400052

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Showing 1-6 of 6 results for "400052" within Papers

Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING.

Marine Bruand et al.

Cell reports, 36(3), 109412-109412 (2021-07-22)

In this study, we investigate mechanisms leading to inflammation and immunoreactivity in ovarian tumors with homologous recombination deficiency (HRD). BRCA1 loss is found to lead to transcriptional reprogramming in tumor cells and cell-intrinsic inflammation involving type I interferon (IFN) and

Monocyte progenitors give rise to multinucleated giant cells.

Anne Kathrin Lösslein et al.

Nature communications, 12(1), 2027-2027 (2021-04-03)

The immune response to mycobacteria is characterized by granuloma formation, which features multinucleated giant cells as a unique macrophage type. We previously found that multinucleated giant cells result from Toll-like receptor-induced DNA damage and cell autonomous cell cycle modifications. However

FBXW7 Triggers Degradation of KMT2D to Favor Growth of Diffuse Large B-cell Lymphoma Cells.

Rizwan Saffie et al.

Cancer research, 80(12), 2498-2511 (2020-05-01)

Mature B-cell neoplasms are the fifth most common neoplasm. Due to significant heterogeneity at the clinical and genetic levels, current therapies for these cancers fail to provide long-term cures. The clinical success of proteasome inhibition for the treatment of multiple

HX008: a humanized PD-1 blocking antibody with potent antitumor activity and superior pharmacologic properties.

Jibin Zhang et al.

mAbs, 12(1), 1724751-1724751 (2020-02-29)

Through reactivating tumor-infiltrating lymphocytes, therapeutics targeting programmed cell death protein 1 (PD-1) demonstrate impressive clinical efficacy in the treatment of multiple cancers. In this report, we characterize HX008, a humanized IgG4S228P anti-PD-1 monoclonal antibody with an engineered Fc domain, in

Visualizing the metazoan proliferation-quiescence decision in vivo.

Rebecca C Adikes et al.

eLife, 9 (2020-12-23)

Cell proliferation and quiescence are intimately coordinated during metazoan development. Here, we adapt a cyclin-dependent kinase (CDK) sensor to uncouple these key events of the cell cycle in Caenorhabditis elegans and zebrafish through live-cell imaging. The CDK sensor consists of

Protein complexes including PGRMC1 and actin-associated proteins are disrupted by AG-205.

Sarah L Teakel et al.

Biochemical and biophysical research communications, 524(1), 64-69 (2020-01-26)

PGRMC1 is a protein from the MAPR family with a range of cellular functions. PGRMC1 has been described to play a role in fertility, neuroprotection, steroidogenesis, membrane trafficking and in cancer cell biology. PGRMC1 represents a likely key regulator of

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