45763

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Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors.

Jeremy G Owen et al.

Proceedings of the National Academy of Sciences of the United States of America, 112(14), 4221-4226 (2015-04-02)

In molecular evolutionary analyses, short DNA sequences are used to infer phylogenetic relationships among species. Here we apply this principle to the study of bacterial biosynthesis, enabling the targeted isolation of previously unidentified natural products directly from complex metagenomes. Our

Coping with matrix effects in headspace solid phase microextraction gas chromatography using multivariate calibration strategies.

Vicente Ferreira et al.

Journal of chromatography. A, 1407, 30-41 (2015-07-15)

SPME is extremely sensitive to experimental parameters affecting liquid-gas and gas-solid distribution coefficients. Our aims were to measure the weights of these factors and to design a multivariate strategy based on the addition of a pool of internal standards, to

An association mapping approach to identify favourable alleles for tomato fruit quality breeding.

Valentino Ruggieri et al.

BMC plant biology, 14, 337-337 (2014-12-04)

Genome Wide Association Studies (GWAS) have been recently used to dissect complex quantitative traits and identify candidate genes affecting phenotype variation of polygenic traits. In order to map loci controlling variation in tomato marketable and nutritional fruit traits, we used

LC-MS/MS and GC-MS/MS measurement of plasma and urine di-paracetamol and 3-nitro-paracetamol: proof-of-concept studies on a novel human model of oxidative stress based on oral paracetamol administration.

Arne Trettin et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 959, 71-81 (2014-04-29)

Paracetamol (acetaminophen) is a widely used safe analgesic drug when administered at therapeutic doses. Given the chemical reactivity of its phenolic group towards electrophilic species, we assumed that detection of paracetamol metabolites distinctly different from its known phase I metabolite

Redox-active biflavonoids from Garcinia brasiliensis as inhibitors of neutrophil oxidative burst and human erythrocyte membrane damage.

Phanuel Saroni Arwa et al.

Journal of ethnopharmacology, 174, 410-418 (2015-09-01)

Garcinia brasiliensis, a plant native to the Brazilian Amazon Rainforest, is used in traditional medicine to treat inflammation of the urinary tract, peptic ulcers, arthritis and other conditions. The purposes of this study were to analyze the chemical constituents of

Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: A targeted metabolomic approach.

Xuan Yao et al.

Prostaglandins & other lipid mediators, 118-119, 11-18 (2015-04-07)

Symptoms of cardiovascular diseases are frequently found in patients with hypothyroidism and hyperthyroidism. However, it is unknown whether arachidonic acid metabolites, the potent mediators in cardiovascular system, are involved in cardiovascular disorders caused by hyperthyroidism and hypothyroidism. To answer this

Atmospheric pressure gas chromatography-time-of-flight-mass spectrometry (APGC-ToF-MS) for the determination of regulated and emerging contaminants in aqueous samples after stir bar sorptive extraction (SBSE).

Marina G Pintado-Herrera et al.

Analytica chimica acta, 851, 1-13 (2014-12-03)

This work presents the development, optimization and validation of a multi-residue method for the simultaneous determination of 102 contaminants, including fragrances, UV filters, repellents, endocrine disruptors, biocides, polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and several types of pesticides in

Analysis of fentanyl in urine by DLLME-GC-MS.

Michael A Gardner et al.

Journal of analytical toxicology, 39(2), 118-125 (2014-12-11)

Fentanyl is a synthetic narcotic anesthetic ∼80-100 times more potent than morphine. Owing to the potential for its abuse, the drug may be included in a forensic toxicology work-up, which requires fast, precise and accurate measurements. Here, the stability of

Urine as a material for evaluation of exposure to manganese in methcathinone users.

Magdalena Golasik et al.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 28(3), 338-343 (2014-05-29)

Chronic exposure even to low doses of manganese may lead to development of neurological syndrome similar to parkinsonism. The aim of this research is to assess the possibility of manganese poisoning based on the level of metal in the urine

Synthesis, characterization, evaluation and molecular dynamics studies of 5, 6-diphenyl-1,2,4-triazin-3(2H)-one derivatives bearing 5-substituted 1,3,4-oxadiazole as potential anti-inflammatory and analgesic agents.

Anupam G Banerjee et al.

European journal of medicinal chemistry, 101, 81-95 (2015-06-29)

A series of triazin-3(2H)-one derivatives bearing 1,3,4-oxadiazole (4a-4o) were synthesized, characterized and evaluated for anti-inflammatory and analgesic activities. Preliminary in vitro anti-inflammatory activity was assessed using an albumin denaturation assay. The promising compounds were further evaluated in acute, sub-chronic and chronic

In vivo imaging of reactive oxygen species in mouse brain by using [3H]hydromethidine as a potential radical trapping radiotracer.

Kohji Abe et al.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(12), 1907-1913 (2014-09-18)

To assess reactive oxygen species (ROS) production by detecting the fluorescent oxidation product, hydroethidine has been used extensively. The present study was undertaken to evaluate the potential of the hydroethidine derivative as a radiotracer to measure in vivo brain ROS

Development of a subcritical water extraction approach for trace analysis of chloramphenicol, thiamphenicol, florfenicol, and florfenicol amine in poultry tissues.

Zhiming Xiao et al.

Journal of chromatography. A, 1418, 29-35 (2015-10-05)

Subcritical water extraction was investigated as a novel and alternative technology for the separation of trace amounts of chloramphenicol, thiamphenicol, florfenicol and its major metabolite florfenicol amine from poultry tissues and its results were compared with those of conventional shaking

Synthesis and characterization of biodegradable polyurethane for hypopharyngeal tissue engineering.

Zhisen Shen et al.

BioMed research international, 2015, 871202-871202 (2015-04-04)

Biodegradable crosslinked polyurethane (cPU) was synthesized using polyethylene glycol (PEG), L-lactide (L-LA), and hexamethylene diisocyanate (HDI), with iron acetylacetonate (Fe(acac)3) as the catalyst and PEG as the extender. Chemical components of the obtained polymers were characterized by FTIR spectroscopy, (1)H

The effect of Piper laetispicum extract (EAE-P) during chronic unpredictable mild stress based on interrelationship of inflammatory cytokines, apoptosis cytokines and neurotrophin in the hippocampus.

Hui Xie et al.

BMC complementary and alternative medicine, 15, 240-240 (2015-07-18)

The Piper laetispicum C.DC. (Piperaceae) is a traditionally used herb in China for invigorating circulation and reducing stasis, detumescence and analgesia, which is distributed in the southern part of China and the southeastern part of Asia. Previous studies demonstrated that

Quantification of circulating steroids in individual zebrafish using stacking to achieve nanomolar detection limits with capillary electrophoresis and UV-visible absorbance detection.

Vincent T Nyakubaya et al.

Analytical and bioanalytical chemistry, 407(23), 6985-6993 (2015-06-05)

Capillary electrophoresis and UV-visible absorbance detection are used with sample stacking to achieve detection limits ranging from 0.2 to 2 ng/mL (0.8 to 6 nM) for steroids. Stacking is accomplished using negatively charged cyclodextrin steroid-carrier molecules at a discrete pH

Hepatic oxidative status and metal homeostasis disturbance of 2-hydroxylated dioxin in ICR mice.

Xuesheng Zhang et al.

Environmental toxicology and pharmacology, 38(3), 881-890 (2014-12-03)

In the present study, the toxic effects of the oral exposure of 2-hydroxylated dioxin (2-HODD) in ICR male mice were examined. The mice were administered different doses (0.2, 2.0 and 20.0mg/kg) of 2-HODD. After 14 days of exposure, the oxidative

Steroids in marine aquaculture farms surrounding Hailing Island, South China: occurrence, bioconcentration, and human dietary exposure.

Shan Liu et al.

The Science of the total environment, 502, 400-407 (2014-10-01)

The occurrence, bioconcentration, and human dietary exposure via seafood consumption of 24 steroids were investigated by rapid resolution liquid chromatography-tandem mass spectrometry (RRLC-MS/MS) in six typical marine aquaculture farms surrounding Hailing Island, South China. Ten, 9, 10, 15 of 24

[HPLC fingerprint of ethyl acetate extraction of Saxifraga stolonifera].

Mei Zhou et al.

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(7), 1026-1029 (2013-07-16)

To establish an HPLC fingerprint of ethyl acetate extraction of Saxifraga stolonifera. The HPLC analysis was performed on a Diamonsil C18 (4.6 mm x 250 mm, 5 microm) column with isocratic elution of acetonitrile-0.05% phosphoric acid at a flow rate

Development of a magnetic solid-phase extraction coupled with high-performance liquid chromatography method for the analysis of polyaromatic hydrocarbons.

Yan Ma et al.

Journal of separation science, 38(14), 2517-2525 (2015-05-02)

A novel magnetic solid phase extraction coupled with high-performance liquid chromatography method was established to analyze polyaromatic hydrocarbons in environmental water samples. The extraction conditions, including the amount of extraction agent, extraction time, pH and the surface structure of the

Melatonin in Arabidopsis thaliana acts as plant growth regulator at low concentrations and preserves seed viability at high concentrations.

Ismaél Gatica Hernández et al.

Plant physiology and biochemistry : PPB, 94, 191-196 (2015-06-27)

Since the discovery of melatonin in plants, several roles have been described for different species, organs, and developmental stages. Arabidopsis thaliana, being a model plant species, is adequate to contribute to the elucidation of the role of melatonin in plants.

The aqueous solubility of some herbicidal by-side toxic impurities: predicted data of the 399 chlorinated trans-azoxybenzene congeners.

Sławomir Piliszek et al.

Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 47(4), 275-287 (2012-03-21)

The quantitative structure - property relationship (QSPR) and the artificial neural networks (ANNs) methods were used to estimate aqueous solubility (log S and μg/L) of polychlorinated trans-azoxybenzenes (PCt-ABs). These QSPR and ANN models are based on geometry optimalization and quantum-chemical

Multivariate optimization for extraction of pyrethroids in milk and validation for GC-ECD and CG-MS/MS analysis.

Leonardo Zanchetti Meneghini et al.

International journal of environmental research and public health, 11(11), 11421-11437 (2014-11-08)

A simple and inexpensive method based on solvent extraction followed by low temperature clean-up was applied for determination of seven pyrethroids residues in bovine raw milk using gas chromatography coupled to tandem mass spectrometry (GC-MS/MS) and gas chromatography with electron-capture

Serum levels of oxylipins in achilles tendinopathy: an exploratory study.

Sandra Gouveia-Figueira et al.

PloS one, 10(4), e0123114-e0123114 (2015-04-16)

Linoleic acid-derived oxidation products are found in experimental pain models. However, little is known about the levels of such oxylipins in human pain. In consequence, in the present study, we have undertaken a lipidomic profiling of oxylipins in blood serum

Molecular mechanism of poly(vinyl alcohol) mediated prevention of aggregation and stabilization of insulin in nanoparticles.

Sanjay Rawat et al.

Molecular pharmaceutics, 12(4), 1018-1030 (2015-02-04)

It is a challenge to formulate polymer based nanoparticles of therapeutic proteins as excipients and process conditions affect stability and structural integrity of the protein. Hence, understanding the protein stability and complex aggregation phenomena is an important area of research

A correlation between tocopherol content and antioxidant activity in seeds and germinating seeds of soybean cultivars.

Yu Young Lee et al.

Journal of the science of food and agriculture, 95(4), 819-827 (2014-12-06)

Tocopherols are crucial lipid-soluble antioxidants and essential nutrients. There is increasing interest in the biofortification of crops with vitamin E for reducing micronutrient malnutrition. However, relatively little is known about the development of soybean cultivars with high levels of tocopherol

Efficient Total Synthesis of Bongkrekic Acid and Apoptosis Inhibitory Activity of Its Analogues.

Kenji Matsumoto et al.

Chemistry (Weinheim an der Bergstrasse, Germany), 21(32), 11590-11602 (2015-07-02)

Bongkrekic acid (BKA), isolated from the bacterium Burkholderia cocovenenans, is an inhibitor of adenine nucleotide translocator, which inhibits apoptosis, and is thus an important tool for the mechanistic investigation of apoptosis. An efficient total synthesis of BKA has been achieved

Effect of trifloxystrobin on hatching, survival, and gene expression of endocrine biomarkers in early life stages of medaka (Oryzias latipes).

Lifei Zhu et al.

Environmental toxicology, 30(6), 648-655 (2014-01-01)

Trifloxystrobin is a systemic broad-spectrum foliar strobilurin fungicides that enters the aquatic environment during agricultural application. It is highly toxic and poses a potential risk to aquatic organisms, whereas the effect on the development of early life stages of fish

Coexistence of and interaction relationships between an aflatoxin-producing fungus and a bacterium.

Quan-Hong Yan et al.

Fungal biology, 119(7), 605-614 (2015-06-11)

The interactions between aflatoxin-producing fungi and bacteria have opened up a new avenue for identifying biological agents suitable for controlling aflatoxin contamination. In this study, we analysed the interactions between A. flavus and the bacterium Burkholderia gladioli M3 that coexist

Simultaneous quantification of chrysophanol and physcion in rat plasma by ultra fast liquid chromatography-tandem mass spectrometry and application of the technique to comparative pharmacokinetic studies of Radix et Rhei Rhizoma extract alone and Dahuang Fuzi Decoction.

Xiao Liu et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 980, 88-93 (2015-01-20)

Most herbal medicines are prescribed in combination based on the theory of TCM to obtain synergistic effects or diminish the possible adverse reactions. Compatibility refers to the combination of two or more herbs based on the clinical settings and the

Simultaneous Quantification of Five Bioactive Flavonoids in High Altitude Plant Actinocarya tibetica by LC-ESI-MS/MS.

Baljinder Singh et al.

Journal of AOAC International, 98(4), 907-912 (2015-08-14)

An LC/MS method has been developed for the simultaneous quantification of five flavonoids, i.e., mosloflavone, negletein, gardenin B, 5-methoxy-6,7-methylenedioxyflavone, and 5,6,7-trimethoxyflavone, in different ultrasound assisted solvent extracts of Actinocarya tibetica. The chromatographic separation was achieved on a Chromolith Speed ROD

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