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Showing 1-30 of 3888 results for "449172" within Papers
Tuyen Thi Ngoc Tran et al.
Bioorganic & medicinal chemistry, 22(18), 5110-5116 (2014-02-18)
Natural products represent compound classes with high chemical and structural diversity and various biological activities. Libraries based on natural products are valuable starting point in the search for novel biologically active substances. Here we report on the identification of the
Harindranath Kadavath et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(24), 7501-7506 (2015-06-03)
The structure, dynamic behavior, and spatial organization of microtubules are regulated by microtubule-associated proteins. An important microtubule-associated protein is the protein Tau, because its microtubule interaction is impaired in the course of Alzheimer's disease and several other neurodegenerative diseases. Here
J H Foley et al.
Journal of thrombosis and haemostasis : JTH, 13(4), 610-618 (2015-01-06)
The plasmin(ogen) and complement systems are simultaneously activated at sites of tissue injury, participating in hemostasis, wound healing, inflammation and immune surveillance. In particular, the C3 proteolytic fragment, iC3b, and its degradation product C3dg, which is generated by cleavage by
Zi-Zhen Zhang et al.
Molecular cancer therapeutics, 14(5), 1162-1170 (2015-01-24)
The objective of this study was to evaluate the role of HOTAIR long noncoding RNA in gastric cancer metastasis. We analyzed HOTAIR expression levels by real-time reverse transcription PCR and Northern blot analysis in 100 gastric tissues (50 gastric cancer
Rajnish Prakash Singh et al.
Journal of plant physiology, 184, 57-67 (2015-07-29)
Plant-growth-promoting bacteria (PGPB) with 1-aminocyclopropane-1-carboxylatedeaminase (ACCD) activity can protect plants from the deleterious effects of abioticstressors. An ACCD bacterial strain, SBP-8, identified as Klebsiella sp., also having other plant-growth-promoting activities, was isolated from Sorghum bicolor growing in the desertregion of
Yan Huang et al.
PloS one, 10(7), e0131053-e0131053 (2015-07-02)
Cronobacter spp. are emerging food-borne pathogens and have been identified as causative agents of meningitis and necrotizing enterocolitis in infants. Dehydrated rice is popular with a wide range of people and it is frequently used as a substitute for infant
Ru-Juan Zuo et al.
The Journal of biological chemistry, 290(35), 21280-21291 (2015-07-17)
Decidualization is an essential process of maternal endometrial stromal cells to support pregnancy. Although it is known that enhanced glucose influx is critical for decidualization, the underlying mechanism in regulating glucose metabolism in decidua remains insufficiently understood. Here, we demonstrate
Loek R van der Kallen et al.
PloS one, 10(5), e0127163-e0127163 (2015-05-21)
Axonal regeneration after injury requires the coordinated expression of genes in injured neurons. We previously showed that either reducing expression or blocking function of the transcriptional repressor NFIL3 activates transcription of regeneration-associated genes Arg1 and Gap43 and strongly promotes axon
Wei Fu et al.
BMC cancer, 14, 463-463 (2014-06-24)
Aberrantly activated Notch signaling has been found in more than 50% of patients with T-cell acute lymphoblastic leukemia (T-ALL). Current strategies that employ γ-secretase inhibitors (GSIs) to target Notch activation have not been successful. Many limitations, such as non-Notch specificity
Mithalesh Kumar Singh et al.
Pathology oncology research : POR, 21(4), 1237-1242 (2015-06-30)
HMGB1 is considered to be DNA chaperone as it binds without any specificity. It is the structural protein which alters nuclear homeostasis and genomic stability of chromatin. Its role in retinoblastoma (Rb) remains unclear. The aim of the present study
Iván Prieto-Potin et al.
BMC musculoskeletal disorders, 16, 226-226 (2015-08-28)
Multinucleated giant cells have been noticed in diverse arthritic conditions since their first description in rheumatoid synovium. However, their role in the pathogenesis of osteoarthritis (OA) or rheumatoid arthritis (RA) still remains broadly unknown. We aimed to study the presence
Laura J Sherrard et al.
The Journal of antimicrobial chemotherapy, 69(10), 2690-2698 (2014-06-12)
To investigate mechanisms of reduced susceptibility to commonly used antibiotics in Prevotella cultured from patients with cystic fibrosis (CF), patients with invasive infection and healthy control subjects and to determine whether genotype can be used to predict phenotypic resistance. The
Thorsten Langner et al.
Eukaryotic cell, 14(9), 846-857 (2015-05-03)
Chitin is an essential component of the fungal cell wall, providing rigidity and stability. Its degradation is mediated by chitinases and supposedly ensures the dynamic plasticity of the cell wall during growth and morphogenesis. Hence, chitinases should be particularly important
Thibault G Sana et al.
mBio, 6(3), e00712-e00712 (2015-06-04)
Invasion of nonphagocytic cells through rearrangement of the actin cytoskeleton is a common immune evasion mechanism used by most intracellular bacteria. However, some pathogens modulate host microtubules as well by a still poorly understood mechanism. In this study, we aim
Bi-Tzen Juang et al.
Human molecular genetics, 23(18), 4945-4959 (2014-05-14)
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a severe neurodegenerative disorder that affects carriers of premutation CGG-repeat expansion alleles of the fragile X mental retardation 1 (FMR1) gene; current evidence supports a causal role of the expanded CGG repeat within the
Yanfei Zhang et al.
Microbial cell factories, 14, 86-86 (2015-06-14)
The overexpression of key enzymes in a metabolic pathway is a frequently used genetic engineering strategy for strain improvement. Metabolic control analysis has been proposed to quantitatively determine key enzymes. However, the lack of quality data often makes it difficult
Divya Pathak et al.
The Journal of biological chemistry, 290(37), 22325-22336 (2015-07-02)
Synaptic mitochondria are thought to be critical in supporting neuronal energy requirements at the synapse, and bioenergetic failure at the synapse may impair neural transmission and contribute to neurodegeneration. However, little is known about the energy requirements of synaptic vesicle
Chunfeng Wang et al.
Pharmaceutical biology, 53(3), 451-456 (2014-12-05)
Given that Pinus massoniana Lamb (Pinaceae) bark extract (PMBE) is a safe and non-toxic flavonoid found abundantly in nature, it was considered a promising novel candidate agent in the treatment of virus infection. Experiments were conducted to assay the antiviral
Apilak Wutthisathapornchai et al.
PloS one, 9(7), e102730-e102730 (2014-07-24)
Pyruvate carboxylase (PC) is an anaplerotic enzyme that regulates glucose-induced insulin secretion in pancreatic islets. Dysregulation of its expression is associated with type 2 diabetes. Herein we describe the molecular mechanism underlying the glucose-mediated transcriptional regulation of the PC gene.
Fumio Nakamura et al.
Nature communications, 5, 5325-5325 (2014-11-02)
Reorganization of the actin cytoskeleton is an early cellular response to various extracellular signals. Sema3A, a repulsive axon guidance molecule, induces the reorganization of actin cytoskeleton in the growth cones. Collapsin response mediator protein 1 (CRMP1) mediates the intracellular Sema3A
Rosalyn R Ram et al.
Molecular and cellular biology, 34(12), 2350-2358 (2014-04-16)
The RASSF1A gene is one of the most frequently inactivated genes in over 30 different types of cancers (H. Donninger, M. D. Vos, and G. J. Clark, J. Cell Sci. 120:3163-3172, 2007, http://dx.doi.org/10.1242/jcs.010389). Despite the prevalence of RASSF1A silencing in
Sandra Murphy et al.
Biology, 4(2), 397-423 (2015-06-13)
In skeletal muscle, the dystrophin-glycoprotein complex forms a membrane-associated assembly of relatively low abundance, making its detailed proteomic characterization in normal versus dystrophic tissues technically challenging. To overcome this analytical problem, we have enriched the muscle membrane fraction by a
Ömer Poyraz et al.
PloS one, 10(3), e0121494-e0121494 (2015-03-26)
In Mycobacterium tuberculosis the sulfate activating complex provides a key branching point in sulfate assimilation. The complex consists of two polypeptide chains, CysD and CysN. CysD is an ATP sulfurylase that, with the energy provided by the GTPase activity of
Sara Karami et al.
Epigenetics, 10(4), 282-292 (2015-02-04)
Higher levels of LINE1 methylation in blood DNA have been associated with increased kidney cancer risk using post-diagnostically collected samples; however, this association has never been examined using pre-diagnostic samples. We examined the association between LINE1 %5mC and renal cell
Myriam M Chaumeil et al.
Cancer research, 74(16), 4247-4257 (2014-05-31)
Mutations of the isocitrate dehydrogenase 1 (IDH1) gene are among the most prevalent in low-grade glioma and secondary glioblastoma, represent an early pathogenic event, and are associated with epigenetically driven modulations of metabolism. Of particular interest is the recently uncovered
Mirella Vivoli et al.
IUCrJ, 1(Pt 1), 28-38 (2014-07-31)
Capsular polysaccharides (CPSs) are protective structures on the surfaces of many Gram-negative bacteria. The principal CPS of the human pathogen and Tier 1 select agent Burkholderia pseudomallei consists of a linear repeat of --3)--2-O-acetyl-6-deoxy-β-d-manno-heptopyranose-(1-. This CPS is critical to the
JeenJoo S Kang et al.
Quarterly reviews of biophysics, 48(4), 453-464 (2015-11-06)
Means to cause an immunogenic cell death could lead to significant insight into how cancer escapes immune control. In this study, we screened a library of five pyrrole-imidazole polyamides coding for different DNA sequences in a model of B-cell lymphoma
Rebekah Baskin et al.
Scientific reports, 5, 17367-17367 (2015-11-28)
Glioma is the most common malignant primary brain tumor and is associated with poor prognosis. Genetic factors contributing to glioma risk have recently been investigated through genome-wide association studies (GWAS), implicating seven independent glioma risk loci in six chromosomal regions.
Melannie Alexander et al.
Oncology reports, 33(2), 935-941 (2014-12-17)
Clock genes are expressed in a self-perpetuating, circadian pattern in virtually every tissue including the human gastrointestinal tract. They coordinate cellular processes critical for tumor development, including cell proliferation, DNA damage response and apoptosis. Circadian rhythm disturbances have been associated
Pietro Mesirca et al.
Nature communications, 5, 4664-4664 (2014-08-22)
The mechanisms underlying cardiac automaticity are still incompletely understood and controversial. Here we report the complete conditional and time-controlled silencing of the 'funny' current (If) by expression of a dominant-negative, non-conductive HCN4-channel subunit (hHCN4-AYA). Heart-specific If silencing caused altered [Ca(2+)]i
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