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Showing 1-30 of 6434 results for "436143" within Papers
Bai-Wei Gu et al.
PloS one, 10(5), e0127414-e0127414 (2015-05-21)
Dyskeratosis congenita (DC) is an inherited bone marrow failure syndrome characterized by the presence of short telomeres at presentation. Mutations in ten different genes, whose products are involved in the telomere maintenance pathway, have been shown to cause DC. The
Hieng-Ming Ting et al.
Molecular plant, 8(3), 454-466 (2015-01-20)
Plants produce numerous terpenes and much effort has been dedicated to the identification and characterization of the terpene biosynthetic genes. However, little is known about how terpenes are transported within the cell and from the cell into the apoplast. To
Yong Yu et al.
Nucleic acids research, 43(6), 3208-3218 (2015-03-05)
Mutations in FUS cause amyotrophic lateral sclerosis (ALS), but the molecular pathways leading to neurodegeneration remain obscure. We previously found that U1 snRNP is the most abundant FUS interactor. Here, we report that components of the U1 snRNP core particle
Min-Sik Lee et al.
Nature communications, 6, 7769-7769 (2015-07-18)
The activity of the phosphatase and tensin homologue (PTEN) is known to be suppressed via post-translational modification. However, the mechanism and physiological significance by which post-translational modifications lead to PTEN suppression remain unclear. Here we demonstrate that PTEN destabilization is
Douglas A Simonetto et al.
Hepatology (Baltimore, Md.), 61(2), 648-659 (2014-08-22)
Chronic passive hepatic congestion (congestive hepatopathy) leads to hepatic fibrosis; however, the mechanisms involved in this process are not well understood. We developed a murine experimental model of congestive hepatopathy through partial ligation of the inferior vena cava (pIVCL). C57BL/6
Kosha Mehta et al.
Blood cells, molecules & diseases, 55(2), 110-118 (2015-07-05)
Iron overload coupled with low hepcidin levels are characteristics of hereditary haemochromatosis. To understand the role of transferrin receptor (TFR) and intracellular iron in hepcidin secretion, Chinese hamster ovary transferrin receptor variant (CHO TRVb-1) cells were used that express iron-response-element-depleted
Gongrui Guo et al.
Journal of structural biology, 192(3), 418-425 (2015-10-04)
Spt5 (NusG in bacteria) is the only RNA polymerase-associated factor known to be conserved in all three domains of life. In archaea and eukaryotes, Spt5 associates with Spt4, an elongation factor that is absent in bacteria, to form a functional
Fang Liu et al.
Molecular medicine reports, 11(5), 3349-3353 (2015-01-22)
Non‑small cell lung cancer (NSCLC) remains the leading cause of cancer‑related mortality despite the fact that great advances have been made in therapeutic treatment methods. Therefore, in the present study, the role of adenovirus-mediated retinoblastoma 94 (Ad‑RB94) gene therapy in
Daniela Sorriento et al.
Journal of cardiovascular translational research, 8(8), 493-502 (2015-08-01)
G protein coupled receptor kinase type 2 (GRK2) plays an important role in the development and maintenance of cardiac hypertrophy and heart failure even if its exact role is still unknown. In this study, we assessed the effect of GRK2
Tiina Hurskainen et al.
The Journal of investigative dermatology, 135(5), 1303-1310 (2014-10-14)
Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering skin disease with a characteristic of pruritus and blistering. BP patients carry inflammation-triggering autoantibodies against the collagen XVII (ColXVII, also known as BP180) juxtamembraneous extracellular noncollagenous 16A (NC16A) domain involved
Henriette Franz et al.
Oncotarget, 6(7), 4773-4789 (2015-03-10)
The histone code reader Spindlin1 (SPIN1) has been implicated in tumorigenesis and tumor growth, but the underlying molecular mechanisms remain poorly understood. Here, we show that reducing SPIN1 levels strongly impairs proliferation and increases apoptosis of liposarcoma cells in vitro
Aristeidis Chiotellis et al.
Amino acids, 46(8), 1947-1959 (2014-05-08)
Amino acid transport is an attractive target for oncologic imaging. Despite a high demand of cancer cells for cationic amino acids, their potential as PET probes remains unexplored. Arginine, in particular, is involved in a number of biosynthetic pathways that
Ana Gil-Bona et al.
Journal of proteome research, 14(1), 142-153 (2014-11-05)
The commensal fungus Candida albicans secretes a considerable number of proteins and, as in different fungal pathogens, extracellular vesicles (EVs) have also been observed. Our report contains the first proteomic analysis of EVs in C. albicans and a comparative proteomic
Milica Jovicic et al.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 16(5), 301-311 (2015-03-10)
To develop a structural equation model of negative affectivity (NA) that involves interaction of glucocorticoid receptor (GR) signaling, personality dimensions and recent stressful life events. Seventy participants - 35 diagnosed with major depression and 35 healthy controls, were enrolled in
Susan W Groth et al.
Biological research for nursing, 17(4), 405-412 (2014-12-17)
Gestational weight gain (GWG) is a modifiable risk factor for obesity in women. Black women have the greatest prevalence of high body mass, which predisposes them to excessive GWG. Increased understanding of genetic influences on GWG has implications for the
Saifeldin N Shehata et al.
The Biochemical journal, 469(3), 409-420 (2015-07-25)
PCTAIRE-1 [also known as cyclin-dependent kinase 16 (CDK16)] is implicated in various physiological processes such as neurite outgrowth and vesicle trafficking; however, its molecular regulation and downstream targets are largely unknown. Cyclin Y has recently been identified as a key
Syed Z Sultan et al.
Infection and immunity, 83(5), 1765-1777 (2015-02-19)
Borrelia burgdorferi must migrate within and between its arthropod and mammalian hosts in order to complete its natural enzootic cycle. During tick feeding, the spirochete transmits from the tick to the host dermis, eventually colonizing and persisting within multiple, distant
Marcia A Shirakawa et al.
Journal of environmental management, 157, 160-167 (2015-04-25)
Sub-aerial biofilm (SAB) development on solar panels was studied in São Paulo. After 6, 12 and 18 months' exposure, photovoltaic panels were covered by increasing proportions of organic matter (42%, 53% and 58%, respectively). Fungi were an important component of
Peter S Hasenhuetl et al.
Molecular pharmacology, 88(1), 12-18 (2015-04-16)
The membrane transporters for the monoamines serotonin (SERT) and dopamine (DAT) are prominent targets of various psychoactive substances, including competitive inhibitors, such as tricyclic antidepressants, methylphenidate, and cocaine. Upon rapid application of a substrate, SERT and DAT display an inwardly
I Traversi et al.
General and comparative endocrinology, 205, 185-196 (2014-07-01)
A wide range of endocrine disrupter chemicals can mimic steroid hormones causing adverse health effects. Nonylphenol (NP) and t-octhylphenol (t-OP) are man-made alkylphenolic environmental contaminants possessing controversial endocrine disruption properties. This study has investigated the effects of NP and t-OP
Raquel Ordoñez et al.
Journal of pineal research, 59(2), 178-189 (2015-05-16)
Autophagy is a process that maintains homeostasis during stress, although it also contributes to cell death under specific contexts. Ceramides have emerged as important effectors in the regulation of autophagy, mediating the crosstalk with apoptosis. Melatonin induces apoptosis of cancer
Devadoss J Samuvel et al.
PloS one, 10(10), e0141781-e0141781 (2015-10-30)
Sphingosine-1-phosphate receptor 1 (S1P1) mediated regulation of lymphocyte egress from lymphoid organs is recognized as the mechanism of FTY720 (Fingolimod, Gilenya) efficacy in relapsing-remitting forms of multiple sclerosis (RRMS). In this study we describe a novel S1P1 agonist AKP-11, next
Masayuki Koizumi et al.
Journal of atherosclerosis and thrombosis, 21(9), 904-916 (2014-04-15)
Vascular senescence, which is accelerated in individuals with chronic kidney disease (CKD), contributes to the development of cardio-renal syndrome, and various uremic toxins may play important roles in the mechanisms underlying this phenomenon. We recently reported that indoxyl sulfate (IS)
Eduardo Parra et al.
Oncology reports, 33(1), 413-418 (2014-10-30)
Inhibition of basal Jun kinase (JNK) activity by small interfering RNAs (siRNAs) enhances cisplatin sensitivity and decreases DNA repair in T98G glioblastoma cells. Although the JNK pathway has been extensively studied in recent years, little is known concerning the signaling
Vera Gesheva et al.
International immunopharmacology, 26(1), 162-168 (2015-03-25)
New generated subunit vaccines are characterized by increased safety and lack of side effects, however they suffer from weak immunogenicity. The adjuvants are substances that have the ability to enhance the magnitude and duration of the immune response and to
Edward T Richardson et al.
Infection and immunity, 83(6), 2242-2254 (2015-03-18)
Mycobacterium tuberculosis survives within macrophages and employs immune evasion mechanisms to persist in the host. Protective T helper type 1 (Th1) responses are induced, and the immune response in most individuals is sufficient to restrict M. tuberculosis to latent infection
Daniel M Lewallen et al.
ACS chemical biology, 10(11), 2520-2528 (2015-09-12)
Anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis (RA) and are routinely used for disease diagnosis. Protein citrullination is also increased in cancer and other autoimmune disorders, suggesting that citrullinated proteins may serve as biomarkers for diseases beyond
Maria F S D Rodrigues et al.
Medicine, 93(28), e192-e192 (2014-12-20)
Homeobox genes are a family of transcription factors that play a pivotal role in embryogenesis. Prospero homeobox 1 (PROX1) has been shown to function as a tumor suppressor gene or oncogene in various types of cancer, including oral squamous cell
Ana M Matas-Cobos et al.
Pancreas, 44(3), 429-433 (2014-11-26)
Toll-like receptors (TLRs) are damage-associated molecular patterns receptors, which are essential in the activation of the inflammasome cascade, required for the initiation of inflammation. We hypothesized that changes in the function of these receptors caused by genetic polymorphisms in their
Xiaoli Yang et al.
Molecular and cellular biochemistry, 407(1-2), 69-76 (2015-05-24)
MicroRNAs (miRNAs) play vital roles in the regulation of cell cycle, cell growth, apoptosis, and tumorigenesis. Our previous studies showed that miR-526a positively regulated innate immune response by suppressing CYLD expression, however, the functional relevance of miR-526a expression and cell
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