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Showing 31-49 of 49 results for "439770" within Papers
Lillian Zhang et al.
The Journal of toxicological sciences, 37(2), 447-453 (2012-04-03)
Liver toxicity is a side effect observed with some herbal treatments, including Piper methysticum. The possible mechanisms responsible include inflammation subsequent to activation of liver macrophages and oxidative damage. Hepatotoxicity of the pharmacologically active component of Piper methysticum (kavalactones) was
Qian Wang et al.
Clinical science (London, England : 1979), 127(2), 91-100 (2014-01-22)
GdCl3 (gadolinium chloride) has been shown to reduce blood glucose; however, the underlying mechanism remains unclear. Liver gluconeogenesis is an important pathway involved in the maintenance of glucose homoeostasis. The aim of the present study was to investigate the role
Elida Amaya et al.
Molecular biology of the cell, 30(18), 2377-2398 (2019-07-19)
Zonula occludens-2 (ZO-2) is a tight junction (TJ) cytoplasmic protein, whose localization varies according to cell density and Ca2+ in the media. In cells cultured in low calcium (LC), ZO-2 displays a diffuse cytoplasmic distribution, but activation of the Ca2+
Tian-Dong Leng et al.
CNS neuroscience & therapeutics, 21(3), 252-261 (2014-12-03)
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor with a dismal prognosis. Despite intensive study on tumor biology, the underlying mechanisms of the unlimited proliferation and progressive local invasion are still poorly understood, and no effective
Quirin Zangl et al.
Anesthesiology, 121(6), 1217-1225 (2014-09-17)
Liver damage by ischemia and reperfusion injury is a risk factor for morbidity and mortality after liver surgery. Postoperative oxygen treatment is routinely applied in the postanesthesia and intensive care unit after liver surgery. The risks of aggravating the injury
Michele Biagioli et al.
Journal of immunology (Baltimore, Md. : 1950), 204(9), 2535-2551 (2020-03-28)
Drug-induced liver injury caused by acetaminophen (acetyl-para-aminophenol [APAP]) is the main cause of acute liver failure and liver transplantation in several Western countries. Whereas direct toxicity exerted by APAP metabolites is a key determinant for early hepatocytes injury, the recruitment
Sébastien Hayoz et al.
BMC neuroscience, 13, 53-53 (2012-05-30)
ATP is an extracellular signaling molecule with many ascribed functions in sensory systems, including the olfactory epithelium. The mechanism(s) by which ATP is released in the olfactory epithelium has not been investigated. Quantitative luciferin-luciferase assays were used to monitor ATP
Tingting Li et al.
Molecular immunology, 53(4), 414-420 (2012-10-30)
The calcium-sensing receptor (CaSR) has been reported to play an important role in many tissues and organs. However, studies about the expression and function of CaSR in T lymphocytes are still not very lucid. In this study, we investigated the
Xuemei Fang et al.
Archives of toxicology, 86(10), 1515-1525 (2012-06-01)
Kupffer cells (KCs) have been demonstrated to play a role in the regulation of intra-hepatic lipid metabolism through the synthesis and secretion of biologically active products. The involvement of KCs in the disturbance of lipid metabolism that induced by perfluorononanoic
Monique Michels et al.
Clinical science (London, England : 1979), 134(7), 765-776 (2020-03-29)
In order to modulate microglial phenotypes in vivo, M1 microglia were depleted by administration of gadolinium chloride and the expression of M2 microglia was induced by IL-4 administration in an animal model of sepsis to better characterize the role of
C Jones et al.
International journal of surgery (London, England), 11(1), 46-51 (2012-11-22)
Depletion of Kupffer cells by gadolinium chloride (GdCl(3)) reduces the systemic response during sepsis. The study aim was to investigate the effect of this depletion on hepatic proinflammatory cytokine response to portal endotoxaemia. Sixteen Wistar rats were randomised to receive
Durga Attili et al.
Biological trace element research, 150(1-3), 467-476 (2012-09-26)
Gadolinium, a member of the lanthanoid family of transition metals, interacts with calcium-binding sites on proteins and other biological molecules. The overall goal of the present investigation was to determine if gadolinium could enhance calcium-induced epithelial cell growth inhibition in
Lili Chen et al.
Hepato-gastroenterology, 59(116), 1208-1212 (2012-02-14)
To address the impact of Kupffer cell ablation via intraperitoneal injection of gadolinium chloride (GdCl3) on hepatosteatosis, intrahepatic inflammation and other metabolic derangements induced by high-fat diet (HFD). C57/BCL male mice were fed with either standard normal diet or HFD.
Xiaojuan Chai et al.
Nature communications, 6, 7979-7979 (2015-08-11)
Sepsis is the host's deleterious systemic inflammatory response to microbial infections. Here we report an essential role for the oestrogen sulfotransferase (EST or SULT1E1), a conjugating enzyme that sulfonates and deactivates estrogens, in sepsis response. Both the caecal ligation and
Christopher C Wong et al.
Acta oto-laryngologica, 133(1), 22-27 (2012-09-21)
The use of both gadolinium chloride (GdCl(3)) and osmium tetroxide (OsO(4)) allowed for the visualization of the membranous labyrinth and other intralabyrinthine structures, at different intensities, as compared with the control sample. This initial comparison shows the advantages of GdCl(3)
Mohammad Mehdi Maneshi et al.
Journal of neurotrauma, 32(13), 1020-1029 (2014-12-03)
Traumatic brain injury (TBI) refers to brain damage resulting from external mechanical force, such as a blast or crash. Our current understanding of TBI is derived mainly from in vivo studies that show measurable biological effects on neurons sampled after
Tanya Duke-Novakovski et al.
Cell and tissue research, 351(1), 149-160 (2012-10-18)
Pulmonary intravascular macrophages (PIMs) are present in species such as cattle, sheep and horse and promote acute lung inflammation (ALI). Rabbits are often used as a model of ALI but there is controversy about the presence of PIMs in these
Yan Yang et al.
European journal of immunology, 44(8), 2468-2477 (2014-04-30)
Basophils have been shown to contribute to anaphylaxis through either an IgE-FcεRI-dependent pathway or an IgG-FcγR pathway. However, it remains largely unclear whether basophils can be activated to promote anaphylaxis via a non-FcR pathway as well. The glycolipid receptor ASGM1
Christopher G J McKenzie et al.
Blood, 123(22), 3496-3503 (2014-03-19)
Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related mortality and can occur with any type of transfusion. TRALI is thought to be primarily mediated by donor antibodies activating recipient neutrophils resulting in pulmonary endothelial damage. Nonetheless, details
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