48554

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Showing 1-26 of 26 results for "48554" within Papers

Differential modification of development of preneoplastic lesions in the Syrian golden hamster initiated with a single dose of 2,2'-dioxo-N-nitrosodipropylamine: influence of subsequent butylated hydroxyanisole, alpha-tocopherol, or carbazole.

M A Moore et al.

Journal of the National Cancer Institute, 78(2), 289-293 (1987-02-01)

The effects of butylated hydroxyanisole [(BHA) CAS: 25013-16-5], alpha-tocopherol [(TC) CAS: 59-02-9], and carbazole [(CA) CAS: 86-74-8] administered subsequent to a single dose of 2,2'-dioxo-N-nitrosodipropylamine [(DOPN) CAS: 60599-38-4] on the development of putative preneoplastic lesions were investigated in Syrian golden

[The carcinogenic activity of N-nitrosodipropylamine administered perorally to C57Bl mice].

L A Gritsiute et al.

Eksperimental'naia onkologiia, 11(3), 10-11 (1989-01-01)

187 female and male C57B1 mice received N-nitrosodipropylamine (NDPA) twice a week for 50 weeks by intragastric intubation. The total dose of NDPA administered to groups I and II was 3 mg or 1 mg per mouse. The main kinds

Target organ and time-course in the mutagenicity of five carcinogens in MutaMouse: a summary report of the second collaborative study of the transgenic mouse mutation assay by JEMS/MMS.

T Suzuki et al.

Mutation research, 444(2), 259-268 (1999-10-16)

We studied five carcinogens for (a) organ-specific mutagenicity and expression time in the transgenic (TG) mouse mutation assay and (b) clastogenicity in the peripheral blood micronucleus assay in the same mice. Groups of mice were injected intraperitoneally (ip) with N-nitroso-di-n-propylamine

N-Nitrosodi-n-propylamine induces organ specific mutagenesis with specific expression times in lacZ transgenic mice.

S Itoh et al.

Mutation research, 444(2), 309-319 (1999-10-16)

The mutagenic and clastogenic effects of N-nitrosodi-n-propylamine (NDPA) in lacZ transgenic mice (MutaMouse) were investigated as a part of the second collaborative study of the transgenic mouse mutation assay by a subgroup of the Mammalian Mutagenesis Study Group, a suborganization

Lesions induced in rodent pancreas by azaserine and other pancreatic carcinogens.

D S Longnecker

Environmental health perspectives, 56, 245-251 (1984-06-01)

Focal proliferative changes in the acinar cells of the pancreas of rats have been induced by several systemically administered carcinogens including azaserine, N-nitrosobis(2-oxopropyl)amine, N-nitroso-(2-hydroxypropyl) (2-oxopropyl)amine, and N delta-(N-methyl-N-nitrosocarbamoyl)-L-ornithine (MNCO). Foci, nodules, and adenomas induced by these carcinogens are usually made

Role of cytochrome P450 in DNA damage induced by N-nitrosodialkylamines in cultured rat hepatocytes.

L Shu et al.

Carcinogenesis, 17(3), 569-576 (1996-03-01)

The involvement of cytochrome P450 in the cytotoxicity and DNA damage-repair induced by N-nitrosodipropylamine (NDPA), N-nitroso-n-butyl-n-propylamine (NBPA), and N-nitrosodibutylamine (NDBA) was investigated in cultured hepatocytes isolated from untreated, phenobarbital (PB)- and pyridine (PYR)-pretreated rats. Pretreatment of rats with PB caused

Genotoxicity of carcinogenic N-nitrosopropylamine derivatives in the hepatocyte primary culture/DNA-repair test.

H Yamazaki et al.

Mutation research, 144(3), 197-202 (1985-11-01)

The genotoxicity of N-nitrosodipropylamine, 8 of its oxidized derivatives and N-nitroso-2,6-dimethylmorpholine was examined in the hepatocyte primary culture (HPC)/DNA repair test. Nine N-nitrosamines which are known to be carcinogenic and mutagenic were clearly positive in the HPC/DNA-repair test. N-Nitroso(2,3-dihydroxypropyl) (2-hydroxypropyl)amine

A new method for quantifying N-nitrosamines in wastewater samples by gas chromatography?triple quadrupole mass spectrometry.

Yoon S, et al.

Talanta, 97, 256-261 (2012)

Identification of the human liver microsomal cytochrome P450s involved in the metabolism of N-nitrosodi-n-propylamine.

J F Teiber et al.

Carcinogenesis, 21(8), 1559-1566 (2000-07-27)

The ability of human liver cytochrome P450s to metabolize the environmental carcinogen N-nitrosodi-n-propylamine (NDPA) was investigated. The maximum rate of NDPA depropylation in seven human liver microsomal samples was 1.15 nmol/min/mg (range 0.53-2.60). Troleandomycin, a P450 3A4/5 inhibitor, inhibited depropylation

N-Nitrosamines (15 listings): N-Nitrosodi-n-propylamine.

Report on carcinogens : carcinogen profiles, 12, 310-311 (2011-08-24)

Metabolism of carcinogenic amino derivatives in various species and DNA alkylation by their metabolites.

H A Schut et al.

Drug metabolism reviews, 15(4), 753-839 (1984-01-01)

N-Nitrosodi-n-propylamine.

Report on carcinogens : carcinogen profiles, 11, III200-III201 (2004-01-01)

Intestinal metabolism of nitrosamines. 1. Transport and metabolism of six nitrosamines in isolated perfused rat small intestinal segments.

E Richter et al.

Carcinogenesis, 7(7), 1207-1213 (1986-07-01)

Possible relationships between structure and metabolism of nitrosamines have been investigated in the rat small intestine. Isolated segments of jejunum and ileum were perfused from the luminal side for 2 h with a Tyrode solution containing one of four symmetrical

Cytochrome P450 hydroxylation of carbon atoms of the alkyl chain of symmetrical N-nitrosodialkylamines by human liver microsomes.

G Bellec et al.

Mutation research, 377(2), 199-209 (1997-07-03)

A panel of 14 human liver microsomal preparations metabolized at variable rates three symmetrical nitrosodialkylamines (N-nitroso-dipropyl, dibutyl and diamyl-amines, NDPA, NDBA, NDAA) into aldehydes and hydroxynitrosamines. Formation of linear aldehydes, convenient probes for alpha-hydroxylation of alkyl chain, and production of

Mutagenicity of some dialkylnitrosamines, cyclic nitrosamines and N,N-diethanolnitrosamine in Salmonella typhimurium with rat and rabbit nasal, lung and liver S9 homogenates.

A R Dahl

Mutation research, 158(3), 141-147 (1985-12-01)

6 nitrosamines, 5 of which cause rat nasal cancer, were tested for mutagenicity in the TA100 strain of S. typhimurium with rat and rabbit nasal, lung and liver S9 homogenates. The TA98 strain also was used with rabbit tissue homogenates.

Detection of mutagenicity in Ames test using a metalloporphyrin/oxidant model system for cytochrome P450.

E Okochi et al.

Mutation research, 373(1), 99-105 (1997-01-03)

A chemical model system for cytochrome P450, a porphyrin and an oxidant, was used in Ames assay as a substitute for S9 mix. In the presence of tetrakis(pentafluorophenyl)porphyrinatoiron(III) chloride [Fe(F5P)Cl] and tert-butyl hydroperoxide (t-BuOOH), mutagenicity of N-nitrosodibutylamine (NDB) in Salmonella

High temperature purge and trap procedure for determining seven volatile N-nitrosamines in animal feed, using gas chromatography/thermal energy analyzer.

S M Billedeau et al.

Journal - Association of Official Analytical Chemists, 67(3), 557-562 (1984-05-01)

A rapid and sensitive procedure is described for determining 4 N-nitrosodialkylamines (dimethyl, diethyl, dipropyl, and dibutyl) and the N-nitroso analogs of piperidine, pyrrolidine, and morpholine in animal feed. The volatile N-nitrosamines were isolated by using a modified high temperature purge

Dietary exposure and urinary excretion of total N-nitroso compounds, nitrosamino acids and volatile nitrosamine in inhabitants of high- and low-risk areas for esophageal cancer in southern China.

Kun Lin et al.

International journal of cancer, 102(3), 207-211 (2002-10-25)

We assessed the exposure of total N-nitroso compounds (TNOCs) in the inhabitants of high- and low-risk areas for esophageal cancer in southern China. Samples of 24 hr diet and 12 hr overnight urine were collected from 120 male adults in

Determination of eight nitrosamines in water at the ng L(-1) levels by liquid chromatography coupled to atmospheric pressure chemical ionization tandem mass spectrometry.

Cristina Ripollés et al.

Analytica chimica acta, 702(1), 62-71 (2011-08-09)

In this work, we have developed a sensitive method for detection and quantification of eight N-nitrosamines, N-nitrosodimethylamine (NDMA), N-nitrosomorpholine (NMor), N-nitrosomethylethylamine (NMEA), N-nitrosopirrolidine (NPyr), N-nitrosodiethylamine (NDEA), N-nitrosopiperidine (NPip), N-nitroso-n-dipropylamine (NDPA) and N-nitrosodi-n-butylamine (NDBA) in drinking water. The method is based

The metabolism of nitrosodi-n-propylamine, nitrosodiallylamine and nitrosodiethanolamine.

J G Farrelly et al.

Carcinogenesis, 5(8), 1015-1019 (1984-08-01)

Nitrosodiallylamine has been reported to be non-carcinogenic in rats while nitrosodipropylamine and nitrosodiethanolamine are liver carcinogens. That nitrosodipropylamine is metabolized at the alpha-position by liver microsomes from Fischer-344 rats supports the widely held contention that such metabolism is responsible for

Comparative study of DNA damage and repair induced by ten N-nitroso compounds in primary cultures of human and rat hepatocytes.

A Martelli et al.

Cancer research, 48(15), 4144-4152 (1988-08-01)

Ten carcinogenic N-nitroso compounds were assayed for DNA-damaging activity in primary cultures of human and rat hepatocytes. DNA fragmentation was measured by the alkaline elution technique, and unscheduled DNA synthesis by quantitative autoradiography. Positive dose-related responses in the range of

Metabolism of N-nitrosodi-n-propylamine and N-nitrosodiallylamine by isolated rat hepatocytes.

P A Bauman et al.

Cancer letters, 28(2), 229-236 (1985-09-15)

Isolated rat hepatocytes were incubated with approximately equimolar amounts of N-nitrosodi-n-propylamine (NDPA) and N-nitrosodiallylamine (NDAA) in order to compare their metabolism. The principal metabolite of NDPA was N-nitroso-(2-hydroxypropyl)propylamine, which was present as a glucuronide. N-Nitroso-(3-hydroxypropyl)propylamine and N-nitrosopropyl-(carboxyethyl)amine were minor metabolites;

Occurrence of nitrosatable amines in some Nigerian medicinal plants.

F O Uhegbu et al.

Bulletin of environmental contamination and toxicology, 55(5), 643-649 (1995-11-01)

Metabolic inactivation of N-nitrosamines by cytochrome P-450 in vitro and in vivo.

K E Appel et al.

IARC scientific publications, (57)(57), 443-451 (1984-01-01)

Nitrite was formed on incubation of N-nitrosamines with both microsomal systems and a reconstituted system consisting of cytochrome P-450 and NADPH P-450 reductase from pig liver. Nitrite was not obtained when the nitrosamines were incubated with NADPH P-450 reductase alone

N-Nitrosodi-n-propylamine.

Report on carcinogens : carcinogen profiles, 10, 180-181 (2004-08-26)

Determination of N-nitrosodipropylamine in trifluralin emulsifiable concentrates using minicolumn cleanup and gas chromatography with thermal energy analyzer.

D Wotherspoon et al.

Journal - Association of Official Analytical Chemists, 71(2), 333-336 (1988-03-01)

A quick method for determining N-nitrosodipropylamine (NDPA) levels in trifluralin emulsifiable concentrate formulations is described. At least 18 samples can be analyzed at one time in a minimum of fumehood space, with up to 90% savings on solvents and materials.

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