48320-U

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Showing 1-25 of 25 results for "48320-U" within Papers

Organosulfur compounds alone or in combination with vitamin C protect towards N-nitrosopiperidine- and N-nitrosodibutylamine-induced oxidative DNA damage in HepG2 cells.

A García et al.

Chemico-biological interactions, 173(1), 9-18 (2008-03-15)

The aim of this study was to investigate the protective effects of organosulfur compounds (OSCs) alone or in combination with vitamin C towards N-nitrosopiperidine (NPIP) and N-nitrosodibutylamine (NDBA)-induced oxidative DNA damage in the single cell gel electrophoresis (SCGE)/HepG2 assay. Diallyl

Antiapoptotic effects of dietary antioxidants towards N-nitrosopiperidine and N-nitrosodibutylamine-induced apoptosis in HL-60 and HepG2 cells.

Almudena García et al.

Journal of applied toxicology : JAT, 29(5), 403-413 (2009-03-21)

The aim of this work was to determine the effect of vitamin C, diallyl disulfide (DADS) and dipropyl disulfide (DPDS) towards N-nitrosopiperidine (NPIP) and N-nitrosodibutylamine (NDBA)-induced apoptosis in human leukemia (HL-60) and hepatoma (HepG2) cell lines using the terminal deoxynucleotidyl

High susceptibility of p53 knockout mice to esophageal and urinary bladder carcinogenesis induced by N, N-dibutylnitrosamine.

Takayuki Nishikawa et al.

Cancer letters, 194(1), 45-54 (2003-04-23)

In human cancer, alterations in the p53 tumor suppressor gene are the most common genetic alterations. The aim of the present study was to detect sensitivity of the p53 (+/-) mice and their littermates p53 (+/+) mice to N, N-dibutylnitrosamine

Protective effect of vitamin C towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.

Nuria Arranz et al.

Toxicology in vitro : an international journal published in association with BIBRA, 21(7), 1311-1317 (2007-05-22)

The aim of this study was to investigate the protective effect of vitamin C towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay. None of the vitamin C concentrations tested (1-10 microM) in presence or absence of formamidopyrimidine-DNA

Determination of eight nitrosamines in water at the ng L(-1) levels by liquid chromatography coupled to atmospheric pressure chemical ionization tandem mass spectrometry.

Cristina Ripollés et al.

Analytica chimica acta, 702(1), 62-71 (2011-08-09)

In this work, we have developed a sensitive method for detection and quantification of eight N-nitrosamines, N-nitrosodimethylamine (NDMA), N-nitrosomorpholine (NMor), N-nitrosomethylethylamine (NMEA), N-nitrosopirrolidine (NPyr), N-nitrosodiethylamine (NDEA), N-nitrosopiperidine (NPip), N-nitroso-n-dipropylamine (NDPA) and N-nitrosodi-n-butylamine (NDBA) in drinking water. The method is based

Cytochrome P450 hydroxylation of carbon atoms of the alkyl chain of symmetrical N-nitrosodialkylamines by human liver microsomes.

G Bellec et al.

Mutation research, 377(2), 199-209 (1997-07-03)

A panel of 14 human liver microsomal preparations metabolized at variable rates three symmetrical nitrosodialkylamines (N-nitroso-dipropyl, dibutyl and diamyl-amines, NDPA, NDBA, NDAA) into aldehydes and hydroxynitrosamines. Formation of linear aldehydes, convenient probes for alpha-hydroxylation of alkyl chain, and production of

Detection of mutagenicity in Ames test using a metalloporphyrin/oxidant model system for cytochrome P450.

E Okochi et al.

Mutation research, 373(1), 99-105 (1997-01-03)

A chemical model system for cytochrome P450, a porphyrin and an oxidant, was used in Ames assay as a substitute for S9 mix. In the presence of tetrakis(pentafluorophenyl)porphyrinatoiron(III) chloride [Fe(F5P)Cl] and tert-butyl hydroperoxide (t-BuOOH), mutagenicity of N-nitrosodibutylamine (NDB) in Salmonella

N-Nitrosamines (15 listings): N-Nitrosodi-n-butylamine.

Report on carcinogens : carcinogen profiles, 12, 303-304 (2011-08-24)

Effect of N-nitrosoamines and nitrosationable pesticide tetramethylthiuram disulfide on soil microbiocenosis and potato yield: a model system.

V N Pishchik et al.

Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 13(4), 235-242 (1994-01-01)

The effect of carcinogenic N-nitrosoamines (NA), NA-producing tetramethylthiuram disulfide (TMTD) pesticide, and of various doses of nitrogen fertilizers (90, 180, and 270 kg/ha) on the forming and vital functions of microbiocenosis of light gray forest soil was studied. The quantity

Rapid semi-quantitative estimation of N-nitrosodibutylamine and N-nitrosodibenzylamine in smoked hams by solid-phase microextraction followed by gas chromatography-thermal energy analysis.

N P Sen et al.

Journal of chromatography. A, 788(1-2), 131-140 (1998-01-07)

A solid-phase microextraction (SPME) analytical method has been developed for the determination of N-nitrosodi-n-butylamine (NDBA) and N-nitrosodibenzylamine (NDBzA) in hams that is based on: (a) isolation of the compounds by steam distillation, (b) SPME from the distillate headspace using a

Effects of ozonation on mutagenic activity of nitrosamines.

B Fouillet et al.

Bulletin of environmental contamination and toxicology, 52(5), 681-686 (1994-05-01)

Loss of SPARC in bladder cancer enhances carcinogenesis and progression.

Neveen Said et al.

The Journal of clinical investigation, 123(2), 751-766 (2013-01-17)

Secreted protein acidic and rich in cysteine (SPARC) has been implicated in multiple aspects of human cancer. However, its role in bladder carcinogenesis and metastasis are unclear,with some studies suggesting it may be a promoter and others arguing the opposite.

Molecular characterization of tumor associated antigen in mice exposed to a hepatocarcinogen.

Anis Alam et al.

Molecular and cellular biochemistry, 271(1-2), 177-188 (2005-05-11)

The present investigation is aimed to identify and characterize tumor-associated antigen (TAA) in animals exposed to hepatocarcinogen. Swiss albino mice showed an enhanced expression of an approximately 58 kDa glycoprotein in liver cells upon exposure to a potential hepatocarcinogen N-nitrosodibutylamine

[Structure and metabolic fate of N-nitrosodialkylamines in relation to their organotropic carcinogenicity with special reference to induction of urinary bladder tumors].

M Mochizuki et al.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 117(10-11), 884-894 (1998-01-01)

The metabolic fates of N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) and N,N-dibutylnitrosamine (DBN) were investigated in the rat and other animal species, to elucidate a possible relationship between metabolism and organotropic carcinogenicity to the urinary bladder of these N-nitrosamines. The principal urinary metabolite of

Protective effects of isothiocyanates alone or in combination with vitamin C towards N-nitrosodibutylamine or N-nitrosopiperidine-induced oxidative DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.

Almudena García et al.

Journal of applied toxicology : JAT, 28(2), 196-204 (2007-06-22)

The aim of this study was to investigate the protective effect of isothiocyanates alone or in combination with vitamin C towards N-nitrosodibutylamine (NDBA) or N-nitrosopiperidine (NPIP)-induced oxidative DNA damage in the single cell gel electrophoresis (SCGE)/HepG2 assay. Phenethyl isothiocyanate (PEITC)

Myricetin, quercetin, (+)-catechin and (-)-epicatechin protect against N-nitrosamines-induced DNA damage in human hepatoma cells.

M E Delgado et al.

Toxicology in vitro : an international journal published in association with BIBRA, 23(7), 1292-1297 (2009-07-25)

The aim of this study was to investigate the protective effect of myricetin, quercetin, (+)-catechin and (-)-epicatechin, against N-nitrosodibutylamine (NDBA) and N-nitrosopiperidine (NPIP)-induced DNA damage in human hepatoma cells (HepG2). DNA damage (strand breaks and oxidized purines/pyrimidines) was evaluated by

Activity of maitake D-fraction to inhibit carcinogenesis and metastasis.

H Nanba

Annals of the New York Academy of Sciences, 768, 243-245 (1995-09-30)

N-nitrosodi-n-butylamine.

Report on carcinogens : carcinogen profiles, 11, III196-III197 (2004-01-01)

Effect of Vicia faba and bran feeding on nitrosamine carcinogenesis and formation.

N I Zakhary et al.

Nutrition and cancer, 21(1), 58-69 (1994-01-01)

The goal of this work was to study the effect of the most common Egyptian food items, Vicia faba beans (VF) and bran, on the carcinogenicity of dibutylnitrosamine (DBN) precursors (dibutylamine and nitrite). Mice receiving DBN precursors showed a delayed

Chemoprevention of rat liver toxicity and carcinogenesis by Spirulina.

Mohamed F Ismail et al.

International journal of biological sciences, 5(4), 377-387 (2009-06-13)

Spirulina platensis (SP) is a filamentous cyanobacterium microalgae with potent dietary phyto-antioxidant, anti-inflammatory and anti-cancerous properties. The present study aimed to investigate the chemopreventive effect of SP against rat liver toxicity and carcinogenesis induced by dibutyl nitrosamine (DBN) precursors, and

Effects of butylated hydroxyanisole pretreatment on low dose N-methyl-N'-nitro-N-nitrosoguanidine- or N,N-dibutylnitrosamine-induced rat forestomach or esophageal carcinogenesis.

M Hirose et al.

Carcinogenesis, 12(10), 1773-1776 (1991-10-01)

The effects of butylated hydroxyanisole (BHA) pretreatment on subsequent low dose N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or N,N-dibutylnitrosamine (DBN) treatment on forestomach or esophageal carcinogenesis were investigated in male F344 rats. Groups of animals were pretreated with 2% BHA or basal diet alone

Volatile N-nitrosamines in selected Italian cheeses.

A Dellisanti et al.

Bulletin of environmental contamination and toxicology, 57(1), 16-21 (1996-07-01)

Induction of apoptosis and reactive oxygen species production by N-nitrosopiperidine and N-nitrosodibutylamine in human leukemia cells.

Almudena García et al.

Journal of applied toxicology : JAT, 28(4), 455-465 (2007-10-12)

N-nitrosopiperidine (NPIP) and N-nitrosodibutylamine (NDBA) belong to a group of N-nitrosamines that are widely distributed in foodstuffs and the occupational environment. In the present study, the human promyelocytic leukemia cell line HL-60, was used to characterize the apoptotic effects of

N-Nitrosodi-n-butylamine.

Report on carcinogens : carcinogen profiles, 10, 175-176 (2004-08-26)

Role of cytochrome P450 in DNA damage induced by N-nitrosodialkylamines in cultured rat hepatocytes.

L Shu et al.

Carcinogenesis, 17(3), 569-576 (1996-03-01)

The involvement of cytochrome P450 in the cytotoxicity and DNA damage-repair induced by N-nitrosodipropylamine (NDPA), N-nitroso-n-butyl-n-propylamine (NBPA), and N-nitrosodibutylamine (NDBA) was investigated in cultured hepatocytes isolated from untreated, phenobarbital (PB)- and pyridine (PYR)-pretreated rats. Pretreatment of rats with PB caused

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