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Showing 1-30 of 137 results for "408727" within Papers
Alex Olson et al.
Viruses, 12(10) (2020-10-16)
The major barrier to HIV-1 cure is the persistence of latent provirus, which is not eradicated by antiretroviral therapy. The "shock and kill" approach entails stimulating viral production with latency-reversing agents followed by the killing of cells actively producing the
Patrick M McNutt et al.
Science translational medicine, 13(575) (2021-01-08)
Botulism is caused by a potent neurotoxin that blocks neuromuscular transmission, resulting in death by asphyxiation. Currently, the therapeutic options are limited and there is no antidote. Here, we harness the structural and trafficking properties of an atoxic derivative of
Hsiu-Fang Fan et al.
ACS omega, 5(31), 19868-19876 (2020-08-18)
Deinococcus ficus CC-FR2-10T, resistant to ultraviolet, ionizing radiation, and chemicals which may cause DNA damage, was identified in Taiwan. The expression level of D. ficus RecA, which has 92% sequence identity with Deinococcus radiodurans (Dr.) RecA, will be upregulated upon
Pengxiang Si et al.
iScience, 24(6), 102652-102652 (2021-06-24)
Nature-inspired materials have been actively developed for anticounterfeiting applications. Among a variety of stimuli-responsive anticounterfeiting strategies, hydrochromic materials exhibit reversible color change in response to moisture or water and have the advantage of being easy to authenticate. However, the security
Philip Kitchen et al.
Cell, 181(4), 784-799 (2020-05-16)
Swelling of the brain or spinal cord (CNS edema) affects millions of people every year. All potential pharmacological interventions have failed in clinical trials, meaning that symptom management is the only treatment option. The water channel protein aquaporin-4 (AQP4) is
Jinfeng Xiong et al.
International journal of nanomedicine, 16, 7609-7622 (2021-11-26)
Persistent HR-HPV (high-risk human papillomavirus) infection is the main cause of cervical cancer. The HPV oncogene E7 plays a key role in HPV tumorigenesis. At present, HPV preventive vaccines are not effective for patients who already have a cervical disease
Alice Migazzi et al.
Cell reports, 35(2), 108980-108980 (2021-04-15)
The huntingtin (HTT) protein transports various organelles, including vesicles containing neurotrophic factors, from embryonic development throughout life. To better understand how HTT mediates axonal transport and why this function is disrupted in Huntington's disease (HD), we study vesicle-associated HTT and
Vikas A Tillu et al.
Nature communications, 12(1), 931-931 (2021-02-12)
Caveolae are spherically shaped nanodomains of the plasma membrane, generated by cooperative assembly of caveolin and cavin proteins. Cavins are cytosolic peripheral membrane proteins with negatively charged intrinsically disordered regions that flank positively charged α-helical regions. Here, we show that
Miao-Ping Chien et al.
Science advances, 7(19) (2021-05-07)
Photoactivated genetically encoded voltage indicators (GEVIs) have the potential to enable optically sectioned voltage imaging at the intersection of a photoactivation beam and an imaging beam. We developed a pooled high-throughput screen to identify archaerhodopsin mutants with enhanced photoactivation. After
Maya Z Piccinni et al.
Cold Spring Harbor protocols, 2020(9), 105585-105585 (2020-01-05)
For work in Xenopus, frog-specific antibodies must usually be raised, although a few antibodies against mammalian proteins cross-react. To produce an immunogen for antibody production, human embryonic kidney (HEK) expression systems can be used as described here. For most laboratories
Yanqiong Chen et al.
Heliyon, 6(8), e04793-e04793 (2020-09-02)
The -1 ribosomal frameshifting is vital for the translation of the open reading frame (ORF)1b in SARS-CoV-2. The products of ORF1b participate in viral replication. Therefore, changing the frameshift frequency reduces the survival of the virus. This study aimed to
Roberta Risoluti et al.
Journal of pharmaceutical analysis, 10(4), 351-355 (2020-09-15)
In this work, functionalized carbon nanotubes (CNTs) using two polyamine polymers, polyethyleneimine (PEI) and polyamidoamine dendrimer (PAMAM), were investigated by thermal analysis in order to address preparation strategies to obtain low cytotoxic compounds with the ability to conjugate microRNAs and
Shin-Heng Chiou et al.
Immunity, 54(3), 586-602 (2021-03-11)
To identify disease-relevant T cell receptors (TCRs) with shared antigen specificity, we analyzed 778,938 TCRβ chain sequences from 178 non-small cell lung cancer patients using the GLIPH2 (grouping of lymphocyte interactions with paratope hotspots 2) algorithm. We identified over 66,000 shared
Mireia Nàger et al.
Autophagy, 14(4), 619-636 (2018-01-10)
WNT-CTNN1B signaling promotes cancer cell proliferation and stemness. Furthermore, recent evidence indicates that macroautophagy/autophagy regulates WNT signaling. Here we investigated the impact of inhibiting WNT signaling on autophagy in glioblastoma (GBM), a devastating brain tumor. Inhibiting TCF, or silencing TCF4
Marco Hoffmann et al.
International journal of molecular sciences, 21(6) (2020-03-28)
Highly efficient, biocompatible, and fast nucleic acid delivery methods are essential for biomedical applications and research. At present, two main strategies are used to this end. In non-viral transfection liposome- or polymer-based formulations are used to transfer cargo into cells
Alexander Rouvinski et al.
Nature communications, 8, 15411-15411 (2017-05-24)
A problem in the search for an efficient vaccine against dengue virus is the immunodominance of the fusion loop epitope (FLE), a segment of the envelope protein E that is buried at the interface of the E dimers coating mature
Ryan J Marina et al.
Cell reports, 33(5), 108350-108350 (2020-11-05)
Site-directed RNA editing approaches offer great potential to correct genetic mutations in somatic cells while avoiding permanent off-target genomic edits. Nuclease-dead RNA-targeting CRISPR-Cas systems recruit functional effectors to RNA molecules in a programmable fashion. Here, we demonstrate a Streptococcus pyogenes
Da Zhu et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 26(10), 2443-2455 (2018-09-23)
Persistent high-risk HPV infection is the main cause of cervical cancer. The HPV oncogene E7 plays an important role in HPV carcinogenesis. Currently, HPV vaccines do not offer an effective treatment for women who already present with cervical disease, and
Jianming Zhang et al.
Frontiers in chemistry, 8, 787-787 (2020-10-17)
Macrophages are potent to modulate inflammation via phenotypic switch and production of inflammatory factors. Baicalein (BCL) is frequently used to alleviate inflammation; however, its application is always hindered due to low solubility. Herein, BCL nanocrystals (BNRs) were prepared to improve
Peng Chen et al.
Cell death & disease, 12(4), 403-403 (2021-04-16)
The genes encoding for neuregulin1 (NRG1), a growth factor, and its receptor ErbB4 are both risk factors of major depression disorder and schizophrenia (SZ). They have been implicated in neural development and synaptic plasticity. However, exactly how NRG1 variations lead
Obayed Raihan et al.
Cell reports, 28(1), 78-90 (2019-07-04)
RNA binding proteins, the key regulators in gene expression at the posttranscriptional level, remain largely uncharacterized with respect to aging and relevant cognitive deterioration. Here, we report that the levels of SFRS11 are substantially decreased in the prefrontal cortex (PFC)
Tian Meng et al.
Cell stress, 3(5), 141-161 (2019-06-22)
Autophagy (here refers to macroautophagy) is a catabolic pathway by which large protein aggregates and damaged organelles are first sequestered into a double-membraned structure called autophago-some and then delivered to lysosome for destruction. Recently, tremen-dous progress has been made to
Wanwisa Dejnirattisai et al.
Cell, 184(11), 2939-2954 (2021-04-15)
Terminating the SARS-CoV-2 pandemic relies upon pan-global vaccination. Current vaccines elicit neutralizing antibody responses to the virus spike derived from early isolates. However, new strains have emerged with multiple mutations, including P.1 from Brazil, B.1.351 from South Africa, and B.1.1.7
Bin Luo et al.
Translational psychiatry, 11(1), 361-361 (2021-07-07)
The precise control of the nervous system function under the vitality of synapses is extremely critical. Efforts have been taken to explore the underlying cellular and molecular mechanisms for synapse formation. Cell adhesion molecules have been found important for synapse
Juhyung Lee et al.
Scientific reports, 8(1), 13676-13676 (2018-09-14)
Cyclin-dependent kinase 5 (CDK5) plays a pivotal role in neural development and neurodegeneration. CDK5 activity can be regulated by posttranslational modifications, including phosphorylation and S-nitrosylation. In this study, we demonstrate a novel mechanism by which the acetylation of CDK5 at
Baoshun Lin et al.
Medicine, 94(31), e1301-e1301 (2015-08-08)
As an immunotoxin, diphtheria toxin has been widely used in gene therapy and gene function assays for its roles in protein synthesis inhibition, and the aim of our study is to set up a nonintegrating lentiviral system for specific expression
Júlia Aguadé-Gorgorió et al.
Blood advances, 4(19), 4823-4833 (2020-10-08)
Despite major advances in the treatment of patients with acute lymphoblastic leukemia in the last decades, refractory and/or relapsed disease remains a clinical challenge, and relapsed leukemia patients have an exceedingly dismal prognosis. Dysregulation of apoptotic cell death pathways is
Ross A Robinson et al.
Cell, 184(8), 2103-2120 (2021-03-20)
During cell migration or differentiation, cell surface receptors are simultaneously exposed to different ligands. However, it is often unclear how these extracellular signals are integrated. Neogenin (NEO1) acts as an attractive guidance receptor when the Netrin-1 (NET1) ligand binds, but
Immacolata Giordano et al.
Frontiers in cell and developmental biology, 9, 715868-715868 (2021-10-09)
Development is orchestrated through a complex interplay of multiple transcription factors. The comprehension of this interplay will help us to understand developmental processes. Here we analyze the relationship between two key transcription factors: CBX4, a member of the Polycomb Repressive
Maria J Gonzalez-Rellan et al.
Nature communications, 12(1), 5068-5068 (2021-08-22)
p53 regulates several signaling pathways to maintain the metabolic homeostasis of cells and modulates the cellular response to stress. Deficiency or excess of nutrients causes cellular metabolic stress, and we hypothesized that p53 could be linked to glucose maintenance. We
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