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Showing 1-30 of 32 results for "48734" within Papers
Suganya Sekaran et al.
Journal of biochemical and molecular toxicology, 26(12), 522-532 (2013-01-03)
The present study aims to investigate the protective effect of quercetin against Aroclor-1254-induced hepatotoxicity in rats. Male Wistar rats were grouped into Group I control received vehicle (corn oil; 1 mL/kg bwt); Group II quercetin alone (50 mg/kg bwt/day orally);
Jiali Cai et al.
Toxicology, 287(1-3), 21-28 (2011-06-15)
The testicular toxicity of polychlorinated biphenyls (PCBs) has been extensively studied. However, the detailed mechanism is still obscure. In the present study, male C57 mice were treated with different doses of Aroclor 1254 (a commercial PCB mixture) once every 3
Mirjam M Schaap et al.
Archives of toxicology, 89(12), 2413-2427 (2014-10-02)
Alternative methods to detect non-genotoxic carcinogens are urgently needed, as this class of carcinogens goes undetected in the current testing strategy for carcinogenicity under REACH. A complicating factor is that non-genotoxic carcinogens act through several distinctive modes of action, which
Nadezhda A Sazonova et al.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 156B(8), 898-912 (2011-09-16)
Polychlorinated biphenyls (PCB) exposure in rodents provides a useful model for the symptoms of Attention deficit hyperactivity disorder (ADHD). The goal of this study is to identify genes whose expression levels are altered in response to PCB exposure. The brains
W Piekoszewski et al.
Folia medica Cracoviensia, 31(3), 201-207 (1990-01-01)
The pharmacokinetics of antipyrine in a dose of 20 mg/kg i.v. and cytochrome P-450 level in liver, were studied in control and pretreated rats with 1, 5, 25 ppm polychlorinated biphenyls in food for up to 120 days. The objective
L A Martin et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(3), 588-595 (2011-12-22)
Polychlorinated biphenyl (PCB) congeners differentially reduce serum thyroxine (T(4)) in rats, but little is known about their ability to affect biliary excretion of T(4). Thus, male Sprague-Dawley rats were orally administered Aroclor-1254, Aroclor-1242 (32 mg/kg per day), PCB-95, PCB-99, PCB-118
Applicability of the TCDD-TEQ approach to predict sublethal embryotoxicity in Fundulus heteroclitus.
Cyril Rigaud et al.
Aquatic toxicology (Amsterdam, Netherlands), 149, 133-144 (2014-03-13)
The 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxic equivalent quantity (TCDD-TEQ) approach was used successfully to predict lethal embryotoxicity in salmonids, but its applicability to sublethal effects of mixtures of organohalogenated compounds in other fish species is poorly known. The sublethal toxicity of two
Jing An et al.
Toxicology, 295(1-3), 8-14 (2012-03-13)
Polychlorinated biphenyls (PCBs) are still prevalent in the environment despite the fact that they have been banned in many countries for several decades. Recent epidemiologic studies have demonstrated a link between PCBs exposure and pathological alterations of bone tissues. The
Jehan A Khan et al.
Toxicology and industrial health, 28(10), 867-875 (2011-10-26)
Origanum majorana L (Doash) is one of the traditional remedy that is used as a tea and to treat ailments, in the Kingdom of Saudi Arabia. The present study has attempted to evaluate the inhibitory action of Doash fractions on
Javier Esteban et al.
Toxicology letters, 229(1), 41-51 (2014-06-03)
Polychlorinated biphenyls (PCBs) induce a broad spectrum of biochemical and toxic effects in mammals including alterations of the vital retinoid (vitamin A) system. The aim of this study was to characterize alterations of tissue retinoid levels in rat offspring and
Lubna E Elabbas et al.
Toxicology letters, 207(1), 82-88 (2011-08-23)
Exposure to polychlorinated biphenyls (PCBs) induce a broad spectrum of toxic effects in various organs including bone. The most susceptible age-groups to the toxic effects of PCBs are foetuses and infants. The aim of the present study was to quantitatively
Saydur Rahman et al.
Journal of toxicology and environmental health. Part B, Critical reviews, 14(5-7), 473-494 (2011-07-28)
Tryptophan hydroxylase (TPH), the rate-limiting enzyme in serotonin (5-HT) synthesis, performs an essential role in the maintenance of serotonergic functions in the central nervous system (CNS), including regulation of the neuroendocrine system controlling reproduction. The results of recent studies in
Yeojin Bang et al.
Neurochemistry international, 59(5), 582-590 (2011-06-23)
Because estrogen plays important neurotrophic and neuroprotective roles in the brain by activating estrogen receptors (ERs), disruption of normal estrogen signaling can leave neurons vulnerable to a variety of insults, including β-amyloid peptide (Aβ). Aroclor1254 (A1254) belongs to the endocrine-disrupting
Takuji Shoda et al.
Drug testing and analysis, 3(9), 594-596 (2011-10-01)
An enzyme-assisted synthesis of psilocin glucuronide (PCG), a metabolite excreted in the urine of magic mushroom (MM) users, is described. In the presence of Aroclor 1254 pretreated rat liver microsomes, psilocin and the cofactor UDPGA were incubated for 20 h.
Sylvie Cotelle et al.
Environmental science and pollution research international, 19(3), 628-635 (2011-09-08)
Assessment of environmental impacts from pesticide utilization should include genotoxicity studies, where the possible effects of mutagenic/genotoxic substances on individuals are assessed. In this study, the genotoxicity profile of the new formicide Macex® was evaluated with two genotoxicity tests, namely
D L Arnold et al.
Fundamental and applied toxicology : official journal of the Society of Toxicology, 31(1), 42-55 (1996-05-01)
A total of 80 menstruating rhesus monkeys (Macaca mulatta) were equally and randomly divided among groups receiving 0, 5, 20, 40, or 80 mu g of Aroclor 1254/kg body weight/day during a 6-year toxicological-reproduction study. During the first 3 years
Te-Hao Chen et al.
Ecotoxicology and environmental safety, 75(1), 207-212 (2011-09-23)
Polychlorinated biphenyls (PCBs) are a group of widespread contaminants, and accumulation of PCBs has been observed in corals in the field. However, the toxic effects of PCBs on corals have not been investigated. In this study, we tested short and
Kyung Ho Kim et al.
Neurotoxicology, 32(6), 981-985 (2011-05-17)
Ortho-substituted polychlorinated biphenyls (PCBs) are a concern to human developmental health. Rat dams were exposed to an environmentally relevant mixture of PCBs, Aroclor 1254, or pure congener PCB 95 (6 mg/kg/day) during the perinatal period (GD 5 through PD 21).
Qing Wang et al.
Ecotoxicology (London, England), 21(6), 1617-1624 (2012-06-12)
To assess the potential toxicity of polycyclic aromatic hydrocarbons and polychlorinated biphenyls on the early development of Meretrix meretrix, the effects of benzo[a]pyrene (Bap) and Aroclor1254 on embryogenesis and larval development were investigated using static laboratory toxicity tests at nominal
Qiuli Shan et al.
Toxicology and applied pharmacology, 276(2), 136-146 (2014-03-04)
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs) are persistent organic pollutants found as complex mixtures in the environment throughout the world. Therefore, humans are ubiquitously and simultaneously exposed to TCDD and PCBs. TCDD and PCBs alone have been linked to atherosclerosis.
Dae Hyun Baek et al.
International journal of toxicology, 30(5), 498-509 (2011-10-21)
We developed a new end point of the mouse stem cell test (EST) for developmental neurotoxicity. We tested 2 developmental neurotoxicants, namely, lead (II) acetate and Aroclor 1254, using this EST. Our results showed that lead (II) acetate is nonembryotoxic
Lidia Strużyńska et al.
Toxicology, 300(1-2), 12-18 (2012-05-26)
Aroclor 1254, a commercially produced mixture of polychlorinated biphenyls, is known to cause many adverse conditions, including neurotoxicity. It has been recently postulated that upregulation of N-methyl-d-aspartate receptors (NMDARs) and enhanced glutamate signalling which leads to excitotoxicity, is the mechanism
Shweta Pathak et al.
Indian journal of experimental biology, 51(6), 477-480 (2013-08-10)
Aroclor 1254, a polychlorinated biphenyl, is present in the environment in low concentration but references on its toxic effects on liver cell membrane proteins and the mechanism of actions are not abundantly available. Therefore, the present study was undertaken to
Donna W Lee et al.
Toxicological sciences : an official journal of the Society of Toxicology, 125(2), 496-508 (2011-11-19)
Recent epidemiologic studies have demonstrated a link between organochlorine and pesticide exposure to an enhanced risk for neurodegenerative disorders such as Parkinson's disease (PD). A common biological phenomenon underlying cell injury associated with both polychlorinated biphenyl (PCB) exposure and dopaminergic
Dae Hyun Baek et al.
Toxicology mechanisms and methods, 22(2), 118-130 (2011-11-16)
We developed and analyzed a new surrogate endpoint of the mouse embryonic stem cell test (EST) for developmental neurotoxicity. To determine the sensitivity, specificity, and transferability of the new endpoint, a pre-validation team from three independent laboratories optimized and standardized
Luigi Formisano et al.
The Journal of pharmacology and experimental therapeutics, 338(3), 997-1003 (2011-06-23)
Chronic exposure to polychlorinated biphenyls (PCBs), a class of ubiquitous environmental toxicants, causes neurocognitive anomalies. The transcription factor repressor element 1-silencing transcription factor (REST) plays a critical role in neuronal phenotype elaboration in both neural progenitor cells and non-neuronal cells.
Steve Wiseman et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 154(3), 254-260 (2011-07-13)
The objective of this study was to investigate the impact of short-term exposure to polychlorinated biphenyls on the acute stress response in rainbow trout. Fish were exposed to dietary Aroclor1254 (10mg kg(-1) body mass/day) for 3 days and then subjected
Wojciech Hilgier et al.
Neurotoxicology, 33(1), 16-22 (2011-11-03)
Aroclor 1254 is a mixture of polychlorinated biphenyls (PCBs), a class of environmental toxins which cause a wide spectrum of neurotoxic effects. Learning and memory deficits are the profound effects of PCBs which may be related to hippocampal dysfunction. To
Prasada Rao S Kodavanti et al.
Toxicology and applied pharmacology, 256(3), 290-299 (2011-07-28)
The vast literature on the mode of action of polychlorinated biphenyls (PCBs) indicates that PCBs are a unique model for understanding the mechanisms of toxicity of environmental mixtures of persistent chemicals. PCBs have been shown to adversely affect psychomotor function
Hamdy A A Aly
Environmental toxicology and pharmacology, 36(2), 274-283 (2013-05-21)
Aroclor 1254, a commercial mixture of highly toxic environmental pollutant, is known to cause testicular toxicity. The present study was undertaken to delineate and elucidate the nature and the mechanism of action of Aroclor 1254 on rat sperm in vitro.
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