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Showing 1-30 of 132 results for "39319" within Papers
Vendula Studentova et al.
Folia microbiologica, 60(2), 119-129 (2014-09-30)
Carbapenemase-mediated resistance to carbapenems in Enterobacteriaceae has become the main challenge in the treatment and prevention of infections recently. The partially unnoticed spread of OXA-48-type carbapenemase producers is usually assigned to low minimum inhibitory concentrations (MICs) of carbapenems that OXA-48-producing
Mounira Krifa et al.
Drug and chemical toxicology, 38(1), 84-91 (2014-04-15)
Evaluation of the immunomodulatory activity of plant extracts is an interesting and growing area of research. In this study, effects of a methanolic extract of Limoniastrum guyonianum stems (M extract) on mice immune cell function in vitro were investigated. These
Ya-Shiuan Lin et al.
Analytical chemistry, 74(22), 5793-5798 (2002-12-05)
This work presents a novel method for direct desorption/ ionization of analytes from sol-gel-derived film. 2,5-Dihydroxy benzoic acid (DHB), a common MALDI matrix, was incorporated into a sol-gel polymeric structure. The sol-gel-derived DHB thin film can assist the mass analysis
Tomohiro Torii et al.
Glycoconjugate journal, 31(9), 671-683 (2014-11-25)
Oligosaccharides of glycoproteins expressed on the cell surface play important roles in cell-cell interactions, particularly sialylated N-glycans having a negative charge, which interact with sialic acid-binding immunoglobulin-like lectins (siglecs). The entire structure of sialylated N-glycans expressed in the mouse brain
John G Swales et al.
Analytical chemistry, 86(16), 8473-8480 (2014-08-02)
Cassette dosing of compounds for preclinical drug plasma pharmacokinetic analysis has been shown to be a powerful strategy within the pharmaceutical industry for increasing throughput while decreasing the number of animals used. Presented here for the first time is data
Laurent Salphati et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(7), 1110-1116 (2014-04-24)
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, and the limited available treatment options have not meaningfully impacted patient survival in the past decades. Such poor outcomes can be at least partly attributed to the inability
Michael P Trombley et al.
PloS one, 10(4), e0124373-e0124373 (2015-04-23)
Haemophilus ducreyi resists the cytotoxic effects of human antimicrobial peptides (APs), including α-defensins, β-defensins, and the cathelicidin LL-37. Resistance to LL-37, mediated by the sensitive to antimicrobial peptide (Sap) transporter, is required for H. ducreyi virulence in humans. Cationic APs
Manoel Marques Evangelista Oliveira et al.
Research in microbiology, 166(2), 102-110 (2015-01-07)
Accurate species identification of the Sporothrix schenckii complex is essential, since identification based only on phenotypic characteristics is often inconclusive due to phenotypic variability within the species. We used matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) for species
Sonal Dalvi et al.
Applied and environmental microbiology, 80(21), 6664-6676 (2014-08-26)
Arhodomonas sp. strain Seminole was isolated from a crude oil-impacted brine soil and shown to degrade benzene, toluene, phenol, 4-hydroxybenzoic acid (4-HBA), protocatechuic acid (PCA), and phenylacetic acid (PAA) as the sole sources of carbon at high salinity. Seminole is
Jean Dubayle et al.
Vaccine, 33(11), 1360-1368 (2015-02-11)
Recently, several virus studies have shown that protein glycosylation play a fundamental role in the virus-host cell interaction. Glycosylation characterization of the envelope proteins in both insect and mammalian cell-derived dengue virus (DENV) has established that two potential glycosylation residues
Balaji Bharatwaj et al.
Molecular pharmaceutics, 12(3), 826-838 (2014-12-03)
The purpose of this study was to determine the effect of PEGylation on the interaction of poly(amidoamine) (PAMAM) dendrimer nanocarriers (DNCs) with in vitro and in vivo models of the pulmonary epithelium. Generation-3 PAMAM dendrimers with varying surface densities of
Jacob Lund et al.
The Journal of biological chemistry, 290(10), 6620-6629 (2015-01-08)
ADAMDEC1 is a proteolytically active metzincin metalloprotease displaying rare active site architecture with a zinc-binding Asp residue (Asp-362). We previously demonstrated that substitution of Asp-362 for a His residue, thereby reconstituting the canonical metzincin zinc-binding environment with three His zinc
Dafni K Paspaliari et al.
The FEBS journal, 282(5), 921-936 (2015-01-08)
Chitinases and chitin-active lytic polysaccharide monooxygenases (LPMOs) are most commonly associated with chitin metabolism, but are also reported as virulence factors in pathogenic bacteria. Listeria monocytogenes, a well-known virulent bacterium, possesses two chitinases (ChiA and ChiB) and a multi-modular lytic
Laura Gallego-Yerga et al.
Organic & biomolecular chemistry, 13(6), 1708-1723 (2014-12-05)
Multi-head/multi-tail facial amphiphiles built on cyclodextrin (CD) and calixarene (CA) scaffolds are paradigmatic examples of monodisperse gene delivery systems. The possibility to precisely control the architectural features at the molecular level offers unprecedented opportunities for conducting structure-activity relationship studies. A
Lionel Faure et al.
Phytochemistry, 110, 58-71 (2014-12-11)
Alkamides and N-acylethanolamines (NAEs) are bioactive, amide-linked lipids that influence plant development. Alkamides are restricted to several families of higher plants and some fungi, whereas NAEs are widespread signaling molecules in both plants and animals. Fatty acid amide hydrolase (FAAH)
Qing Shen et al.
Analytical and bioanalytical chemistry, 407(5), 1475-1484 (2014-12-11)
Salmon is a popular food but it is easily susceptible to spoilage by contamination with microorganisms. In this study, a method using hydrophilic interaction chromatography (HILIC)-based solid-phase extraction (SPE) and matrix-assisted laser desorption and ionization time-of-flight/time-of-flight mass spectrometry was developed
Sana Nafees et al.
The Journal of pharmacy and pharmacology, 64(2), 259-267 (2012-01-10)
This study evaluated the protective effects of gentisic acid (GA) against genotoxicity and hepatotoxicity induced by cyclophosphamide (CP) in Swiss albino mice. Mice were pretreated with GA orally at doses of 50 and 100 mg/kg for 14 consecutive days before
B J Verhaeghe et al.
Clinical chemistry, 34(6), 1077-1083 (1988-06-01)
This is a new method for isolating and concentrating urinary organic acids before gas chromatography--mass spectrometry. Sulfate and phosphate anions are removed by precipitation with Ba(OH)2, and the urine pH is adjusted to 8-8.5. The sample is then applied onto
Fabian N Svara et al.
Analytical chemistry, 83(21), 8308-8313 (2011-09-24)
Secondary ion mass spectrometry (SIMS) is a desorption/ionization method in which ions are generated by the impact of a primary ion beam on a sample. Classic matrix assisted laser desorption and ionization (MALDI) matrices can be used to increase secondary
Shadi Toghi Eshghi et al.
ACS chemical biology, 9(9), 2149-2156 (2014-07-17)
Aberrant glycosylation is associated with most of the diseases. Direct imaging and profiling of N-glycans on tissue sections can reveal tissue-specific and/or disease-associated N-glycans, which not only could serve as molecular signatures for diagnosis but also shed light on the
AeRyon Kim et al.
Nature communications, 5, 5369-5369 (2014-11-22)
Immunodominant epitopes are few selected epitopes from complex antigens that initiate T-cell responses. Here to provide further insights into this process, we use a reductionist cell-free antigen-processing system composed of defined components. We use the system to characterize steps in
Vasudevan Aparna et al.
PloS one, 9(7), e101840-e101840 (2014-07-16)
Pseudomonas aeruginosa and Escherichia coli are resistant to wide range of antibiotics rendering the treatment of infections very difficult. A main mechanism attributed to the resistance is the function of efflux pumps. MexAB-OprM and AcrAB-TolC are the tripartite efflux pump
H Peleg et al.
Chemical senses, 20(4), 393-400 (1995-08-01)
Sensory properties of equimolar concentrations of benzoic acid derivatives were examined using time-intensity procedures. Significant differences in maximum intensities (P < 0.005) were found for astringency, bitterness, prickling, sourness and sweetness. Although these compounds differed only in the number and
Yoann Gut et al.
Journal of pharmaceutical and biomedical analysis, 105, 91-100 (2014-12-30)
During drug product development, the nature and distribution of the active substance have to be controlled to ensure the correct activity and the safety of the final medication. Matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI), due to its structural
[3-hydroxybenzoate and 2,5-dihydroxybenzoate metabolism in Rhodococcus opacus 1CP strain].
N M Subbotina et al.
Mikrobiologiia, 81(3), 325-331 (2012-08-14)
Yuko Fukuyama et al.
Analytical chemistry, 84(9), 4237-4243 (2012-04-18)
Hydrophobic peptides are generally difficult to detect using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) because the majority of MALDI matrixes are hydrophilic and therefore have a low affinity for hydrophobic peptides. Here, we report on a novel matrix additive, o-alkylated
Yanbo Wei et al.
The Analyst, 140(4), 1298-1305 (2015-01-09)
A very uniform 2,5-dihydroxybenzoic acid (DHB) layer was for the first time constructed and used as a matrix for matrix-assisted laser desorption ionization Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FTICR MS) for quickly exploring the changes in lipids within
M Grootveld et al.
The Biochemical journal, 237(2), 499-504 (1986-07-15)
Attack by .OH radicals, generated by a Fenton system, upon salicylate produces 2,3-dihydroxybenzoate and 2,5-dihydroxybenzoate as major products and catechol as a minor product. H.p.l.c. separation combined with electrochemical detection was used to identify and quantify 2,3-dihydroxybenzoate and 2,5-dihydroxybenzoate in
Dan Zhang et al.
Proteomics. Clinical applications, 14(1), e1900016-e1900016 (2019-11-11)
The authors aimed to separate Fc N-glycopeptides of disease-specific immunoglobulin G (DSIgG) as personalized biomarkers to distinguish non-small cell lung cancer (NSCLC) from benign lung diseases (BLDs). DSIgG from 509 BLDs patients and 477 NSCLC patients was isolated using native
Lei Zhou et al.
Carbohydrate research, 402, 180-188 (2014-12-17)
C-type lectin-like receptor 2 (CLEC-2) is a newly identified receptor expressed on the platelet surface. It has been reported that CLEC-2 exists as a higher molecular weight (HMW) and a lower molecular weight (LMW) form, which share the same protein
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