488577

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Showing 1-16 of 16 results for "488577" within Papers

Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics.

Xianlin Han et al.

PloS one, 6(7), e21643-e21643 (2011-07-23)

The development of plasma biomarkers could facilitate early detection, risk assessment and therapeutic monitoring in Alzheimer's disease (AD). Alterations in ceramides and sphingomyelins have been postulated to play a role in amyloidogensis and inflammatory stress related neuronal apoptosis; however few

Prenatal exposure to the contaminant perfluorooctane sulfonate elevates lipid peroxidation during mouse fetal development but not in the pregnant dam.

Y Y Lee et al.

Free radical research, 49(8), 1015-1025 (2015-03-20)

Perfluorooctane sulfonate (PFOS), a member of the perfluorinated chemical family, has been convincingly demonstrated to affect lipid metabolism in animals and humans and readily crosses the placenta to exert its effects on the developing fetuses. While its exact mechanism is

PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity.

Fubito Nakatsu et al.

The Journal of cell biology, 199(6), 1003-1016 (2012-12-12)

Plasma membrane phosphatidylinositol (PI) 4-phosphate (PtdIns4P) has critical functions via both direct interactions and metabolic conversion to PI 4,5-bisphosphate (PtdIns(4,5)P₂) and other downstream metabolites. However, mechanisms that control this PtdIns4P pool in cells of higher eukaryotes remain elusive. PI4KIIIα, the

LDL induces cholesterol loading and inhibits endothelial proliferation and angiogenesis in Matrigels: correlation with impaired angiogenesis during wound healing.

Yedida Y Bogachkov et al.

American journal of physiology. Cell physiology, 318(4), C762-C776 (2020-01-30)

Hypercholesterolemia is a major risk factor for adverse cardiovascular outcomes, but its effect on angiogenesis and wound healing is not well understood. In this study, using a combination of mass spectrometry and laurdan two-photon imaging, we show that elevated levels

Lipid Deposition on Contact Lenses when Using Contemporary Care Solutions.

Negar Babaei Omali et al.

Optometry and vision science : official publication of the American Academy of Optometry, 94(9), 919-927 (2017-08-18)

There remains only a small amount of data from human studies demonstrating the effect of contact lens/lens care solution combinations on the deposition of lipids. Therefore, information on the degree to which modern materials deposit lipids when used with contemporary

A microbubble-sparged yeast propagation-fermentation process for bioethanol production.

Vijayendran Raghavendran et al.

Biotechnology for biofuels, 13, 104-104 (2020-06-12)

Industrial biotechnology will play an increasing role in creating a more sustainable global economy. For conventional aerobic bioprocesses supplying O2 can account for 15% of total production costs. Microbubbles (MBs) are micron-sized bubbles that are widely used in industry and

Neuropeptide Y and orexin immunoreactivity in the sparrow brain coincide with seasonal changes in energy balance and steroids.

H Bobby Fokidis et al.

The Journal of comparative neurology, 527(2), 347-361 (2018-09-19)

The transition between the breeding and nonbreeding states is often marked by a shift in energy balance. Despite this well-known shift in energy balance, little work has explored seasonal differences in the orexigenic neuropeptides that regulate food intake in wild

A nematode sterol C4α-methyltransferase catalyzes a new methylation reaction responsible for sterol diversity.

Wenxu Zhou et al.

Journal of lipid research, 61(2), 192-204 (2019-09-25)

Primitive sterol evolution plays an important role in fossil record interpretation and offers potential therapeutic avenues for human disease resulting from nematode infections. Recognizing that C4-methyl stenol products [8(14)-lophenol] can be synthesized in bacteria while C4-methyl stanol products (dinosterol) can

Role of 6-O-α-maltosyl-β-cyclodextrin in lysosomal cholesterol deprivation in Npc1-deficient Chinese hamster ovary cells.

Yasuyo Okada et al.

Carbohydrate research, 455, 54-61 (2017-11-25)

We aimed to investigate whether 6-O-α-maltosyl-β-cyclodextrin (Mal-βCD) is incorporated into cells and lysosomes during the release of unesterified cholesterol in Npc1-deficient Chinese hamster ovary (CHO) cells (Npc1 KO cells) and CHO-JP17 cells (JP17 cells). Internalization of Mal-βCD in cells and lysosomes and

Sex dimorphism in an animal model of multiple sclerosis: Focus on pregnenolone synthesis.

S Giatti et al.

The Journal of steroid biochemistry and molecular biology, 199, 105596-105596 (2020-01-21)

Neuroactive steroids, molecules produced from cholesterol in steroidogenic cells (i.e., peripheral glands and nervous system) are physiological modulators and protective agents of nervous function. A possible role for neuroactive steroids in the sex-dimorphic clinical manifestation, onset and progression of Multiple

A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis.

David Wheeler et al.

Brain : a journal of neurology, 131(Pt 11), 3092-3102 (2008-09-06)

Maintaining the appropriate complement and content of lipids in cellular membranes is critical for normal neural function. Accumulating evidence suggests that even subtle perturbations in the lipid content of neurons and myelin can disrupt their function and may contribute to

Simultaneous Analysis of Free and Sulfated Steroids by Liquid Chromatography/Mass Spectrometry with Selective Mass Spectrometric Scan Modes and Polarity Switching.

Su Hyeon Lee et al.

Analytical chemistry, 88(23), 11624-11630 (2016-12-10)

Sulfated steroids can act as a latent form of active free steroids, coexisting with them in biological specimens. To evaluate the metabolic significance of free and sulfated steroid species, a simultaneous analysis of eight free steroids [cholesterol, pregnenolone, 17α-hydroxypregnenolone, progesterone

The Production of Matchout-Deuterated Cholesterol and the Study of Bilayer-Cholesterol Interactions.

Sarah Waldie et al.

Scientific reports, 9(1), 5118-5118 (2019-03-28)

The deuteration of biomolecules provides advanced opportunities for neutron scattering studies. For low resolution studies using techniques such as small-angle neutron scattering and neutron reflection, the level of deuteration of a sample can be varied to match the scattering length

Efficacy of Cholesterol Nose-to-Brain Delivery for Brain Targeting in Huntington's Disease.

Alice Passoni et al.

ACS chemical neuroscience, 11(3), 367-372 (2019-12-21)

The current pharmacological treatment of Huntington's disease (HD) is palliative, and therapies to restore functions in patients are needed. One of the pathways affected in HD involves brain cholesterol (Chol) synthesis, which is essential for optimal synaptic transmission. Recently, it

Influence of the sebaceous gland density on the stratum corneum lipidome.

Matteo Ludovici et al.

Scientific reports, 8(1), 11500-11500 (2018-08-02)

The skin surface lipids (SSL) result from the blending of sebaceous and epidermal lipids, which derive from the sebaceous gland (SG) secretion and the permeability barrier of the stratum corneum (SC), respectively. In humans, the composition of the SSL is

A low carbohydrate, high protein diet suppresses intratumoral androgen synthesis and slows castration-resistant prostate tumor growth in mice.

H Bobby Fokidis et al.

The Journal of steroid biochemistry and molecular biology, 150, 35-45 (2015-03-24)

Dietary factors continue to preside as dominant influences in prostate cancer prevalence and progression-free survival following primary treatment. We investigated the influence of a low carbohydrate diet, compared to a typical Western diet, on prostate cancer (PCa) tumor growth in

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