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Showing 1-30 of 317 results for "411000" within Papers
Judi A Sgambato et al.
Stem cells translational medicine, 4(8), 878-886 (2015-06-13)
Gaucher disease (GD) is the most common lysosomal storage disease resulting from mutations in the lysosomal enzyme glucocerebrosidase (GCase). The hematopoietic abnormalities in GD include the presence of characteristic Gaucher macrophages that infiltrate patient tissues and cytopenias. At present, it
Luigino Grasso et al.
Analytical and bioanalytical chemistry, 407(18), 5425-5432 (2015-05-01)
We report on a generic method to detect and identify the molecular profile of exosomes either derived from cultured cell lines or isolated from biofluids. Exosomes are nanovesicles shed by cells into their microenvironment and carry the molecular identity of their
Sang Duck Jeon et al.
International journal of biological macromolecules, 75, 1-6 (2015-01-21)
Clostridium cellulovorans, produce multi-enzymatic complexes known as cellulosomes, which assemble via the interaction of a dockerin module in the cellulosomal subunit with one of the several cohesin modules in the scaffolding protein, to degrade the plant cell wall polymer. An
Danielle A Garsin
Nature reviews. Microbiology, 8(4), 290-295 (2010-03-18)
Ethanolamine is a compound that can be readily derived from cell membranes and that some bacteria can use as a source of carbon and/or nitrogen. The complex biology and chemistry of this process has been under investigation since the 1970s
Dequina A Nicholas et al.
Mediators of inflammation, 2015, 196297-196297 (2015-12-04)
High levels of serum long chain saturated fatty acids (LCSFAs) have been associated with inflammation in type 2 diabetes. Dietary SFAs can promote inflammation, the secretion of IgG antibodies, and secretion of the proinflammatory cytokine IL-1β. This study characterizes anti-LCSFA
Roland G Heym et al.
Biochimica et biophysica acta, 1854(8), 979-986 (2015-04-18)
Evaluation of drug-target interaction kinetics is becoming increasingly important during the drug-discovery process to investigate selectivity of a drug and predict in vivo target occupancy. To date, it remains challenging to obtain kinetic information for interactions between G-protein-coupled receptors (GPCRs)
Diego A Fernández et al.
Toxicon : official journal of the International Society on Toxinology, 91, 23-34 (2014-09-03)
Cylindrospermopsin is a freshwater and widespread cyanotoxin considered hazardous for human health. Climate change and eutrophication are the main factors influencing the increasing presence of cylindrospermopsin producers that can contaminate human and animal drinking waters, leading to a rise in
Ge-Gu Chen et al.
Scientific reports, 5, 16405-16405 (2015-11-10)
A facile and environmentally friendly method was introduced to incorporate montmorillonite (MMT) as an inorganic phase into quaternized hemicelluloses (QH) for forming hemicellulose-based films. Two fillers, polyvinyl alcohol (PVA) and chitin nanowhiskers (NCH), were added into the hemicelluloses/MMT hybrid matrices
Priya S George et al.
Diabetes, 64(6), 2234-2241 (2015-01-17)
Individuals with long-standing type 1 diabetes (T1D) are at increased risk of severe hypoglycemia secondary to impairments in normal glucose counterregulatory responses (CRRs). Strategies to prevent hypoglycemia are often ineffective, highlighting the need for novel therapies. ATP-sensitive potassium (KATP) channels
Marcela S Villaverde et al.
International immunopharmacology, 22(1), 167-175 (2014-06-29)
In an aggressive B16-F10 murine melanoma model, we evaluated the effectiveness and antitumor mechanisms triggered by a surgery adjuvant treatment that combined a local suicide gene therapy (SG) with a subcutaneous genetic vaccine (Vx) composed of B16-F10 cell extracts and
Achilleas Savva et al.
ACS applied materials & interfaces, 7(44), 24608-24615 (2015-10-16)
A detailed investigation of the functionality of inverted organic photovoltaics (OPVs) using bare Ag contacts as the top electrode is presented. The inverted OPVs without a hole-transporting layer (HTL) exhibit a significant gain in hole-carrier selectivity and power-conversion efficiency (PCE)
Rhoda E Kuc et al.
Life sciences, 118(2), 391-396 (2014-03-04)
In pulmonary arterial hypertension (PAH), increases in endothelin-1 (ET-1) contribute to elevated pulmonary vascular resistance which ultimately causes death by right ventricular (RV) heart failure. ET antagonists are effective in treating PAH but lack efficacy in treating left ventricular (LV)
Marco Cespi et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 954-961 (2014-09-10)
The purpose of this study was to develop and evaluate a delivery system comprising a thermosensitive gel for the sustained release of steroidal hormones in fish, over an extended period of time after a single intramuscular (i.m.) injection and for
Luxi Sun et al.
Nucleic acids research, 43(13), 6334-6347 (2015-06-18)
Cellular DNA is organized into chromosomes and capped by a unique nucleoprotein structure, the telomere. Both oxidative stress and telomere shortening/dysfunction cause aging-related degenerative pathologies and increase cancer risk. However, a direct connection between oxidative damage to telomeric DNA, comprising
Trudy H Grossman et al.
Antimicrobial agents and chemotherapy, 59(3), 1534-1541 (2014-12-24)
Previous studies indicated that inhibition of efflux pumps augments tuberculosis therapy. In this study, we used timcodar (formerly VX-853) to determine if this efflux pump inhibitor could increase the potency of antituberculosis (anti-TB) drugs against Mycobacterium tuberculosis in in vitro
Sang-Soo Kim et al.
ACS nano, 8(6), 5494-5514 (2014-05-09)
Temozolomide (TMZ)-resistance in glioblastoma multiforme (GBM) has been linked to upregulation of O(6)-methylguanine-DNA methyltransferase (MGMT). Wild-type (wt) p53 was previously shown to down-modulate MGMT. However, p53 therapy for GBM is limited by lack of efficient delivery across the blood brain
Marianela Garcia-Munoz et al.
Neuropharmacology, 89, 54-63 (2014-09-23)
N-methyl-D-aspartate receptors (NMDAR) are crucial for the function of excitatory neurotransmission and are present at the synapse and on the extrasynaptic membrane. The major nucleus of the basal ganglia, striatum, receives a large glutamatergic excitatory input carrying information about movements
U Eletxigerra et al.
Biosensors & bioelectronics, 70, 34-41 (2015-03-21)
A highly sensitive amperometric magnetoimmunosensor for the determination of ErbB2 protein, a well-known biomarker related to high-impact high-incidence diseases such as breast cancer, is described. A sandwich format involving the covalent immobilization of a specific capture antibody onto magnetic beads
Collin C Luk et al.
Scientific reports, 5, 9523-9523 (2015-04-02)
Highly coordinated and coincidental patterns of activity-dependent mechanisms ("fire together wire together") are thought to serve as inductive signals during synaptogenesis, enabling neuronal pairing between specific sub-sets of excitatory partners. However, neither the nature of activity triggers, nor the "activity
Fei Li et al.
Journal of proteome research, 14(4), 1937-1946 (2015-02-26)
Colon cancer is the most common cancer and the third leading cause of cancer mortality in humans. Using mass spectrometry-based metabolomics, the current study revealed the accumulation of four uremic toxins (cresol sulfate, cresol glucuronide, indoxyl sulfate, and phenyl sulfate)
Andre F Correa et al.
Infection and immunity, 82(12), 5154-5165 (2014-10-01)
Tuberculosis (TB) remains a major global health problem, and although multiple studies have addressed the relationship between Mycobacterium tuberculosis and the host on an immunological level, few studies have addressed the impact of host physiological responses. Proteases produced by bacteria
O Renkonen
Journal of lipid research, 9(1), 34-39 (1968-01-01)
The plasmalogenic, alkyl-acyl, and diacyl forms of ethanolamine glycerophosphatides were completely separated from each other as methylated dinitrophenyl derivatives by thin-layer chromatography on Silica Gel G. The relatively high resolving power needed was obtained by multiple unidimensional development with solvents
Elaine L Ferguson et al.
Molecular pharmaceutics, 11(12), 4437-4447 (2014-11-02)
Polymer therapeutics offer potential benefits in the treatment of multidrug resistant (MDR) infections; affording targeted delivery of biologically active agents to the site of inflammation, potential decreases in systemic toxicity, and the retention of antimicrobial activity at the target site.
Kate Cameron et al.
The Journal of biological chemistry, 290(21), 13578-13590 (2015-04-10)
Protein-protein interactions play a pivotal role in the assembly of the cellulosome, one of nature's most intricate nanomachines dedicated to the depolymerization of complex carbohydrates. The integration of cellulosomal components usually occurs through the binding of type I dockerin modules
Kitiya Suhem et al.
International journal of food microbiology, 215, 157-160 (2015-10-05)
The aim of this study was to improve the antifungal activity of the volatile Litsea cubeba essential oil and its main components (citral and limonene) on brown rice snack bars by applying He-Ne laser treatment. Different volumes (50-200 μL) of
Sung Ki Cho et al.
Journal of the American Chemical Society, 137(20), 6638-6642 (2015-05-06)
We demonstrate the feasibility of semiconductor deposition via the electrochemical reduction of gaseous precursors by the use of an anhydrous proton-conducting membrane, the solid acid CsHSO4, at 165 °C. This membrane electrode assembly was operated within the oxidation of hydrogen
Ye Tao et al.
Toxicology and applied pharmacology, 286(1), 44-52 (2015-03-23)
The neurotoxic effects of N-methyl-N-nitrosourea (MNU) on the inner retinal neurons and related visual signal circuits have not been described in any animal models or human, despite ample morphological evidences about the MNU induced photoreceptor (PR) degeneration. With the helping
Adrian Losoya-Leal et al.
Talanta, 141, 253-258 (2015-05-13)
The therapeutic drug monitoring (TDM) of pharmaceutical drugs with narrow therapeutic ranges is of great importance in the clinical setting. It provides useful information towards the enhancement of drug therapies, aiding in dosage control and toxicity risk management. Amikacin is
G S Yánez-Jácome et al.
Journal of chromatography. A, 1405, 126-132 (2015-06-17)
The usefulness of terbium oxide nanoparticles (Tb4O7NPs) as post-column derivatizing reagent for the liquid chromatographic determination of residues of quinolone antibiotics in milk samples has been studied. Seven quinolones of veterinary use have been chosen as model analytes to develop
Wioletta Przystas et al.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 46(2), 415-424 (2015-08-15)
Dyes are the most difficult constituents to remove by conventional biological wastewater treatment. Colored wastewater is mainly eliminated by physical and chemical procedures, which are very expensive and have drawbacks. Therefore, the advantage of using biological processes, such as the
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