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Showing 1-30 of 3448 results for "49781" within Papers
Daniel J O'Neill et al.
Epigenetics, 9(7), 942-950 (2014-04-23)
The lysine methyltransferase SETD6 modifies the histone variant H2AZ, a key component of nuclear receptor-dependent transcription. Herein, we report the identification of several factors that associate with SETD6 and are implicated in nuclear hormone receptor signaling. Specifically, SETD6 associates with
Thaisa Moro Cantu-Jungles et al.
Carbohydrate polymers, 122, 276-281 (2015-03-31)
Primary cell wall polysaccharides from aqueous extract of buriti fruit pulp (Mauritia flexuosa, an exotic tropical palm) were isolated and characterized. After freeze-thaw and α-amylase treatments, extracted polysaccharides were purified by sequential ultrafiltration through membranes. Two homogeneous fractions were obtained
Katsuhiro Hayashi et al.
International journal of clinical oncology, 19(4), 731-738 (2013-07-25)
Low-grade osteosarcoma, including low-grade central osteosarcoma and parosteal osteosarcoma, is an extremely rare variant, and the diagnosis is occasionally difficult. In this article we present cases of low-grade osteosarcomas that should be reviewed by a clinical oncologist. Nine cases of
Matthew B Brecher et al.
Protein science : a publication of the Protein Society, 24(1), 117-128 (2014-10-30)
Methylation of flavivirus RNA is vital for its stability and translation in the infected host cell. This methylation is mediated by the flavivirus methyltransferase (MTase), which methylates the N7 and 2'-O positions of the viral RNA cap by using S-adenosyl-l-methionine
Liberty François-Moutal et al.
Pain, 156(7), 1247-1264 (2015-03-19)
Targeting proteins within the N-type voltage-gated calcium channel (CaV2.2) complex has proven to be an effective strategy for developing novel pain therapeutics. We describe a novel peptide aptamer derived from the collapsin response mediator protein 2 (CRMP2), a CaV2.2-regulatory protein.
Dominik R Haudenschild et al.
Biochemical and biophysical research communications, 455(1-2), 84-89 (2014-12-03)
In order to realize the goal of stratified and/or personalized medicine in the clinic, significant advances in the field of biomarker discovery are necessary. Adding to the abundance of nucleic acid biomarkers being characterized, additional protein biomarkers will be needed
Kerstin Klare et al.
The Journal of cell biology, 210(1), 11-22 (2015-07-01)
Kinetochores are multisubunit complexes that assemble on centromeres to bind spindle microtubules and promote faithful chromosome segregation during cell division. A 16-subunit complex named the constitutive centromere-associated network (CCAN) creates the centromere-kinetochore interface. CENP-C, a CCAN subunit, is crucial for
Tracy A Mask et al.
Theriogenology, 84(2), 261-267 (2015-04-30)
Immunocontraception with porcine ZP (pZP) can be an effective means of fertility control in feral horses. Previous studies suggest that antibodies produced after pZP vaccination may both inhibit fertilization and cause follicular dysgenesis. Zonastat-H, PZP-22, and SpayVac are three pZP
Carsten Külheim et al.
BMC genomics, 16, 450-450 (2015-06-13)
Terpenoids are abundant in the foliage of Eucalyptus, providing the characteristic smell as well as being valuable economically and influencing ecological interactions. Quantitative and qualitative inter- and intra- specific variation of terpenes is common in eucalypts. The genome sequences of
Jeffrey C Chandler et al.
Journal of proteome research, 14(2), 664-675 (2014-12-17)
Francisella tularensis causes disease (tularemia) in a large number of mammals, including man. We previously demonstrated enhanced efficacy of conventional antibiotic therapy for tularemia by postexposure passive transfer of immune sera developed against a F. tularensis LVS membrane protein fraction
Weixing Zhao et al.
Nucleic acids research, 43(8), 4055-4066 (2015-03-31)
The evolutionarily conserved Hop2-Mnd1 complex is a key cofactor for the meiosis-specific recombinase Dmc1. However, emerging evidence has revealed that Hop2-Mnd1 is expressed in somatic tissues, primary human fibroblasts and cell lines, and that it functions in conjunction with the
V Quisth et al.
Diabetologia, 48(5), 946-953 (2005-03-22)
The regulation of skeletal muscle lipolysis is not fully understood. In the present study, the effects of systemic and local noradrenaline administration on lipolysis and blood flow rates in skeletal muscle and adipose tissue were studied in vivo. First, circulating
Juliana Ben et al.
Neurochemical research, 39(12), 2492-2500 (2014-10-16)
The epileptogenesis process involves cell signaling events associated with neuroplasticity. The mitogen-activated protein kinases (MAPKs) integrate signals originating from a variety of extracellular stimuli and may regulate cell differentiation, survival, cell death and synaptic plasticity. Here we compared the total
Tawut Rudtanatip et al.
Fish & shellfish immunology, 47(1), 231-238 (2015-09-13)
Previous studies demonstrated that sulfated galactans (SG) from Gracilaria fisheri (G. fisheri) exhibit immunostimulant activity in shrimp. The present study was conducted to test the hypothesis that SG stimulates signaling molecules of the immune response of shrimp by binding to
Reeder M Robinson et al.
Archives of biochemistry and biophysics, 550-551, 58-66 (2014-04-29)
The mechanism of Mycobacterium smegmatis G (MbsG), a flavin-dependent l-lysine monooxygenase, was investigated under steady-state and rapid reaction conditions using primary and solvent kinetic isotope effects, substrate analogs, pH and solvent viscosity effects as mechanistic probes. The results suggest that
Yang Yu et al.
Journal of neural transmission (Vienna, Austria : 1996), 122(4), 593-606 (2014-08-13)
Sporadic Alzheimer's disease (AD) is a multifactorial metabolic brain disorder characterized by progressive neurodegeneration. Decreased brain energy and glucose metabolism occurs before the appearance of AD symptoms and worsens while the disease progresses. Deregulated brain insulin signaling has also been
Mona El Refaey et al.
PloS one, 9(4), e91108-e91108 (2014-04-15)
The physiologic oxygen pressures inside the bone marrow environment are much lower than what is present in the peripheral circulation, ranging from 1-7%, compared to values as high as 10-13% in the arteries, lungs and liver. Thus, experiments done with
Benita Sjögren et al.
PloS one, 10(5), e0123581-e0123581 (2015-05-15)
The ubiquitin-proteasome system for protein degradation plays a major role in regulating cell function and many signaling proteins are tightly controlled by this mechanism. Among these, Regulator of G Protein Signaling 2 (RGS2) is a target for rapid proteasomal degradation
Anshul Sharma et al.
Macromolecular bioscience, 15(2), 200-214 (2014-10-11)
Here we report on the modular synthesis and characterization of biodegradable, controlled porous, liquid crystal elastomers (LCE) and their use as three-dimensional cell culture scaffolds. The elastomers were prepared by cross-linking of star block-co-polymers with pendant cholesterol units resulting in
Björn Boll et al.
Pharmaceutical research, 32(12), 3952-3964 (2015-07-22)
The goal of this study was to compare and evaluate two preparative techniques for fractionation of proteinaceous subvisible particles. This work enables future studies to address the potential biological consequences of proteinaceous subvisible particles in protein therapeutic products. Particles were
Zachary DeLoughery et al.
Toxicological sciences : an official journal of the Society of Toxicology, 143(1), 54-63 (2014-10-08)
Hexavalent chromium is a human respiratory carcinogen that undergoes intracellular activation in vivo primarily via reduction with ascorbate. Replication of Cr-adducted DNA triggers mismatch repair that generates toxic DNA double-strand breaks (DSBs) as secondary lesions. Here, we examined the intranuclear distribution
Dailun Hu et al.
Journal of translational medicine, 13, 205-205 (2015-07-01)
The failure in standard triple therapy has recently increased to high levels in China, primarily because of insufficient patient compliance, antimicrobial resistance, and high costs. Effective prevention and eradication of Helicobacter pylori (H. pylori) by artificial passive immunization with orally
Guillaume Desnoyers et al.
Molecular cancer research : MCR, 13(10), 1421-1430 (2015-06-10)
The eIF3e protein is a component of the multisubunit eIF3 complex, which is essential for cap-dependent translation initiation. Decreased eIF3e expression is often observed in breast and lung cancer and has been shown to induce epithelial-to-mesenchymal transition (EMT) in breast
Tanusree Paul et al.
European journal of cancer (Oxford, England : 1990), 50(11), 1855-1863 (2014-05-27)
Epidermal growth factor receptor inhibitor (EGFRI) induced skin toxicity has a prognostic value suggesting skin toxicity can be a useful surrogate marker for successful epidermal growth factor receptor (EGFR) inhibition, improved response and survival. But the pathophysiology of EGFRI induced
Melinda L Micallef et al.
BMC microbiology, 14, 213-213 (2014-09-10)
The hapalindole-type family of natural products is a group of hybrid isoprenoid-indole alkaloids, produced solely by members of the Subsection V cyanobacterial strains. This family broadly includes the hapalindoles, welwitindolinones, fisherindoles and ambiguines amongst others, all of which have an
Xiaobin Yang et al.
European journal of pharmacology, 765, 209-216 (2015-08-25)
This work aimed to investigate the therapeutic effect of curcumin on sublesional bone loss induced by spinal cord injury (SCI) in rats. SCI model in this work was generated in rats by surgical transaction of the cord at the T10-12
Kaihua Zhang et al.
Oncotarget, 5(19), 9281-9294 (2014-09-23)
In head and neck squamous cell cancer (HNSCC), four intrinsic subtypes (or groups) have been identified, and each one possesses a unique biology that will require specific treatment strategies. We previously reported that mesenchymal (group 2) tumors exhibit reduced levels
Chih-Hung Chiang et al.
Cell transplantation, 24(3), 541-559 (2015-02-11)
Acute hepatic failure (AHF) is a severe liver injury leading to sustained damage and complications. Induced pluripotent stem cells (iPSCs) may be an alternative option for the treatment of AHF. In this study, we reprogrammed human dental pulp-derived fibroblasts into
B Rasti et al.
Journal of liposome research, 24(2), 99-105 (2013-10-09)
This study presents the application of the response surface methodology (design) to develop an optimal preparation condition (independent variables) namely shear rate (600-1000 rpm), mixing time (30-60 min), and sonication time (10-20 min) for polyunsaturated fatty acids (docosahexaenoic acid and
L H Vähätalo et al.
Acta physiologica (Oxford, England), 213(4), 902-919 (2014-12-09)
Neuropeptide Y (NPY) co-localized with noradrenaline in central and sympathetic nervous systems seems to play a role in the control of energy metabolism. In this study, the aim was to elucidate the effects and pathophysiological mechanisms of increased NPY in
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