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Showing 1-30 of 2746 results for "51976" within Papers
Zachary Yu-Ching Lin et al.
Developmental biology, 400(1), 43-58 (2015-01-28)
Mammalian spermatogenesis has been investigated extensively in rodents and a strictly controlled developmental process has been defined at cellular and molecular levels. In comparison, primate spermatogenesis has been far less well characterized. However, important differences between primate and rodent spermatogenesis
Maria A Agapito et al.
Endocrinology, 155(7), 2578-2588 (2014-05-07)
Early-life ethanol feeding (ELAF) alters the metabolic function of proopiomelanocortin (POMC)-producing neurons and the circadian expression of clock regulatory genes in the hypothalamus. We investigated whether the circadian mechanisms control the action of ELAF on metabolic signaling genes in POMC
Talent Chipiti et al.
Acta poloniae pharmaceutica, 72(1), 119-127 (2015-04-09)
The study was intended to explore the antioxidant potential and phytochemical content of the ethanol and aqueous extracts of the leaf and root samples of Cissus cornifolia (Baker) Splanch (Vitaceae) across a series of four in vitro models. The results
Francesco Del Giudice et al.
Lab on a chip, 15(3), 783-792 (2014-12-02)
A novel method to estimate the relaxation time of viscoelastic fluids, down to milliseconds, is here proposed. The adopted technique is based on the particle migration phenomenon occurring when the suspending viscoelastic fluid flows in microfluidic channels. The method is
J N Gutiérrez-Rivera et al.
Diseases of aquatic organisms, 112(3), 185-197 (2015-01-16)
Proliferation of Perkinsus marinus (Dermo) in vitro is inhibited by the action of 2 serine protease inhibitors belonging to the I-84 family. We compared the levels of expression of serine protease inhibitors 1 and 2 (SPI-1 and SPI-2) in 2
Elisabetta Casarin et al.
Fitoterapia, 98, 241-247 (2014-08-12)
A different behavior of the two dibenzocyclooctadiene lignans (+)-deoxyschisandrin (1) and (-)-gomisin N (2), from Schisandra chinensis fruits, was observed against two human tumour cell lines, (2008 and LoVo). These lignans inhibited cell growth in a dose-dependent manner on both
Frithjof Lohmann et al.
Biochimica et biophysica acta, 1842(7), 945-958 (2014-03-04)
Podocytes are terminally differentiated cells of the glomerular filtration barrier that react with hypertrophy in the course of injury such as in membranous nephropathy (MGN). The neuronal deubiquitinase ubiquitin C-terminal hydrolase L1 (UCH-L1) is expressed and activated in podocytes of
Shannon M Clarke et al.
PloS one, 9(4), e93392-e93392 (2014-04-18)
Accurate pedigree information is critical to animal breeding systems to ensure the highest rate of genetic gain and management of inbreeding. The abundance of available genomic data, together with development of high throughput genotyping platforms, means that single nucleotide polymorphisms
Ana Belen Lopez-Rodriguez et al.
Cerebral cortex (New York, N.Y. : 1991), 25(1), 35-45 (2013-08-21)
Traumatic brain injury (TBI) and its consequences represent one of the leading causes of death in young adults. This lesion mediates glial activation and the release of harmful molecules and causes brain edema, axonal injury, and functional impairment. Since glial
Miglė Graužinytė et al.
Angewandte Chemie (International ed. in English), 54(5), 1456-1460 (2014-12-10)
Millimeter-scale tubes are observed to sprout from water droplets injected into a bath of toluene containing ethanol and silica colloids. This phenomenon requires that first a membrane is formed by the colloids which self-assemble at the droplet interface, and second
Karpagavalli Ramji et al.
Journal of biomaterials applications, 29(3), 411-422 (2014-04-09)
Electrospun fibers with an average fiber diameter in the nanometer range were prepared from soy protein isolate to develop scaffolds for tissue engineering applications. Poly(ethylene oxide) was added to facilitate fiber formation. The influence of processing parameters such as applied
Luka Mihajlovic et al.
Phytochemistry, 109, 125-132 (2014-12-04)
Phenolic composition of Ambrosia artemisiifolia L. pollen and sub-pollen particles (SPP) aqueous extracts was determined, using a novel extraction procedure. Total phenolic and flavonoid content was determined, as well as the antioxidative properties of the extract. Main components of water-soluble
Emily E Noble et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(6), R737-R745 (2014-07-06)
Central oxytocin reduces food intake and increases energy expenditure. The ventromedial hypothalamic nucleus (VMN) is associated with energy balance and contains a high density of oxytocin receptors. We hypothesized that oxytocin in the VMN is a negative regulator of energy
Qiaozhen Yu et al.
Journal of biomedical materials research. Part A, 103(2), 721-729 (2014-05-16)
An axially aligned three-dimensional (3-D) fibrous scaffold was fabricated with regenerated spider silk protein (RSSP)/poly (l-lactic acid) (PLLA) through electrospinning and post treatment. The morphology, mechanical and degradation properties of the scaffold were controlled through the weight ratio of RSSP
Huiping Zhang et al.
Human genetics, 133(11), 1383-1394 (2014-07-31)
Chronic alcohol consumption may induce gene expression alterations in brain reward regions such as the prefrontal cortex (PFC), modulating the risk of alcohol use disorders (AUDs). Transcriptome profiles of 23 AUD cases and 23 matched controls (16 pairs of males
Dafna Kanny et al.
MMWR. Morbidity and mortality weekly report, 63(53), 1238-1242 (2015-01-13)
Alcohol poisoning is typically caused by binge drinking at high intensity (i.e., consuming a very large amount of alcohol during an episode of binge drinking). Approximately 38 million U.S. adults report binge drinking an average of four times per month
Jara Majuelos-Melguizo et al.
Oncotarget, 6(7), 4790-4803 (2015-01-13)
Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and one of the most aggressive cancers. PARP-1 is a nuclear protein involved in multiple facets of DNA repair and transcriptional regulation. In this study we dissected the
Jeongyub Kim et al.
Stem cells and development, 24(3), 284-295 (2014-09-18)
There is a growing body of evidence that small subpopulations of cells with stem cell-like characteristics within most solid tumors are responsible for the malignancy of aggressive cancer cells and that targeting these cells might be a good therapeutic strategy
Charles S Elmore et al.
Journal of labelled compounds & radiopharmaceuticals, 57(5), 342-349 (2014-04-05)
In support of a program to develop an alpha 7 agonist as a treatment for Alzheimer's disease, three drug candidates, 1, 2, and 3, were prepared in labeled forms. Compound 1 was prepared in C-14 labeled form by lithiation of
Shanshan Cheng et al.
The international journal of biochemistry & cell biology, 57, 186-196 (2014-12-03)
Impairment in the microRNA (miRNA) network causes a number of neurodegenerative diseases. Endoribonuclease Dicer is a key RNase to produce mature miRNAs. It has been shown that Dicer is important for the maintenance of excitatory neuron survival during early postnatal
William J Chapin et al.
Pharmacogenetics and genomics, 25(3), 126-133 (2015-01-08)
Despite of the common usage of glucocorticoids (GCs), a significant portion of asthma patients exhibit GC insensitivity. This could be mediated by diverse mechanisms, including genomics. Recent work has suggested that measuring changes in gene expression may provide more predictive
Federico Colombo et al.
PloS one, 9(12), e114787-e114787 (2014-12-11)
Despite continuous improvements in therapeutic protocols, cancer-related mortality is still one of the main problems facing public health. The main cause of treatment failure is multi-drug resistance (MDR: simultaneous insensitivity to different anti-cancer agents), the underlying molecular and biological mechanisms
Malgorzata Kotula-Balak et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(3), 529-537 (2015-01-03)
Our previous studies revealed that in bank vole testicular cells octylphenol (OP) action is related either to its binding to estrogen receptors or increasing cAMP level that modulates spermatozoa motility and acrosome reaction (AR), (Kotula-Balak et al., 2011, 2014). To
H M S Qodriyah et al.
Pakistan journal of biological sciences : PJBS, 16(23), 1815-1818 (2014-02-11)
The effect of treatment with Radix on ethanol-induced gastric lesions was investigated. The main ingredient of Radix is Eurycoma longifolia. Twenty-four rats of the Sprague-Dawley species were randomly divided into four groups. Three groups were given 0.5 mL 100% ethanol
Célia Chamontin et al.
Nucleic acids research, 43(1), 336-347 (2014-12-10)
HIV-1, the agent of the AIDS pandemic, is an RNA virus that reverse transcribes its RNA genome (gRNA) into DNA, shortly after its entry into cells. Within cells, retroviral assembly requires thousands of structural Gag proteins and two copies of
Alfonso Pérez-Garrido et al.
Bioorganic & medicinal chemistry, 17(2), 896-904 (2008-12-06)
This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoretical molecular descriptors, calculated solely from the molecular structure of the compounds under investigation
Michael D Weber et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(1), 316-324 (2015-01-09)
Exposure to acute and chronic stressors sensitizes the proinflammatory response of microglia to a subsequent immune challenge. However, the proximal signal by which stressors prime microglia remains unclear. Here, high mobility group box-1 (HMGB-1) protein was explored as a potential
Takao Saito et al.
Materials science & engineering. C, Materials for biological applications, 49, 256-261 (2015-02-18)
We investigated the ability of the microscale topography of a three-dimensional (3-D) structure arrayed on the surface of a substrate to induce and maintain a cell pattern by controlling cell behavior. Arrayed 3-D structures having different topographical characteristics, i.e., geometry
Elizabeth A Hedges et al.
International journal of molecular sciences, 15(9), 15061-15072 (2014-08-29)
The α-chemokine, stromal-derived factor-1 (SDF-1), has been linked to the homing of circulating tumor cells to bone. SDF-1 is expressed by bone microvascular cells and osteoblasts and normally functions to attract blood-borne hematopoietic stem and progenitor cells to marrow. It
Saurav Bhattacharya et al.
Biomaterials, 51, 91-107 (2015-03-17)
Thymoquinone (TQ), a major active constituent of black seeds of Nigella sativa, has potential medical applications including spectrum of therapeutic properties against different cancers. However, little is known about their effect on breast cancer cell migration, which is the cause
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