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Showing 1-30 of 2808 results for "439134" within Papers
François Versace et al.
Bioanalysis, 6(15), 2043-2055 (2014-10-18)
Direct-infusion ESI-MS/MS is a powerful approach for the identification of substances in complex mixtures. The aim of this work was to investigate its applicability to the toxicological screening of blood samples. A simple protein precipitation was used, followed by a
Lea Ann Dailey et al.
Nanotoxicology, 9(1), 106-115 (2014-03-14)
Inhaled nanomaterials present a challenge to traditional methods and understanding of respiratory toxicology. In this study, a non-targeted metabolomics approach was used to investigate relationships between nanoparticle hydrophobicity, inflammatory outcomes and the metabolic fingerprint in bronchoalveolar fluid. Measures of acute
Ping Du et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967, 28-35 (2014-07-27)
Docetaxel lipid microsphere (DT-LM) is a novel formulation of docetaxel without Tween-80. A sensitive, robust and reproducible ultrafiltration (UF) followed by UPLC-MS/MS method was developed and validated for the quantification of unbound docetaxel in human plasma using paclitaxel as IS.
Morten S Opstrup et al.
Contact dermatitis, 72(1), 55-58 (2014-09-12)
Chlorhexidine may cause type I and type IV allergy. Some chlorhexidine-allergic individuals have been exposed in the healthcare setting as patients or healthcare workers, but for others the source of sensitization is unknown. Chlorhexidine may be used as a preservative
Tara Man Kadayat et al.
Bioorganic & medicinal chemistry, 23(1), 160-173 (2014-12-08)
For the development of potential anticancer agents, we designed and synthesized 30 new 2,4-diaryl-5H-indeno[1,2-b]pyridine derivatives containing aryl moiety such as furyl, thienyl, pyridyl, and phenyl at 2- and 4-position of 5H-indeno[1,2-b]pyridine. They were evaluated for topoisomerase I and II inhibitory
J L Ordóñez et al.
Food chemistry, 178, 221-228 (2015-02-24)
This paper studies the amino acid profile of beverages obtained through the fermentation of strawberry purée by a surface culture using three strains belonging to different acetic acid bacteria species (one of Gluconobacter japonicus, one of Gluconobacter oxydans and one
James M Starr et al.
Toxicology, 320, 15-24 (2014-03-19)
National surveys of United States households and child care centers have demonstrated that pyrethroids are widely distributed in indoor habited dwellings and this suggests that co-exposure to multiple pyrethroids occurs in nonoccupational settings. The purpose of this research was to
A Marechal et al.
Journal of chromatography. A, 1365, 140-147 (2014-09-25)
This paper presents a photografting process of monolithic silica capillary columns based on the ene-thiol click chemistry. This study is performed on a "generic" vinyl-functionalized silica monolith (Hmin 6±1μm). The photoclick reaction is investigated using different thiol monomers (octadecanethiol, cysteine
Weijun Ke et al.
Nature communications, 6, 6700-6700 (2015-03-24)
Efficient lead halide perovskite solar cells use hole-blocking layers to help collection of photogenerated electrons and to achieve high open-circuit voltages. Here, we report the realization of efficient perovskite solar cells grown directly on fluorine-doped tin oxide-coated substrates without using
Ting Yang et al.
Clinica chimica acta; international journal of clinical chemistry, 436, 283-289 (2014-06-28)
P-glycoprotein (P-gp) can efflux drugs from cancer cells, and its overexpression is commonly associated with multi-drug resistance (MDR). Thus, the accurate quantification of P-gp would help predict the response to chemotherapy and for prognosis of breast cancer patients. An advanced
Yuanyuan Chen et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 1-5 (2015-02-04)
Solasonine, a known glycoalkaloid, is a potential anti-cancer agent. In this work, a simple, sensitive and fast ultra performance liquid chromatography with tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the quantitative determination of solasonine in rat plasma.
Wen Shi et al.
Biomaterials, 35(22), 5760-5770 (2014-04-24)
N-(2-hydroxypropyl)-methacrylamide (HPMA) copolymers have shown promise for application in the detection and staging of cancer. However, non-target accumulation, particularly in the liver and spleen, hinders the detection of resident or nearby metastatic lesions thereby decreasing diagnostic effectiveness. Our laboratory has
Arminja N Kettenbach et al.
Journal of proteomics, 114, 48-60 (2014-12-03)
The study of cellular signaling remains a significant challenge for translational and clinical research. In particular, robust and accurate methods for quantitative phosphoproteomics in tissues and tumors represent significant hurdles for such efforts. In the present work, we design, implement
Alberto Sánchez-Guijo et al.
Journal of lipid research, 56(2), 403-412 (2014-12-17)
Steroid sulfatase (STS) deficiency is the underlying cause of the skin condition known as recessive X-linked ichthyosis (RXLI). RXLI patients show scales on their skin caused by high concentrations of cholesterol sulfate (CS), as they are not capable of releasing
Manuela Calin et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 89, 18-29 (2014-12-02)
Chemokines are critically involved in the development of chronic inflammatory-associated diseases such as atherosclerosis. We hypothesized that targeted delivery of compounds to the surface of activated endothelial cells (EC) interferes with chemokine/receptor interaction and thereby efficiently blocks inflammation. We developed
Kıvılcım Çaktü et al.
Artificial cells, nanomedicine, and biotechnology, 42(6), 365-375 (2013-12-07)
Cholesterol-imprinted monosize poly(glycidyl methacrylate-N-methacryloyl-(L)-tyrosine methylester) microspheres were embedded into the poly(hydroxyethyl methacrylate) (PHEMA) cryogels and the resulting composite cryogel was used for the selective removal of cholesterol. Composite cryogels were characterized by swelling tests, multipoint BET apparatus, SEM, FTIR and
Rostyslav Zvanych et al.
Molecular bioSystems, 11(1), 97-104 (2014-09-12)
Streptococcus mutans, a Gram-positive human commensal and pathogen, is commonly recognized as a primary causative agent in dental caries. Metabolic activity of this strain results in the creation of acids and secreted products are recognized as pathogenic factors and agents
Dong-Sheng Lian et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 978-979, 29-42 (2014-12-23)
To develop a highly sensitive method for analyzing nucleic acids using capillary gel electrophoresis with ultraviolet detection (CGE-UV), we combined matrix field-amplified with head-column field-amplified stacking injection (C-FASI) to employ the advantages of two methods. Without diminishing the resolution, a
Porkodi Kadhirvel et al.
Journal of chromatography. A, 1358, 93-101 (2014-07-22)
Straightforward crushing and sieving bulk polymeric R-aminoglutethimide-imprinted materials were prepared by classical free radical polymerization, whereas nano thin walled grafted imprinted materials were prepared using RAFT mediated control polymerization technique. A stoichiometric non-covalent approach based on a triply hydrogen bonding
Ramprasad Kandavar et al.
Journal of clinical hypertension (Greenwich, Conn.), 17(1), 14-19 (2014-12-17)
Prehypertension is an important phenotype for cardiovascular risk and development of established hypertension. To better understand the early circulatory changes in this group, the authors studied 34 patients with prehypertension (blood pressure 120-139/80-89 mm Hg) using digital plethysmography for measurement
Joao N Dos Santos Pereira et al.
The AAPS journal, 16(6), 1247-1258 (2014-08-27)
Variations in influx transport at the blood-brain barrier might affect the concentration of psychotropic drugs at their site of action and as a consequence might alter therapy response. Furthermore, influx transporters in organs such as the gut, liver and kidney
Meng Gao et al.
Drug development and industrial pharmacy, 40(11), 1557-1564 (2013-09-26)
This paper describes the development and optimization of curcumin thermosensitive hydrogels (CTH), a kind of gel injection for intratumoral injection treatment. Aimed at increasing the content and stability of effective components, an optimal formulation of CTH was chosen based on
Dahae Lim et al.
Journal of ethnopharmacology, 160, 41-51 (2014-12-06)
Stemona tuberosa (ST) is a traditional herbal medicine used for the treatment of various respiratory diseases in eastern Asia. We investigated the anti-inflammatory effects of a ST water extract in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and in cigarette smoke (CS)-induced
Nicolas Marincek et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(2), 171-176 (2015-01-17)
Meningiomas express members of the somatostatin receptor family. The present study assessed the long-term benefits and harm of somatostatin-based radiopeptide therapy in meningioma patients. Patients with progressive unresectable meningioma were treated with (90)Y-DOTATOC and (177)Lu-DOTATOC until tumor progression or permanent
Karen Staines et al.
PloS one, 9(11), e110330-e110330 (2014-11-13)
Sequences of peptides from a protein specifically immunoprecipitated by an antibody, KUL01, that recognises chicken macrophages, identified a homologue of the mammalian mannose receptor, MRC1, which we called MRC1L-B. Inspection of the genomic environment of the chicken gene revealed an
Xiaoping Li et al.
Fitoterapia, 95, 220-228 (2014-04-09)
In an effort to identify natural compounds with immunosuppressive activity, nine new flavonoids, including one isoflav-3-ene derivative (1), one coumaronochromone (2), two isoflavanones (3, 4), one isoflavone derivative (6), one isoflavone (7), three flavonols (8, 9, 10), as well as
Jiang Ma et al.
Journal of ethnopharmacology, 162, 61-68 (2015-01-06)
Polygoni Multiflori Radix (PMR) has been traditionally used as a tonic and an anti-aging remedy for centuries; however, hepatic lesions linked to PMR have been frequently reported. This work attempted to investigate the hepatotoxic potential of PMR extract and the
Francesco Menichini et al.
Journal of enzyme inhibition and medicinal chemistry, 29(5), 677-685 (2013-10-10)
Cardiospermum halicacabum is widely used in traditional medicine. Previous studies have focused on the aerial parts, while the seeds have been poorly investigated. This work aimed to analyse the chemical composition of extracts from aerial parts and seeds obtained using
Xiao-Cui Qian et al.
Journal of pharmaceutical and biomedical analysis, 105, 64-73 (2014-12-30)
Rhizoma coptidis (R.C.), a widely used traditional Chinese medicine, has been used for centuries in the treatment of hypertension, inflammation, dysentery and liver diseases, etc. Wine-processing is a specialized technology by sautéing crude herbal medicine using Chinese rice wine. This
Laurence Ridoux et al.
Anti-cancer drugs, 26(3), 350-358 (2014-12-03)
Cabazitaxel is a semisynthetic taxane approved for the treatment of patients with hormone-refractory metastatic prostate cancer (now known as metastatic castration-resistant prostate cancer) treated previously with a docetaxel-containing treatment regimen. The human plasma pharmacokinetics of cabazitaxel have been described previously
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