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Showing 1-30 of 698 results for "450243" within Papers
Philip M Tedeschi et al.
Molecular pharmacology, 88(4), 720-727 (2015-07-30)
NAD(+) kinase (NADK) is the only known cytosolic enzyme that converts NAD(+) to NADP(+), which is subsequently reduced to NADPH. The demand for NADPH in cancer cells is elevated as reducing equivalents are required for the high levels of nucleotide
Chanyu Yue et al.
Cancer immunology research, 3(8), 864-870 (2015-05-31)
One of the obstacles for cancer immunotherapy is the inefficiency of CD8(+) T-cell recruitment to tumors. STAT3 has been shown to suppress CD8(+) T-cell antitumor functions in various cancer models, in part by restricting accumulation of CD8(+) T cells. However
Divya Pathania et al.
British journal of pharmacology, 172(1), 50-63 (2014-07-23)
Pancreatic cancer is characterized by alterations in several key signalling proteins, including increased expression and activity of the Src tyrosine kinase and focal adhesion kinase (FAK), which have been linked to its chemoresistance. Sustained Src inhibition reactivates survival pathways regulated
Béatrice Dirat et al.
Molecular cancer therapeutics, 14(2), 586-596 (2014-12-21)
Cell migration is a critical step in the progression of prostate cancer to the metastatic state, the lethal form of the disease. The antidiabetic drug metformin has been shown to display antitumoral properties in prostate cancer cell and animal models;
Filippa Fleetwood et al.
Scientific reports, 4, 7518-7518 (2014-12-18)
Angiogenesis plays an important role in cancer and ophthalmic disorders such as age-related macular degeneration and diabetic retinopathy. The vascular endothelial growth factor (VEGF) family and corresponding receptors are regulators of angiogenesis and have been much investigated as therapeutic targets.
Songtae Kim et al.
Pancreas, 43(6), 886-890 (2014-04-11)
The aim of this study was to investigate the synergistic inhibitory effects of gemcitabine and losartan, angiotensin II type 1 (AT1) receptor blockers, on an orthotopic rat pancreatic cancer model. The rat orthotopic pancreatic cancer model was prepared using DSL-6A/C
Hyung Joon Kim et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(44), 14872-14884 (2015-11-06)
RE-1 silencing transcription factor (REST), a master negative regulator of neuronal differentiation, controls neurogenesis by preventing the differentiation of neural stem cells. Here we focused on the role of REST in the early steps of differentiation and maturation of adult
Stefan Niekamp et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(10), 4275-4284 (2019-02-17)
Light microscopy is a powerful tool for probing the conformations of molecular machines at the single-molecule level. Single-molecule Förster resonance energy transfer can measure intramolecular distance changes of single molecules in the range of 2 to 8 nm. However, current
Céline Schwalm et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(8), 3515-3526 (2015-05-10)
In humans, nutrient deprivation and extreme endurance exercise both activate autophagy. We hypothesized that cumulating fasting and cycling exercise would potentiate activation of autophagy in skeletal muscle. Well-trained athletes were divided into control (n = 8), low-intensity (LI, n =
Daniel J Smit et al.
Cells, 9(9) (2020-09-24)
Circulating tumor cells (CTCs) are cells shed from the primary tumor into the bloodstream. While many studies on solid tumor cells exist, data on CTCs are scarce. The mortality of cancer is mostly associated with metastasis and recent research identified
Lin Sha et al.
Clinical and experimental medicine, 15(1), 55-64 (2014-08-02)
The function of the epithelial-to-mesenchymal transition (EMT) during hepatocellular carcinoma (HCC) progression is well established. However, the regulatory mechanisms modulating this phenomenon remain unclear. Homeobox B9 (HOXB9) has been proposed as an oncogene in many cancer developments, but its function
Marina Campos Rocha et al.
PloS one, 10(8), e0135195-e0135195 (2015-08-22)
Aspergillus fumigatus is an opportunistic human pathogen, which causes the life-threatening disease, invasive pulmonary aspergillosis. In fungi, cell wall homeostasis is controlled by the conserved Cell Wall Integrity (CWI) pathway. In A. fumigatus this signaling cascade is partially characterized, but
Masato Terashima et al.
SpringerPlus, 3, 417-417 (2014-08-21)
Triple-negative breast cancer (TNBC) is associated with a higher incidence of recurrence and distant metastasis and a poor prognosis, whereas effective treatment strategies remain to be established. Finding an effective treatment for TNBC has become imperative. We examined the effect
Alastair Khodabukus et al.
Journal of cellular physiology, 230(10), 2489-2497 (2015-04-11)
The role of factors such as frequency, contraction duration and active time in the adaptation to chronic low-frequency electrical stimulation (CLFS) is widely disputed. In this study we explore the ability of contraction duration (0.6, 6, 60, and 600 sec) to
Nikos Koundouros et al.
Cell, 181(7), 1596-1611 (2020-06-20)
Oncogenic transformation is associated with profound changes in cellular metabolism, but whether tracking these can improve disease stratification or influence therapy decision-making is largely unknown. Using the iKnife to sample the aerosol of cauterized specimens, we demonstrate a new mode
Nathali Kaushansky et al.
The Journal of biological chemistry, 290(24), 15260-15278 (2015-04-26)
Gene-wide association and candidate gene studies indicate that the greatest effect on multiple sclerosis (MS) risk is driven by the HLA-DRB1*15:01 allele within the HLA-DR15 haplotype (HLA-DRB1*15:01-DQA1*01:02-DQB1*0602-DRB5*01:01). Nevertheless, linkage disequilibrium makes it difficult to define, without functional studies, whether the
Rosa Fernandes et al.
Canadian journal of physiology and pharmacology, 92(12), 1037-1043 (2014-11-19)
Insulin resistance, a key feature of obesity, metabolic syndrome, and type 2 diabetes mellitus (T2DM), results in a variety of metabolic and vascular abnormalities. Metabolic disturbances associated with diabetes could contribute to disrupting the structural and (or) functional integrity of
Yanyan Yang et al.
Journal of ethnopharmacology, 154(1), 218-228 (2014-04-17)
Korean Red Ginseng (KRG) is one of the representative traditional herbal medicines prepared from Panax ginseng Meyer (Araliaceae) in Korea. It has been reported that KRG exhibits a lot of different biological actions such as anti-aging, anti-fatigue, anti-stress, anti-atherosclerosis, anti-diabetic
Céline Loinard et al.
Circulation. Cardiovascular genetics, 7(6), 799-805 (2014-09-02)
Vascular aneurysm is an abnormal local dilatation of an artery that can lead to vessel rupture and sudden death. The only treatment involves surgical or endovascular repair or exclusion. There is currently no approved medical therapy for this condition. Recent
Caroline M Weight et al.
Microbes and infection, 17(10), 698-709 (2015-07-18)
Toxoplasma gondii is an obligate intracellular parasite infecting one third of the world's population. The small intestine is the parasite's primary route of infection, although the pathway of epithelium transmigration remains unclear. Using an in vitro invasion assay and live
Shinji Hayano et al.
Journal of molecular and cellular cardiology, 88, 55-63 (2015-09-24)
Myocardial infarction is a leading cause of death, and cardiac rupture following myocardial infarction leads to extremely poor prognostic feature. A large body of evidence suggests that Akt is involved in several cardiac diseases. We previously reported that Akt-mediated Girdin
Stephen P McAdoo et al.
Kidney international, 88(1), 52-60 (2015-02-26)
Spleen tyrosine kinase (SYK) is an important component of the intracellular signaling pathway for various immunoreceptors. Inhibition of SYK has shown promise in preclinical models of autoimmune and glomerular disease. However, the description of SYK expression in human renal tissue
Francisco A Aguilar-Alonso et al.
Molecular and cellular biochemistry, 404(1-2), 161-170 (2015-03-01)
Renal cell carcinoma (RCC) is asymptomatic at early stages, and thus, initial diagnosis frequently occurs at advanced or even metastatic stages, leading to a high rate of mortality. Ferric nitrilotriacetate (FeNTA)-induced RCC model is a useful tool to analyze molecular
Siddappa Manjunath et al.
Veterinary research, 46, 15-15 (2015-04-02)
Peste des petits ruminants (PPR), is an acute transboundary viral disease of economic importance, affecting goats and sheep. Mass vaccination programs around the world resulted in the decline of PPR outbreaks. Sungri 96 is a live attenuated vaccine, widely used
Hongjie Wang et al.
Molecular neurobiology, 58(5), 2269-2283 (2021-01-09)
Nonamyloidogenic processing of amyloid precursor protein (APP) by augmenting ADAM10 is a promising therapeutic strategy for Alzheimer's disease (AD). Therefore identification of molecular pathways that regulate ADAM10 expression is crucial. Autophagy is strongly dysregulated in AD, and TFEB was recently
Matthew C Walsh et al.
Journal of immunology (Baltimore, Md. : 1950), 193(8), 3992-4001 (2014-09-10)
Naive T cell populations are maintained in the periphery at relatively constant levels via mechanisms that control expansion and contraction and are associated with competition for homeostatic cytokines. It has been shown that in a lymphopenic environment naive T cells
Meghana Gupta et al.
The Journal of biological chemistry, 289(24), 17195-17202 (2014-04-30)
Rho GTPases are molecular "switches" that cycle between "on" (GTP-bound) and "off" (GDP-bound) states and regulate numerous cellular activities such as gene expression, protein synthesis, cytoskeletal rearrangements, and metabolic responses. Dysregulation of GTPases is a key feature of many diseases
Manish Dixit et al.
Bioorganic & medicinal chemistry letters, 15(14), 3394-3397 (2005-06-14)
Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Studies have shown that PTP1B knock-out mice showed increased insulin sensitivity in muscle and liver as well
Pietro Rizza et al.
Breast cancer research : BCR, 16(1), R21-R21 (2014-02-21)
The two isoforms of estrogen receptor (ER) alpha and beta play opposite roles in regulating proliferation and differentiation of breast cancers, with ER-alpha mediating mitogenic effects and ER-beta acting as a tumor suppressor. Emerging data have reported that androgen receptor
Caroline Measso do Bonfim et al.
PloS one, 10(7), e0132325-e0132325 (2015-07-08)
A significant proportion of recurrent respiratory papillomatosis (RRP) is caused by human papillomavirus type 6 (HPV-6). The long control region (LCR) contains cis-elements for regulation of transcription. Our aim was to characterize LCR HPV-6 variants in RRP cases, compare promoter
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