Mihály Tapolyai et al.
Journal of clinical hypertension (Greenwich, Conn.), 16(12), 895-899 (2014-10-21)
The authors examined the relationship between thiazide-type diuretics and fluid spaces in a cohort of hypertensive patients in a retrospective study of 60 stable hypertensive patients without renal abnormalities who underwent whole-body bioimpedance analysis. Overhydration was greater in the diuretic
C A Van Gestel
Ecotoxicology and environmental safety, 23(2), 221-236 (1992-04-01)
To investigate whether results of laboratory toxicity tests with earthworms are capable of being used to predict effects in the field, a literature study was carried out. Benomyl, its metabolite carbendazim, carbofuran, and carbaryl were chosen as model substances. From
Masashi Yukawa et al.
G3 (Bethesda, Md.), 9(1), 269-280 (2018-11-23)
The Kinesin-5 motor Cut7 in Schizosaccharomyces pombe plays essential roles in spindle pole separation, leading to the assembly of bipolar spindle. In many organisms, simultaneous inactivation of Kinesin-14s neutralizes Kinesin-5 deficiency. To uncover the molecular network that counteracts Kinesin-5, we
Christoph Thalhammer et al.
Nephrology (Carlton, Vic.), 20(2), 91-95 (2014-10-28)
Haemodynamic stability of patients during haemodialysis (HD) sessions is of pivotal importance and accurate determination of dry weight remains a challenge. Little information is available about central venous and aortic pressure during dialysis. In this pilot study we used a
Przemyslaw Szafranski et al.
European journal of human genetics : EJHG, 23(2), 173-179 (2014-05-16)
Genomic copy-number variations (CNVs) constitute an important cause of epilepsies and other human neurological disorders. Recent advancement of technologies integrating genome-wide CNV mapping and sequencing is rapidly expanding the molecular field of pediatric neurodevelopmental disorders. In a previous study, a
Almudena Vega et al.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 25(5), 420-425 (2015-04-25)
Dialysis machines use the Watson formula (Vwatson) to estimate the urea distribution volume (UDV) to calculate the online Kt/V for each dialysis session. However, the equation could give rise to inaccuracies. The present study analyzes whether body composition affects UDV
S Purushothaman et al.
Bioorganic & medicinal chemistry letters, 20(24), 7288-7291 (2010-11-12)
Synthesis of a series of novel hexahydrochromenopyrrole analogues has been accomplished through an intramolecular 1,3-dipolar cycloaddition (1,3-DC reaction) of azomethine ylides, generated by the aldehyde induced decarboxylation of secondary amino acids. These compounds were screened for antibacterial and antifungal activities
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