395R-1

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Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis.

Bora Gurel et al.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 21(9), 1156-1167 (2008-06-24)

The MYC onco-protein is a transcription factor that regulates cell proliferation, metabolism, protein synthesis, mitochondrial function and stem cell renewal. A region on chromosome 8q24 encompassing the MYC locus is amplified in prostate cancer, but this occurs mostly in advanced

High levels of nuclear MYC protein predict the presence of MYC rearrangement in diffuse large B-cell lymphoma.

Tina Marie Green et al.

The American journal of surgical pathology, 36(4), 612-619 (2012-02-09)

Determining the presence of MYC gene rearrangements is becoming an increasingly important part of the diagnostic workup in aggressive lymphoma. Cytogenetic MYC alterations aid in differentiating diffuse large B-cell lymphoma (DLBCL) from Burkitt lymphoma. In addition, MYC aberrations are associated

Protein expression and molecular analysis of c-myc gene in primary breast carcinomas using immunohistochemistry and differential polymerase chain reaction.

Rakesh Naidu et al.

International journal of molecular medicine, 9(2), 189-196 (2002-01-12)

Overexpression of c-myc protein and amplification of c-myc were investigated by immunohistochemistry and differential polymerase chain reaction (dPCR) in 440 formalin-fixed primary breast carcinoma tissues, respectively. Overexpression of c-myc was detected in 45% (199/440) and amplification of c-myc was observed

Immunohistochemistry for myc predicts survival in colorectal cancer.

Christopher W Toon et al.

PloS one, 9(2), e87456-e87456 (2014-02-08)

MYC over-expression as determined by molecular means has been reported as a favorable prognostic biomarker in colorectal carcinoma (CRC). However MYC expression analysis is not available in the routine clinical setting. We investigated whether immunohistochemistry (IHC) for the myc protein

Double-hit B-cell lymphomas.

Sietse M Aukema et al.

Blood, 117(8), 2319-2331 (2010-12-02)

In many B-cell lymphomas, chromosomal translocations are biologic and diagnostic hallmarks of disease. An intriguing subset is formed by the so-called double- hit (DH) lymphomas that are defined by a chromosomal breakpoint affecting the MYC/8q24 locus in combination with another

c-Myc target genes involved in cell growth, apoptosis, and metabolism.

C V Dang

Molecular and cellular biology, 19(1), 1-11 (1998-12-22)

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