491985

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Showing 1-7 of 7 results for "491985" within Papers

Evolution of Mechanisms that Control Mating in Drosophila Males.

Osama M Ahmed et al.

Cell reports, 27(9), 2527-2536 (2019-05-30)

Genetically wired neural mechanisms inhibit mating between species because even naive animals rarely mate with other species. These mechanisms can evolve through changes in expression or function of key genes in sensory pathways or central circuits. Gr32a is a gustatory

Metabolomics study of hepatocellular carcinoma: discovery and validation of serum potential biomarkers by using capillary electrophoresis-mass spectrometry.

Jun Zeng et al.

Journal of proteome research, 13(7), 3420-3431 (2014-05-24)

Hepatocellular carcinoma (HCC) is one of the most lethal malignancies. The lack of effective screening methods for early diagnosis has been a longstanding bottleneck to improve the survival rate. In the present study, a capillary electrophoresis-time-of-flight mass spectrometry (CE-TOF/MS)-based metabolomics

Succinate Can Shuttle Reducing Power from the Hypoxic Retina to the O2-Rich Pigment Epithelium.

Celia M Bisbach et al.

Cell reports, 31(5), 107606-107606 (2020-05-07)

When O2 is plentiful, the mitochondrial electron transport chain uses it as a terminal electron acceptor. However, the mammalian retina thrives in a hypoxic niche in the eye. We find that mitochondria in retinas adapt to their hypoxic environment by

Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages.

Amanda Swain et al.

Nature metabolism, 2(7), 594-602 (2020-07-23)

Following activation, macrophages undergo extensive metabolic rewiring1,2. Production of itaconate through the inducible enzyme IRG1 is a key hallmark of this process3. Itaconate inhibits succinate dehydrogenase4,5, has electrophilic properties6 and is associated with a change in cytokine production4. Here, we

Growth strategy of microbes on mixed carbon sources.

Xin Wang et al.

Nature communications, 10(1), 1279-1279 (2019-03-22)

A classic problem in microbiology is that bacteria display two types of growth behavior when cultured on a mixture of two carbon sources: the two sources are sequentially consumed one after another (diauxie) or they are simultaneously consumed (co-utilization). The

FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle.

M Zaeem Cader et al.

Cell, 180(2), 278-295 (2020-01-25)

Mutations in FAMIN cause arthritis and inflammatory bowel disease in early childhood, and a common genetic variant increases the risk for Crohn's disease and leprosy. We developed an unbiased liquid chromatography-mass spectrometry screen for enzymatic activity of this orphan protein.

Simplified Intestinal Microbiota to Study Microbe-Diet-Host Interactions in a Mouse Model.

Petia Kovatcheva-Datchary et al.

Cell reports, 26(13), 3772-3783 (2019-03-28)

The gut microbiota can modulate human metabolism through interactions with macronutrients. However, microbiota-diet-host interactions are difficult to study because bacteria interact in complex food webs in concert with the host, and many of the bacteria are not yet characterized. To

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