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Showing 1-30 of 40 results for "45368" within Papers
Jie Lin et al.
Journal of natural products, 73(5), 905-910 (2010-04-23)
The new polyketides leptosphaerins A-G (1-7) and the known compounds monodictysin B (8), 2-(2,6-dihydroxybenzoyl)-3-hydroxy-5-methylbenzoic acid (9), and 2-(2,6-dihydroxy-4-methylbenzoyl)-6-hydroxybenzoic acid (10) have been isolated from solid cultures of the ascomycete fungus Leptosphaeria sp. The absolute configurations of compounds 1, 2, and
Xiangxiang Jin et al.
Environmental science and pollution research international, 20(9), 6282-6289 (2013-04-17)
The effect of coexisting pesticide on adsorption/desorption and mobility of another one was investigated with carbendazim (CBD), imidacloprid (IDP), and atrazine (ATR). The data indicated that adsorption of CBD, ATR, and IDP on the tested soil was fitted well by
Natarajan Arumugam et al.
Bioorganic & medicinal chemistry letters, 22(3), 1375-1379 (2012-01-11)
A facile and efficient synthesis of novel chromeno[4,3-b]pyrroles has been accomplished by intramolecular 1,3-dipolar cycloaddition which on subsequent Pictet-Spengler cyclisation in presence of p-toluenesulfonic acid yielded indolizino[6,7-b]indoles. The synthesized chromenopyrroles and indolizinoindoles were evaluated for their antimicrobial and antioxidant activities.
Rolf Schiffmann et al.
Journal of medicinal chemistry, 49(2), 511-522 (2006-01-20)
We report the discovery of thiabendazole as a potent inhibitor (K(i) = 0.4 microM) of Escherichia coli methionine aminopeptidase (ecMetAP) and the synthesis and pharmacological evaluation of thiabendazole congeners with activity in the upper nanomolar range. Elucidation of the X-ray
Natarajan Arumugam et al.
Bioorganic & medicinal chemistry letters, 20(12), 3698-3702 (2010-05-21)
Synthesis of novel beta-lactam fused spiroisoxazolidine chromanones and tetralones ring systems has been achieved by intermolecular 1,3-dipolar cycloaddition reaction of bicyclic nitrone with unusual dipolarophiles, arylidene chromanones/tetralones under different reaction conditions. The synthesized compounds were evaluated for antimicrobial activities. It
Subhamoy Dasgupta et al.
The Journal of clinical investigation, 125(3), 1174-1188 (2015-02-11)
Metabolic pathway reprogramming is a hallmark of cancer cell growth and survival and supports the anabolic and energetic demands of these rapidly dividing cells. The underlying regulators of the tumor metabolic program are not completely understood; however, these factors have
Nancy E McCarroll et al.
Mutation research, 512(1), 1-35 (2002-09-11)
The known aneuploidogens, benomyl and its metabolite, carbendazim (methyl 2-benzimidazole carbamate (MBC)), were selected for the third in a series of ongoing projects with selected pesticides. Mutagenicity and carcinogenicity data submitted to the US Environmental Protection Agency's (US EPA's) Office
R Suhas et al.
European journal of medicinal chemistry, 46(2), 704-711 (2011-01-08)
The peptides of elastin sequences chosen for the present study included tetrapeptides, pentapeptides and tricosapeptides (30 amino acids), synthesized by classical solution phase method and conjugated to [3-(4-piperidyl)-6-fluoro-1,2-benzisoxazole]. The structures of the compounds were confirmed by physical and spectroscopic techniques
Tessa Gargett et al.
Journal of immunotherapy (Hagerstown, Md. : 1997), 38(1), 12-23 (2014-11-22)
Cancer immunotherapy has long been used in the treatment of metastatic melanoma, and an anti-CTLA-4 monoclonal antibody treatment has recently been approved by the US Food and Drug Administration. Targeted therapies such as small molecule kinase inhibitors targeting deregulated mitogen-activated
Mihály Tapolyai et al.
Journal of clinical hypertension (Greenwich, Conn.), 16(12), 895-899 (2014-10-21)
The authors examined the relationship between thiazide-type diuretics and fluid spaces in a cohort of hypertensive patients in a retrospective study of 60 stable hypertensive patients without renal abnormalities who underwent whole-body bioimpedance analysis. Overhydration was greater in the diuretic
C A Van Gestel
Ecotoxicology and environmental safety, 23(2), 221-236 (1992-04-01)
To investigate whether results of laboratory toxicity tests with earthworms are capable of being used to predict effects in the field, a literature study was carried out. Benomyl, its metabolite carbendazim, carbofuran, and carbaryl were chosen as model substances. From
Christoph Thalhammer et al.
Nephrology (Carlton, Vic.), 20(2), 91-95 (2014-10-28)
Haemodynamic stability of patients during haemodialysis (HD) sessions is of pivotal importance and accurate determination of dry weight remains a challenge. Little information is available about central venous and aortic pressure during dialysis. In this pilot study we used a
S Purushothaman et al.
Bioorganic & medicinal chemistry letters, 20(24), 7288-7291 (2010-11-12)
Synthesis of a series of novel hexahydrochromenopyrrole analogues has been accomplished through an intramolecular 1,3-dipolar cycloaddition (1,3-DC reaction) of azomethine ylides, generated by the aldehyde induced decarboxylation of secondary amino acids. These compounds were screened for antibacterial and antifungal activities
Petra Hegerová et al.
Nutrition (Burbank, Los Angeles County, Calif.), 31(1), 166-170 (2014-12-04)
An acute disease is regularly associated with inflammation, decreased food intake, and low physical activity; the consequence is loss of muscle mass. However, the restoration of muscle tissue is problematic, especially in older patients. Loss of muscle mass leads to
Qiong Chen et al.
European journal of medicinal chemistry, 43(3), 595-603 (2007-07-10)
In order to search novel agrochemicals with higher antifungal activity, a series of new 1,2,4-triazolo[1,5-a]pyrimidine derivatives bearing 1,3,4-oxadiazole moieties were designed and synthesized. Their antifungal activities against Rhizoctonia solani were evaluated in vitro. By determining the EC(50) values of all
R Suhas et al.
European journal of medicinal chemistry, 48, 179-191 (2012-01-03)
Forty five new derivatives of ureas and thioureas were synthesized by the reaction of peptide conjugated heterocycles with isocyanates and isothiocyanates respectively. All the compounds have been characterized by IR, (1)H NMR, mass and elemental analysis. The compounds were evaluated
Magid A Fahim et al.
Clinical journal of the American Society of Nephrology : CJASN, 10(4), 620-629 (2015-02-26)
Monitoring N-terminal pro-B-type natriuretic peptide (NT-proBNP) may be useful for assessing cardiovascular risk in dialysis patients. However, its biologic variation is unknown, hindering the accurate interpretation of serial concentrations. The aims of this prospective cohort study were to estimate the
Synthesis of novel spiropyrrolizidines as potent antimicrobial agents for human and plant pathogens.
Govindasami Periyasami et al.
Bioorganic & medicinal chemistry letters, 18(7), 2342-2345 (2008-03-18)
A series of novel dispirooxindolopyrrolizidine derivatives have been synthesized through 1,3-dipolar cycloaddition reaction of azomethine ylide generated from proline and isatin with the dipolarophile (E)-2-arylidine-1-keto carbazoles. The synthesized cycloadducts were evaluated for antimicrobial activities. Compounds 7d and 7e showed relatively
Robert L Unckless et al.
PLoS genetics, 11(3), e1005030-e1005030 (2015-03-13)
Both malnutrition and undernutrition can lead to compromised immune defense in a diversity of animals, and "nutritional immunology" has been suggested as a means of understanding immunity and determining strategies for fighting infection. The genetic basis for the effects of
Ashley Parrott et al.
American journal of medical genetics. Part A, 167A(2), 363-370 (2014-11-28)
The 7q11.23 microduplication syndrome, caused by the reciprocal duplication of the Williams-Beuren syndrome deletion region, is a genomic disorder with an emerging clinical phenotype. Dysmorphic features, congenital anomalies, hypotonia, developmental delay highlighted by variable speech delay, and autistic features are
Ismail Kocyigit et al.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 34(7), 781-790 (2014-01-05)
In this study our aim was to evaluate the relationship between degree of fluid status and arterial stiffness measured by pulse wave velocity (PWV) in peritoneal dialysis (PD) patients. Fluid status was determined by different methods including fluid overload measured
Perumal Rajakumar et al.
European journal of medicinal chemistry, 44(7), 3040-3045 (2008-09-10)
A series of carbazole based macrocyclic diamides with thia and oxy linkages have been synthesized and the inhibitory activity of the cyclophane amides against human pathogenic bacteria and plant pathogenic fungi are documented. (S)-1,10-Bi-2-naphthol [(S)-BINOL] based chiral carbazolophane amide emerged
P Ahila Devi et al.
Environmental monitoring and assessment, 187(1), 4142-4142 (2014-11-20)
A supervised field trial was conducted at four different agroclimatic locations in India to evaluate the dissipation pattern and risk assessment of carbendazim and mancozeb in mango fruits following foliar application of mixed formulation of carbendazim 12% and mancozeb 63%
Natalie Kozyrev et al.
PloS one, 10(3), e0121130-e0121130 (2015-04-01)
Ejaculation is controlled by a spinal ejaculation generator located in the lumbosacral spinal cord, consisting in male rats of lumbar spinothalamic (LSt) cells and their inter-spinal projections to autonomic and motor centers. LSt cells co-express several neuropeptides, including gastrin releasing
Bin He et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(51), 18261-18266 (2014-12-10)
The androgen receptor (AR) is a key driver of prostate cancer (PC), even in the state of castration-resistant PC (CRPC) and frequently even after treatment with second-line hormonal therapies such as abiraterone and enzalutamide. The persistence of AR activity via
Przemyslaw Szafranski et al.
European journal of human genetics : EJHG, 23(2), 173-179 (2014-05-16)
Genomic copy-number variations (CNVs) constitute an important cause of epilepsies and other human neurological disorders. Recent advancement of technologies integrating genome-wide CNV mapping and sequencing is rapidly expanding the molecular field of pediatric neurodevelopmental disorders. In a previous study, a
Carolina Gracia-Iguacel et al.
Clinical nephrology, 82(4), 247-256 (2014-09-13)
End-stage renal disease (ESRD) conveys high mortality risk by complex mechanisms not fully elucidated but possibly linked to hormonal abnormalities, including cortisol. Whereas a high serum cortisol level has recently been linked with increased mortality in the general population, there
Sara C Novais et al.
Ecotoxicology (London, England), 23(7), 1220-1233 (2014-06-11)
The present study aimed to investigate the effects of dimethoate, atrazine and carbendazim on the antioxidant defences and neuronal function of the soil organism Enchytraeus albidus. Effects were studied at concentrations known to affect their reproduction (EC20, EC50 and EC90)
Zhiyi Yu et al.
European journal of medicinal chemistry, 44(11), 4726-4733 (2009-06-30)
A series of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7(1-piperazinyl)quinoline-3-carboxylic acid (norfloxacin) derivatives were prepared according to the principle of combinating bioactive substructures and tested for their activities against five plant pathogenic bacteria and three fungi in vitro. The preliminary bioassays indicated that almost all synthesized
Jingjing Li et al.
Molecular systems biology, 10, 774-774 (2015-01-01)
Autism is a complex disease whose etiology remains elusive. We integrated previously and newly generated data and developed a systems framework involving the interactome, gene expression and genome sequencing to identify a protein interaction module with members strongly enriched for
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