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Showing 31-60 of 6434 results for "436143" within Papers
Tianxiao Li et al.
Molecular medicine reports, 12(5), 6976-6984 (2015-09-10)
Colorectal cancer (CRC) is a worldwide malignancy of high incidence and mortality. At present, there is a lack of effective drugs against CRC. The B‑cell leukemia/lymphoma 2 (Bcl‑2) protein family members are considered to be closely associated with tumorigenesis and
Diogo de Azevedo Miranda et al.
The European journal of esthetic dentistry : official journal of the European Academy of Esthetic Dentistry, 8(1), 88-102 (2013-02-08)
The aim of this in vitro study was to evaluate the sorption (Sp) and solubility (Sl) of a nanofilled composite (Filtek Z350) light-activated from the top in three curing light distances (0 mm, 3 mm and 6 mm) and immersed
Theodoros Eleftheriadis et al.
Experimental and therapeutic medicine, 10(5), 1959-1966 (2015-12-08)
Activated T cells rely on aerobic glycolysis and glutaminolysis in order to proliferate and differentiate into effector cells. Therefore, intervention in these metabolic pathways inhibits proliferation. The aim of the present study was to evaluate the effects of Krebs' cycle
Joanna Piasecka-Zelga et al.
Journal of occupational health, 57(3), 275-284 (2015-03-20)
Many employees working outside are exposed to the harmful effects of UV radiation. A growing problem is also sensitization to textile materials and allergic reactions to active compounds. Groups of inorganic UV blockers with nanoparticles may provide superior properties over
Shahnaz Begum et al.
Scientific reports, 5, 13236-13236 (2015-09-01)
In spite of significant technical advances, genesis and progression of non-small cell lung cancer (NSCLC) remain poorly understood. We undertook an integrated genetic approach to discover novel microRNAs that were deregulated in NSCLCs. A total 119 primary NSCLCs with matched
Dieter A Kubli et al.
PloS one, 10(6), e0130707-e0130707 (2015-06-26)
Myocyte function and survival relies on the maintenance of a healthy population of mitochondria. The PINK1/Parkin pathway plays an important role in clearing defective mitochondria via autophagy in cells. However, how the PINK1/Parkin pathway regulates mitochondrial quality control and whether
Xiaomeng Liu et al.
Endocrinology, 156(7), 2461-2469 (2015-04-02)
Increasing evidence indicates that brown adipose tissue (BAT) transplantation enhances whole-body energy metabolism in a mouse model of diet-induced obesity. However, it remains unclear whether BAT also has such beneficial effects on genetically obese mice. To address this issue, we
Guillaume Roussel et al.
Current protocols in protein science, Chapter 28, Unit28-Unit28 (2013-04-03)
Currently, the investigation of protein refolding processes involves several time-consuming stages that require large amounts of protein and costly chemicals. Consequently, there is great interest in developing new approaches to the study of protein renaturation that are more technically and
Kimberly-Ann Bordun et al.
American journal of physiology. Heart and circulatory physiology, 309(4), H692-H701 (2015-06-21)
The recent introduction of novel anticancer therapies, including bevacizumab (BVZ) and sunitinib (SNT), is associated with an increased risk of cardiotoxicity. However, early identification of left ventricular (LV) systolic dysfunction may facilitate dose modification and avoid the development of advanced
Valentina Franceschi et al.
BMC veterinary research, 11, 224-224 (2015-08-27)
Bovine herpesvirus 4 (BoHV-4) is a gammaherpesvirus whose genome was cloned as Bacterial Artificial Chromosome (BAC) and exploited as a gene delivery vector for vaccine purposes. Although BoHV-4 genome has been completely sequenced and its open reading frames (ORFs) structurally
Jessica Aceto et al.
PloS one, 10(6), e0126928-e0126928 (2015-06-11)
Teleost fish such as zebrafish (Danio rerio) are increasingly used for physiological, genetic and developmental studies. Our understanding of the physiological consequences of altered gravity in an entire organism is still incomplete. We used altered gravity and drug treatment experiments
M Witzig et al.
Journal of applied microbiology, 119(1), 33-46 (2015-04-17)
To investigate the effect of donor animal species and their feeding on the composition of the active fraction of rumen microbiota established during in vitro experiments with different forages. Rumen simulation experiments were conducted with maize silage (MS) and grass
Xi Xia et al.
Scientific reports, 5, 17077-17077 (2015-11-21)
Mycoplasma gallisepticum is a significant pathogenic bacterium that infects poultry, causing chronic respiratory disease and sinusitis in chickens and turkeys, respectively. M. gallisepticum infection poses a substantial economic threat to the poultry industry, and this threat is made worse by
Marek M Nagiec et al.
PloS one, 10(3), e0120295-e0120295 (2015-03-27)
Recent genome wide association studies have linked tribbles pseudokinase 1 (TRIB1) to the risk of coronary artery disease (CAD). Based on the observations that increased expression of TRIB1 reduces secretion of VLDL and is associated with lower plasma levels of
Eun Young Kim et al.
Food & function, 6(11), 3512-3521 (2015-08-25)
The aim of the current study is to investigate the antioxidant and hepatoprotective effects of germinated and fermented soybean extract (GFSE) on tert-butyl hydroperoxide (t-BHP)-induced oxidative stress in HepG2 cells and in the rat liver. High performance liquid chromatography (HPLC)
Xi Luo et al.
PLoS pathogens, 11(6), e1004965-e1004965 (2015-06-13)
The opportunistic intracellular pathogen Legionella pneumophila is the causative agent of Legionnaires' disease. L. pneumophila delivers nearly 300 effector proteins into host cells for the establishment of a replication-permissive compartment known as the Legionella-containing vacuole (LCV). SidC and its paralog
Hyung Joon Kim et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(44), 14872-14884 (2015-11-06)
RE-1 silencing transcription factor (REST), a master negative regulator of neuronal differentiation, controls neurogenesis by preventing the differentiation of neural stem cells. Here we focused on the role of REST in the early steps of differentiation and maturation of adult
Juan Ouyang et al.
The Journal of biological chemistry, 290(37), 22782-22794 (2015-07-04)
Sox2 is a key factor in maintaining self-renewal of embryonic stem cells (ESCs) and adult stem cells as well as in reprogramming differentiated cells back into pluripotent or multipotent stem cells. Although previous studies have shown that Sox2 is phosphorylated
Joseph A Caruso et al.
Toxicology and applied pharmacology, 276(1), 47-54 (2014-01-21)
Network and protein-protein interaction analyses of proteins undergoing Hg²⁺-induced phosphorylation and dephosphorylation in Hg²⁺-intoxicated mouse WEHI-231 B cells identified Lyn as the most interconnected node. Lyn is a Src family protein tyrosine kinase known to be intimately involved in the
Jessica A Chadwick et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(11), 4544-4554 (2015-07-17)
Early treatment with heart failure drugs lisinopril and spironolactone improves skeletal muscle pathology in Duchenne muscular dystrophy (DMD) mouse models. The angiotensin converting enzyme inhibitor lisinopril and mineralocorticoid receptor (MR) antagonist spironolactone indirectly and directly target MR. The presence and
Xiaoqun Zhang et al.
Neuropharmacology, 92, 108-115 (2015-01-27)
The GluN2B subunit of NMDA receptors (NMDARs) is an attractive drug target for therapeutic intervention in Parkinson's disease (PD). We have used whole-cell patch clamp recordings in brain slices to examine the contribution of GluN2B and GluN2D to functional NMDARs
Lydia Chang et al.
PloS one, 10(6), e0130162-e0130162 (2015-06-16)
Ubiquilin proteins facilitate delivery of ubiquitinated proteins to the proteasome for degradation. Interest in the proteins has been heightened by the discovery that gene mutations in UBQLN2 cause dominant inheritance of amyotrophic lateral sclerosis (ALS). However, the mechanisms by which
Tomohiko Ohno et al.
PloS one, 10(4), e0124081-e0124081 (2015-04-17)
Obesity and related metabolic disorders, such as diabetes mellitus, raise the risk of liver carcinogenesis. Metformin, which is widely used in the treatment of diabetes, ameliorates insulin sensitivity. Metformin is also thought to have antineoplastic activities and to reduce cancer
Emiley A Eloe-Fadrosh et al.
mBio, 6(2) (2015-04-16)
A mechanistic understanding of the purported health benefits conferred by consumption of probiotic bacteria has been limited by our knowledge of the resident gut microbiota and its interaction with the host. Here, we detail the impact of a single-organism probiotic
Louise M Collins et al.
Molecular neurobiology, 51(3), 1432-1442 (2014-07-30)
Small molecule histone deacetylase inhibitors (HDIs) hold much promise as pharmacological modifiers of the epigenetic status of the central nervous system (CNS), given their ability to cross the blood-brain barrier. This is particularly relevant given the lack of disease-modifying therapies
Prakash Parajuli et al.
AMB Express, 4, 31-31 (2014-06-21)
Epothilones are extremely cytotoxic chemotherapeutic agents with epoxide, thiazole, and ketone groups that share equipotent kinetic similarity with taxol. The in vitro glycosylation catalyzed by uridine diphosphate glucosyltransferase (YjiC) from Bacillus licheniformis generated six novel epothilone A glycoside analouges including
Stefania Ghisaura et al.
Proteome science, 12(1), 44-44 (2014-10-25)
The zootechnical performance of three different commercial feeds and their impact on liver and serum proteins of gilthead sea bream (Sparus aurata, L.) were assessed in a 12 week feeding trial. The three feeds, named A, B, and C, were subjected
Joanne E Mallinson et al.
The Journal of physiology, 593(5), 1239-1257 (2015-01-27)
Statins are associated with muscle myalgia and myopathy, which probably reduce habitual physical activity. This is particularly relevant to older people who are less active, sarcopaenic and at increased risk of statin myalgia. We hypothesised that statin myalgia would be
Vera Gesheva et al.
International immunopharmacology, 26(1), 162-168 (2015-03-25)
New generated subunit vaccines are characterized by increased safety and lack of side effects, however they suffer from weak immunogenicity. The adjuvants are substances that have the ability to enhance the magnitude and duration of the immune response and to
Edward T Richardson et al.
Infection and immunity, 83(6), 2242-2254 (2015-03-18)
Mycobacterium tuberculosis survives within macrophages and employs immune evasion mechanisms to persist in the host. Protective T helper type 1 (Th1) responses are induced, and the immune response in most individuals is sufficient to restrict M. tuberculosis to latent infection
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