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Showing 1-30 of 36 results for "38490" within Papers
Jesse C Patterson et al.
Cell systems, 8(2), 163-167 (2019-02-25)
Although elevated levels of reactive oxygen species (ROS) have been observed in cancer cells and cancer cells aberrantly proliferate, it is not known whether the level of reactive oxygen species and the accumulation of oxidative damage to macromolecules vary across
Rebecca N Burns et al.
The Journal of pharmacology and experimental therapeutics, 339(3), 914-921 (2011-09-16)
Reactive oxygen species (ROS), including hydrogen peroxide (H(2)O(2)), have recently been shown to be generated upon agonism of several members of the G protein-coupled receptor (GPCR) superfamily, including β(2)-adrenergic receptors (β(2)ARs). Previously, we have demonstrated that inhibition of intracellular ROS
Patrick M Dansette et al.
Chemical research in toxicology, 23(7), 1268-1274 (2010-06-19)
Metabolic activation of the tetrahydro-thienopyridine antithrombotic prodrug, prasugrel, involves two steps: an esterase-dependent hydrolysis of its acetate function leading to thiolactone 6 and a cytochrome P450 (P450)-catalyzed oxidative cleavage of this thiolactone. This article shows that this second step involves
Antonio Evidente et al.
Journal of natural products, 74(4), 757-763 (2011-02-24)
Sphaeropsidone and episphaeropsidone are two phytotoxic dimedone methyl ethers produced by Diplodia cupressi, the causal agent of a canker disease of cypress in the Mediterranean area. In this study, eight derivatives obtained by chemical modifications and two natural analogues were
Candice E Paulsen et al.
Chemistry & biology, 16(2), 217-225 (2009-02-24)
Saccharomyces cerevisiae responds to elevated levels of hydrogen peroxide in its environment via a redox relay system comprising the thiol peroxidase Gpx3 and transcription factor Yap1. In this signaling pathway, a central unresolved question is whether cysteine sulfenic acid modification
Joseph R Burgoyne et al.
Biochemical Society transactions, 39(5), 1260-1267 (2011-09-23)
Elevated protein oxidation is a widely reported hallmark of most major diseases. Historically, this 'oxidative stress' has been considered causatively detrimental, as the protein oxidation events were interpreted simply as damage. However, recent advances have changed this antiquated view; sensitive
Beatriz Alvarez et al.
Methods in enzymology, 473, 117-136 (2010-06-02)
Protein sulfenic acids (R-SOH) are receiving increased interest as intermediates in redox processes. Human serum albumin, the most abundant protein in plasma, possesses a single free thiol. We describe herein the different methodologies that we have employed to study the
Angel Stanoev et al.
Cell systems, 7(3), 295-309 (2018-08-27)
The proto-oncogenic epidermal growth factor receptor (EGFR) is a tyrosine kinase whose sensitivity to growth factors and signal duration determines cellular behavior. We resolve how EGFR's response to epidermal growth factor (EGF) originates from dynamically established recursive interactions with spatially
Eugenia Eftimie Totu et al.
Journal of dentistry, 59, 68-77 (2017-02-23)
The aim of this study was to obtain a Poly(methylmethacrylate) (PMMA)-TiO 0.2, 0.4, 0.6, 1, 2.5 by weight% of TiO SEM images and EDX results highlighted the presence of TiO Significant improvements in polymer characteristics and nice dispersion of the
C H Shandrenko et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 83(6), 110-115 (2012-03-01)
A method for endogenous formaldehyde (FA) level evaluation has been worked out. The method involves the administration of dimedone, which forms the stable complex with FA, and the determination of formaldimedone concentration in biological samples by the fluorescence approach. The
Douglas S Rehder et al.
BMC biochemistry, 11, 25-25 (2010-07-03)
Cysteine sulfenic acid (Cys-SOH) plays important roles in the redox regulation of numerous proteins. As a relatively unstable posttranslational protein modification it is difficult to quantify the degree to which any particular protein is modified by Cys-SOH within a complex
Hooshang Hamidian et al.
Molecules (Basel, Switzerland), 16(11), 9041-9048 (2011-10-28)
A novel synthesis of triazolo[1,2-a]indazole-1,3,8-trione derivatives by reaction of urazole, dimedone and aromatic aldehydes under conventional heating and microwave irradiation and solvent-free conditions using silica nanoparticles prepared from rice husk ash as catalyst is described. The new method features high
The reaction of aromatic aldehydes and 5,5-dimethyl-1,3-cyclohexandione under solvent-free grinding conditions
Jin, T.-S., et al.
Indian J. Chem. B, 45, 470-474 (2006)
György Kátay et al.
Biomedical chromatography : BMC, 23(4), 412-418 (2008-11-29)
The effect of ascorbigen and 1'-methylascorbigen as a model compound pair was studied on the phytopathogenic bacterium Pseudomonas savastanoi pv. phaseolicola in the BioArena experimental system after overpressured layer chromatography. Results showed a characteristic, strong antibacterial effect of 1'-methylascorbigen and
Quantification of protein sulfenic acid modifications using isotope-coded dimedone and iododimedone.
Young Ho Seo et al.
Angewandte Chemie (International ed. in English), 50(6), 1342-1345 (2011-02-04)
Michael J Lynch et al.
Nature chemical biology, 15(10), 959-965 (2019-08-14)
The flagellar hook protein FlgE from spirochaete bacteria self-catalyzes the formation of an unusual inter-subunit lysinoalanine (Lal) crosslink that is critical for cell motility. Unlike other known examples of Lal biosynthesis, conserved cysteine and lysine residues in FlgE spontaneously react
Open season for hunting and trapping post-translational cysteine modifications in proteins and enzymes.
Claus Jacob et al.
Chembiochem : a European journal of chemical biology, 12(6), 841-844 (2011-03-30)
Yuande Yang et al.
Biochemical and biophysical research communications, 363(4), 1013-1019 (2007-10-12)
Cyclophilins, which are found in all cellular compartments and with diverse biological roles, are now drug targets for a number of diseases including HIV infection, malaria and ischaemia. We used the database-mining program LIDAEUS and in silico screening to discover
Trace analysis of aldehydes by reversed-phase high-performance liquid chromatography and precolumn fluorigenic labeling with 5, 5-dimethyl-1, 3-cyclohexanedione.
Kenneth M
Journal of Chromatography A, 256, 243-252 (1983)
Kimberly J Nelson et al.
Methods in enzymology, 473, 95-115 (2010-06-02)
Reversible thiol modification is a major component of the modulation of cell-signaling pathways by reactive oxygen species. Hydrogen peroxide, peroxynitrite, or lipid hydroperoxides are all able to oxidize cysteines to form cysteine sulfenic acids; this reactive intermediate can be directly
Katie E Crump et al.
European journal of immunology, 42(8), 2152-2164 (2012-06-08)
B-cell receptor (BCR) ligation generates reactive oxygen intermediates (ROIs) that play a role in cellular responses. Although ROIs can oxidize all macromolecules, it was unclear which modifications control B-cell responses. In this study, we demonstrate the importance of the first
Ayako Okado-Matsumoto et al.
Free radical biology & medicine, 43(5), 830-836 (2007-08-01)
The Cu,Zn-superoxide dismutase (SOD1) has been reported to exert an S-nitrosylated glutathione (GSNO) denitrosylase activity that was augmented by a familial amyotrophic lateral sclerosis (FALS)-associated mutation in this enzyme. This putative enzymatic activity as well as the spontaneous decomposition of
S N Lavergne et al.
The Journal of pharmacology and experimental therapeutics, 331(2), 372-381 (2009-08-12)
Antigen-presenting cells (APC) are thought to play an important role in the pathogenesis of drug-induced immune reactions. Various pathological factors can activate APC and therefore influence the immune equilibrium. It is interesting that several diseases have been associated with an
Solid-State Condensation Reactions Between Aldehydes and 5, 5-Dimethyl-1, 3-cyclohexanedione by Grinding at Room Temperature.
Tong-shou J
Synthetic Communications, 35 (17), 2339-2345 (2005)
Chananat Klomsiri et al.
Methods in enzymology, 473, 77-94 (2010-06-02)
Sulfenic acids, formed as transient intermediates during the reaction of cysteine residues with peroxides, play significant roles in enzyme catalysis and regulation, and are also involved in the redox regulation of transcription factors and other signaling proteins. Therefore, interest in
Bahjat A Saeed et al.
Molecules (Basel, Switzerland), 14(6), 2278-2285 (2009-06-26)
Symmetrical and non-symmetrical diimines derived from dimedone were synthesized by the reaction of their corresponding enaminothiones with primary amines. The synthesized compounds were characterized using micro analytical data and NMR spectroscopy. Theoretical calculations by B3LYP/6-31G(d,p) level of theory show that
Osama I El-Sabbagh et al.
Archiv der Pharmazie, 343(9), 519-527 (2010-09-04)
New nonclassical acridines, quinolines, and quinazolines were prepared starting from cyclic β-diketones, namely dimedone, through application of Hantzsch addition, Michael addition, and Mannich reactions, respectively. The antimicrobial activity revealed that decahydroacridin-1,8-dione 2e bearing a 3-nitrophenyl group and hexahydroquinoline 4e having
Julie A Reisz et al.
The FEBS journal, 280(23), 6150-6161 (2013-10-10)
Cellular exposure to reactive oxygen species induces rapid oxidation of DNA, proteins, lipids and other biomolecules. At the proteome level, cysteine thiol oxidation is a prominent post-translational process that is implicated in normal physiology and numerous pathologies. Methods for investigating
Susan M Hutson et al.
Methods in molecular biology (Clifton, N.J.), 476, 139-152 (2009-01-23)
The human branched chain aminotransferase enzymes are key regulators of glutamate metabolism in the brain and are among a growing number of redox-sensitive proteins. Studies that use thiol-specific reagents and electrospray ionization mass spectrometry demonstrate that the mitochondrial BCAT enzyme
K O Tokarchuk et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(1), 25-31 (2013-05-30)
We investigated the changes in the forms of plasma iron and participation of aldehydes in the development of oxidative stress under glycerol-induced rhabdomyolysis in rats. Rhabdomyolysis was caused by intramuscular injection of 50% glycerol in the dose 10 ml/kg. We
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