439193

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Qualitative and quantitative analysis of N-acetyllactosamine and lacto-N-biose, the two major building blocks of human milk oligosaccharides in human milk samples by high-performance liquid chromatography-tandem mass spectrometry using a porous graphitic carbon column.

Réka Balogh et al.

Journal of chromatography. A, 1422, 140-146 (2015-10-20)

This study presents a validated, porous graphitic carbon stationary phase-based LC-MS/MS method for the identification and quantification of lacto-N-biose (LNB) and N-acetyllactosamine (LacNAc). These compounds are the major building blocks of human milk oligosaccharides, however the presence of their unbound

The Moon as a recorder of organic evolution in the early solar system: a lunar regolith analog study.

Richard Matthewman et al.

Astrobiology, 15(2), 154-168 (2015-01-24)

The organic record of Earth older than ∼3.8 Ga has been effectively erased. Some insight is provided to us by meteorites as well as remote and direct observations of asteroids and comets left over from the formation of the Solar System.

Investigation of Blue Bedding in Cages Housing Treatment-Naïve Hamsters.

Vishal D Shah et al.

Journal of the American Association for Laboratory Animal Science : JAALAS, 54(6), 799-802 (2015-12-04)

During the acclimation phase of a preclinical safety study involving Syrian golden hamsters, some of the cages of treatment-naïve animals were noted to contain blue-tinged bedding; the urine of these hamsters was not discolored. We sought to understand the underlying

The influence of residual water on the secondary structure and crystallinity of freeze-dried fibrinogen.

Verena Wahl et al.

International journal of pharmaceutics, 484(1-2), 95-102 (2015-02-24)

The purpose of this work was to investigate the influence of water content on the secondary structure of a freeze-dried protein (fibrinogen) after a storage period of two weeks. To that end, attenuated reflectance Fourier transformed infrared (ATR-FTIR) and Raman

Tautomeric and Microscopic Protonation Equilibria of Anthranilic Acid and Its Derivatives.

Lidia Zapała et al.

Journal of solution chemistry, 43, 1167-1183 (2014-07-30)

The acid-base chemistry of three zwitterionic compounds, namely anthranilic (2-aminobenzoic acid)

Rapid and sensitive detection of the inhibitive activities of acetyl- and butyryl-cholinesterases inhibitors by UPLC-ESI-MS/MS.

Wei Liu et al.

Journal of pharmaceutical and biomedical analysis, 94, 215-220 (2014-03-19)

Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are legitimate therapeutic targets for Alzheimer's disease. The classical approach for screening potential AChE/BChE inhibitors was developed by Ellman. However, the background color of compounds or plant extracts remained uncertain and frequently interfered with the

Protein engineering of a nitrilase from Burkholderia cenocepacia J2315 for efficient and enantioselective production of (R)-o-chloromandelic acid.

Hualei Wang et al.

Applied and environmental microbiology, 81(24), 8469-8477 (2015-10-04)

The nitrilase-mediated pathway has significant advantages in the production of optically pure aromatic α-hydroxy carboxylic acids. However, low enantioselectivity and activity are observed on hydrolyzing o-chloromandelonitrile to produce optically pure (R)-o-chloromandelic acid. In the present study, a protein engineering approach

Pharmacokinetics of geniposide by monoclonal antibody-based icELISA in mice after oral administration of Huanglian-Jiedu-Tang.

Hui-Hua Qu et al.

Biological & pharmaceutical bulletin, 37(9), 1525-1533 (2014-09-02)

Geniposide, Geniposide, the main active component in extracts of Gardenia jasminoides ELLIS., is one of the main components of Huanglian-Jiedu-Tang (HJT). This study aimed to validate an indirect competitive enzyme-linked immunosorbent assay (icELISA) based on monoclonal antibodies (mAb) against geniposide

Oral caffeine administration ameliorates acute colitis by suppressing chitinase 3-like 1 expression in intestinal epithelial cells.

In-Ah Lee et al.

Journal of gastroenterology, 49(8), 1206-1216 (2013-08-09)

The initial trigger of inflammatory bowel disease (IBD) can be partly attributed towards the interaction and invasion of intestinal epithelial cells (IECs) and submucosal compartments. Identifying safe and economical methods to block these interactions may help prevent the onset of

Validation and application of a reporter gene assay for the determination of estrogenic endocrine disruptor activity in milk.

E Wielogorska et al.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 69, 260-266 (2014-04-29)

Endocrine disruptors (EDs) are compounds known to interfere with the endocrine system by disturbing the action or pathways of natural hormones which may lead to infertility or cancer. Our diet is considered to be one of the main exposure routes

Tandem amine and ruthenium-catalyzed hydrogenation of CO2 to methanol.

Nomaan M Rezayee et al.

Journal of the American Chemical Society, 137(3), 1028-1031 (2015-01-17)

This Communication describes the hydrogenation of carbon dioxide to methanol via tandem catalysis with dimethylamine and a homogeneous ruthenium complex. Unlike previous examples with homogeneous catalysts, this CO2-to-CH3OH process proceeds under basic reaction conditions. The dimethylamine is proposed to play

The urinary proteome and metabonome differ from normal in adults with mitochondrial disease.

Andrew M Hall et al.

Kidney international, 87(3), 610-622 (2014-09-11)

We studied the extent and nature of renal involvement in a cohort of 117 adult patients with mitochondrial disease, by measuring urinary retinol-binding protein (RBP) and albumin; established markers of tubular and glomerular dysfunction, respectively. Seventy-five patients had the m.3243A>G

Simultaneous quantification of 21 water soluble vitamin circulating forms in human plasma by liquid chromatography-mass spectrometry.

Karine Meisser Redeuil et al.

Journal of chromatography. A, 1422, 89-98 (2015-11-03)

This manuscript reports a validated analytical approach for the quantification of 21 water soluble vitamins and their main circulating forms in human plasma. Isotope dilution-based sample preparation consisted of protein precipitation using acidic methanol enriched with stable isotope labelled internal

Enantioseparation of pyroglutamide derivatives on polysaccharide based chiral stationary phases by high-performance liquid chromatography and supercritical fluid chromatography: a comparative study.

Davy Baudelet et al.

Journal of chromatography. A, 1363, 257-269 (2014-07-21)

Analytical enantioseparation of three pyroglutamide derivatives with pharmacological activity against the purinergic receptor P2X7, was run in both high-performance liquid chromatography and supercritical fluid chromatography. Four polysaccharide based chiral stationary phases, namely amylose and cellulose tris (3,5-dimethylphenylcarbamate), amylose tris ((S)-α-methylbenzylcarbamate)

Ion mobility spectrometry evaluation of cocaine occupational exposure in forensic laboratories.

Sergio Armenta et al.

Talanta, 130, 251-258 (2014-08-28)

An approach, based on ion mobility spectrometry (IMS) has been developed for the control of cocaine in air of the breathing zone of operators, in laboratory surfaces and in nasal mucus of employees to evaluate cocaine exposure in a forensic

Inhibition of IL-6/STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian cancer cells.

Young-Ah Suh et al.

International journal of oncology, 46(3), 1405-1411 (2014-12-30)

Ovarian cancer is the number one cause of death from gynaecological malignancy. Platinum-based and taxol-based chemotherapy has been used as a standard therapy, but intrinsic and acquired resistance to chemotherapy is a major obstacle to treat the disease. In the

Global metabolomic profiling of acute myocarditis caused by Trypanosoma cruzi infection.

Núria Gironès et al.

PLoS neglected tropical diseases, 8(11), e3337-e3337 (2014-11-21)

Chagas disease is caused by Trypanosoma cruzi infection, being cardiomyopathy the more frequent manifestation. New chemotherapeutic drugs are needed but there are no good biomarkers for monitoring treatment efficacy. There is growing evidence linking immune response and metabolism in inflammatory

Effect of feeding on the pharmacokinetics of oral minocycline in healthy research dogs.

Melanie L Hnot et al.

Veterinary dermatology, 26(6), 399-405 (2015-08-19)

The effect of food on minocycline oral absorption in dogs is unknown. The objective was to determine the pharmacokinetics of minocycline after administration of a single oral dose in fed and fasted dogs. Ten research hounds were administered oral minocycline

Methanol.

R Von Burg

Journal of applied toxicology : JAT, 14(4), 309-313 (1994-07-01)

Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes.

J P Webber et al.

Oncogene, 34(3), 290-302 (2014-01-21)

Activation of myofibroblast rich stroma is a rate-limiting step essential for cancer progression. The responsible factors are not fully understood, but TGFβ1 is probably critical. A proportion of TGFβ1 is associated with extracellular nano-vesicles termed exosomes, secreted by carcinoma cells

Accumulation of 19 environmental phenolic and xenobiotic heterocyclic aromatic compounds in human adipose tissue.

Lei Wang et al.

Environment international, 78, 45-50 (2015-03-10)

The extensive use of environmental phenols (e.g., bisphenol A) and heterocyclic aromatic compounds (e.g., benzothiazole) in consumer products as well as widespread exposure of humans to these compounds have been well documented. Biomonitoring studies have used urinary measurements to assess

Textiles with gallic acid microspheres: in vitro release characteristics.

Meritxell Martí et al.

Journal of microencapsulation, 31(6), 535-541 (2014-04-05)

Abstract The aim of this study was to demonstrate the skin penetration of an antioxidant, gallic acid (GA), encapsulated in poly-ε-caprolactone (PCL) microspheres and applied onto textile fabrics, by a specific in vitro percutaneous absorption methodology. Two techniques (particle size

Integrated pharmacokinetics of five protoberberine-type alkaloids in normal and insomnic rats after single and multiple oral administration of Jiao-Tai-Wan.

Wei He et al.

Journal of ethnopharmacology, 154(3), 635-644 (2014-05-13)

Jiao-Tai-Wan (JTW), an important herbal formula consists of Rhizoma coptidis and Cortex cinnamomi powder, is a famous prescription which has been used for centuries to treat insomnia in Traditional Chinese Medicine. The purpose of this study is to compare the

Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging Agents.

Sarah R Sabir et al.

PloS one, 10(10), e0140975-e0140975 (2015-10-27)

The Nek11 kinase is a potential mediator of the DNA damage response whose expression is upregulated in early stage colorectal cancers (CRCs). Here, using RNAi-mediated depletion, we examined the role of Nek11 in HCT116 WT and p53-null CRC cells exposed

Lyophilized silica lipid hybrid (SLH) carriers for poorly water-soluble drugs: physicochemical and in vitro pharmaceutical investigations.

Rokhsana Yasmin et al.

Journal of pharmaceutical sciences, 103(9), 2950-2959 (2014-03-04)

Lyophilization was investigated to produce a powdery silica-lipid hybrid (SLH) carrier for oral delivery of poorly water-soluble drugs. The silica to lipid ratio, incorporation of cryoprotectant, and lipid loading level were investigated as performance indicators for lyophilized SLH carriers. Celecoxib

Assessment of toxic effects of the methanol extract of Citrus macroptera Montr. Fruit via biochemical and hematological evaluation in female Sprague-Dawley rats.

Nizam Uddin et al.

PloS one, 9(11), e111101-e111101 (2014-11-05)

Citrus macroptera Montr. (C. macroptera) is locally known as Satkara. The fruit of this plant is used as appetite stimulant and in the treatment of fever. This study therefore aimed to evaluate the toxic effects of the fruit extract using

Structure-activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors.

Son T Nguyen et al.

Bioorganic & medicinal chemistry, 23(9), 2024-2034 (2015-03-31)

Recently we described a novel pyranopyridine inhibitor (MBX2319) of RND-type efflux pumps of the Enterobacteriaceae. MBX2319 (3,3-dimethyl-5-cyano-8-morpholino-6-(phenethylthio)-3,4-dihydro-1H-pyrano[3,4-c]pyridine) is structurally distinct from other known Gram-negative efflux pump inhibitors (EPIs), such as 1-(1-naphthylmethyl)-piperazine (NMP), phenylalanylarginine-β-naphthylamide (PAβN), D13-9001, and the pyridopyrimidine derivatives. Here

Phenolic compounds and expression of 4CL genes in silver birch clones and Pt4CL1a lines.

Suvi Sutela et al.

PloS one, 9(12), e114434-e114434 (2014-12-17)

A small multigene family encodes 4-coumarate:CoA ligases (4CLs) catalyzing the CoA ligation of hydroxycinnamic acids, a branch point step directing metabolites to a flavonoid or monolignol pathway. In the present study, we examined the effect of antisense Populus tremuloides 4CL

Polyvinylpyrrolidone oral films of enrofloxacin: film characterization and drug release.

G Prem Kumar et al.

International journal of pharmaceutics, 471(1-2), 146-152 (2014-05-27)

Enrofloxacin is a fluoroquinolone derivative used for treating urinary tract, respiratory and skin infections in animals. However, low solubility and low bioavailability prevented it from using on humans. Polyvinylpyrrolidone (PVP) is an inert, non toxic polymer with excellent hydrophilic properties

Preparative separation and identification of novel subsidiary colors of the color additive D&C Red No. 33 (Acid Red 33) using spiral high-speed counter-current chromatography.

Adrian Weisz et al.

Journal of chromatography. A, 1380, 120-129 (2015-01-17)

Three low-level subsidiary color impurities (A, B, and C) often present in batches of the color additive D&C Red No. 33 (R33, Acid Red 33, Colour Index No. 17200) were separated from a portion of R33 by spiral high-speed counter-current

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